ALL PRAISE TO ALLAH ALMIGHTY, THE MOST BENEFICENT AND THE MERCIFUL!

20-12-22
1. External Beam Radiation therapy due to some metastatic disease done, damage caused to DNA by… DNA
double helix breakage
2. An experimental question where a protein was added to DNA sequence and increases its
survival/replication (i don’t remember exactly) … Promoter sequence
3. Splicing of RNA… 5’GU 3’AG
4. CDK inhibited, which tumor sup gene affected… p53
5. Six subunit receptor causes ... Transport of solutes/ions across membrane
6. A child with hepatomegaly, hypotonia, craniofacial dysmorphism. Long scenario. But in the end CV gave
accumulation of pipecolic acid & LCFA. Which organelle affected… Peroxisomes
7. Paclitaxel affects ... Tubulin
8. Flow cytometry graph, showing Cd4 and Cd8 positive cells, asking organ where they’d be present… Thymus
9. A newborn got infected from the hospital, gel electrophoresis was given. From where did the newborn got
infection. (Physician was the ans in my case, choose the one matching with the newborn)

10. A pt with sickle cell disease, now on hydroxyurea. What would be the pattern on electrophoresis? Choose
the one with HbS & HbF (A would be the option)

11. A pt with signs of precocious puberty (Vaginal bleeding, breast bud and pubic hairs at 6 years of age), café-
au-lait spots, what would be the mutation? GNAS activation mutation/McCune Albright syndrome
12. Autosomal recessive pedigree … chances of newborn
13. CV of CAH, what would be the risk of CAH in female born to the parents, one girl is already with CAH
14. A female with CGG tri nucleotide, which of the following has increased risk in other males/family…
Intellectual disability (Fragile X)
15. Pt with CF, recurrent sinopulmonary infections, purulent sputum now ... pt wasn’t a child, so Pseudomonas
would be the ans
16. CV of a pt with brachycephaly, atlantoaxial joint instability, low set ears, broad flat nasal bridge, gap b/w
fingers … Downs syndrome/trisomy 21
17. CV of a pt with micrognathia, hypertelorism, post folded ears, sandle gap in toes, holoprosencephaly …
Patau syndrome/trisomy 13
18. CV of a pt with chronic diarrhea, weird rash on neck (picture was given) … Vit B3 def
19. CV of a pt with dryness, xerosis, eye problems … Vit A def
20. A newborn born at home, hx of excessive bleeding. What process is deficient? Carboxylation
21. CV of a pt with increased homocysteine and methylmalonic acid. What would be present? Ab against
parietal cells
22. Warfarin was given to a pt. what process was inhibited in him? Carboxylation
23. In alocoholic, NADH increased, what process was inhibited? TCA cycle was the only sensible option
24. G6PD def scenario, arrow question (GSSG, NADPH, reduced glutathione)
25. CV showing increased Methionine & Homocysteine, what would be deficient? Cystathionine synthase/B6
26. A weird graph where a wild type was compared with mutated LOXI gene & 3 diff graphs were given. LOXI
resembles with which enzyme? Options were Glucokinase, Glucose 6 phosphatase (Do confirm it)

27. Barret esophagus scenario. What was seen in the image? Intestinal metaplasia

28. Adult man with rash all over back. Dx … Pityriasis rosea

29. Picture given. Gottron papules, fam hx of hypothyroidism/auto immune disease. What needs to be checked
in this patient? Muscle Strength/chest expansion
30. Picture given. A pt had Vitiligo, which layer would be the affected in this pt? Basal layer would be the ans

31. CV where a pt had impaired sensation along with allodynia features after CVA. Motor system was
preserved. Where is the defect? Thalamic pain syndrome, mark thalamus on the picture (20)

