SKIN

PRIVILEDGE
Hyper Pulsed RF microneedle system
Repeated hyper pulsed RF energy selectively
works on abnormal blood vessels and
strengthen the basement membrane.
Accurate and Powerful
Hyper Pulse Effect
Sylfirm uses repeated short pulses that specifically target
abnormal blood vessels. Remodeling basement membrane
and dermal rejuvenation that positively influences on redness,
vascular regins, PIH and melasma.

Features

In Vitro bovine liver study during very early conduction time

Proximal

Mid

Distal

coagulation Time
1 2 3 4 5
of basement
membrane
SCARLET SYLFIRM
coagulation
of abnormal
blood vessels

Single short pulse Multiple short pulses

What is basement membrane?

The basement membrane is the very first skin layer made from the embrya and essential part of the skin that acts as
a nutrient supply to the skin. The aging of the skin is started from losing elasticity with the weak basement membrane.

Repeated hyper pulsed RF energy Sylfirm strengthens the basement

Basement membrane gets selectively works on abnormal membrane, and regenerated
thinner and weaker by aging blood vessels and strengthens collagen removes the various
the basement membrane. causes of skin diseases.
Pathologic Study
Reduction of senescent cells is associated with improvement of pigmentation. Clinical photographs of participants at
baseline, 8wks and 12wks of microneedle fractianal radiofrequency treatment, showing gradual improvement in
pigmentation. Changes in the number of p16 INK4A-positive cells and expression of prodollangen-1 and melanin
pigmentation in lesional skinafter RF treatment. The scal bar indicates 200µm.
Kang HY. et al. Senescent fibroblasts in melasma pathophysiology. Exp Dermatol. 2018;03. https://doi.org/10.1111/ecd13814

Baseline 8 week 12 week Baseline Sylfirm Tx After 12 weeks

A reduction in p16 INK4A
positive cells (senescent fibroblast)

p16 INK4A
An increase in density of procollagen-1 (young fibroblast)

Procollagen-1

A Marked decrease in pigmentation of lesional skin(melanin)

Forntana-Masson

Histologic Study
Efficacy of hyper pulsed RF on basment menbranes. increased type IV collagen fiber along the basement membrane (BM)
on post-treatment day 7 and 14, PAS stain.

Day 0 Day 1 Day 7 Day 14

Transmission electron microscopic features of basement membranes. Remarkable thickening of lamina densa on
post-treatment day 7 and 14. *BK: Basal Keratinoctye / D: Dermis / HD: HemiDesmosome / KF: Keratin Filament / LD: Lamina Densa

Day 0 Day 1 Day 7 Day 14

Efficacy of Hyper Pulsed RF on vascular components. Pathogenic(Abnormal) and collapsed blood vessels in dermis and
distended blood vessels in subcutaneous fat on day 7 and 14.
Cho SB, Na J, Zheng Z, et al. In vivo skin reactions from pulsed-type, bipolar, alternating current radiofrequency treatment using invasive noninsulated
electrodes. Skin Res Technol. 2018;00;1-8. https://doi.org/10.1111/srt.12433

Day 0 Day 1 Day 7 Day 14

Clinical Results
This is an actual treatment with Sylfirm.

Redness Melasma

Melasma & Skin toning Redness PIH

Before After

Melasma Melasma
Before After Before After

Rosacea Eye wrinkles

Before After Before After
 EXPERIMENTAL DERMATOLOGY PUBLISHED

Senescent fibroblasts
in melasma
Clinical pathophysiology
Results
Author: H.Y. Kang (Department of Biomedical Science, The Graduate School, Ajou University, Suwon, South Korea)
Scarlet S delivers RF energy to the skin through microneedles
to treat various skin problems such as acne, wrinkles and scars.

Purpose of Study Methods of Study

Understanding correlation between Melasma and senescent Study1 – Verification of the number of senescent fibroblasts and
fibroblasts. distribution in Melasma skin.

Study2 – Verification of the efficacy of SYLFIRM treatment in

Melasma skin.
Results of Study
Melasma contains senescent fibroblasts in dermis and the removal of senescent fibroblasts through the SYLFIRM
treatment can be possible to improve Melasma skin.

Details of Study
Study 1 Study 2

Method Biopsy of Melasma Skin / 38 cases SYLFIRM treatment to Melasma skin / 3 cases

Melasma skin contains a lot of SYLFIRM treatment decreased the number of

Results senescent fibroblasts senescent fibroblasts which improved Melasma Skin.

Toning efficacy after the treatment

Baseline 8 week 12 week
Perilesion

Senescent fibroblasts decreased

after the treatment

Melasma
p16

Details
The density of Procollagen-1 increased
after the treatment
Procollagen-1

Senescent fibroblasts increased between

epidermis and dermis in Melasma Skin
Red area is senescent fibroblasts p16INK4 The epidermal pigmentation decreased
after the treatment
No difference of the number of senescent
Forntana-Masson

fibroblasts in dermis.
 THERANOSTICS, PUBLISHED

Senescent fibroblasts drive aging pigmentation:

A potential
Clinical therapeutic target for senile lentigo
Results
Author: H.Y. Kang (Department of Biomedical Science, The Graduate School, Ajou University, Suwon, South Korea)
Scarlet S delivers RF energy to the skin through microneedles
to treat various skin problems such as acne, wrinkles and scars.

