Activity 2 - Lymphatic System

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Activity 2: Lymphatic system


Due: 11:59pm on Wednesday, February 15, 2023
You will receive no credit for items you complete after the assignment is due. Grading Policy

*Building Vocabulary Activity: Lymphatic System and Body Defenses

Part A - Prefixes, Roots and Suffixes


Match these prefixes, suffixes and roots to their meanings.

ANSWER:

Reset Help

The prefix anti- means "against."

The prefix lympho- means "lymph."

The prefix hyper- means "above," "beyond" or "over."

The prefix immuno- means "immune."

The prefix allo- means "different."

Correct

Part B - Vocabulary terms


Match these vocabulary terms to their meanings.
ANSWER:

Reset Help

A molecule that works against a pathogen to protect the body is a(n) antibody .

A tissue graft from another person is a(n) allograft .

When the immune system does not work properly, the patient has a(n) immunodeficiency .

A hypersensitivity results when the immune system is overstimulated.

A blood cell that travels the body in lymphatic fluid is called a(n) lymphocyte .

Correct

Audio Summary: The Lymphatic System and Body Defenses

Listen to the audio summary of chapter 12 and answer the following questions.

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Part A
Select the correct statement about adaptive immunity.

Hint 1. There are two types of defense mechanisms in the body: innate and adaptive defenses.
Adaptive immunity is subdivided into two types: humoral immunity (also known as antibody-mediated immunity) and cellular immunity (also known as cell-mediated
immunity).

ANSWER:

Adaptive defense has memory.

B cells participate in the cell-mediate immunity.

Adaptive defense is also referred as the body's second line of defense.

T cells become immunocompetent in the red bone marrow.

Adaptive defense is nonspecific.

Correct
Great job! In the adaptive defense mechanism, some activated cells will remain as a record of the immune response mounted against a particular antigen
(invader). These memory cells can reactivate a quick and vigorous response if we're reinfected with the same antigen in the future.

Part B
Which type of cells produces antibodies?

Hint 1. The crucial cells of the adaptive defense mechanism are lymphocytes and antigen-presenting cells (APCs).
There are three types of lymphocytes: NK cells, B cells, and T cells.

ANSWER:

NK cells.

Plasma cells.

Phagocytes.

Cytotoxic T cells.

Helper T cells.

Correct
Great job! Humoral or antibody-mediated immunity is provided by antibodies (immune proteins) present in the body's fluids ("humors"). When a B cell is activated,
it proliferates to form clones. Clones differentiate mostly into antibody-producing plasma cells, but some differentiate into memory cells.

Part C
Select the correct statement about T cells.

Hint 1. There are three types of T cells that play specific roles in the adaptive immune response. They include helper T cells, cytotoxic T cells, and regulatory T cells.
T cells fight their antigens directly in "cell-to-cell combat." Immunocompetent T cells are activated to form a clone by binding with a "recognized" antigen.

ANSWER:

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Regulatory T cells produce antibodies.

Cytotoxic T cells release chemicals that suppress the activity of B cells.

Helper and cytotoxic T cells become immunocompetent in the thymus while regulatory T cells become immunocompetent in the red bone marrow.

T cells are able to bind with free antigens.

Helper T cells can stimulate clone production of B cells.

Correct
Great job! Helper T cells direct and manage the adaptive cell-mediated response. Cytotoxic T cells kill cells harboring internal antigens. Regulatory T cells turn off
adaptive immune responses.

Part D
Select the correct order of events of the cell-mediated adaptive immune response:

Hint 1. T lymphocytes (T cells) participate in the cell-mediated immune response and fight intracellular antigens.
T cells can recognize and eliminate specific virus-infected or tumor cells. Antigen-presenting cells (APCs) do not respond to specific antigens but instead play an
essential role in activating the T lymphocytes that do.

ANSWER:

A cytotoxic T cell is activated; the cytotoxic T cell releases perforins and granzymes to kill virus-infected cells or cancer cells; an APC then presents the antigen
and co-stimulatory molecules.

