Conflits of Interest

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Conflicts of interest

Interest:
An interest may be defined as a commitment, goal, or value held by an
individual or an institution.

Examples include a research project to be completed, gaining status


through promotion or recognition, and protecting the environment. Interests
are pursued in the setting of social interactions.
Conflict of Interest (COI):
Researcher’s interests can and often do conflict with one another.
A conflict of interest exists when two or more contradictory interests relate
to an activity by an individual or an institution. The conflict lies in the
situation, not in any behavior or lack of behavior of the individual. That
means that a conflict of interest is not intrinsically a bad thing.
Other definitions include:
Conflicts of interest are "situations in which financial or other personal
considerations may compromise, or have the appearance of compromising.
Conflict of interest also known as competing interest.
In other words, a conflict of interest arises when what is in a person’s best
interest is not in the best interest of another person or organization to which
that individual owes loyalty.
A conflict of interest can also exist when a person must answer to two
different individuals or groups whose needs are at odds with each other.
For example: An employee may simultaneously help himself but hurt his
employer by taking a bribe to purchase inferior goods for his company’s
use.

It is important to understand that conflicts of interest are not inherently


wrong. The complex and demanding nature of research today inevitably
gives rise to competing obligations and interests. Researchers are
expected to serve on committees, to train young researchers, to teach, and
to review grants and manuscripts at the same time they pursue their own
research. Conflicts of interest cannot and need not be avoided.
However, in three crucial areas:

• financial gain,
• work commitments, and
• intellectual and personal matters,

special steps are needed to assure that conflicts do not interfere with the
responsible practice of research.

How to manage conflict of interest:


If a researcher has a significant conflict of interest, as defined by Federal,
state, institutional, journal, or other policies, it must be reported and
managed or eliminated. “Managing” a conflict means finding a way to
assure that the interests do not adversely influence the research. Some
options for managing conflicts of interest include:

• requiring full disclosure of all interests so that others are aware of


potential conflicts and can act accordingly;
• monitoring the research or checking research results for accuracy
and objectivity; or
• removing the person with the conflict from crucial steps in the
research process, such as the interpretation of data or participating in
a particular review decision.

These and other options are either worked out by a conflict of interest
review committee or an administrator charged with overseeing conflicts of
interest.
If the conflicts cannot be managed and could have an adverse impact on
the research, then they must be eliminated, by divesting equity, reducing
the income received from the research, assigning supervisory
responsibilities to someone else, stepping out of the room when a particular
proposal is discussed, or some other action.

Conclusions:
Conflicts of interest are pervasive in medical research but must be
managed effectively to maintain the integrity of research and public trust.
Although most of the focus on conflicts and their management has been on
financial conflicts, it is likely that non-financial and intrinsic conflicts have
similar potential for creating bias and exerting undue influence on the
judgment and actions of the investigator. Further efforts are needed to
develop and test methods for effectively identifying conflicts of interest, and
strategies for their management should be evaluated for their capacity to
promote high quality research, protection for research subjects, and public
trust in medical research.

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