32. Women says her husband had 8 months of rapid behavioral change. He also got complains at work saying
he cannot do simple task and was scolded to take early retirement by boss. Serial Seven test is also weak
and go-no-go test also mentioned. MRI head given. Spherical tau proteins (Frontotemporal dementia)
33. A man lands in ER with right sided hemiparesis and eye deviated to the left. Loss of conjugate eye
movement. Had hx of uncontrolled HTN. This ocular finding is due to lesion at? Frontal eye field would be
the ans

34. Expansive population pyramid given. What will be best? increase primary school teacher

35. CV with a female pt having seizures since last 5-6 months, off & on headaches. MRI given. What would be in
biopsy. Whorled concentric tissue (Meningioma)

36. A mayor of city tries to remove cold beverages and promotes exercise activity to all as obese and diabetes
are raising. What will be the prevention type for Non-obese and Non-diabetes? Secondary for both
37. An elderly male came to physician for Erectile dysfunction. He had an aortic surgery few months back. He
now also has tingling sensation in buttock area while exercise. What is the cause? pelvic ischemia
38. A 6 yr girl started urinating in bed at night. Her brother got diagnosed with leukemia few weeks back.
Cause? Reaction to stress
39. A pt with multiple medications, takes lisinopril, carvedilol and diphenhydramine. Found unconscious on
floor. Pulse -120, Bp – 80/40. What finding will be seen? Mydriasis
40. Elderly female with G4P4 comes with leakage of urine during the day while coughing and all. What caused
it? decreased urethral support
41. During delivery there is gush of blood from uterus and while trying to pull the umbilical cord. Placenta
doesn’t separate. What abnormality has caused it? decidua basalis
42. A 4 yr boy comes to clinic with external urethral meatus opening on ventral surface of penis. This is due to
the defect of? Closure of urethral folds
43. A teenager female comes saying bleeding occurs during menses even though she keeps a tampon. On
examination you find that there is vaginal septum. What other abnormality will be seen in this patient?
Uterus didelphys
44. Left sided adnexal pain in a female. Decreased flow will be seen in which vessel? ovarian vein
45. CV of a pt on OCPs. Now she has developed painful, s/c nodules over shin. What would be it? Erythema
nodosum
46. 0.8 mm polyp removed from colon. What will be seen in original polyp removed mucosa site after 1 yr?
normal mucosa
47. A laryngoscope is passed intranasally. What will be the next thing visible as it passes caudally from
oropharynx? Epiglottis
48. Experiment done on a woman. Women kept to increase altitude. This shows inc in 2,3 BPG. What will
happen? Decreased affinity of Hb with O2
49. A man comes to clinic 5 days after RTA where he had cut. What will do remodeling in this wound? MMP
50. Hx of death and shows gross pic of bronchus. What caused death in the person? Cor pulmonale

(picture wasn’t as clear as this :)

51. A person with asthma, long scenario. What would be the additional cause of death? Mucus plugging
52. Severe respiratory distress in baby in 1 day age in NICU. CV of congenital diaphragmatic hernia. What
findings will be observed? Abdomen Scaphoid, bowel sound dec
53. Chest finding needed to diagnose Pleural effusion. Breath sounds dec, Percussion dull, deviated to opp side
54. Construction Worker falls from height and is admitted now. Urine showed blood but no RBCs but dies.
What will be seen in histo of kidney? Tubular cast
55. An elderly male with diff urinating. On examination, he has diffuse and smooth enlargement of prostate.
What drug to be given to reduce epithelial component? 5 alpha red inhibitors
56. A graph was given. What would be it? AMP-Allosteric activator
57. Histo shows coiled tortuous glands in uterus. What is responsible? Progesterone D graph.

58. Woman came to the physician. She has started taking calcium already due to fear as her mother had
osteoporosis. Now she comes and asks the physician what exercise will be best to reduce osteoporosis.
What is it? I marked preparation (there was an option for action, too)
59. CV explaining about ischemic attack showing the effect presents on the following region of brain. Pt is now
dead. Which of the following nuclei will be atrophied in this patient histo?

