EP0878455A1
EP0878455A1
EP0878455A1
E U R O P E A N PATENT A P P L I C A T I O N
(57) Methyl chloride is prepared by effecting liquid- stoichiometric excess of hydrogen chloride. The last
phase reaction between hydrogen chloride and metha- stage of reaction is effected in a stoichiometric excess
nol in the absence of a catalyst. The reaction is effected of methanol. The invention is industrially advantageous
in divided stages including at least an early stage and a in that methyl chloride can be prepared at a high con-
last stage. The early stage of reaction is effected in a version of hydrogen chloride while suppressing the for-
mation of dimethyl ether by-product.
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EP 0 878 455 A1
Description
This invention relates to processes for preparing methyl chloride by reacting hydrogen chloride with methanol.
5 BACKGROUND
A number of processes have been proposed for the preparation of methyl chloride from reaction of hydrogen
chloride with methanol. Reaction is generally carried out in a vapor or liquid phase in the presence or absence of a
catalyst. Most known processes use catalysts for promoting reaction and carry out reaction in an atmosphere containing
10 a stoichiometric excess of hydrogen chloride relative to methanol.
However, methyl chloride production processes including the above-mentioned ones, which are currently imple-
mented in the industry, have several drawbacks. The process of effecting vapor-phase reaction in the presence of a
catalyst is disadvantageous in that reaction temperatures as high as 300 to 450°C cause more amounts of dimethyl
ether and other decomposed products to form than other processes and the catalyst needs to be replaced or regen-
ts erated. This process requires gaseous hydrogen chloride which is anhydrous or dried to a nearly anhydrous extent
and gaseous methanol as the reactants.
The process of effecting liquid-phase reaction in the presence of a catalyst is disadvantageous in that the reaction
temperature is higher than in the liquid-phase non-catalyzed process, more dimethyl ether by-product is formed due
to the use of the catalyst, and the catalyst must be periodically renewed because impurities accumulate in the catalyst.
20 While hydrogen chloride by-product obtained in a silicone manufacturing plant contains silicones and hydrogen
chloride by-product resulting from other processes contains organic impurities, the use of such hydrogen chloride by-
product as the reactant is not suitable for the catalyzed vapor- or liquid-phase processes because the catalyst can be
deactivated by silicones or other organic impurities. A limit is imposed on the reactants which can be used in these
processes.
25 The process of effecting liquid-phase reaction in the absence of a catalyst suffers from a low reaction rate. Since
methanol is reacted with a stoichiometric excess of hydrogen chloride, the concentration of hydrogen chloride in the
reactor exceeds the azeotropic concentration so that a substantial fraction of hydrogen chloride may be distilled off
the reactor along with the methyl chloride gas produced, leading to a noticeably reduced utilization of hydrogen chloride.
Illustratively, US Patent Nos. 3,981 ,938, 4,220,609 and 4,922,043 describe a process for forming methyl chloride
30 by reacting methanol with a stoichiometric excess or equivalent amount of hydrogen chloride. This process has the
above-mentioned disadvantage that the concentration of hydrogen chloride in the reactor approaches the azeotropic
concentration so that a large fraction of hydrogen chloride may be evaporated from the reactor along with the methyl
chloride gas produced, leading to a noticeably reduced utilization of hydrogen chloride. An aqueous solution of unre-
acted hydrogen chloride in water by-product can be separated from the crude product gas by cooling, but this solution
35 is corrosive and very difficult to treat, requiring an additional expense for disposal.
US Patent No. 4,935,564 discloses a process for preparing an alkyl halide by passing a hydrogen halide and a
stoichiometric excess (typically about 20 to 200 mol% excess) of an alcohol in the absence of a catalyst in a single
pass through a plug-flow reactor. As the amount of alcohol is increased (in stoichiometric excess relative to hydrogen
halide), the amount of dimethyl ether by-product increases. As the amount of alcohol is reduced, the conversion of
40 hydrogen chloride declines. It is difficult to determine optimum reaction conditions. A single stage of plug-flow reactor
is insufficient in order to suppress formation of by-products and to increase the conversion of hydrogen chloride.