A cytotoxic T cell releases perforins and granzymes to kill virus-infected cells or cancer cells; a cytotoxic T cell is activated; an APC then presents the antigen and
co-stimulatory molecules.

An APC presents an antigen and co-stimulatory molecules; a cytotoxic T cell releases perforins and granzymes to kill virus-infected cells or cancer cells; a
cytotoxic T cell is then activated.

An APC presents an antigen and co-stimulatory molecules; a cytotoxic T cell is activated; a cytotoxic T cell then releases perforins and granzymes to kill virus-
infected cells or cancer cells.

A cytotoxic T cell is activated; an APC presents an antigen and co-stimulatory molecules; a cytotoxic T cell then releases perforins and granzymes to kill virus-
infected cells or cancer cells.

Correct
Great job! The cell-mediated immune response begins with an antigen-presenting cell ingesting and processing a foreign antigen to display on its surface. A naive
cytotoxic T cell specific for the same antigen binds and recognizes the displayed antigen and a co-stimulatory molecule. Once activated, the cytotoxic T cell locates
cells displaying this foreign antigen and destroys them using perforins and granzymes to induce apoptosis.

Art Labeling Activity: Figure 12.2a,b

Part A
Drag the appropriate labels to their respective targets.

ANSWER:

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Reset Help

Blood capillaries Lymphatic capillaries

Flaplike minivalve Endothelial cell

Answer Requested

Art Labeling Activity: Figure 12.3

Part A
Drag the appropriate labels to their respective targets.
ANSWER:

Reset Help

Cervical nodes

Right lymphatic duct

Axillary nodes

Thoracic duct

Cisterna chyli

Inguinal nodes

Correct

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Chapter 12 Multiple Choice, Part I, Question 12

Part A
Fluids that have escaped the cardiovascular system are picked up by the ________.
ANSWER:

immune system

endocrine system

lymphatic system

respiratory system

Answer Requested

Chapter 12 Multiple Choice, Part I, Question 5

Part A

Using the figure, identify the following:

Lymphatic collecting vessels are indicated by ________.


ANSWER:

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Label A

Label B

Label C

Label D

Label E

Answer Requested

Chapter 12 Multiple Choice, Part I, Question 4

Part A

Using the figure, identify the following:

Blood capillaries are indicated by ________.

ANSWER:

Label A

Label B

Label C

Label D

Label E

Answer Requested

Chapter 12 Multiple Choice, Part II, Question 4

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Part A
Which one of the following is not a mechanism that aids lymph return to the heart?

ANSWER:

Smooth muscle contractions within the lymphatic vessels

The pumping action of the heart

Presence of valves within the larger lymph vessels

Pressure changes within the thorax

Milking action of skeletal muscles

Answer Requested

Chapter 12 True/False Question 1

Part A
The two main structures of the lymphatic system are the lymphatic vessels and the blood vessels.
ANSWER:

True

False

Answer Requested

Chapter 12 True/False Question 2

Part A
All lymph rejoins the bloodstream via the subclavian veins.
ANSWER:

True

False

Answer Requested

Art Labeling Activity: Figure 12.4

Part A

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2/13/23, 12:48 AM Activity 2: Lymphatic system
Drag the labels to the appropriate location in the figure.
ANSWER:

Reset Help

Afferent lymphatic
vessels Germinal center in
follicle Capsule

Subcapsular sinus

Trabecula

Efferent lymphatic
vessels

Hilum

Cortex
Medullary cord

Medullary sinus
Follicle

Answer Requested

Chapter 12 End of Chapter Review Reading Question 3

Part A
What tissue or organ filters lymph?
ANSWER:

tonsils

spleen

lymph node

Peyer's patches

Answer Requested

Chapter 12 Essay Question 2

Part A
Mona had some axillary lymph nodes and lymphatic vessels removed from her left arm during a recent surgery. Determine why she experiences edema (swelling) in that
arm.

