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Human Physiology/The Urinary System
Functions of the Urinary System
 The urinary system's function is to filter blood and create urine as a waste by-
product.
 The urinary system organs include the two kidneys, two ureters, bladder, and
urethra.
The kidneys
• The kidneys are solid, bean-shaped organs.
• The kidneys are located at the rear wall of the abdominal cavity just above
the waistline.
• They are covered by the renal capsule, which is a tough capsule of fibrous
connective tissue.
• There is a concaved side of the kidney that has a space where a renal artery
enters, and a renal vein and a ureter exit the kidney.
• There are three major regions of the kidney, renal cortex, renal medulla and
the renal pelvis. The outer, granulated layer is the renal cortex.
• The inner radially striated layer is the renal medulla. This contains pyramid
shaped tissue called the renal pyramids, separated by renal columns.
 Six important roles of the kidneys are:
1. Regulation of plasma ionic composition. Ions such as sodium, potassium,

calcium, magnesium, chloride, bicarbonate, and phosphates are regulated by
the amount that the kidney excretes.
2. Regulation of plasma osmolarity. The kidneys regulate osmolarity because

they have direct control over how many ions and how much water a person
excretes.
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3. Regulation of plasma volume. The kidneys control plasma volume by

controlling how much water a person excretes.
4. Regulation of plasma hydrogen ion concentration (pH). The kidneys partner

up with the lungs and they together control the pH. The kidneys help maintain
the blood Ph mainly by excreting hydrogen ions and reabsorbing bicarbonate
ions.
5. Removal of metabolic waste products and foreign substances from the

plasma. One of the most important things the kidneys excrete is nitrogenous
waste. As the liver breaks down amino acids it also releases ammonia. The
liver then quickly combines that ammonia with carbon dioxide, creating urea
which is the primary nitrogenous end product of metabolism in humans.
6. Secretion of Hormones . Renin is released by the kidneys. Renin leads to the

secretion of aldosterone which is released from the adrenal cortex.
Aldosterone promotes the kidneys to reabsorb the sodium (Na+) ions.
Renal Vein
 The renal veins are veins that drain the kidney.
 They connect the kidney to the inferior vena cava.
Renal Artery
 The renal arteries normally arise off the abdominal aorta and supply the
kidneys with blood.
 The renal arteries carry a large portion of the total blood flow to the kidneys.
Ureters
 The ureters are two tubes that carry urine from the kidneys to the bladder.
 Each ureter is a muscular tube about (25 cm) long.

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Urinary Bladder
 The urinary bladder is a hollow, muscular and distendible or elastic organ that
stores urine temporarily.
 When the bladder fills with urine (about half full), stretch receptors send
nerve impulses to the spinal cord, which then sends a reflex nerve impulse
back to the sphincter (muscular valve) at the neck of the bladder, causing it to
relax and allow the flow of urine into the urethra.
Urethra
 The urethra is a muscular tube that connects the bladder with the outside of
the body.
 The function of the urethra is to remove urine from the body.
 The urethral sphincter is a muscles used to control the flow of urine from the
urinary bladder. These muscles surround the urethra, so that when they
contract, the urethra is closed.
Nephrons
 A nephron is the basic structural and functional unit of the kidney.
 Its chief function is:
1. To regulate water and soluble substances by filtering the blood,
reabsorbing what is needed and excreting the rest as urine.
2. Nephrons eliminate wastes from the body.
3. Regulate blood volume and pressure.
4. Regulate blood pH.
Each nephron consists of:

1. The renal corpuscle consists of two parts (Glomerulus, Bowman's capsule)
2. Proximal convoluted tubule.
3. Loop of Henle.
4. distal convoluted tubule.
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Glomerulus
 The glomerulus is a set of a net of blood capillaries contained in a capsule-

shaped structure called the glomerular capsule or the Bowman’s capsule.
 The plasma of the blood and the small molecules contained in plasma are
pressure filtered into the Bowman’s capsule. Large blood proteins and blood
cells and platelets are too big to be pressure filtered and remain in the
arteriole.
Glomerular Capsule or Bowman's Capsule

