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Note Sinh Lý

The document discusses glomerular filtration rate (GFR) and how it is calculated based on inulin clearance over 24 hours, noting a GFR of 125 mL/min. It also examines factors that influence glomerular filtration pressure such as arterial and venous blood pressures and how they determine the net filtration pressure driving filtration across the glomerular membrane. Protein levels and concentrations in different parts of the circulatory system are also evaluated in relation to glomerular filtration.

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100% found this document useful (1 vote)
653 views8 pages

Note Sinh Lý

The document discusses glomerular filtration rate (GFR) and how it is calculated based on inulin clearance over 24 hours, noting a GFR of 125 mL/min. It also examines factors that influence glomerular filtration pressure such as arterial and venous blood pressures and how they determine the net filtration pressure driving filtration across the glomerular membrane. Protein levels and concentrations in different parts of the circulatory system are also evaluated in relation to glomerular filtration.

Uploaded by

Ngân Trần
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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①T iao mise Fi 2GD

sink ia
sinkch - / A
:

Tloe can than S


-
-
GT TIT & bai tiet
theo this i t
·
Mang Loc can than long mas mach vai baw

Bowman :

Lop B no : mo mas mach can than


↑ -
:
the hi "caso" 160A .

-
lop many day collagen &-
proteoglycan
:

,
khe loc 110A
g

I bin no bao Bowman


bamman deale
(ingan cha
-

khe hi 70

Mang loc ngan pri c AK>7O*# protein co M =


70000 .

·
Tink tham cochon loc wa -
- mig loc can than phy thre 2 yo'
L
:

kich this & wapte


tring hig : Albumin myoglobin
-

, ....
·

I
- Tick tich dien ac pr : albumin (GO-rich dienam)
I

· Thank phan
dichlo#hugitrg :

+
Kost man .

0 , 032
+ 19 protein = huyet
thing .

-
Nice in It (C- , HC037 huyettrong 5% (Can bang
Donnan :

Butricho pro(- ) ·
.

Ngotiion (1) <hugit+; 54


+

· Coche'lo qua mig loc can than w

⑦ As High via MM can than (PH) 60mmHy (HA maomach)


:

~

Stay
& AS keo MM can than
-
(P) :
32
mmHg

gi
~) it
As
thing Mong law Bowman (PB) :

18 mmHg
↳ day
④ As loccan than : Pc =

PH -

(Pk +

PB)
= 60 -(32 18
18mmHg
+
=

①T loc chi say P >


blei

sa :
,

=) PH > Pi +

PB
·
Mic loccan than (GFR)
L

ca'2 than
trong Ip"
8 eaceans than
Long dich lo. two a
-

Trong Ip 1200mLmai quacan than ~ (2than)


#650m) huyet trong
125 m huyit thing did loc I I
(Dich (oc)
=>

Miloc et bth =

125m)/phit
Tylilo =

5 =
198

Trong 24h d dich


I
loc
↳ 992 tai
hap the
L1 52 miss tiew
,
-
P

asytahlenGFR
· e

② He solo K400lan so vo. MMI

Lamoto can than #As lo= 1 mmHg


-

S / .

kq = 125mL /
phil/10mmHg
= 12
5m)/pluit/1mmHg
,

Alg khang loca mach can than mas


-
.

phi these dien Tich mach.


yto'
I
-
Bi & mar

tham
tuch
-
~ -
DTD,
TIA-mglocdaylen
S
-> itubtham->4 Ke
③ As loc caithan (PL) W
:

GRF pla this whic vio PL


) GRF ple = PH , PK : PB
PH /hwhier : PHY - GFRT
& b alhbor
: : HAAM 80-178 Thi than con kharig
60mmHg
I dici

Sco dan
ho (P+#60)
Toi AM was

I
- Mais den than -> Hi AN var co lai
Tri
·
Strin
AMcang ra
·
Khich TG2
+ Mais din than - Hi AN vo dan ra
S

·
It lathich cation

backing than-cat
i
Sfeed
I
a

- Manden than - feedback ong than


ine than

·
Nei AMracolan- Tight dining
MMlai -
locwhit+tng doproht
-> TASbeo-blo

Feedbackingthan- canthan L

W
dich
L locchay chain get W

Engthan- L
MT Nat +

tacting "vitdac" ong luanoca-

dan Hi AM vo
E
=>

Fit renin - he RAA+ co mach (TiAMra) ->


↑ PH
P ASkeoY + ↓GFR

32 Iit thay dor'- ko /h whin


triso thap it thay do ah
B ,
-

it

t r
do soi , do ↑PB-
nghen ong than u GFR
+
...