ANSWER:
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2/13/23, 12:48 AM Activity 2: Lymphatic system

3785 Character(s) remaining

(none provided)

Answer Requested

Chapter 12 Multiple Choice, Part II, Question 9

Part A
What lymphoid organ stores platelets and acts as a blood reservoir?
ANSWER:

thymus

appendix

Peyer's patches

tonsils

spleen

Answer Requested

Chapter 12 Multiple Choice, Part II, Question 8

Part A
Which of the following lymphoid organs functions at peak level during youth?
ANSWER:

tonsils

Peyer's patches

lymph nodes

spleen

thymus

Answer Requested

Chapter 12 Multiple Choice, Part II, Question 6

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Part A
Which of the following is not a lymphoid organ?
ANSWER:

Thymus gland

Peyer's patches

Appendix

Spleen

Thyroid gland

Answer Requested

Art Labeling Activity: Figure 12.5

Part A
Drag the labels to the appropriate location in the figure.
ANSWER:

Reset Help

Tonsils

Thymus

Red bone marrow

Spleen

Peyer's patches
Appendix

Answer Requested

Chapter 12 Multiple Choice, Part I, Question 6

Part A

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Using the figure, identify the following:

The spleen is indicated by ________.


ANSWER:

Label A

Label B

Label C

Label D

Answer Requested

Chapter 12 Multiple Choice, Part I, Question 7

Part A

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Using the figure, identify the following:

The tonsils are indicated by ________.


ANSWER:

Label A

Label B

Label C

Label D

Answer Requested

Chapter 12 Multiple Choice, Part I, Question 11

Part A

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Using the figure, identify the following:

The lymphoid tissues that trap and remove bacteria that enter the throat are indicated by ________.
ANSWER:

Label A

Label B

Label C

Label D

Answer Requested

Chapter 12 Multiple Choice, Part I, Question 17

Part A
Peyer's patches and the tonsils are part of the collection of small lymphoid tissues that protect the upper respiratory and digestive tracts from infection and are referred to as
________.
ANSWER:

germinal centers

MALT or mucosa-associated lymphoid tissue

lymph nodes

lymphatics

Answer Requested

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Chapter 12 End of Chapter Review Reading Question 5

Part A
What is the function of complement proteins?

ANSWER:

stimulate fever

bind to foreign cells and punch holes in their surfaces

interfere with viral replication

activate antibodies

Answer Requested

Art Labeling Activity: Figure 12.9b

Part A
Drag the labels to the appropriate location in the figure.

ANSWER:

Reset Help

Phagocyte adheres to
pathogens.

Phagocyte engulfs the


particles, forming a
Phagosome phagosome.
(phagocytic vesicle)

Lysosome
Lysosome fuses with
the phagocytic vesicle,
forming a
phagolysosome.
Acid hydrolase
enzymes

Lysosomal enzymes
digest the pathogens,
leaving a residual body.

Exocytosis of the
vesicle removes
indigestible and
residual material.

Answer Requested

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2/13/23, 12:48 AM Activity 2: Lymphatic system

"Did You Get It?": Chapter 12 Question 2

Part A
What lymphoid organ produces hormones that direct the maturation of T lymphocytes?

ANSWER:

tonsil

spleen

thymus

mucosa-associated lymphoid tissue

Answer Requested

"Did You Get It?": Chapter 12 Question 5

Part A
What two cell types provide humoral and cell-mediated immunity against specific foreign antigens?
ANSWER:

B and T lymphocytes

antigen-presenting cells and B lymphocytes

T lymphocytes and antigen-presenting cells

helper T cells and cytotoxic T cells

Answer Requested

"Did You Get It?": Chapter 12 Question 6

Part A
Which cells stimulate the antibody-secreting cells and cytotoxic T cells?

