FLCCC.

net
DISCLAIMER
This information is offered as a basis to assist mutual decision-making.
Cancer care should always be supervised by a healthcare provider. The
treatment interventions outlined in this monograph should be used as
adjunctive therapy in addition to the treatment provided by an
oncologist.

Seek the advice of a medical professional for proper application of any

material in this document to your specific situation. Never stop or
change your medications without consulting your provider.

Please note that this is the first iteration of this document which, as a
“living” document, will be continuously updated and refined. Please
ensure you are reviewing the most recent version.

Page 2 FLCCC.net
WHAT IS THIS GUIDE?
Cancer Care is a review of the This information is offered as a
published literature showing basis to assist mutual decision-
options for repurposed drugs making. Cancer care should
that can be used in cancer always be supervised by a
treatment. It is not intended as a healthcare provider.
stand-alone guide to treating
cancer. Patients with cancer should
ALWAYS consult with their
Nothing in this document should regular oncologist as well as an
be taken as a basis to initiate integrative provider/oncologist,
treatment without guidance or in addition to their primary care
avoid any treatment prescribed provider.
by your treating physician.

Page 3 FLCCC.net
HOW SHOULD IT BE USED?
The treatment interventions Patients should review this
outlined in this monograph information, independently
should be used as adjunctive validate the reliability of the data,
therapy in addition to the and discuss the treatment
treatment provided by an options with their
oncologist. family/healthcare advocates.

The goal is to reduce the toxicity Patients should formulate a

of standard chemotherapy treatment plan with their
and/or radiotherapy (and lower healthcare provider that is
the dose of chemotherapy when compatible with their values and
possible) to prevent severe goals.
immunosuppression, organ
toxicities, and death from
standard chemotherapy.

Page 4 FLCCC.net
WHAT ARE REPURPOSED DRUGS?

A repurposed drug is one that is Bringing new drugs to market

used “off-label,” a common basis can take decades and cost
for prescribing, but which means billions of dollars.
that it has not been reviewed
and approved by the U.S. Food Existing licensed drugs can be
and Drug Administration for that repositioned to offer safe,
particular indication. affordable, and effective
treatments in a far shorter
Around 30 percent of all timeframe.
prescriptions in the United States
are written for off-label uses.

Page 5 FLCCC.net
ON WHAT BASIS ARE THERAPIES
INCLUDED?
Dr. Marik studied over 1200 peer- and that in these models the
reviewed papers looking for data agent favorably alters the tumor
that demonstrates that the microenvironment.
compound kills cancer cells
(apoptosis) and that this killing is Furthermore, there needs to be
enhanced in the presence of sufficient scientific evidence that
chemotherapeutic drugs. the agent is both “safe and
effective”. This does not require
There should also be evidence the “gold standard” randomized
that the agent kills/inhibits controlled trial, but sufficient and
cancer stem cells, that the reproducible data from case
compound kills cancer cells in reports, case series and
animal models (in vivo), observational studies.

Page 6 FLCCC.net
 THE 'TOTALITY OF EVIDENCE'
The following criteria were used to stratify the recommendations:

1. Meta analysis of observational and/or randomized controlled trials

(RCTs).
2. Prospective RCTs and/or observational studies.
3. Epidemiological data demonstrating that the agent reduces the risk
of cancer and/or improves survival in those with cancer.
4. Case series (≥ 3 cases).
5. Individual case reports (at least 2).
6. In Vivo model demonstrating favorable effect on tumor
microenvironment.
7. In Vivo/In Vitro model demonstrating synergistic/additive cancer cell
killing in presence of cancer chemotherapeutic agent(s).
8. In Vivo model demonstrating killing of tumor cells and/or cancer
stem cells.
9. In Vitro model (cell culture) demonstrating killing of cancer cells

Page 7 FLCCC.net
CANCER IS A METABOLIC DISEASE
(NOT A GENETIC DISEASE)
“No researcher can point to any single mutation or
combination of mutations and say with confidence that it is
alone the cause of cancer. Nor can researchers point to a
series of cellular systems rendered dysfunctional by
mutations and make the same claims with confidence.”
- Travis Christofferson, author of 'Tripping Over The Truth'