60. CV with Plantar fibromatosis. What will be associated with? Dupuytrens contracture
61. CV of asthma & miscarriage. Bradford criteria was asked. No asthma, asthma 1 ep but no hosp admn,
asthma 2 ep with hosp admn, asthma with multiple ep of hosp admn… relationship was shown with
miscarriage. I don’t remember the exact ques. Options include, biological plausibility, dose response,
temporality, reverse association.
62. A CV of a man describing dilated blown, down and out pupil. The pathology is? PCom aneurysm
63. A graph was given, asked about relation. Gender effect present but no drug effect

64. An experiment is done to see the effect of aerobic exercise on muscle. The man starts doing exercise and
now muscle changes are being studied. What change is seen in the muscle because of this? Increase in
mitochondria
65. A patient with HIV received t/m for PCP pneumonia and CMV retinitis. After treatment CD4 cell count
increased to 350 from 50 and viral load decreased than before. Pneumonia and CMV retinitis both treated
but again after a week of evaluation left eye shows features of retinitis and right eye showed inflammation.
What is the likely cause or the presentation of this Visit even after improvement of cd4 count and dec of
viral count? Immune reconstitution inflammatory syndrome
66. Mother saw a mass protruding from vagina while changing the diaper of daughter. The mass mostly arises
from? Mesenchymal origin (sarcoma botryoids)
67. A lady comes for the hearing of her biopsy report which shows adenocarcinoma. The physician has already
broken the bad news and now needs to discuss further management plan. Lady tells the physician that she
feels overwhelmed with the news and she further adds she has always believed in faith and the decisions of
her pastor. Pastor has always helped him with her life problem. What will be the response of the physician?
You seem to have a good relation with pastor. You both decide and let me know about the decision, I’ll be
okay with whatever you decide
68. A group of friends went to a birthday party. Most of them developed features of gastroenteritis in 4-6 hrs.
But clinical features subside in 24 hrs. The symptoms resolved on its own, likely reason for this is?
Vomiting washed the toxins & bacteria
69. Pt needs to have colonoscopy due to family hx. Pt has previously cancelled 5 appointments for colonoscopy
and not rescheduled it. What will be the response by the physician? What are your thoughts regarding
colonoscopy?
70. A teenager came with a hx of pimple on penis. Asking the physician whether it is STI or not. Physicians
response? Let’s talk about sexual health/safer sexual practices
71. A known case of breast Ca under Rx. Needs further testing but refuses, saying I don’t want it. I just want to
spend rest of my life with my fam & local community center helping other pts. With same Dx. Altruism
72. Pt with incr wt for 8 months, job stress, BMI raised, TSH normal, BP 120/80, BSR 99mg/dl. Just wt gain
problem. Cause? Idiopathic/Metabolic syndr (Do confirm it)
73. Female with hx of fatigue, decr reflexes, ptosis of eye. Cause? Mark in figure. Lambert eaton

