CLUSTAL O(1.2.

4) multiple sequence alignment

sp|Q9EQU3|TLR9_MOUSE
MVLRRRTLHPLSLLVQAAVLAETLALGTLPAFLPCELKPHGLVDCNWLFLKSVPRFSAAA 60
NP_059138.1
------------------------------------------------------------ 0
XP_014339214.1
------------------------------------------------------------ 0
CAI92124.1
------------------------------------------------------------ 0
NP_001272352.1
------------------------------------------------------------ 0
NP_058599.1
------------------------------------------------------------ 0

sp|Q9EQU3|TLR9_MOUSE SCSNITRLSLISNRIHHLHNSDFVHLSNLRQLNLKWNCPPTGLS--
PLHFSCHMTIEPRT 118
NP_059138.1
------------------------------------------------------------ 0
XP_014339214.1 -----------------
MMAENNFKMLKIQQCVAAANKLPRN------------------ 25
CAI92124.1 --------------------------
MSLPRCTLLWARLPAGRGAGPRAAPCSA------ 28
NP_001272352.1
------------------------------------------------------------ 0
NP_058599.1
------------------------------------------------------------ 0

sp|Q9EQU3|TLR9_MOUSE
FLAMRTLEELNLSYNGITTVPRLPSSLVNLSLSHTNILVLDANSLAGLYSLRVLFMDGNC 178
NP_059138.1
------------------------------------------------------------ 0
XP_014339214.1
------------------------------------------------------------ 25
CAI92124.1 ------
LRALVGSFPGA------------------------------------------- 39
NP_001272352.1
------------------------------------------------------------ 0
NP_058599.1
------------------------------------------------------------ 0

sp|Q9EQU3|TLR9_MOUSE YYKNPCTGAVKVTPGALLGL---------------------
SNLTHLSLKYNNLTKVPRQ 217
NP_059138.1
------------------------------------------------------------ 0
XP_014339214.1
------------------------------------------------------------ 25
CAI92124.1
SGRVPCLAASSSASGGSKAPNTSLFVPLTVKPQGPSADGDVGAELTRPLDKNEVKKIXDK 99
NP_001272352.1 -----------------------------------------------------
MVTISAP 7
NP_058599.1
------------------------------------------------------------ 0
sp|Q9EQU3|TLR9_MOUSE LPPSL------------------------
EYLLVSYNLIVKLGPEDLANLTSLRVLDVGG 253
NP_059138.1
------------------------------------------------------------ 0
XP_014339214.1 ------------------------------------------RPY--
ICNICFKHFETPS 41
CAI92124.1 FYKRQEIQKRSADYGLDARLFHQAFISFRNYIMQSHSLDVDIHIV--
LNDICFSAAHVDG 157
NP_001272352.1 FPPRR---------------------------------RMALKQI--
SSNRCFGG----- 27
NP_058599.1 ---------------------------------------MALKQI--
SSNRCFGG----- 14

sp|Q9EQU3|TLR9_MOUSE -----
NCRRCDHAPNPCIECGQKSLHLHPETFHHLSHLEGLVLKDSSLHTLNSSWFQGLV 308
NP_059138.1
------------------------------------------------------------ 0
XP_014339214.1 KLARHYLIHTGQKPFECDVCHKTF--------
RQLVHL---------------------- 71
CAI92124.1 -LF-PFFLRHAKQIFPVLECKDDL--------
RKISDL---------------------- 185
NP_001272352.1 -LQ-KVFEHS----SVELKCKMRF--------A----
V---------------------- 47
NP_058599.1 -LQ-KVFEHS----SVELKCKMRF--------A----
V---------------------- 34

sp|Q9EQU3|TLR9_MOUSE
NLSVLDLSENFLYESITHTNAFQNLTRLRKLNLSFNYRKKVSFARLHLASSFKNLVSLQE 368
NP_059138.1
------------------------------------------------------------ 0
XP_014339214.1 ----------------------------ERHQLTHNLPFKCSICQRH----
FKN------ 93
CAI92124.1 ----------------------------
R------------------------------- 186
NP_001272352.1 ----------------------------
Y------------------------------- 48
NP_058599.1 ----------------------------
Y------------------------------- 35

sp|Q9EQU3|TLR9_MOUSE
LNMNGIFFRLLNKYTLRWLADLPKLHTLHLQMNFINQAQLSIFGTFRALRFVDLSDNRIS 428
NP_059138.1
------------------------------------------------------------ 0
XP_014339214.1
------------------------------------------------------------ 93
CAI92124.1
------------------------------------------------------------ 186
NP_001272352.1
------------------------------------------------------------ 48
NP_058599.1
------------------------------------------------------------ 35