US Patent No. 5202512 describes a process for preparing a C1-C4 halogenoalkane by reacting a C1-C4 alkanol
with a hydrogen halide in the presence of a catalyst. On account of the catalyst used, this process has the drawbacks
including increased by-products, attachment of an extra equipment for adding the catalyst, difficulty to control the
45 catalyst concentration, deactivation of the catalyst by impurities in the starting hydrogen chloride, and treatment of the
deactivated catalyst.
According to the invention, reaction of hydrogen chloride with methanol to form methyl chloride is carried out in a
liquid phase without requiring a catalyst and in a system having at least two stages of reactors including an early stage
and a last stage. The early stage of reaction is effected in a stoichiometrically excessive hydrogen chloride environment
so to increase the reaction rate and to suppress the formation of dimethyl ether by-product. The last stage of reaction is
effected in a stoichiometrically excessive methanol environment to reduce the concentration of hydrogen chloride below
the azeotropic concentration and to increase the conversion of hydrogen chloride. Since the formation of dimethyl ether
is initially suppressed, and the evaporation of hydrogen chloride is restrained by reducing the concentration of hydrogen
chloride in the last stage reactor belowthe azeotropic concentration, the utilization of hydrogen chloride is outstandingly
55 improved over the prior art processes. Since no catalyst is required, even a reactant containing an impurity capable
of deactivating the catalyst can be used. Then methyl chloride can be prepared in an industrially advantageous manner.
Briefly stated, in one aspect we provide a process for preparing methyl chloride by effecting liquid-phase reaction
between hydrogen chloride and methanol in the absence of a catalyst. The liquid-phase reaction is effected in divided
2
EP 0 878 455 A1
stages including at least an early stage and a last stage. The early stage of liquid-phase reaction is effected in a
stoichiometrically excessive hydrogen chloride environment. The last stage of liquid-phase reaction is effected in a
stoichiometrically excessive methanol environment.
In testing these new methods we have noted the following practical benefits.
5
(1) When the reaction is effected in two or more divided stages, both the reaction rate and the conversion of
hydrogen chloride are good. The amount of methanol which is excessive over stoichiometry can be less than that
required in a single stage process. The amount of dimethyl ether by-product formed can be reduced. More partic-
ularly, in reaction prior to the last stage, the reaction rate is increased and formation of dimethyl ether is suppressed.
10 In the last stage of reaction, water by-product can be selectively distilled out of the system while suppressing the
evaporation of hydrogen chloride from the reactor. Thus the conversion of hydrogen chloride can be significantly
improved.
(2) When no catalyst is used, extra equipment for adding the catalyst and the control of the catalyst concentration
are unnecessary.
is (3) A hydrogen chloride product containing silicones obtained from a silicone manufacturing plant, and other hy-
drogen chloride products containing impurities capable of deactivating catalyst, may be used as the reactant.
20 FIG. 1 schematically illustrates one exemplary system for preparing methyl chloride according to the invention.
FIG. 2 is a schematic view of a comparative system.
FURTHER EXPLANATIONS
25 According to the invention, methyl chloride is prepared by effecting liquid-phase reaction between hydrogen chlo-
ride and methanol in the absence of a catalyst. The liquid-phase reaction is effected in at least two divided stages, that
is, at least an early stage and a last stage. The number of reaction stages or reactors is not particularly limited as long
as more than one stage is included. Usually, two to four stages, especially two or three stages are used. In most cases,
satisfactory results are obtained with two stages.
30 The early stage of liquid-phase reaction, especially reaction prior to the last stage, is effected in a stoichiometrically
excessive hydrogen chloride environment that is, using a stoichiometrically smaller amount of methanol relative to
hydrogen chloride. The last stage of liquid-phase reaction is effected in a stoichiometrically excessive methanol envi-
ronment, that is, using a stoichiometric excess of methanol relative to hydrogen chloride as a result of additional feed
of methanol, thereby reducing the concentration of hydrogen chloride in the reactor below the azeotropic concentration.