ANSWER:

memory cells

helper T cells

plasma cells

regulatory cells

Answer Requested

"Did You Get It?": Chapter 12 Question 7

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Part A
Which of these is found on the surface of an antigen-presenting cell (APC)?
ANSWER:

self-antigen

cytokines

fragments of foreign pathogens ingested by the cell

antibodies

Answer Requested

Art Labeling Activity: Figure 12.16

Part A
Drag the labels to the appropriate location in the figure.
ANSWER:

Reset Help

Antigen-antibody
complex

Complement
Neutralization Agglutination Precipitation
activation

Phagocytosis Inflammation Cell lysis

Chemotaxis

Histamine release

Answer Requested

"Did You Get It?": Chapter 12 Question 10

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Part A
What type of T cell directly attacks infected cells?
ANSWER:

helper T cells

regulatory T cells

cytotoxic T cells

plasma cells

Answer Requested

Chapter 12 End of Chapter Review Reading Question 10

Part A
Why are the elderly more susceptible to infection and cancers?

ANSWER:

because the efficiency of the immune system increases with age

because immune cells proliferate in old age

because the efficiency of the immune response decreases in old age

because thinning of the skin increases the number of bacteria that breach this barrier

Answer Requested

Chapter 12 End of Chapter Review Reading Question 11

Part A
What type of immunity do vaccines provide?

ANSWER:

active, artificially acquired immunity

active, naturally acquired immunity

passive, artificially acquired immunity

passive, naturally acquired immunity

Answer Requested

Chapter 12 End of Chapter Review Reading Question 12

Part A
Where do lymphatic vessels originate during fetal development?

ANSWER:

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2/13/23, 12:48 AM Activity 2: Lymphatic system

They grow out from lymph nodes.

They bud from veins of the cardiovascular system.

Cells from the spleen migrate and form tubes that parallel blood vessels.

They bud from arterioles of the cardiovascular system.

Answer Requested

Chapter 12 Multiple Choice, Part I, Question 26

Part A
Which of the following is not a cell that behaves as an antigen-presenting cell (APC)?

ANSWER:

Dendritic cells

Macrophages

B lymphocytes

Virus

Answer Requested

Chapter 12 Multiple Choice, Part I, Question 25

Part A
T cells or B cells that are capable of responding to a specific antigen by binding to it with antigen-specific receptors that appear on the lymphocyte's surface are considered
________.

ANSWER:

self-tolerant

clones

immunocompetent

complement

Answer Requested

Chapter 12 Multiple Choice, Part I, Question 24

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Part A
Which of the following is least likely to provoke an immune response?
ANSWER:

Self-antigens

Nonself-antigens

Haptens

Incomplete antigens

Answer Requested

Chapter 12 Matching Question 14-20

Part A
Match the following biological function with its antibody class.

Match the words in the left column to the appropriate blanks in the sentences on the right. Make certain each sentence is complete before submitting your
answer.
ANSWER:

Reset Help

1. Memory cell Cell that may exist in the body for years and enable a quick response to subsequent

meetings with the same antigen

2. Regulatory T cell Cell that slows or stops B and T cell activity once infection has been conquered

3. Plasma cell Cell that produces huge numbers of the same antibody (immunoglobulin)

4. Cytotoxic T cell Cell that kills virus-infected cells, cancerous cells, and is involved in graft

rejection

5. Antigen-presenting cell (APC) Cells that engulf and present parts of antigens on the membrane

for recognition by T cells bearing receptors for the same antigen

6. B cell Cell that develops immunocompetence in the bone marrow

7. Helper T cell Cell that directs the adaptive immune response by recruiting other cells to fight the

invaders

Answer Requested

Chapter 12 Matching Question 7-13

Part A
Match the following terms with the correct description.

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2/13/23, 12:48 AM Activity 2: Lymphatic system
Match the words in the left column to the appropriate blanks in the sentences on the right. Make certain each sentence is complete before submitting your
answer.
ANSWER:

Reset Help

1. Antigen Any substance capable of provoking an immune response

2. Interferon Small protein that binds with receptors on healthy cells to promote protein synthesis

and prevent viruses from binding

3. Pyrogen Chemical secreted by white blood cells and macrophages to raise the body's

temperature

4. Perforins Chemical released by natural killer cells (NK) to cause cell lysis

5. Cytokines Chemical released by macrophages and dendritic cells to activate many other immune

cells

6. Antibody Vaccines stimulate the production of these soluble proteins

7. Keratin Chemical that provides resistance to intact skin against acids, alkalis, and bacterial

enzymes

Answer Requested

Chapter 12 Multiple Choice, Part I, Question 28

Part A
Antibodies provided by serum from an immune donor or an animal donor do not challenge the B cells and thus provide ________.

