Mindfulness and Chronic Pain 2
Mindfulness and Chronic Pain 2
Mindfulness and Chronic Pain 2
2, 1985
'Stress Reduction and Relaxation Program, Division of Preventive and Behavioral Medicine,
Department of Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts
01605.
21o whom correspondence should be addressed.
3Department of Family and Community Medicine, Universily of Massachusetts Medical Center,
Worcester, Massachusetts 01605.
"Pain Control Center, Department of Anesthesiology, University of Massachusetts Medical
Center, Worcester, Massachusetts 01605.
163
0160-7715/85/0600 0163504.50/0 9 1985 Plenum PublishingCorporation
164 Kabat-Zinn, Lipworth, and Burney
INTRODUCTION
METHODS
Program Design
and self-report questionnaires (see below) was given. The information from
these instruments constituted the pre-meditation-training data base (pre).
The SR&RP courses are conducted in cycles three times a year. Each
cycle consists of ten 2-hr classes, one per week, in which a variety of forms of
fulness meditation are taught and practiced [for details see Discussion and
Kabat-Zinn (1982)].5 All subjects in this study were required to meditate for-
mally for a minimum of 45 min per day, 6 days per week, for homework,
using an audiocassette tape in the beginning weeks for guidance. Instruction
and practice of Hatha Yoga were included as a form of meditative exercise
for those who could do it. It functioned primarily to improve musculoskele-
tal strength and flexibility and reduce disuse atrophy. The Yoga was taught
emphasizing mindfulness (Kabat-Zinn, 1982).
Each SR&RP course was conducted by an instructor on the SR&RP
staff. The instructors have practiced mindfulness meditation regularly for
many years and continue to engage in periodic retreats for intensive training
and practice.
Following the course, each patient was seen individually in a second
evaluation interview, during which post-meditation-training data (post) were
obtained.
Patient Characteristics
5The SR&RP was recentlychanged to an 8-week course including an additional 8-hr intensive
"retreat" session.
168 Kabat-Zinn, Lipworth, and Burney
pooled and averaged in reporting the results except for the follow-up study,
in which each cycle is plotted separately. The patient characteristics are shown
in Table IA. The majority had long histories of medical treatment for their
conditions, with little or no improvement in either pain status or affective
and" cognitive/behavioral status prior to enrolling in the SR&RP.
Subsequent Intervention. The SR&RP offers as a sequel an "advanced"
course to deepen the process begun in the initial mediation training. This
graduate SR&RP is an 8-week course with a format similar to that the of
basic SR&RP. The periods of meditation are longer and less guided. Some
of the patients in this study had taken one or more graduate courses at the
time some of the follow-up data were obtained (see Results).
Follow-Up
Follow-up data were solicited from all patients who completed the
SR&PR by periodic mailing of questionnaires at approximately 2.5, 4.5, 7,
12, and 15 months after completion of the program. In addition to follow-
up information on pain and psychological status, detailed information was
obtained about whether and how much individuals were meditating and about
the techniques they had found the most useful.
Comparison Group
e,
ca.
Meditation for Self-Regulation of Pain 171
ceived distress (Derogatis, 1977). The SCL-90-R has been shown to corre-
late well with comparable scales on the M M P I (Derogatis et al., 1976).
The POMS and the SCL-90 (R) were employed together to obtain pro-
files of affective status and psychological symptoms since chronic pain is
known to cause or be accompanied by severe mood disturbance as well as
by depression, loss of self-esteem, irritability, and anxiety. These instruments
have been shown to have independent predictive variance (Haskell et al.,
1969).
A Summary Outcome Questionnaire was used with the SR&RP patients
both post-meditation training and at follow-up. This instrument was designed
to yield a single number representative of the average degree of change in
10 relevant symptom and behavioral parameters since taking the SR&RP.
It consisted of 10 questions pertaining to pain frequency, severity, use of
drugs to control pain, activity levels, attendance at work, energy levels, feel-
ings in general, ability to cope with stress, frequency of physician visits, and
blood pressure. The rating scale was from 1 to 5, where 3 represented "no
change," 5 "great improvement," 4 "some improvement," 2 "worse," and 1
"much worse," with the exact wording of each scale topic appropriate. Rat-
ings for the 10 questions were averaged to give the Summary Outcome Score.
If certain items were not applicable, the patient circled an option to that ef-
fect, and the average was calculated for the number of questions answered.