sp|Q9EQU3|TLR9_MOUSE
GPSTLSEATPEEADDAEQEELLSADPHPAPLSTPASKNFMDRCKNFKFTMDLSRNNLVTI 488
NP_059138.1
------------------------------------------------------------ 0
XP_014339214.1
------------------------------------------------------------ 93
CAI92124.1
------------------------------------------------------------ 186
NP_001272352.1
------------------------------------------------------------ 48
NP_058599.1
------------------------------------------------------------ 35

sp|Q9EQU3|TLR9_MOUSE
KPEMFVNLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKLDLYHWKSFSELPQL 548
NP_059138.1
------------------------------------------------------------ 0
XP_014339214.1
------------------------------------------------------------ 93
CAI92124.1
------------------------------------------------------------ 186
NP_001272352.1
------------------------------------------------------------ 48
NP_058599.1
------------------------------------------------------------ 35

sp|Q9EQU3|TLR9_MOUSE
QALDLSYNSQPFSMKGIGHNFSFVTHLSMLQSLSLAHNDIHTRVSSHLNSNSVRFLDFSG 608
NP_059138.1
------------------------------------------------------------ 0
XP_014339214.1
------------------------------------------------------------ 93
CAI92124.1
------------------------------------------------------------ 186
NP_001272352.1
------------------------------------------------------------ 48
NP_058599.1
------------------------------------------------------------ 35

sp|Q9EQU3|TLR9_MOUSE
NGMGRMWDEGGLYLHFFQGLSGLLKLDLSQNNLHILRPQNLDNLPKSLKLLSLRDNYLSF 668
NP_059138.1
------------------------------------------------------------ 0
XP_014339214.1
------------------------------------------------------------ 93
CAI92124.1
------------------------------------------------------------ 186
NP_001272352.1
------------------------------------------------------------ 48
NP_058599.1
------------------------------------------------------------ 35

sp|Q9EQU3|TLR9_MOUSE
FNWTSLSFLPNLEVLDLAGNQLKALTNGTLPNGTLLQKLDVSSNSIVSVVPAFFALAVEL 728
NP_059138.1
------------------------------------------------------------ 0
XP_014339214.1
------------------------------------------------------------ 93
CAI92124.1
------------------------------------------------------------ 186
NP_001272352.1
------------------------------------------------------------ 48
NP_058599.1
------------------------------------------------------------ 35

sp|Q9EQU3|TLR9_MOUSE
KEVNLSHNILKTVDRSWFGPIVMNLTVLDVRSNPLHCACGAAFVDLLLEVQTKVPGLANG 788
NP_059138.1
------------------------------------------------------------ 0
XP_014339214.1
------------------------------------------------------------ 93
CAI92124.1
------------------------------------------------------------ 186
NP_001272352.1
------------------------------------------------------------ 48
NP_058599.1
------------------------------------------------------------ 35

sp|Q9EQU3|TLR9_MOUSE
VKCGSPGQLQGRSIFAQDLRLCLDEVLSWDCFGLSLLAVAVGMVVPILHHLCGWDVWYCF 848
NP_059138.1
------------------------------------------------------------ 0
XP_014339214.1
------------------------------------------------------------ 93
CAI92124.1
------------------------------------------------------------ 186
NP_001272352.1
------------------------------------------------------------ 48
NP_058599.1
------------------------------------------------------------ 35

sp|Q9EQU3|TLR9_MOUSE
HLCLAWLPLLARSRRSAQTLPYDAFVVFDKAQSAVADWVYNELRVRLEERRGRRALRLCL 908
NP_059138.1
------------------------------------------------------------ 0
XP_014339214.1 ------------------------
LKTFVKHQQLHDETY--------------------- 108
CAI92124.1 ---------------------------------
IPPNWY--------------------- 192
NP_001272352.1 ---------------------------------
LPP------------------------ 51
NP_058599.1 ---------------------------------
LPP------------------------ 38

sp|Q9EQU3|TLR9_MOUSE
EDRDWLPGQTLFENLWASIYGSRKTLFVLAHTDRVSGLLRTSFLLAQQRLLEDRKDVVVL 968
NP_059138.1
------------------------------------------------------------ 0
XP_014339214.1
------------------------------------------------------------ 108
CAI92124.1
------------------------------------------------------------ 192
NP_001272352.1
------------------------------------------------------------ 51
NP_058599.1
------------------------------------------------------------ 38