ANSWER:

active immunity

cellular or cell-mediated immunity

natural immunity

passive immunity

Answer Requested

Chapter 12 Multiple Choice, Part I, Question 29

Part A
What is the region of the antibody that varies from antibody to antibody?

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2/13/23, 12:48 AM Activity 2: Lymphatic system
ANSWER:

variable or V region

constant or C region

regional or R region

stable or S region

Answer Requested

Chapter 12 Multiple Choice, Part I, Question 30

Part A
Antibody binding that tags an antigen on a cellular target for phagocytosis is known as ________.
ANSWER:

opsonization

agglutination

precipitation

neutralization

Answer Requested

Chapter 12 Multiple Choice, Part I, Question 27

Part A
Which of the following provides active immunity that is artificially acquired?

ANSWER:

Vaccines

Serum

Antivenom

Antitoxin

Answer Requested

Chapter 12 Multiple Choice, Part I, Question 34

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Part A
AIDS cripples the immune system by interfering with the activity of cells called ________.
ANSWER:

helper T cells

antigen-presenting cells

memory cells

plasma cells

Answer Requested

Chapter 12 Multiple Choice, Part I, Question 35

Part A
Developmentally, what is the origin of lymphatic vessels?

ANSWER:

Veins of the blood vascular system

The glands of the endocrine system

The organs of the digestive system

Arteries of the blood vascular system

Answer Requested

Chapter 12 Multiple Choice, Part II, Question 28

Part A
The development of self-tolerance of ________ is critical for the T lymphocytes (T cells) and B lymphocytes (B cells) to function properly.
ANSWER:

Bacteria

Foreign blood cells

Fungi

The body's own cells

Viruses

Answer Requested

Chapter 12 Multiple Choice, Part II, Question 29

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Part A
Where do B cells develop immunocompetence?
ANSWER:

thymus gland

lymph nodes

spleen

bone marrow

thyroid gland

Answer Requested

Chapter 12 Multiple Choice, Part II, Question 35

Part A
Which one of the following is not true of the constant (C) regions of antibodies?

ANSWER:

The constant regions form the "stem" of an antibody.

The constant regions form an antigen-binding site.

The constant regions determine the specific type of antibody class formed.

The constant regions determine how an antibody class will carry out its immune role.

The constant regions are the same or nearly the same on all antibodies of a given class.

Answer Requested

Chapter 12 Multiple Choice, Part II, Question 36

Part A
Which antibody class is found in the secretions that bathe body surfaces, such as tears and mucus?

ANSWER:

IgG

IgM

IgE

IgD

IgA

Answer Requested

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Chapter 12 Multiple Choice, Part II, Question 34

Part A
Which portion of the antibody's structure determines the antibody's class?

ANSWER:

disulfide bonds

heavy chain

constant region

variable region

light chain

Answer Requested

Chapter 12 Multiple Choice, Part II, Question 33

Part A
Due to a recent respiratory illness from a viral infection, Jennifer has now developed ________.

ANSWER:

artificially acquired passive immunity

naturally acquired passive immunity

passively acquired natural immunity

naturally acquired active immunity

artificially acquired active immunity

Answer Requested

Chapter 12 Multiple Choice, Part II, Question 43

Part A
Cedric needs a kidney transplant. Which type of graft is least likely to be successful?

ANSWER:

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2/13/23, 12:48 AM Activity 2: Lymphatic system

A graft from a sibling

A graft from a friend

A graft from a recently deceased individual

A xenograft

An allograft

Answer Requested

Chapter 12 True/False Question 17

Part A
The constant region of the antibody joins heavy and light chains to form an antigen-binding site specifically made to fit an antigen.

