Summary Pharmaco - Pathology MSK
Summary Pharmaco - Pathology MSK
Summary Pharmaco - Pathology MSK
Pharmacology of muscle
f
I. Immune response during inflam •
'
LOX
•
eicosanoid :& ioñpnuñsiiiioirinmionirou
→
-
Arachidonic acid iitwairoisoiwfwmrroiiseicosanoid
Eicosanoid
Clinical
pharmacology of
② Reproductive system
-
Abortion
-
PGE & PG Fu
,
UÑsoonwmow9nÑ noon - ÑU Waren
Lothian's : Dino pro stone coils PGE 2)
PGE , I PGF , a
uÉswou
-
;;;÷:*
. ""
ICOXI 1 Lox ] ② Renal system
L Leukotrienes
L Posta
gland in Battery syndrome
•
{ Prostacydin
↳
target "> asthma _
mini , > prostaglandin oonanioo =
,
www.ou
fi
Udon IÑOOUN -
③ Cardiovascular system
cepoprostenohnihiuaonnwoiwlnoahidoo.no
-
Libo .
n-wtsitu-irfonnisoislbutmrn-isiwvotmtaioicso.in
ñismÉopn induce iidwantiplatet
COX -2 : a- cex . onion -46 low dose aspirin
lwioihsñw cardiovascular nisñ 2
'
induce →
⑤ Respiratory system 6. Piroxicam
nifiiunonnsnunois
PGF ITXA
strong Broncho constriction
- :
,, ,
⑨
-
Asthma :
Monte / ukast a- block leukotriene receptor 7 .
Mefenamic acid I Ponstan )
-
Corticosteroid -
HñJsaUtinÑow t
Dysmenorrhea )
⑥ Gastrointestinal
system Non opioid analgesic
-
glutathione Yaiwo
Nga , g → Liver cell death
↑ N -
µ
coronary
:
- -
Osteoarthritis
-
mild -
moderate pain
-
Ad effect : -
is
g-
-
in hemophilia
-
iiiontuntaiueyn I -
riowwiño
Topical
'
-
G- 6- Po -
near term
pregnancy NSAID
loinñoia viral I (
Cooter irritant mnniar.mu/oFos
-
-
Kinnan -
-
-
:
6
-
ASA + Probenecideniñi =
ineffective antidote : NAHCO
,
ASA + Anti -
winner
8. Coxib
-
selective block cox -2 if .
:uaoaÑonñYnpnwñ , ) 1 .
Rubefacients
buaooifoodnunoiahnrostoiw-oe.org *
→ vanish edema →
congestive heart failure 2.
Salicylate
→
hypertension
* -
methyl salicylate :
cooter pain uiuaios
,
Cooter irritant
myocardial infarction cna-wiiioii.to ones -
-
-
inhibit Cox -2 -
Cox -
2. Diclofenac 3 .
Menthol
-
Eis -
frnñu Cliver function -
3.
Ibuprofen 4. Capsaicin
Ñ TRPV channel Iifwoio
sensory
-
4. lndomethacin -
Phase 1 :
nr=oIw vanilla'd receptor .
you win
in ductus arteriosus -
Phase 2 : Desensitize plasma membrane TRPV , receptor
Ysiisr " " Nian criifu-hiiiun.in
5. Naproxen
-
selective Cox 2
Gout _
fiwnwñ
'
mirror :
now Vos monosodium urate Yayoi
-
Aim roses
-
s week ñoo4i
-
Ad effect 61 irritation : - -
nephrotic syndrome
-
Rash
Note Benzbomarone
:
-
idiosyncratic hepatotoxicity
1.