sp|Q9EQU3|TLR9_MOUSE
VILRPDAHRSRYVRLRQRLCRQSVLFWPQQPNGQGGFWAQLSTALTRDNRHFYNQNFCRG 1028
NP_059138.1
------------------------------------------------------------ 0
XP_014339214.1 ------------QND---
VKQVRRLLEAKQEKPVYGMYHTFTPEERW------------- 140
CAI92124.1 ------------PEA---
RARQRKIIFHSGPTNSGKTYHAIQRYLSA------------- 224
NP_001272352.1 ------------------------------QAESGKCP-----
ALYW------------- 63
NP_058599.1 ------------------------------QAESGKCP-----
ALYW------------- 50

sp|Q9EQU3|TLR9_MOUSE
PTAENPmgfcrsalhplsllvqaimlamtlalgtlpaflpcelqphglvncnwlflksvp 1088
NP_059138.1 ------
MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVP 54
XP_014339214.1 ------------ALHPCSKSDPSK----------------
KKKDIHACTICGKMFPSQSK 172
CAI92124.1 ---------------------------------------------
TSGVYCGPL-----K 234
NP_001272352.1 ---------------------------------------------
LSGLTCTEQ-----N 73
NP_058599.1 ---------------------------------------------
LSGLTCTEQ-----N 60
. *

sp|Q9EQU3|TLR9_MOUSE
hfsmaaprgnvtslslssnrihhlhdsdfahlpslrhlnlkwncppvglspmhfpchmti 1148
NP_059138.1
HFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTI 114
XP_014339214.1 L---------------------------------DRHALI-------
HTGQRPFKCVLCS 192
CAI92124.1 L---------------------------------LAHEIF------
EKSNAAGVPCDLVT 255
NP_001272352.1 F---------------------------------ISKSGY------
QQAAS--------- 85
NP_058599.1 F---------------------------------ISKSGY------
QQAAS--------- 72
:

sp|Q9EQU3|TLR9_MOUSE epstfla-
vptleelnlsynnimtvpalpkslislslshtnilmldsaslaglhalrflf 1207
NP_059138.1 EPSTFLA-
VPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLF 173
XP_014339214.1 KSFRQST-HLKIHQL----------------------THSE---------------
ERPF 214
CAI92124.1 GEERL-TVEPEGKQA----------------------THVS---------------
CTV- 276
NP_001272352.1 -EHGLVVIAPD---------------------------------------------
TSP- 98
NP_058599.1 -EHGLVVIAPD---------------------------------------------
TSP- 85
 .

sp|Q9EQU3|TLR9_MOUSE mdgncyyknpcrqaleva---------------
pgallglgnlthlslkynnltvvprnl 1252
NP_059138.1 MDGNCYYKNPCRQALEVA---------------
PGALLGLGNLTHLSLKYNNLTVVPRNL 218
XP_014339214.1 --QCCFCQKGFKIQSKLLKHKQI-H--TRNKTFQ--TLSLKV------
KSSESCSLPNKL 261
CAI92124.1 --EMCNVATPYE--VAVIDEIQMIRDPARGWAWTRALLGLCA------
EEVHLCGESAAI 326
NP_001272352.1 --RGCNI-----------------KGEDDSWDFGTGA-
GF-------------------- 118
NP_058599.1 --RGCNI-----------------KGEDDSWDFGTGA-
GF-------------------- 105
* .:

sp|Q9EQU3|TLR9_MOUSE
pssleylllsynrivklapedlanltalrvldvggncrrcdhapnpcmecprhfpqlhpd 1312
NP_059138.1
PSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPD 278
XP_014339214.1 NAKQDG----FENGNIGAS------EENNQLDVHSVY-
IVPFQCPECEECFESEQIL--- 307
CAI92124.1 NLVSELL---YTTGEEVEVQKYERLTPISVLDHALES-
LDNLQPGDCIVCFSKNDIY--- 379
NP_001272352.1 ----------YVNAT--------------------------------------
EDPW--- 127
NP_058599.1 ----------YVNAT--------------------------------------
EDPW--- 114
:

sp|Q9EQU3|TLR9_MOUSE
tfshlsrleglvlkdsslswlnaswfrglgnlrvldlsenflykcitktkafqgltqlrk 1372
NP_059138.1
TFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRK 338
XP_014339214.1 --------------------------KGHKCFPARS-------GKIPSK-----
LKS--- 326
CAI92124.1 --------------------------SVSRQIEIRGLESAVIYGSLPPGT---
KLAQAR- 409
NP_001272352.1 --------------------------KANY----------RMYSYV--TE---
ELPQLI- 145
NP_058599.1 --------------------------KANY----------RMYSYV--TE---
ELPQLI- 132
: * .