74. A young man came to hospital due to knee pain, started after fall while playing when he collided in a
football match. Exam shows abrasion in Rt hand & knee. Pt is febrile & on hydrochlorothiazide already.
Findings? Crystals, cloudy fluid with lymphocytes
75. Mother brings her child to dr due to hematuria and decr hearing. His brother also uses hearing aid and has
terminal CKD. Defect is present in… Col4A2
76. SSRIs prescribed. Pt. comes again saying I’ll have adverse reactions. Dr.s response? What are your
concerns regarding medication?
77. Experimental Q where there is increased cyclin activity by increased cyclin-cyclin d1 pathway. Increased cell
turnover happens. This occurs by phosphorylation of what? A) Tp53 B) Rb C) E2F
78. Paint spill occurs, which layer protects from harmful effects? Stratum corneum
79. CV of a child with hepatomegaly, cardiomyopathy, hypotonia, weak sucking reflex. What enzyme would be
deficient? Alpha 1,4, glucosidase
80. CV of a child with hepatosplenomegaly, developmental delay, enlarged skull, corneal clouding. Which
organelle is affected causing these symptoms? Lysosomes
81. Malonyl-Co A inhibits what process in the body? Beta oxidation of FA
82. Experimental Q where linoleic acid was given. It is related to which of the given things in the body? I
marked TXA2
83. A man was given trans FA, decr amount of Linoleic & Linolenic acid in the body. What would be deficient in
the body? Pancreatic Lipase
84. LPL activity affected, what would be increased in body? TGs
85. A long CV with multiple symptoms like hepatosplenomegaly, xanthomas, fam hx, blah blah. In the end, it
was given that on labs, there was a creamy supernatant over tube. What would be deficient in this pt? LPL
86. A CT was given where sth was marked around aorta. Which nodes will drain corresponding area tumor?
Para-aortic LN
87. Experimental Q where it was infected with an organism. LPS was present there, it will act through which
receptors? TLR4
88. CV of a person with lip swelling, edema, cough etc. What would be increased in him? Bradykinin
89. After an infection, which of the following would cause defensive cells to come over there? (Basically asking
about chemotaxis) C5A
90. There was a Q about cytokines, too. I forgot now but it was doable.
91. Monoclonal Ab was given to a pt. After 3 weeks, developed rash, arthralgias etc. Type 3 hypersensitivity
92. CV of recurrent bacterial infections to a child, esp Staph aureus. What would be the abnormality? NADPH
oxidase
93. A pt returned 3 weeks after transplant with deranged creatinine, fever, graft tenderness. Biopsy shows
dense mononuclear infiltrates. Acute transplant rejection
94. CV of UTI in a young woman, nitrites negative. Organism involved? Staph saprophyticus
95. A person had colon CA, after undergoing some endoscopy, he developed subacute endocarditis. Valve
involved? I marked Aortic but there was an option for Mitral, too. Do confirm it before marking.
96. Why Neisseria vaccine is not that much effective? Due to antigenic variation in pilli
97. CV of a child with bouts & paroxysms of cough, no fever. Which vaccine could have protected this child?
Acellular pertussis vaccine
98. There was a Q about infection after having a hot tub bath. Either organism (Pseudomonas) was asked or
site of infection (Follicles) was asked. I don’t remember exact Q but it was doable.
99. A child with bloody diarrhea, HUS like picture. Mechanism or strain was asked. Mechanism (Shiga like
toxin), Strain (EHEC)
100. CV of a pt. with pancytopenia, splenomegaly, LAD, lung granulomas with calcifications, living in
Kentucky/Ohio. Causative agent? Histoplasma (in the macrophages)
101. An ICU pt. with CV line got worsening of symptoms, culture on Saboraud’s agar positive. (I think an
image was given or just randomly written over there) pseudo hyphae with budding yeasts. What would be
the Rx? Inhibition of beta D Glucan/Echinocandins (others options were there, too. I chose it but mark it
after confirming)
102. CV of an AIDS pt. with pneumonia like symptoms. Picture was given. Diffuse, B/L ground glass
opacities with pneumatoceles. Rx? TMP/SMZ
103. CV of a young hiker, camping and using wild berries. Now, he has foul-smelling diarrhea. Dx?
Giardia lamblia