Bowman's capsule (also called the glomerular capsule) surrounds the glomerulus
and is composed of visceral (simple squamous epithelial cells) (inner) and parietal
(simple squamous epithelial cells) (outer) layers.
Proximal Convoluted Tubule (PCT)
 The proximal convoluted tubule has one layer of cuboidal cells in the lumen.
 These cells are covered with millions of microvilli. The microvilli serve to
increase surface area for reabsorption.
 At this point in the nephron, the filtrate from the
blood contains both waste molecules like urea
and useful molecules like amino acids, glucose, and salt.
 The proximal convoluted tubule works to actively transport for nutrients
(glucose, amino acids, and salts) back into the blood capillaries so they are not
lost in the urine.
 The cells of the tubule also contain many mitochondria that produce the ATP
required for the large amount of active transport.
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Loop of the Nephron or Loop of Henle

 The loop of Henle is a U-shaped tube that consists of a descending limb and
ascending limb.
 It begins in the cortex, receiving filtrate from the proximal convoluted tubule,
extends into the medulla, and then returns to the cortex to empty into the
distal convoluted tubule.
Distal Convoluted Tubule (DCT)

 The distal convoluted tubule is similar to the proximal convoluted tubule in
structure and function.
 Cells lining the tubule have numerous mitochondria, enabling active transport
to take place by the energy supplied by ATP.
 Much of the ion transport taking place in the distal convoluted tubule is
regulated by the endocrine system.
 In the presence of parathyroid hormone, the distal convoluted tubule
reabsorbs more calcium and excretes more phosphate.
 When aldosterone is present, more sodium is reabsorbed and more potassium
excreted.
 The tubule also secretes hydrogen and ammonium to regulate pH.
Formation of Urine
Urine is formed in three steps: Filtration, Reabsorption, and Secretion.
Filtration
 Blood enters the afferent arteriole and flows into the glomerulus.
 Blood in the glomerulus has both filterable blood components and non-
filterable blood components.
 Filterable blood components move toward the inside of the glomerulus while
non-filterable blood components bypass the filtration process by exiting
through the efferent arteriole.
 Filterable Blood components now take on plasma like form called glomerular
filtrate.
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 A few of the filterable blood components are water, nitrogenous waste,

nutrients and salts (ions). Non-filterable blood components include blood cells
and platelets along with plasma proteins.
Reabsorption
 Is the movement of substances out of the renal tubules back into the blood
capillaries located around the tubules (called the peritubular capillaries).
 Substances reabsorbed are water, glucose and
other nutrients, and sodium (Na+) and other ions. Reabsorption begins in the p
roximal convoluted tubules and continues in the loop of
Henle, distal convoluted tubules, and collecting
Tubules.
Secretion
 Some substances are removed from blood through the peritubular capillary
network into the distal convoluted tubule or collecting duct.
 These substances are Hydrogen ions, creatinine, and drugs.
 Urine is a collection of substances that have not been reabsorbed during
glomerular filtration or tubular reabsorption.

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Human Physiology/The Urinary System

Functions of the Urinary System

 Six important roles of the kidneys are:

1. Regulation of plasma ionic composition. Ions such as sodium, potassium,

2. Regulation of plasma osmolarity. The kidneys regulate osmolarity because

3. Regulation of plasma volume. The kidneys control plasma volume by

4. Regulation of plasma hydrogen ion concentration (pH). The kidneys partner

5. Removal of metabolic waste products and foreign substances from the

6. Secretion of Hormones . Renin is released by the kidneys. Renin leads to the

 Each ureter is a muscular tube about (25 cm) long.

Each nephron consists of:

 The glomerulus is a set of a net of blood capillaries contained in a capsule-

Glomerular Capsule or Bowman's Capsule

Proximal Convoluted Tubule (PCT)

Loop of the Nephron or Loop of Henle

Distal Convoluted Tubule (DCT)

 A few of the filterable blood components are water, nitrogenous waste,

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