sp|Q9EQU3|TLR9_MOUSE
lnlsfnyqkrvsfahlslapsfgslvalkeldmhgiffrsldettlrplarlpmlqtlrl 1432
NP_059138.1
LNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRL 398
XP_014339214.1 ---SYNYKTIVK----------KILAKLKRAGGKKLD--NFQADK--
KVFK--------- 360
CAI92124.1 ---KFNDPNDPC----------KILVATDAIGM-GLNL-S--------
IRR--------- 437
NP_001272352.1 ---NANFPVDPQ----------RMSIFGHSMGGHGALICALKNPG--
KYRS--------- 181
NP_058599.1 ---NANFPVDPQ----------RMSIFGHSMGGHGALICALKNPG--
KYRS--------- 168
. * . .

sp|Q9EQU3|TLR9_MOUSE qmnfinqaqlgifrafpglryvdlsdnrisgaselt--------
atmgeadgge------ 1478
NP_059138.1 QMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELT--------
ATMGEADGGE------ 444
XP_014339214.1 -------------NTFMKNRD------LISGEQRPE-
QTQRTCLSSLGKHGTYKTVGNKK 400
CAI92124.1 ----------IIFYSLIKPSI------
NEKGEKELEPITTSQALQIAGRAGRFSSH---- 477
NP_001272352.1 ---------VSAFAPICNPVL------CSWGKKAF-----------
SGYLGPDESK---- 211
NP_058599.1 ---------VSAFAPICNPVL------CSWGKKAF-----------
SGYLGPDESK---- 198
: * . * . .

sp|Q9EQU3|TLR9_MOUSE ------kvwlqpg--------------dlapapvdtpssedfrpncstlnf-
tldlsrnn 1517
NP_059138.1 ------KVWLQPG--------------DLAPAPVDTPSSEDFRPNCSTLNF-
TLDLSRNN 483
XP_014339214.1 KTLTLPFSWQKHCQTQNMGKN----VKGILT----PE------------
NMLTMDNPV-- 438
CAI92124.1 --------FKE-
GQVTTMHRDDLALLKDILNRPVDPIQAAGLHPTAEQIEMFAYHLPETT 528
NP_001272352.1 --------WKA-YDA-------
TCLVKAY------------------------------- 224
NP_058599.1 --------WKA-YDA-------
TCLVKAY------------------------------- 211
:

sp|Q9EQU3|TLR9_MOUSE
lvtvqpemfaqlshlqclrlshncisqavngsqflpltglqvldlshnkldlyhehsft- 1576
NP_059138.1
LVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFT- 542
XP_014339214.1 H-KKDISIY-----------------GS-
SGEEFFENCQVLQCGFSVPSGNIHTGHKMCP 479
CAI92124.1 L-SNLIDIFVDF--------------AQVDGQYFVCNMD----DF-----------
KFSA 558
NP_001272352.1 S-GSQIDILIDQ--------------GKDDE--FLSNGQLLP-DN-----------
FIAA 255
NP_058599.1 S-GSQIDILIDQ--------------GKDDE--FLSNGQLLP-DN-----------
FIAA 242
.: .
*. . :

sp|Q9EQU3|TLR9_MOUSE ------elprlealdl--------
synsqpfgmqgvghnfsfvahlrtlrhlslahnnih 1622
NP_059138.1 ------ELPRLEALDL--------
SYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIH 588
XP_014339214.1 CDKCEKVFPSVSKLQRHYLIH----TGQRPFGCNVCGKSFRQSAH---
LK---------- 522
CAI92124.1 E--LIQHIPLSLR--
VRYVFCTAPINKKQPFVCSSLLQFARQYSRNEPLT---------- 604
NP_001272352.1 C--TEKKIPVVFR--
LQ------------------------------------------- 268
NP_058599.1 C--TEKKIPVVFR--
LQ------------------------------------------- 255
:*

sp|Q9EQU3|TLR9_MOUSE
sqvsqqlcstslraldfsgnalghmwaegdlylhffqglsgliwldlsqnrlhtllpqtl 1682
NP_059138.1
SQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTL 648
XP_014339214.1 -----------------------RHKLTHID-----------KL------------
PY-- 534
CAI92124.1 -----------------------FAWLRRYI-----------KW---------
PLLPP-- 619
NP_001272352.1
------------------------------------------------------------ 268
NP_058599.1
------------------------------------------------------------ 255

