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    Anatomy 2

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    Ahmed Adel
    This document summarizes the classification and properties of various antiarrhythmic drugs. It describes: 1) Class 1A drugs like quinidine and procainamide which block sodium channels and prolong the action potential duration, but can cause paradoxical tachycardia or torsades de pointes. 2) Class 1B lidocaine which only blocks sodium channels and is used for ventricular arrhythmias associated with myocardial infarction. 3) Class 1C drugs like flecainide and propafenone which block sodium and calcium channels and are mainly used for supraventricular arrhythmias.

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    Anatomy 2

    Uploaded by

    Ahmed Adel
    12 views2 pages
    This document summarizes the classification and properties of various antiarrhythmic drugs. It describes: 1) Class 1A drugs like quinidine and procainamide which block sodium channels and prolong the action potential duration, but can cause paradoxical tachycardia or torsades de pointes. 2) Class 1B lidocaine which only blocks sodium channels and is used for ventricular arrhythmias associated with myocardial infarction. 3) Class 1C drugs like flecainide and propafenone which block sodium and calcium channels and are mainly used for supraventricular arrhythmias.

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    This document summarizes the classification and properties of various antiarrhythmic drugs. It describes: 1) Class 1A drugs like quinidine and procainamide which block sodium channels and prolong the action potential duration, but can cause paradoxical tachycardia or torsades de pointes. 2) Class 1B lidocaine which only blocks sodium channels and is used for ventricular arrhythmias associated with myocardial infarction. 3) Class 1C drugs like flecainide and propafenone which block sodium and calcium channels and are mainly used for supraventricular arrhythmias.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    12 views2 pages

    Anatomy 2

    Uploaded by

    Ahmed Adel
    This document summarizes the classification and properties of various antiarrhythmic drugs. It describes: 1) Class 1A drugs like quinidine and procainamide which block sodium channels and prolong the action potential duration, but can cause paradoxical tachycardia or torsades de pointes. 2) Class 1B lidocaine which only blocks sodium channels and is used for ventricular arrhythmias associated with myocardial infarction. 3) Class 1C drugs like flecainide and propafenone which block sodium and calcium channels and are mainly used for supraventricular arrhythmias.

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    Anti

    arrhythmic
    Class 1A Class 1B Class 1C

    Quinidine Procainamide Disopyramide Lidocaine Phenytoin Flecainide


    (I.V infusion) (Orally &I.V) Propafenone

    1- block Na channel →  automaticity , excitability , conductivity of ectopic tissue


    Mech
    - block K channel → Prolong APD & RP 2- Activate K channel → Prolong APD & RP 2- No effect on K

    - Atropine like - Less - More - No

    ( moderate) Propafenone
    (3 x 1)
    -  blocking (VD) - NO - No - NO Block Na channel
    Action
    Block Ca channel
    - others Block B receptors
    -M by acetylation
    Antimalaria
    (in slow acetylator)
    Antipyretic
    → Systemic lupus
    Oxytocic
    Muscle relaxant like ( reversible)
    Rare use Mainly Mainly Only in ventricular arrhythmia Mainly
    USES Ventricular Supraventricular - MI Supraventricular
    arryhthmia Arryhthmia - Digitalis toxicity
    - Cardiac Surgery
    1- Paradoxical tachycardia ?
    Convulsion ? 1- Heart block ,
    2- torsade de points ( long Q-T interval ) d.t toxic metabolite Heart failure
    after extensive 1st pass
    3- embolism in old AF metabolism if oral 2- Bronchospasm

    4-GIT ( N, V ,D ) Common 5- Allergy (Sensitivity test ) 3- Proarrythmic in


    S.E. ventricular
    Mexiletine arrhythmia &
    6- idiosyncrasy :
    Like lidocaine but MI
    hepatitis , thrombocytopenia & angioedema
    7- Cinchonism used oral
    4- CI in ischemic
    heart disease

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