“We may have to turn our main research focus away from
decoding the genetic instructions behind cancer and toward
understanding the metabolism within cancer cells.”
- James Watson, Nobel Prize-winning geneticist

Page 8 FLCCC.net
WHAT IS THE METABOLIC THEORY
OF CANCER?
Conventional thinking suggests Hundreds of experiments now
that cancer arises because of bear this out.
genetic mutations. However,
there is more and more evidence In simple terms, this means that
to show this theory may not be cancer cells use glucose as their
correct. primary source of energy rather
than oxygen.
An alternate theory, put forward
by scientists such as Otto Accepting this theory leads to
Warburg and Thomas Seyfried, is very different treatment
that cancer is caused by strategies than the ones
disordered energy production traditionally used.
and cellular metabolism.

Page 9 FLCCC.net
CONTRASTING PERSPECTIVES
Metabolic Theory: Genetic Mutation Theory:

Altered metabolism is the Specific genetic mutations in

primary driver of cancer normal cells transform them
development, with genetic into cancer cells, leading to
mutations potentially arising as uncontrolled cell growth and
a consequence. proliferation.
Any cell within the body has the Therapies should focus on
potential to become a cancer targeting specific genetic
cell if metabolic alterations mutations or pathways
occur. associated with cancer cells.
Targeting cancer metabolism Cancer cells harboring specific
may offer new therapeutic genetic mutations may
strategies to inhibit tumor respond differently to targeted
growth and survival. therapies that address those
mutations.

Page 10 FLCCC.net
 THE METABOLISM CANCER AS A
OF TUMOURS METABOLIC DISEASE

Otto H. Warburg Thomas N. Seyfried

Page 11 FLCCC.net
WHY CANCER MATTERS

Nearly 2 million new cases of cancer are

expected to be diagnosed in the US in 2023.

Approximately 609,820 people are expected

to die from cancer in the US in 2023.

That's about 1,670 deaths per day.

Source: American Cancer Society. Cancer Facts & Figures 2023. Atlanta: American Cancer Society; 2023.

Page 12 FLCCC.net
IT DOESN'T HAVE TO BE THIS WAY

At least 42% of newly diagnosed cancers in the US —

excluding non-melanoma skin cancer — are potentially
avoidable.

19% of cancers are caused by smoking

18% of cancers are caused by a combination of excess
body weight, alcohol consumption, poor nutrition,
and physical inactivity.

Source: American Cancer Society. Cancer Facts & Figures 2023. Atlanta: American Cancer Society; 2023.

Page 13 FLCCC.net
HOW TO PREVENT CANCER:
THE BASICS
Tackle insulin resistance
Quit smoking
Limit alcohol
Get enough Vitamin D
Avoid processed foods
Avoid sugary drinks and pure fruit juice
Get enough exercise (aerobic and resistance
training)
Reduce stress
Get at least 8 hours of quality sleep

Page 14 FLCCC.net
HOW TO PREVENT CANCER:
VITAMINS AND NUTRIENTS
Vitamin D3: 5000 u daily (adjusted according to
baseline levels)
Omega-3 fatty acids: 2-4 g daily
Green tea catechins: 500-1000 mg daily
Melatonin: 0.75-5 mg (slow release) nightly
Metformin: 250 mg-2000 mg daily

Page 15 FLCCC.net
TOP 10 METABOLIC INTERVENTIONS
TO CONTROL CANCER

1) Low-carb, high- 2) Green tea 3) Melatonin 4) Vitamin D3: 5) Metformin:

fat, ketogenic diet catechins: (slow release): 20,000-50,000 IU 1000 mg
+ time-restricted 500-1000 mg start 1 mg nightly daily twice daily
eating daily and increase

6) Curcumin: 7) Mebendazole: 8) Omega-3 9) Berberine: 10) Exercise and

(nanocurcumin) 100–200 mg fatty acids: 500–600 mg stress reduction:
600 mg daily 4 g daily twice daily 30 minutes daily
twice daily

Page 16 FLCCC.net
flccc.net/cancer-care