sp|Q9EQU3|TLR9_MOUSE rnlpkslqvlrlrdnylaffkwwslhflpklevldl---
agnqlkaltngslp------- 1732
NP_059138.1 RNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDL---
AGNQLKALTNGSLP------- 698
XP_014339214.1 RKSLCQVEL----E-NFNKLLIHQGDNV-SYSASQQCQTL----------GF----
QKYK 574
CAI92124.1 KNIKDLMDLEAVHD-
VFDLYLWLSYRFIDMFPDSSLVRSLQKELDAIIQEGVHNITKLIK 678
NP_001272352.1 -------------E-GYD----HSYYFIATFIADHI-
RHHAKYLNA-------------- 295
NP_058599.1 -------------E-GYD----HSYYFIATFIADHI-
RHHAKYLNA-------------- 282
: . :

sp|Q9EQU3|TLR9_MOUSE --agtrlrrldvscnsisfvapg-------------------------
ffskakelreln 1765
NP_059138.1 --AGTRLRRLDVSCNSISFVAPG-------------------------
FFSKAKELRELN 731
XP_014339214.1
VSESDQMSEIKVKAESEDFILGAPCRSREPYLSSTLLESEQSHHSHCSYSGRAERNDGLL 634
CAI92124.1 ISESRKLLNLES-----------------------LPSGDQSRLSGASK-
SPARRTRGTK 714
NP_001272352.1
------------------------------------------------------------ 295
NP_058599.1
------------------------------------------------------------ 282

sp|Q9EQU3|TLR9_MOUSE lsan----alktvdhswfgplasa---
lqildvsanplhcacgaafmdfllevqaavpgl 1818
NP_059138.1 LSAN----ALKTVDHSWFGPLASA---
LQILDVSANPLHCACGAAFMDFLLEVQAAVPGL 784
XP_014339214.1 YQ-------CSVCSKSF--
RSPSKLERHYLIHAGQKPFECS------------------- 666
CAI92124.1 SAGNKATEPLSPSDKEL--
PLASRLVQQGLLTA--------------------------- 745
NP_001272352.1
------------------------------------------------------------ 295
NP_058599.1
------------------------------------------------------------ 282

sp|Q9EQU3|TLR9_MOUSE
psrvkcgspgqlqglsifaqdlrlcldealswdcfalsllavalglgvpmlhhlcgwdlw 1878
NP_059138.1
PSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCGWDLW 844
XP_014339214.1 -----------------------------------------------------
VCGKT-- 671
CAI92124.1 -------------------------------------------------------
DML-- 748
NP_001272352.1
------------------------------------------------------------ 295
NP_058599.1
------------------------------------------------------------ 282

sp|Q9EQU3|TLR9_MOUSE
ycfhlclawlpwrgrqsgrdedalpydafvvfdktqsavadwvynelrgqleecrgrwal 1938
NP_059138.1
YCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWAL 904
XP_014339214.1 --FRQAPHWKRH---
QLTHFKE-------------------------------------- 688
CAI92124.1 --RQLQKEWLTQ---QPEHSREKVGT------------------------------
R--- 770
NP_001272352.1
------------------------------------------------------------ 295
NP_058599.1
------------------------------------------------------------ 282

sp|Q9EQU3|TLR9_MOUSE
rlcleerdwlpgktlfenlwasvygsrktlfvlahtdrvsgllrasfllaqqrlledrkd 1998
NP_059138.1
RLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLEDRKD 964
XP_014339214.1
------------------------------------------------------------ 688
CAI92124.1
------------------------------------------------------------ 770
NP_001272352.1
------------------------------------------------------------ 295
NP_058599.1
------------------------------------------------------------ 282

sp|Q9EQU3|TLR9_MOUSE
vvvlvilspdgrrsryvrlrqrlcrqsvllwphqpsgqrsfwaqlgmaltrdnhhfynrn 2058
NP_059138.1
VVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHFYNRN 1024
XP_014339214.1
------------------------------------------------------------ 688
CAI92124.1
-----------------------------------------------------------R 771
NP_001272352.1
------------------------------------------------------------ 295
NP_058599.1
------------------------------------------------------------ 282

sp|Q9EQU3|TLR9_MOUSE fcqgptae 2066