35 In conventional processes, the total molar ratio of methanol to hydrogen chloride is from about 1.0 to about 2.0. Ac-
cording to the invention, it is preferred that the molar ratio is from 0.7 to 0.95, especially from 0.8 to 0.95 prior to the
last stage, and the total molar ratio of the HCI to the methanol employed during the overall process including the last
stage is from 1.05 to 1.4, especially from 1.05 to 1.3. outside these ranges, there is a tendency that below the ranges,
the conversion of hydrogen chloride may be less, and beyond the ranges, the amount of dimethyl ether by-product
40 tends to be larger. With these molar ratios met, it is further preferred that the liquid phase in the early stage, especially
the liquid phase prior to the last stage have a hydrogen chloride concentration of 22 to 30% by weight and a methanol
concentration of 3 to 8% by weight, and the liquid phase during the last stage have a hydrogen chloride concentration
of 8 to 17% by weight and a methanol concentration of 1 to 5% by weight. This concentration setting is found particularly
effective for the reaction rate and the conversion of hydrogen chloride while suppressing the formation of dimethyl
45 ether by-product.
The reaction temperature is preferably 90 to 130°C, especially 100 to 110°C in the early stage, especially prior to
the last stage, and preferably 100 to 150°C, especially 110 to 130°C in the last stage because a sufficient reaction rate
is ensured and the formation of by-products is suppressed. The reaction time is not critical although the total reaction
time is generally about 2 to 8 hours, especially about 3 to 4 hours. The reaction time in the last stage may be e.g. 2 to
so 8 hours, especially about 3 to 4 hours. Other reaction conditions may be as in conventional processes.
Since the methyl chloride preparing process of the invention can be carried out in the absence of a catalyst, the
reactants used therein need not be of high purity. Even a reactant containing an impurity capable of exhausting or
poisoning a catalyst may be used. For example, a hydrogen chloride by-product resulting from a silicone manufacturing
plant and containing silanes and silicones may be used as the reactant. Unreacted methanol may be recycled for reuse.
55 For example, where the last stage reactor contains methyl chloride and by-product water as the outcome of reaction
and unreacted methanol fed in excess, these components may be gasified and distilled off the last stage reactor, the
resulting crude gas separated into methyl chloride gas and an aqueous methanol solution, the aqueous methanol
solution separated into methanol and water, and the methanol recycled for reuse as a reactant.
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EP 0 878 455 A1
FIG. 1 shows one exemplary preferred system for use in carrying out the process of the invention although the
invention is not limited thereto. Using this system, methyl chloride can be advantageously prepared as follows.
The system includes a first stage reactor 1-1, a last stage reactor 1-2, a hydrogen chloride source (11), methanol
sources (12, 21), a reboiler 2, a condenser 3, and a distillation column 4, which are connected through conduits as
5 illustrated in FIG. 1.
Two reactants, hydrogen chloride and methanol are fed into the first stage reactor 1-1 through conduits 11 and 12.
The amounts of the reactants are adjusted such that methanol is stoichiometrically less than hydrogen chloride, es-
tablishing a hydrogen chloride excess environment.
In the first stage reactor 1-1 , hydrogen chloride reacts with methanol to form methyl chloride. This reaction is not
10 complete. A gaseous mixture composed mainly of methyl chloride and a liquid mixture composed mainly of water by-
product and unreacted reactants are transferred to the last stage reactor 1-2 through conduits 22 and 23, respectively.
Methanol is additionally fed to the last stage reactor 1-2 through a conduit 21 such that methanol is in stoichio-
metrical excess to hydrogen chloride, establishing a methanol excess atmosphere. The solution in the reactor 1-2 is
heated by the reboiler 2 for promoting reaction and selectively distilling off water.
is The crude gas produced in the last stage reactor 1-2 is delivered through a conduit 31 to the condenser 3 where
it is cooled for condensation and separated into methyl chloride gas and an aqueous methanol solution containing a
minor amount of unreacted hydrogen chloride. The methyl chloride gas is taken out through a conduit 32.
The aqueous methanol solution separated by condensation is delivered through a conduit 33 to the distillation
column 4 where it is separated into methanol and water containing a minor amount of unreacted hydrogen chloride.