Synoviocyteouñis uric an Hindi ow ←
I 00AM colchicine -
Yainortiiñu kidney disease
o_0
2. PG
nigh PMN hell 12in lion V12 )
3. 1L -1 nr.o.in MNPC
macrophage > Nouri u 2.2 Xanthine oxidase inhibitor : block mirin uric an
uric oi → Uniounrironinu IL -
MO -
Allopurinol
lndomethacinl NSAID -
ñhnrionoiins
Chronic urate
lowering therapy niki : uric
-
-
-
twins nihilo cnn.uaiiburitaissoimri.hu
:
-
-1-0
1. Colchicine
-
anas
-
a- uñu protein tubulin Cisneros microtubule riaiwooiomriniiowtua ) ↑ oiosmrso HLA-B# 5801 how
→ inhibit leukocyte -
-
Acute
gout attack -
Ad effect : -
hepatic toxicity
-
Ad effect : -
Diarrhea often)* -
-1
NSAID in
gout =
block titi azathioprine inactive nikitin toxicity
lndomethacin used replacement for colchicine ) oicsno dose azathioprine
commonly as i. as
-
except aspirin +
-
-
=
, ,
lowering agents
2. I Uricosuric agent : iuuricoonanni.is Tinio goutrinnviiu -
Febuxostat
-
purine inhibitor
-
own iioo
like uricaseñiihiers allantois
ikr "
minion Pegloticase :
uric a' →
( renal allopurinol
↳
uric oiiooonsnnii IIÑ
two excreation impairment / chronic kidney disease
-
wean
mood change
Rheumatoid arthritis CRA )
-
autoimmune disease
in flam
Aim reduce pain improve functioning
-
→ -
slow
→
joint damage
Pathogenesis
1.
nr-o.in innate cellular immune response
I. Methotrexate
- Prints ,
01 Ñw
,
as ID
-
folic an antagonist →
on 's
supply a- so folic d / ucovorin
-
uiwiihrnwnis
2. Azathioprine
-4in'u allopurinol oicsfiidose anas
3.
Cyclophosphamide
-
-
n' hi cell D- wake
a.
Cyclosporine & Tacrolimus
-
hypertension -
Bladder cancer
sterility iefuuaiw
5. Chloroquine &
Hydroxychloroquine
Ocular -4in unionists
toxicity
-
-
Slide Bone : & joint parts
J Psh
Achondroplasia
.
I. nnr=
disease / Osteitis
-
↳ linin
long bone -
wuhinwoiqioo.mn
-42hr.nu mental &
intelligent -
FGFRS
gene
IÑU Ñsnw
2.
Osteogenesis imperfecta or :pnWn=
abnormal collagen synthesis
type 1
-
type I a- monsoon
3.
Osteoporosis nr-pnwr.ir
-
reduction of bone mass win:p -nésUnÑoÉ
-
in onn →
age postmenopausal
to Yw n' oufiisiw localized
,
'
ex own win
( endocrine disturbance
-
,
neoplasm ,
61 ,
corticosteroid
Bone mineral
density ( BMD ) S D
-
< 2.5 -
.
arts n' on
-
kypho scoliosis
Irian Vit D
deficiency / pain Vit D YñYaiñ
-
,
frontal
bossing no
:p nuiiiwnfu's ,
rachitic
rosary nr-rifnb.vn
IV. noisy
, pigeon breast
-
thicket :
triathlon
-
-
bone pain , easy fracturing , bending bone a adult
severe
primary hyperparathyroidism
-
a- lieu nr.ph /
Ñwfwosy
6. Renal osteo
dystrophy
Dinu "nñuYé9aiÑ
chronic osteo
dystrophy n' Ca
-
7.
Osteopetrosis riparia
-
inherited disease c autosomal recessive & dominant )
dense bone bmalignant hdenign
-
abnormally
-
stone bone
-
cause unknown
cause unknown
-
inuifoo -
curettage 4iiÑ"osÑoyo
ten bloc resection oiaoonri's block
V10 Info or
linen trauma ,
radiation , systemic disease
Infection osteomyelitis :
I. Suppurative
osteomyelitis
5.
-
hematogenous route
aureus arms (1%00)
-
loinwniilw
-
Subperiosteal abscesses
, draining sinus uwcsoonnis
drain + hi antibiotic
guns
↑ strum lhionrpnñiw I lÑwuw
segue ,
-
-
↑ involucrum inion pnriaiisfudnnwo-wn.tw'ÑU
:
2. Tuberculous osteomyelitis
muscle to
'
win no :p nirwuris
psoas
-