ANSWER:

True

False

Answer Requested

Chapter 12 True/False Question 18

Part A
Antibodies can inactivate an antigen in many ways, including complement fixation, neutralization, and opsonization.
ANSWER:

True

False

Answer Requested

Chapter 12 True/False Question 20

Part A
Macrophages and dendritic cells release interferons to trigger an immune response from T cells.

ANSWER:

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2/13/23, 12:48 AM Activity 2: Lymphatic system

True

False

Answer Requested

Chapter 12 True/False Question 19

Part A
The process that occurs when antibodies clump foreign cells is called agglutination.
ANSWER:

True

False

Answer Requested

IP: Overview of Innate and Adaptive Body Defenses

Click on the link or the image below to view an animation on the innate and adaptive body defenses from Interactive Physiology (IP), then answer the questions to the right.

IP: Overview of Innate and Adaptive Body Defenses

Part A
Tears and mucus membranes would be a part of which defense system?

Hint 1.

The skin would also be considered to be in this defense system.

ANSWER:

adaptive defenses

innate internal defenses

innate external defenses

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Correct
Yes, innate external defenses (surface barriers) are the first line of defense and include tears, mucus membranes, and the skin.

Part B
Phagocytotic cells such as macrophages identify a variety of enemies by recognizing markers unique to pathogens. They would be classified as which type of defense
system?

Hint 1.
They recognize more than one specific marker. This would be considered a nonspecific defense mechanism.

ANSWER:

adaptive defenses

innate external defenses

innate internal defenses

Correct
Yes, the macrophage recognizes many molecules found on pathogens that are not present on normal body cells.

Part C
What cells make antibodies?

Hint 1.

This cell would be part of humoral immunity.

ANSWER:

memory B cells

plasma B cells

memory T cells

cytotoxic T cells

Correct
Yes, the plasma B cells make antibodies in response to specific antigens.

Part D
What is the name of the unique area (specific region) that a lymphocyte recognizes and binds to?

Hint 1.

This area is also called an epitope.

ANSWER:

antigen

pathogen

antibody

an antigenic determinant

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Correct
Yes, also called an epitope, the antigenic determinant is the specific part of an antigen that the antibody or lymphocyte antigenic determinant receptor binds to.

Part E
What type of immunity can be transferred by bodily fluids from one person to another, thus conferring immunity to the recipient?

Hint 1.
This immunity is directed against pathogens in the extracellular fluid.

ANSWER:

humoral immunity

cell-mediated immunity

cellular immunity

Correct
Yes, humoral immunity involves antibodies that can be transferred from one person to another.

Part F
If a virus attacks a cell, which type of immunity would be activated?

Hint 1.

The attacking virus would be considered an intracellular pathogen.

ANSWER:

humoral immunity

cell-mediated immunity (cellular immunity)

antibody-mediated immunity

Correct
Yes, cell-mediated immunity involves an intracellular pathogen such as a virus.

Part G
Cancer cells would be attacked by which of the following cells?

Hint 1.

This pathogen would be inside the cell.

ANSWER:

Cytotoxic T cells

B cells

macrophages

Correct
Yes, cytotoxic T cells attack cancer cells, since they are part of cell-mediated immunity.

IP: Class I and Class II MHC Proteins

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2/13/23, 12:48 AM Activity 2: Lymphatic system
Click on the link or the image below to view an animation on class I and class II MHC proteins from Interactive Physiology (IP), then answer the questions to the right.

IP: Class I and Class II MHC Proteins

Part A
Class II MHC proteins are found on which of the following cell types?

Hint 1.

MHC proteins are "self-proteins" that cradle antigens for presentation to T cells.

ANSWER:

antigen-presenting cells

all nucleated cells

Correct
Yes, class II MHC proteins are found only on antigen-presenting cells.

Part B
Which class of MHC proteins presents exogenous antigens?

Hint 1.

Exogenous antigens are those antigens that originated outside the cell.

ANSWER:

class I MHC proteins

class II MHC proteins

Correct
Yes, class II MHC proteins present antigens that originated from outside the cell (phagocytized extracellular pathogens).

Part C
Class I MHC proteins are recognized by which of the following cell types (that are destined to become T cells)?