20 Substantially pure methanol emerging from the top of the column 4 is fed back to the first stage reactor 1-1 through a
conduit 13 for reuse as the reactant. The by-product water containing a minor amount of unreacted hydrogen chloride
is discharged from the column bottom through a conduit 41 .
In this system, the amount of methanol fed is manually or automatically adjusted relative to the amount of hydrogen
chloride fed by monitoring the flow rates of hydrogen chloride and methanol by means of flow meters (not shown)
25 attached to the conduits 11,12 and 21 . Alternatively, the amount of hydrogen chloride fed is adjusted relative to the
amount of methanol fed. It is also effective to adjust the feed ratio of hydrogen chloride and methanol by sampling out
the liquids in the reactors, analyzing the samples for the concentrations of hydrogen chloride and methanol, and ef-
fecting flow rate control in accordance with the analytic results.
We find that in this way, methyl chloride can be prepared through reaction of hydrogen chloride with methanol in
30 an industrially advantageous manner, that is, at a high conversion of hydrogen chloride while suppressing the formation
of dimethyl ether by-product.
EXAMPLE
35 Examples of the invention are given below by way of illustration and not by way of limitation. All parts are by weight.
Example 1
The inventive process was carried out in an experimental system as shown in FIG. 1.
40 Anhydrous hydrogen chloride was fed to the first stage reactor 1-1 through the conduit 11 at a flow rate of 3,500
g/hr., and methanol was fed to the first stage reactor 1-1 through the conduit 12 at a flow rate of 2,460 g/hr. (including
methanol recycled through the conduit 13). Additional methanol wasted to the last stage reactor 1-2 through the conduit
21 at a flow rate of 770 g/hr. The first and last stage reactors 1-1 and 1-2 were maintained at internal temperatures of
105°C and 120°C, respectively. After a steady state was reached, methyl chloride was delivered through the conduit
45 32 at a flow rate of 4,760 g/hr., which corresponded to a conversion of hydrogen chloride of 98.2%. The total molar
ratio of methanol to hydrogen chloride was 1.05. The methyl chloride product contained 0.3% by weight of dimethyl
ether.
Example 2
50
Example 1 was repeated except that the amounts of methanol fed to the first and last stage reactors were changed.
Anhydrous hydrogen chloride was fed to the first stage reactor 1-1 through the conduit 11 at a flow rate of 3,500
g/hr., and methanol was fed to the first stage reactor 1-1 through the conduit 12 at a flow rate of 2,770 g/hr. (including
methanol recycled through the conduit 13). Additional methanol wasted to the last stage reactor 1-2 through the conduit
55 21 at a flow rate of 620 g/hr. The first and last stage reactors 1-1 and 1-2 were maintained at internal temperatures of
105°C and 120°C, respectively. After a steady state was reached, methyl chloride was delivered through the conduit
32 at a flow rate of 4,810 g/hr., which corresponded to a conversion of hydrogen chloride of 99.2%. The total molar
ratio of methanol to hydrogen chloride was 1.1. The methyl chloride product contained 0.3% by weight of dimethyl ether.
4
EP 0 878 455 A1
Comparative Example 1
Using the same system as in Example 1, reaction was carried out using a stoichiometrically smaller amount of
methanol relative to the hydrogen chloride feed.
5 Anhydrous hydrogen chloride was fed to the first stage reactor 1-1 through the conduit 11 at a flow rate of 3,500
g/hr., and methanol was fed to the first stage reactor 1-1 through the conduit 12 at a flow rate of 2,460 g/hr. (including
methanol recycled through the conduit 13). Additional methanol wasted to the last stage reactor 1-2 through the conduit
21 at a flow rate of 310 g/hr. The first and last stage reactors 1-1 and 1-2 were maintained at internal temperatures of
105°C and 120°C, respectively. After a steady state was reached, methyl chloride was delivered through the conduit
10 32 at a flow rate of 4,040 g/hr., which corresponded to a conversion of methanol of 92.6%. The total molar ratio of
methanol to hydrogen chloride was 0.9. The methyl chloride product contained 0.3% by weight of dimethyl ether.