Data Analysis
Data were analyzed using standard SPSS programs. The matched t test
was used to determine significance for paired pre-post or pre-follow-up
results for the same subjects over time. The unmatched t test was used to
determine significance in the comparison of outcomes for the PC patients
trained in meditation with the patients in the PC comparison group. The
Bonferroni adjustment was then applied to the P values from all t tests as
recommended by Ingelfinger et al. (1983) to reduce the risk of type 1 error
from multiple comparisons. Further analyses to identify possible predictors
of outcome were undertaken using linear regression and discriminatory anal-
ysis (unpublished results).
RESULTS
Pain Outcome
Outcome was first analyzed for the total group. For every pain index,
the mean value was reduced significantly (P < 0.003) between pre- and postin-
172 Kabat-Zinn, Lipworth, and Burney
In parallel with the pain outcome, the mean scores for the n u m b e r
of symptoms reported for the preceding m o n t h (MSCL), m o o d disturbance
Medilation for Self-Regulation of Pain 173
Overall Outcome
7Due to negative scaling in the low range of the T M D scale, changes in an individual's T M D
cannot be expressed readily as a percentage.
8The one exception was the number of symptoms reported in the previous m o n t h (MSCL pre
mean, 23.3), which exceeded that for the low back-pain patients.
174 Kabat-Zinn, Lipworth, and Burney
Table III. Symptom, Mood, and Psychological Outcomes for the Total Population
(A) Group means ~
MSCL TMD GSI
Pre 22.3 47.8 0.77
Post 14.4 21.5 0.50
% change in mean 35* 55* 35*
N 87 73 74
AMSCL AGSI
Level of reduction (%) _>33.3 _>50 _>33.3 _>50
N u m b e r reaching
this level 47/87 32/87 44/74 29/74
~ of
total patients 54 37 59 39
aMSCL, number of symptoms on a Medical Symptom Checklist; TMD, Total Mood
Disturbance score on the Profile of M o o d States (POMS); GSI, General Severity
Index (SCL-90-R).
bThe T M D is excluded because the percentage change could not be calculated due
to negative scaling.
*P < 0.003 in t test adjusted for multiple comparisons using the Bonferroni method
(Ingelfinger et al., 1983).
headache patients, and 3.9 for the patients with neck and shoulder pain. These
differences were not statistically significant. Patients with neck and shoul-
der pain had higher mean pre and post values than the low back-pain pa-
tients on the BPPA, MSCL, TMD, and GSI. Neck a n d / o r shoulder pain
was consistently reported as more severe and more debilitating than low back
pain.
Analysis by Gender
The female-to-male ratio for the population was 2:1 (Table IVB). Males
consistently had higher initial mean levels of mood disturbance (TMD) and
of psychological symptomatology (GSI) than females. They were also less
successful in lowering the mean scores on these indices than the females dur-
ing meditation training. SCL-90-R profiles for the males showed higher lev-
els of Somatization, Depression, Anxiety, Hostility, and Phobic Anxiety than
those for the females both before and after meditation training (unpublished
data).
The mean Summary Outcome Score for the females in cycles 3, 4, and
5 ( N = 41) was 4.0, and that for the males (N = 18) was 3.8 (Table IVB).
This difference was not statistically significant. Forty-four percent of the
males and sixty-eight percent of the females were in the 3.8 to 5.0 range,
reflecting a moderate to great overall improvement.
"Fable IV. Group Mean Values Pre- and Post-Meditation Training: Breakdown by (A) Diagnosis and (B) Sex"
Mean post
PR1 BPPA BPM TLI MSCL TMD GSI Summary
Outcome
Pre Post Pre Post Pre Post Pre Post Pre Post Pre Post Score b
(A)
L B P ( N = 31) 17.6 8.7 41.2 27.2 1.3 14.5 I1.1 20.8 1 3 . 1 51.2 18.8 0.78 0.47 4.0
( N = i6)
Headaches
(N = 24) 12.5 3.4 34.8 33.6 1.3 8.6 4.7 23.3 14.8 39.4 19.8 0.71 0.47 3.9
(N = 13)
Neck/shoulder
(N = 15) 16.9 8.0 57.5 37.6 1.6 12.1 9.7 25.5 20.9 58.7 33.4 1.0 0.74 3.9
(N 14)
(8)
Males
(N = 30) 16.1 7.3 45.8 33.1 1.3 10.9 8.1 19.4 12.5 51.0 33.1 0.84 0.60 3.8
(N = 18)
Females
(N = 60) 16.1 6.4 40.0 27.2 1.6 12.3 8.3 23.8 15.2 45.1 1 8 . 3 0.75 0.45 4.0
(N = 41)
"PRI, Pain Rating Index; BPPA, Body Parts Problem Assessment score; BPM, Body Pain Map. BPM group
outcomes are expressed as the numerical averages of individual change scores. Numerical values were assigned
as follows: - = - 1 ; 0 0; + = +1; + + = +2; + + + = +3. TLI, Table of Levels of lnterference with
daily activities; MSCL, number of symptoms on a Medical Symptom Checklist; TMD, Total Mood Disturbance
score on the Profile of Mood State (POMS); GSI, General Severity Index (SCL-90-R).