ANSWER:

CD8

CD4

Correct
Yes, class I MHC proteins are recognized by CD8 cells.

Part D
Which of the following types of cells display protein fragments produced by the cancer within them?

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Hint 1.

These protein fragments are considered endogenous proteins.

ANSWER:

macrophages

dendritic cells

B cells

all nucleated cells

Correct
Yes, nucleated body cells bring pieces of endogenous proteins to the surface to display on the MHC protein.

Part E
Which major class of lymphocytes become cytotoxic T cells?

Hint 1.

There are two major populations of T cells named by the glycoproteins expressed on the cell membrane.

ANSWER:

CD6 cells

CD4 cells

CD8 cells

Correct
Yes, CD8 cells become cytotoxic T cells.

Reading Question: Antibodies

Part A - Monoclonal Antibodies


Monoclonal antibodies are commercial preparations of a pure antibody that reacts to a single antigen. Which of these are examples of current uses of monoclonal
antibodies?
Select all that apply.
ANSWER:

diagnosis pregnancy

treat hepatitis

treat rabies

deliver drugs to fight cancer

early cancer diagnosis

Answer Requested

Reading Question: Effects of Aging on Immunity

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Part A - Effects of Aging on Immunity


As with many other body systems, immune system function decreases with age. Which of the following statements describe(s) the effects of aging on immunity?
Select all correct answers.

ANSWER:

Antibody production increases.

The chance of developing an autoimmune disease increases.

Immunodeficiency disease is less likely to occur.

Cancer becomes more common.

Answer Requested

Reading Question: Origin of Lymphatic System

Part A - Origin of Lymphatic System


The lymphatic system includes vessels and organs to transport fluids and defense elements. Which of the following statements describe(s) its development?
Select all correct statements.

ANSWER:

Lymph organs are all formed from lymph nodes.

Lymphatic vessels are formed from veins beginning before the fifth week of development.

Lymphocytes populate lymphatic tissues and organs by the fifth week of development.

Shortly after birth, lymphocytes are common in lymphoid organs.

The thymus and spleen are the first lymph organs to appear in the embryo.

Answer Requested

Interactive Activity: Types of Adaptive Immunity

Part A - Arms of the Adaptive Defense System


Adaptive immunity comprises two branches: humoral immunity and cellular immunity. What are the characteristics of each of the two arms of the adaptive defense system?
Sort the listed characteristics of adaptive immunity into the correct bin.

ANSWER:

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Reset Help

Cellular immunity Humoral immunity Both cellular and humoral immunity

Responds to specific antigens


Cytotoxic T lymphocytes
Produces antibodies B lymphocytes
Originates from hemocytoblasts in red
Immunocompetency develops in
marrow
thymus Immunocompetency develops in bone
marrow
Immunocompetent cells found in
Activated by exposure to APCs
lymphoid tissues

Answer Requested

IP: Innate Internal Defenses

Click on the link or the image below to view an animation on innate internal defenses from Interactive Physiology (IP), then answer the questions to the right.

IP: Innate Internal Defenses

Part A
Which of the following is NOT a characteristic of Natural Killer (NK) cells?

Hint 1.

NK cells are part of the innate internal defense system.

ANSWER:

NK cells recognize abnormal or cancer cells by a specific antigen on their cell membrane.

NK cells attack infected or cancerous cells.

NK cells induce the target cell to undergo “apoptosis” (cell suicide).

NK cells attack transplanted organs.

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Correct
Correct answer. NK cells do not recognize abnormal or cancer cells by a specific antigen on their cell membrane. NK cells to do not have specific antigen receptors
– like T cells do. NK cells look for the absence of normally occurring “self” proteins on infected or cancerous cells.

Part B
Which of the following innate internal defenses work by interfering with viral replication?

Hint 1.
These are classified as antimicrobial proteins.

ANSWER:

T lymphocytes

interferons

phagocytes

complement proteins

Correct
Yes, interferons are antimicrobial proteins that interfere with viral replication. They are produced by a virus-infected cell. Although the infected cell will die, it sends
out interferons that protect the neighboring cells from the virus.