104. CV of a pt. who got rapidly developing confusion, headache, fever, photophobia. Encephalitis like
features. (I think he died, too xD) Hx of jet-ski was also there. Dx? Naegleria fowleri
105. CV of a pt. with fever, hemolytic anemia, high grade fever, headache, flu-like symptoms.
Intraerythrocytic rings were also present in the picture. Pt was resident of Connecticut; he came back from
 Uganda a week ago when these symptoms develop. Cause of this Dx was asked. I marked Resident of
Connecticut (since babesiosis is more common here) there was an option of travel hx to Uganda
106. CV of a pt. with hepatosplenomegaly, portal tract inflammation, picture showed organism with
lateral spine. Source of infection was asked. Fresh water (Schistosoma mansoni/snails)
107. CV of a pt. from nursing home, with multiple eczematous lesions, b/w finger webs. Dx? Scabies
108. Long scenario where fever, right upper quadrant pain was given. Multiple Ag/Ab given but HepEAg
was positive. Dx? Acute Hep E
109. CV of a young man with multiple pruritic, vesicles and ulcers with an erythematous base on penis
along with systemic signs. Tzanck smear shows multi-nucleated giant cells, intranuclear inclusions &
acantholytic cells. Dx? Genital herpes
110. A flow cytometry was given where Cd4T & B cells were given. B cell count was decreased.
Heterophile Ab test was negative. Dx? CMV
111. CV of a child with high grade fever followed by generalized rose-colored rash over body. Dx?
Human herpes virus 6
112. CV of influenza. Medication is given to target which of the following viral component?
Neuraminidase
113. A pt. from Uganda (lol again), had symptoms of severe polyarthralgia, myalgia, retro-orbital pain,
fever and maculopapular rash. Dx? Chikungunya virus
114. A female pt. with dyspareunia, greenish vaginal discharge. Wet mount shows pear shaped, motile
green protozoa with nuclei. What’s the mechanism of drug used to Rx it? Free radical generation
(Metronidazole)
115. A newborn with seizures, petechial rash, retinitis and CT shows periventricular calcifications. Dx?
CMV
116. A hypothyroid pt. was taking levothyroxine along with Ca supplements but effects were not
observed. What causes the decreased efficacy of drug? Chelation of drugs with Ca (Chelation affects
absorption of drugs like tetracyclines, fluroquinolones & levothyroxine)
117. Leflunomide inhibits synthesis of? Pyrimidines, TMP inhibits synthesis of? Pyrimidines
118. Isoniazid causes resistance due to? Mutations in KatG
119. CV where a diabetic pt has black necrotic ulcer, rapidly destroying bones and invading to brain,
scenario of Mucor. What causes it? Invasion into bone
120. A pt. had herpes, scenario with recurrent herpes labialis, gingivostomatitis. The drug used to Rx it is
activated by? Thymidine kinase
121. In CMV pt, drug is given to Rx it shows mechanism of resistance by? DNA polymerase (Do confirm,
if there’s an option of viral kinase then mark it)
122. Size of prostate decr through apoptosis. It occurs due to expression of which signal on outer
membrane of prostate cell? Phosphatidyl serine
123. There was a Q with brain infarct, a scenario was given. Asked about of type of necrosis.
Liquefactive
124. Keloid is formed. Rx is directed against what? TGF-beta
125. During an acute infection, rolling of lymphocytes is mediated by? Selectins
126. There was a Q on immune checkpoints (CTLA4/PD1/PDL1) that was doable. I don’t remember it
now.
127. A drug has T1/2 of 2 min. How long will it take to reach steady state? 10 mins
128. Case control & Cohort scenario
129. Research was conducted establishing a relation b/w coffee & pancreatic cancer that showed positive
association. It was also positive when relation was established with smoking. What was it? Confounder
130. Best measure of central tendency in a skewed distribution. Median
131. A child got his PDA repaired. What is at highest risk of damage with this operation? Recurrent
laryngeal nerve
132. CV of an old lady, with SOB, orthopnea, harsh systolic murmur (more prominent at Rt sternal
border), radiating to carotids. Audio was also there. Dx? Aortic stenosis
133. Another audio & scenario of MS
134. An ECG given, showing atrial flutter. From where the abnormality arises? Atria
135. CV of a young athlete who suddenly got syncope, bradycardia etc. ECG was given. Long QT
syndrome