1'For patients in cycles 3, 4, and 5 only. N 59, of whom 43 were in the three dominant pain categories.
176 Kabat-Zinn, Lipworth, and Burney
the patients achieved the greater than 33.3% reduction level in the number
of medical symptoms (MSL) and in overall psychological symptomatology
(GSI). These individuals constituted a much smaller fraction of their cohort
than did those among the PC referrals trained in the meditation (Table VB).
Individuals achieving greater than a 50% reduction level were far less evi-
dent in the traditional-care cohort than among the meditators.
9The post Summary Outcome Score was missing for one responder.
4The one exception was the BPPA for cycle 1.
178 Kabat-Zinn, Lipworth, and Burney
~
25 PRI TMD
(~)Ns
20 40
15 30
xIlOINS O|I6)NS
X (10}NS
I0
(211"~-X"
5 IO
i i I ~ i i [ I I 1
PRE POST 25 I0 12,5 ~ONTHS PRE POST 2.5 5 I0 12.5
50 .8 GSI
40 NS NS .7
(H) {16)~
50 .6
X (1~
20 (O)NS .5
I0 .4
z-Y- (20#t~X" ~ X (7 ) ~
I I I I I I .~
.3
PRE POST 2.5 5 I0 12.5
.2
25 MSCL .I
20
PRE POST 2 5 !5 I 12.5
O~X{II) NS
15
Fig. 1. Time dependency of outcome measures with follow-up. (A) Pain Rating Index; (B)
Body Parts Problem Assessment score; (C) number of symptoms on a Medical Symptom Check-
list; (D) Total M o o d Disturbance score on the POMS; (E) General Severity Index on the
SCL-90-R. Pre represents the initial m e a n levels for the patients in each cycle; post represents
the mean levels after the 10-week meditation training. Follow-up times are expressed as months
following the completion of the SR&RP. Open squares represent patients in cycle 1 ( N =
10); crosses, patients in cycle 2 (N = 16); filled circles, patients in cycle 3 (N = 24); and open
triangles, patients in cycle 4 (N = 21). The numbers of individuals responding to follow-up
questionnaires are given in parentheses next to the corresponding data points. The follow-up
points represent the mean scores for the respondents. P values for each follow-up point represent
paired t-tests with pre values. Paired t tests grouping 2.5- to 7-month returns together gave
P values of < 0.0001 on all indices except the PRI when comparing pre and follow-up levels
for each responder. Similarly, t tests for the 12- to 15-month returns gave P values of < 0.01
for the B P P A and MSCL. All P values are adjusted values after application of the Bonferro-
ni correction for multiple tests. The PRI values have been corrected for zero values (Melzack,
1975).
Meditation for Self-Regulation of Pain 179
PC comparison group
(nonmeditators)
Pre 32.5 44.4 17.7 22.9 51.1 0.74
Post 32.4 43.4 15.0 20.6 39.3 0.66
o70 change in mean 0 (ns) 2 (ns) 15 (ns) 10 (ns) 22 (ns) 11 (ns)
N 20 21 21 21 20 20 ,'7
Mean % change - 2 - 4 7 - 5 -- - 6
(B) Individual gains ~
DISCUSSION
COMMENT
NOTE ADDED IN P R O O F
ACKNOWLEDGMENTS
The first author would like to thank Mr. Byran Tucker, Ms. N o r m a
Rosiello, Ms. Debbie Hanna, R.N., Ms. Suzie Pilapel, and Mr. William Sellers,
B.S., for their assistance in assembling the data files; Drs. James E. Dalen,
Judith Ockene, Robert Goldberg, and Basil Barr for their critical readings
of the manuscript; and A m y Singer for the graphics in Fig. 1.
This work was carried out in conformity with N I H guidelines for
research on human subjects.
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Meditation for Self-Regulation of Pain 189