Purpose of Study Methods of Study

Identifying the impact of senescent fibroblasts on aging Study1 – Verification of the number of senescent fibroblasts and
pigmentationVerifying the effect of remo-ving senescent fibroblasts distribution in Lentigo Senilis
via SYLFIRM treatment.
Study2 – Verification of the efficacy of SYLFIRM treatment in
Lentigo Senilis
Results of Study
Senescent fibroblasts promote pigmentation and cause deficiency of SFD1. SYLFIRM treatment can be used to increase SDF1 and help
toning effect by removing senescent fibroblasts in Lentigo Senilis. *SDF1 : A kind of the stem cells helpful for toning effect

Details of Study
Study 1 Study 2

Method Biopsy of Lentigo Senilis / 17 cases SYLFIRM treatment of Lentigo Senilis / 10 cases

Senescent fibroblasts promote pigmentation SYLFIRM treatment can be used to increase SDF1
Results and cause deficiency of SFD1. and helping toning effect by removing senescent
fibroblasts in Lentigo Senilis.

Ab : p16INK4A Skin tone brightening and pigmentation

improved after the treatment on Lentigo Senilis.
Distribution of the red in Lentigo Senilis skin
comparing with Normal skin

Perilesional normal Senile lentigo

SDF1 and Procollagen 1 increased after the

treatment on Lentigo Senilis.
Details
Most senescent
fibroblasts(93.8%)
are located in the
upper dermis
Published Articles
Sylfirm is a proven product in several papers.

Hee Young Kang Sung Bin Cho Hee Young Kang

Published by Experimental Dermatology / 2018.10.25 Published by Skin Research and Technology / 2018.01.01 Published by Theranostics / 2018.10.25
Kang, HY, Kim, M et al. Cho,SB. et al. Kang, HY. Et al.
Senescent Fibroblasts in Melasma Pathophysiology In vivo skin reactions from pulsed-type, bipolar, Senescent Fibroblasts Drive Ageing Pigmentation:
Experimental Dermatology, 2018 alternating current radiofrequency treatment using invasive A Potential Therapeutic Target for Senile Lentigo
noninsulated electrodes. Theranostics 2018, Vol. 8, Issue 17
Skin Res Technol. 2018, 24(2):318-325 Med LASER 44:631-636(2012)

Tae Hwan Ahn Tae Hwan Ahn Jin Soo Kang

Published by PRS / 2018.01.16 Published by KSLMS / 2017.06.12 / Medical Lasers; Published by KSLMS / 2016.01.21 / Medical Lasers;
Ahn, TH, Cho,SB. et al. Ahn, TH, Cho,SB. Kang, JS. Et al.
Adjuvant Therapy for Revision Rhinoplasty of Invasive Pulsed-type, Bipolar, Alternating Current Improvement of Periorbital Wrinkles Treated
Contracted Nose Using Polydeoxyribonucleotide Radiofrequency Treatment Using Microneedle with an Invasive Non-insulated Microneedle
and Invasive Bipolar Radiofrequency. Electrodes for Nasal Rosacea. Pulsed Electric Signal device
Plast Reconstr Glob Open 2018, 6(1): e1645 Med. LASER., 2017; 6(1):32-36 Med. LASER., 2017; 5(1):34-38

Hyoung Moon Kim Jong Ju Na Jin Soo Kang

Published by KSLMS / 2017.06.21 / Medical Lasers; Published by SCIENTIFIC REPORTS / 2015.11.13 Published by KSLMS / 2016.01.21 / Medical Lasers;
Kim, HM. Et al. Na, JJ, Cho,SB. Cho, SB. Et al.
Therapeutic Efficacy and Safety of Invasive Pulsed-Type Electromagnetic Initiation and Propagation High-Frequency Alternating Electrical Current:
Bipolar Alternating Current Radiofrequency on Melasma of Bipolar Radiofrequency Tissue Reactions Selective Electromagnetic Tissue Reaction
and Rebound Hyperpigmentation. via Invasive Non-Insulated Microneedle Electrodes Med. LASER., 2016; 5(1):1-6
Med. LASER., 2017; 6(1):17-23 Sci Rep. 2015; 5; 16735

If you would like to have further information on the above published articles of Sylfirm,
please contact via email or visit our website presented.

[email protected] / www.viol.co.kr / www.serendia.us

#806, Bundang-Technopark D, 700 Pangyo-Ro, Bundang-Gu, Seongnam-Si, Gyeonggi-Do, Republic of Korea (13516)
TEL. +82-31-8017-7893 FAX. +82-31-8016-7894 E-MAIL. [email protected]