136. After Fonton Procedure, a pt. had muscle loss and weakness etc. What complication has occurred?
Protein losing enteropathy
137. CV of a child who was asymptomatic at birth, now developed cyanosis, wide split of S2. VSD with
shunt reversal
138. Another long scenario, a child with continuous murmur at Left sternal border at 2nd IC space. Dx?
PDA
139. CV of a pt. with acute MI, cardiac Trop I was raised. What causes this finding? Rupture of cell
membranes
140. Another scenario where ST elevations in 2,3 and aVf. What portion of heart affected? Inferior
border of heart.
141. Inferior wall MI, highest risk of which complication? Bradyarrhythmia
142. CV of a pt. with electrical alternans, swinging heart and pulsus paradoxus. What is the cause? Cor
pulmonale/Cardiac tamponade
143. A case of myxoma. Picture was given almost same like UW. From where the tissue is taken? Left
atrium
144. Experimental Q where Arginine was given to both groups. Ach stimulation causes vasodilation in one
group but not in the other group. Which substance/enzyme was absent in the group not undergoing
vasodilation? NO synthase
145. Experimental Q where rats on treadmill, Size increased. What causes increase in size? GH
146. Increased IGF-1, increased GH, still height was short. Reason? IGF-1 resistance
147. A pt. with thyroid swelling, clear nucleus & psammoma bodies on biopsy. Dx? Papillary thyroid Ca
148. PTH graph. Secondary hyperparathyroidism.
149. CV of a pt. with episodic HTN, thyroid swelling & difficulty closing mouth due to in due to mucosal
neuromas. Mutation causing it? RET
150. Pt. having hypoglycemia & neuroglycopenic symptoms after exercise. Symptoms resolved after
having orange juice. It is due to tumor of which cells? Beta cells of pancreas
151. Diabetic & obese advised exercise & dietary modification for weight loss, labs were given, HbA1c =
8.5, other labs normal, no improvement in weight, next appropriate therapy acts on what? Hepatic
gluconeogenesis & increase insulin sensitivity/Metformin
152. CV of a pt. with pancreatitis, major papillary duct obstructed, tumor of head of pancreas. Now came
with jaundice. Most likely site of obstruction? Ampulla of Vater
153. During hepatic surgery, excessive bleeding is controlled by a surgeon. He has occluded?
Hepatoduodenal ligament
154. During surgery, gastroduodenal artery is clamped. What is responsible for blood supply to
duodenum/greater curvature of stomach? Splenic (Due to left Gastroepiploic vessel) do confirm it
155. CT was given. Pt. has pre/peri prandial pain & swelling in gland. Cause? Precipitation of mineral of
gland secretion

