Meningitis Tutorial
Meningitis Tutorial
Meningitis Tutorial
Diagnosis
1. Lumbar puncture and CSF analysis 1. Lumbar puncture and CSF analysis
• Many mononuclear cells • Strongly elevated WBCs
• Normal protein count mainly neutrophils
• Normal glucose • Strongly elevated protein
• Decreased glucose
CSF/blood ratio
2. Virus identification in CSF by • Increased lactate
isolation from cultures 2. Bacterial identification by Gram
staining and culture
3. Cranial CT
Main causative Streptococcus pneumoniae
Enteroviruses
organisms (pneumococcus)
Treatment • Antipyretics 1. Antibiotics mosly cephalosporins
of third (ceftriaxone, cefotaxime) and
• Antiviral (if herpes was the cause forth generations (cefepime)+
of meningitis) ampicillin and/or vancomycin
2. Corticosteroids (dexamethasone)
3. Immunization (vaccination)
Complications
• Fatal condition
Mild condition that spontaneously • Major complications include (brain
resolves within 2 weeks edema, hydrocephalus, hearing
loss, vascular complications and
sepsis in addition to neurological
deficits that may become
persistent)
A three-month-old infant was brought to a clinic for pediatric
evaluation. The infant had had a mild fever (101 °F) for the past 24
hours and was described as very irritable and fussy by the mother.
Physical examination results were normal. A lumbar puncture was
performed, a complete blood cell count and blood cultures were
obtained, and urine was collected for urinalysis and culture. The
results are given in Table I.
Reference ranges in CSF are:
WBCs: 0-300 mm3, Dominant cell type: lymphocytes, Glucose level: 50-100 mg/dL and protein 20-45
mg/dL.