Comparative Example 2
is This Example used a single stage reactor as shown in FIG. 2. The system of FIG. 2 is different from FIG. 1 in that
only a single reactor 1 is included while a condenser 3 and a distillation column 4 are similarly connected to the reactor.
Reactants, hydrogen chloride and methanol were fed to a reactor 1 through the conduits 11 and 12, respectively.
The liquid in the reactor was heated by a reboiler 2 for promoting reaction and gasifying the entire contents, which
were distilled out of the reactor 1.
20 Thereafter, as in Example 1, the crude gas product was fed to the condenser 3 where it was cooled and separated
into methyl chloride gas and an aqueous methanol solution. The aqueous methanol solution was distilled in the column
4 whereby substantially pure methanol was recovered and fed back to the reactor 1 for reuse. The reactor volume was
equal to the sum of the volumes of the first and last stage reactors in Example 1.
In this single reactor system, anhydrous hydrogen chloride was fed to the reactor 1 through the conduit 11 at a
25 flow rate of 3,500 g/hr., and methanol was fed to the reactor 1 through the conduit 12 at a flow rate of 3,390 g/hr.
(including methanol recycled through the conduit 13). The reactor 1 was maintained at an internal temperature of
120°C. Methyl chloride was delivered through the conduit 32 at a flow rate of 4,250 g/hr., which corresponded to a
conversion of hydrogen chloride of 87.7%. The total molar ratio of methanol to hydrogen chloride was 1.1. The methyl
chloride product contained 1.0% by weight of dimethyl ether.
30 The results are summarized in Table 1.
Table 1
E1 E2 CE1 CE2
5
EP 0 878 455 A1
Claims
1. A process for preparing methyl chloride by effecting liquid-phase reaction between hydrogen chloride and methanol
without requiring a catalyst, wherein an early stage of the liquid-phase reaction is effected with a stoichiometric
5 excess of hydrogen chloride, and the last stage of the liquid-phase reaction is effected with a stoichiometric excess
of methanol.
2. The process of claim 1 wherein the molar ratio of methanol to hydrogen chloride is from 0.7 to 0.95 prior to the
last stage, and the molar ratio of methanol to hydrogen chloride is from 1.05 to 1.4 during the overall process
10 including the last stage.
3. The process of claim 2 wherein the liquid phase prior to the last stage has a hydrogen chloride concentration of
22 to 30% by weight and a methanol concentration of 3 to 8% by weight, and the liquid phase during the last stage
has a hydrogen chloride concentration of 8 to 17% by weight and a methanol concentration of 1 to 5% by weight.
15
4. The process of claim 1 wherein the reactor of the last stage contains methyl chloride and by-product water as the
outcome of reaction and unreacted methanol fed in excess,
25 5. The process of claim 1 wherein hydrogen chloride which is obtained as a by-product in a silicone manufacturing
plant is used as a reactant.
6. The process of claim 5 wherein the hydrogen chloride used as a reactant contains silanes and silicones.
6
EP 0 878 455 A1
F I G . 1
12 21
22 31
1-1
23
13
41
EP 0 878 455 A1
F I G . 2
12
41
EP 0 878 455 A1
DATABASE WPI
Section Ch, Week 9617
Derwent Publications Ltd., London, GB;
Class E16. AN 96-170208
XP002071593
& RU 2 041 188 C (CHEBOKSARY KHIMPROM
PR0DN ASSOC)
* abstract *
TECHNICALFIELDS
SEARCHED (lnt.CI.6)
C07C
The present search report has been drawn up for all claims
Placeofsearch Dateofcompletionotthesearch Examiner
MUNICH 15 July 1998 Goetz, G
CATEGORYOFCITEDDOCUMENTS T:theory or principle underlying the invention
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X:particularly relevant iJtaken alone after the filing date
Y:particularly relevant it combined with another D:document cited in the application
document ofthe same category L: document cited for other reasons
A:technological background
O:non-written disclosure & member of the same patent family, corresponding
P: intermediate document document