156. A Q on GERD/Barret esophagus

157. CV of a pt. with chronic diarrhea, aphthous ulcers, anemia, mucosal bleeding. Colonoscopy was done
but couldn’t proceed further. Reason? Fibrosis (Crohn’s Disease)
158. Rx of UC pt. TNF-alpha inhibitors
159. CV of a pt. with hx of bloody diarrhea, p-ANCA positive, jaundice, beading of intra & extra hepatic
ducts. Dx? Primary Sclerosing cholangitis
160. A long scenario of Meckel’s diverticulum. After laparotomy, which cells were seen at ileocecal
junction? Parietal cells
161. A pt. comes with absolute constipation for 5 days. She has hx of appendectomy, myomectomy, c-
sec. What was the cause of it? Adhesions due to multiple surgeries
162. A chronic alcoholic came to ER in a comatose state. What would be increased in him? TGs
163. When a vessel is stripped, immediate vasodilation occurs via? NO
164. CV of a child with abdominal pain, pallor, hand weakness etc. Picture was given. Defect in heme
synthesis pathway

165. 2 Qns on Megaloblastic anemia.

166. CV of a pt. with hematuria, abdominal pain, backache, pancytopenia. Sucrose lysis test was positive.
Dx? Defect of complement inhibitors
167. CV of TTP/HUS, it was doable. I don’t remember it now.
168. A female came with pain & swelling in leg after a long flight. She was on some administrative post.
Reason? Factor V Leiden mutation
169. A Q on Burkitt lymphoma, picture was also given. I don’t remember now but it was an easy Q
170. CV of a pt. with aquagenic pruritis, thrombocytosis, increased RBCs. Occurs due to mutation of?
JAK2 kinase mutation
171. Long vignette about injury of median nerve. What would be affected the most? Thumb opposition
172. A newborn with signs of hip dislocation (kind of). On manipulation, clinking & clunking sounds. Dx?
DDD
173. A pt. with Earlin Meyer deformity on X-ray, bright white shadows. Mutation of Cl channel. What
function would be impaired? Bone resorption/Osteoclasts
174. CV of a pt. with hip pain & decreased range of motion. Affected leg appears shorter. X-ray was given.
Vessels causing it? Medial circumflex femoral artery (It looked like avascular necrosis to me)

175. CV of a young pt. with morning stiffness & other signs of RA. Most diagnostic? Anti CCPs
176. A pt. with amenorrhea & anosmia. Where would be the defect? Diencephalon
177. A female with seizures, intellectual disability, double cortex on CT. Defect? Radial migration defect
178. CV of a pt. with cape-like loss of pain & temp sensation bilaterally. Where would be the defect. Had
to mark syringomyelia in picture.