&

· Tha ihn sabainit :


--
Eng than L

1 NG LIN GAN THI BT

Nat 653 Ht

Glucose htoar NH3


AA
.
& pro Creatinin
&
Nice Ko THT de BT 1 it
652
In door
,

140 lan

d'652 & urea50

HC05/CO2
acetracetat , ic

k 655
+

Bolongong Bmang day (43b mo-dich()


-
(long +
iBbmo) .
L

Tich ai
Khurch tain the
cong nguyen phat
·
Nat 1 .

theoning do & dienrich


~ L
Nat-k+-ATPase
Tich aic thes phat St !
Dich ke

!
2 .

S
g L

protein mang Nat-glucose 3 Nat


Na-K-ATPase
at
Nat- a a .

2k+ < 2kt
4

Nat-Ca2t ------
than wai lau
Nat-Mg2 =>
2 htg:
Nlat -

Phosphat 1
.
Nat/TBbmo< NaY or

2 .
Athe'/TBbm<AT/oT
(- 70)
Glucose THThtoan p .
dai OLG ↳Khurch tan hotre
Tich aic
~
thisphat (protein mang)
(Nat-glucose)
Inquoc
~bac
thy
·

m
W

do
ng v

Acid amin i glucose


A A
.
Ting
>
Protein
Protein mbo a .

amin Khrich tan hitro


(bb chal .

Nice Tham than >

( Khi Nat , glucose THT)

--Noted realotange in
Urea

d--Khich tan the dong

I
L

chinhlichathe" (Nat
~

ve the
phat (Nat)
-

Urea Khuchtan thu cong

L
Dien hod
DA DAY

Cohoc

Tiet dich

① Dich i
-

pH = 1, 5 -
3

Senzymchink pepsin chimosine , lipase


- :

-
Drior Het sa bi :

- Nhom
Tryin da day : Hel , pepsinogen chat
whay , .

gastein peprirogen char whaij


~
Nho'n
tayen mon vi
- :

,
, .

Thank phanmen dich wi :

+ Hel be
hip pepsinogen chai wha ma

i
:
-
, ,

(Chi ye
sat him cai In sai , E coli
tring
:

L
, .

tap mo
~
mar vi
ngam voi or

Pepsin pHhoat 1 , 6-2 , 4


M
+
tong
: :

HCl
Pepsinogen Peprin
chink)
/

(i (they' phan prozv



pepringen bofaipepsin thank albumose
[
pepton
Chimosine (Presure)
+
pHhoatcong 5-6
:

Daday tem
dang be /Cat/ding tu sia-casein ko ho a tan
+
Lipase pHhoating 4-5
:

Tim how mo Hat eat who bes glycerol


,tanhution g how ,
a .
,

Misa (48) long do ting , .

+
Yen to norte :

Hap thu B12


~ glucoprotein
+ Chai
whaty :
Bes
tuyen it'
/Lip mong 1mm

Glycoprotein (Mucopolysacaride)
H20, Mic Hel &
->
minim
mac DD L pepsin .

*↳ Trak zitieu

② Co che dii hoa bai Het dich vi

Dich or thay cor-GD ba an


-

I
/ngoi bra
I ⑭P it's an
this
Vi An an
trong ong it
⑪ 2 yeu to cici la :

↳) Than kinh

sam
Pho
giao Tang tit dich : (pepsinogen cha what
- :

, ,

Hel ,
gastim)
-
Acetylcholin
Day X (chink)
·
:
4 Hdl do trit die & eding DD

1 B thank -

Tuictip He

I
:
.

Gian tep
·

Hang oi (gastrin)
:

Lam B vin man cam vo gastin


>
/Gastin
- 3

zing lam Brin man cam vo

Aduia day x)
2 .
chink (peplinogen la di ye)
3 .
Beotuyen co'tryen (nim dich)
,

4 .

Xung ding cobop DD

-
Gao cam :
" che hit ret DD .

i wan
L
mach.
-
Cat be hi
lin lac binngri ,
van tiet dich dis do dain ro
-
S

M nor Zai Anerbach & Meissner (D : cang DD bich thich damn ro

qua day X) .

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