Part C
How do phagocytes recognize foreign cells or bacteria?

Hint 1.

The foreign cells or bacteria do not “look” like normal body cells.

ANSWER:

Phagocytes recognize a specific antigen on the cell surface.

The phagocytes look for the absence of “self” proteins.

The phagocytes recognize molecules on pathogens not normally found on body cells.

All the foreign cells or bacteria are marked with opsonins that the phagocytes recognize.

Correct
Yes, they use mannose and Toll-like receptors to bind to the molecules found on pathogens.

Part D
Which of the innate defense mechanisms can lyse bacteria and mark cells for phagocytosis?

Hint 1.

This defense mechanism is classified as an antimicrobial protein.

ANSWER:

natural killer (NK) cells

cytokines

interferons

complement proteins

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Correct
Yes, the complement proteins can lyse microorganisms using the MAC (membrane attack complex) system to form pores, mark cells for phagocytosis
(opsonization), and promote inflammation.

Part E
Which of the following can act as opsonins on bacteria, thus enhancing phagocytosis?

Hint 1.
This process is called opsonization. The opsonins mark the target cell for destruction.

ANSWER:

natural killer (NK) cells

antibodies and complement proteins

T cells

interferons

Correct
Yes, both antibodies and complement proteins can act as opsonins on bacteria.

IP: Lymphatic Organs

Click on the link or the image below to view an animation on lymphatic organs from Interactive Physiology (IP), then answer the questions to the right.

IP: Lymphatic Organs

Part A
Which of the following are primary lymphoid organs?

Hint 1.
Primary lymphoid organs are sites where lymphocytes mature and become immunocompetent.

ANSWER:

bone marrow and thymus

spleen and thymus

lymph nodes and tonsils

appendix and spleen

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Correct
The B lymphocytes are named B cells because they mature in the Bursa of Fabricus (a lymphoid organ of birds, where they were first discovered) and the T
lymphocytes are named T cells because they mature in the Thymus. This is also where they become immunocompetent.

Part B
Which of the following areas in a secondary lymphoid organ allows intimate contact between blood and the lymphocytes?

Hint 1.
This is the largest secondary lymphoid organ that also acts to cleanse the blood.

ANSWER:

Hassall’s corpuscles of the thymus

red pulp of the spleen

germinal centers of the lymph nodes

white pulp of the spleen

Correct
Yes, the white pulp is where lymphocytes are concentrated and the immune functions take place in the spleen.

Part C
Where in the lymph node do the T cells first encounter antigens presented by dendritic cells?

Hint 1.

This would be in the outer area of the organ.

ANSWER:

germinal centers of the cortex

medullary cords in the medulla

lymphoid follicles of the outer cortex

deep in the cortex

Correct
Yes, the T cells encounter antigens presented by dendritic cells in the deeper part of the cortex. The cortex is the outer area of the lymph node.

Part D
Collections of lymphoid tissues, called MALT, are strategically placed throughout the respiratory, digestive, and genitourinary systems. Which one of these is located at the
end of the small intestine?

Hint 1.

These collections of lymphoid tissue are located in the plicae circularis of the ileum.

ANSWER:

appendix

tonsils

Peyer’s patches

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2/13/23, 12:48 AM Activity 2: Lymphatic system

Correct
Yes, Peyer’s patches are located in the small intestine, and they guard against bacteria from the large intestine.

Part E
There is a decrease in our ability to fight infection as we age. Which lymphoid organ may have a role in this decline?

Hint 1.
This organ atrophies as we age.

ANSWER:

spleen

lymph nodes

thymus

Correct
Yes, the relative size of the thymus as well as its function decreases with age. Thymic atrophy may be one reason the elderly are more susceptible to infection.

Chapter 12 End of Chapter Review Reading Question 4

Part A
What is the function of histamine?

ANSWER:

activates complement

triggers inflammatory response

enzymatically destroys bacteria

triggers fever

Answer Requested

Score Summary:
Your score on this assignment is 8.0%.
You received 5.01 out of a possible total of 63 points.

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