179. After ischemia/neurological insult, which cells would be responsible for repair? Astrocytes
180. After cellular injury, cells retract & others cells swell, new sprouting etc. What process is occurring?
Wallerian degeneration
181. Defect in ADH secretion (Sth like that). Where would be the defect? Supraoptic nucleus
182. Truncal ataxia, wide based gait, Romberg positive. Lesion at? Cerebellar vermis (Other options
were also there, do confirm)
183. CT was given. Injury? Contusion on same side & subdural hematoma too. Scenario of an
unconscious pt. with no lucid interval. Image somewhat like this. I chose contusion on the same side &
rupture of bridging veins on the same side. Anyways do confirm
184. CV of a pt. with severe headache, nuchal rigidity & fever. What would you ask about fam hx of the
pt.? Hx of polycystic kidneys
185. CV of a child with hx of blank stare, 3Hz spike & wave discharges on EEG. Drug given to Rx acts on?
Ca channels
186. CV of a pt. with rapidly progressive dementia, ataxia & myoclonus. What would be seen on biopsy?
Neuronal loss, intracytoplasmic vacuoles (CJ disease)
187. CV of a pt. with visual loss, eye pain with movement. Oligoclonal bands were present. Which cells
would be involved? Oligodendrocytes
188. Another scenario of optic neuritis/MS. Investigation? Fundoscopy
189. CV of a child with upward gaze palsy, hydrocephalus etc. What tumor would be present?
Pinealoma
190. Loss of white reflex, visual loss, etc. Picture was also given. Gene involved? Rb (Another tumor
involved, Osteosarcoma)
191. For the Rx of Al-Zheimer, Rx? Anti-muscarinic
192. A cancer pt. after being diagnosed, doesn’t want to undergo any investigation/Rx.
Denial/Dissociation
193. CV of a child with hyperactivity, ADHD. Rx given has MOA? Increased uptake of biogenic amines
194. Scenario of patchy hair loss, hair follicles observed, not completely bald. Picture was also given. Dx?
Trichotillomania
195. CV of a pt. with poor interpersonal relations, timid but desires relations with others. Avoidant
196. A pt. with HTN, tachycardia, irritability, diaphoresis etc. a) MDMA b)Heroin C)PCP
197. Alcohol withdrawal symptoms, Diazepam 5 mg given no improvement, dose was increased to 40 mg
symptoms improved, 1 hour later withdrawal symptoms reappeared, why? Tolerance - receptor
desensitization
198. A Q on Diabetic glomerulonephropathy/Kimmelstiel-wilson nodules.
199. A pt. with rash, fever hematuria after NSAIDs. Dx? Acute interstitial nephritis
200. A drug used to Rx edema, HF (asking about loop diuretics) Where would it act? TAL
201. ACE inhibitors given. Up down arrows for angiotensin, bradykinin, renin etc.
202. A female pt. gave birth to a child with multiple skeletal anomalies, uterus didelphys. She was on
isotretinoin. What gene is involved in it? HOX gene
203. An old lady with vaginal bleeding, dyspareunia, endometrial thickness is increased. What hormone is
involved in it? Estrogen
204. CV of a pt. with webbed neck, shield chest, streak ovaries, cubitus valgus. Genetic analysis will
show? Iso-chromosome
205. A Q on ovarian torsion
206. CV of a pt. with heavy vaginal bleeding, pelvic pain & irregularly enlarged, non-tender uterus. 2 Histo
slides were also given. Asked about origin of tumor. Benign Mesesnchymal
207.
208. A pt. with excessive sweating on stress. Glands involved? Sympathetic, eccrine glands
209. CV of a pt. with tinea capitis. What would be observed on KOH? Hyphae
210. Drug used to terminate pregnancy, progesterone analogue. Mifepristone
211. A long scenario mentioning pleural plaques in the end. Dx/Reason? Mesothelioma/Asbestos
212. A pt. with some malignancy, long scenario. Pt. had effusion that was exudative acc to Light’s criteria.
Reason? Increased capillary permeability
213. CV of a male child with palpable U/L flank mass & absence of iris. Mutated gene? WT1
214. A nurse accidently pricked needle with hep B pt. She was already vaccinated. What would be
present in her blood already? HBsAb
215. In an asthmatic pt., other than bronchoconstriction, most important cause of death? Mucous
plugging of bronchioles
216. CV of a pt. with deep peroneal nerve injury, loss of sensation at web space b/w 1st 2 fingers. What
would be lost? Extension of toe
217. Rupture of ectopic pregnancy. Fluid will accumulate in? Rectouterine pouch
218. CV of a pt. with acute exacerbation of asthma. Samter’s triad positive. Nasal polyp, rhinosinusitis,
asthma. Inhibition of which enzyme has caused it? COX-1
219. NRDS scenario. What would have occurred? A) Increased surface tension B) Decreased surfactant
D (Do confirm it)
220. 9 yrs old child diagnosed with ALL, asking Physician what’s wrong with me/Am I going to die?
Parents have already told the physician not to disclose this with their son. What will be the physician’s
response? What have your parents told you about Dx
221. Child with Down syndrome came to the clinic with his mother, asking physician about sex. Mother
says ‘shut up’ & apologizes the physician. What will be the physician’s response? What do u know
about sex
222. Patient taking acetaminophen, no improvement, increased dose, now present with symptoms of
hepatotoxicity, toxicity due to? NAPQI induced damage
223. 19 yrs old, syncope after running, holosystolic murmur on apex, slight LV hypertrophy, No displaced
beat, No family hx, murmur on Valsalva maneuver? Increased (HCM)
224. Change in gastrocnemius muscle after Cycling & running? Inc Mitochondria
225. Pt presented with SOB, Orthopnea, pedal edema & other features suggesting HF, Hx of anthracycline
use, this is due to? Dec CO
226. Substrate Reaction without drug Reaction with drug
2 40 20
3 50 30
5 60 40
8 80 80
9 90 90 Asking about drug acting as
Competitive Antagonist
227. 75 yrs old man presents with pain in LLQ & Hematochezia, Hx of chronic constipation, gross pic of
colon given. Asking about pathophysiology? Mucosa & submucosa protrusion
 (image was somehow resembling this one)
228. After giving NS to a pt. at ER, he developed fever, chills etc. What’s the reason? Release of pre-
formed cytokines from the NS
229. Kaplan-Meir curve given. Must watch Randy Neil video regarding this. Easy but helpful during exam.
230. CV of a pt. with bradykinesia, rigidity, dementia. Asked where would be the defect? Substantia
nigra (had to mark on specimen)

That was all I could remember. Good luck everyone & remember me in prayers!