L-Arginine HCL - Kyowa Shangai MSDS

SAFETY DATA SHEET ACCORDING TO 2001/58/EC
ISSUED DATE: September 1, 2008 Page 1 of 3
1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND OF THE

COMPANY/UNDERTAKING
1.1. Identification of the substance or preparation : L-Arginine monohydrochloride
1.2. Use of the substance/preparation :
pharmaceutical bulk, food additive, intermediate for synthesis, etc.
1.3. Company/undertaking identification
Company : Shanghai Kyowa Amino Acid Co., Ltd.
Department for information : Quality Assurance Dept.
Address : 158, Xintuan Road, Qingpu Industrial Zone, Shanghai, China, 201700
TEL-No. : +86-21-59701998 FAX-No. : +86-21-59701135
1.4. Emergency contact : Kyowa Hakko Europe GmbH
TEL-No. : +49-211-17545-0 FAX-No. : +49-211-17545-441
2. COMPOSITION/INFORMATION ON INGREDIENTS
2.1 The product is highly purified substance.
L-ARGININE MONOHYDROCHLORIDE (C6H14N4O2･HCl = 210.66)
2.2 The product is not and does not include dangerous substances classified according to
Directive 1999/45/EC.
CAS-Number of the product : 1119-34-2
3. HAZARD IDENTIFICATION
The product is not dangerous and hazards to man and the environment according to
classification rules in Directives 67/548/EEC or 1999/45/EC. Skin or eye irritant is not
expected.
4. FIRST AID MEASURES

General Instructions : Avoid direct contact with the product.
Eye contact : Wash thoroughly with water. If irritation occurs, consult a physician.
Skin contact : Wash thoroughly with water. If irritation occurs, consult a physician.
Ingestion : Rinse out with water. If any symptoms appear, consult a physician.
Inhalation : If irritation occurs, consult a physician.
Notes to the physician : There is no special information available. Treat
symptomatically.
Information given above is to the best of our knowledge and is only related to the product as
delivered in order to give a complete review of safety aspects accurate as of the date indicated.
All data given are never meant to guarantee product properties.
BRANDNAME : L-ARGININE HCL
Page 2 of 3
5. FIRE FIGHTING MEASURES

- Suitable extinguishing media : water
- Extinguishing media which must not be used for safety reasons : none
- Special exposure hazards arising from substance or preparation itself, combustion
products, resulting gases : This product is decomposed to CO2 and H2O by burning.
- Special protective equipment required for fire-fighting
: In case of fire, wear a self-containing breathing apparatus and full protective clothing.
6. ACCIDENTAL RELEASE MEASURES

Wear protective equipment (see chapter 8.2).
The product is solid at room temperature. Use solid waste clean-up procedures.
7. STORAGE AND HANDLING

7.1. Handling : Wear protective equipment (see chapter 8.2).
7.2. Storage : Controlled room temperature in tight container.
7.3. Specific use : not applicable
8. EXPOSURE CONTROLS / PERSONAL PROTECTION

8.1. Exposure limit values : Exposure limit value for health hazard is not determined.
8.2. Exposure controls
8.2.1. Occupational exposure control
Follow the general guidelines of good industrial hygiene. Do not breathe product
dusts. Change contaminated clothing and thoroughly clean before re-use.
- Respiratory : Mask is recommended to use.
- Hand protection : Gloves is recommended to use.
- Eye protection : Goggles is recommended to use.
- Skin protection : Head cover, coverall or laboratory coat buttoned to neck,
long sleeves is recommended to use.
8.2.2. Environmental exposure control
- Facility design : It is recommended to install an efficient exhaustion system.
- Components with exposure limits :
The product does not contain any components with exposure limits.
BRANDNAME : L-ARGININE HCL
Page 3 of 3
9. PHYSICAL AND CHEMICAL PROPERTIES

9.1 General information
Appearance : solid (at 20°C), white Odor : odorles s
9.2. Important health, safety and environmental information
- pH : 4.7 - 6.2 at 10 g per 100 ml of water
- Boiling point : Not applicable
- Flash point : Not applicable
- Flammability : See Section 16.
- Explosive properties : No
- Oxidising properties : No
- Vapor pressure : Not applicable
- Relative density : No data
- Solubility : Freely soluble in water, very slightly soluble in alcohol
- Partition coefficient (n-octanol/water) : no data
- Viscosity : not applicable
- Vapor density : not applicable
- Evaporation rate : not applicable
9.3. Other information
- Melting point : 235°C (decomposition)
10. STABILITY AND REACTIVITY
This product is stable under controlled room temperature in tight container.
- Conditions to avoid : High temperature, high humidity or light
- Materials to avoid : oxidizers
- Hazardous decomposition products : None
11. TOXICOLOGICAL INFORMATION
LD 50 : > 16 g/kg rat (oral), Skin or eye irritant is not expected.
12. ECOLOGICAL INFORMATION
L-Arginine HCl is one of common substances (amino acids) composing animal or plant
body and is degraded by oxidation and hydrolysis. No serious influence to environment is
expected.
13. DISPOSAL CONSIDERATIONS
Waste disposal method : With chemical wastes.
14. TRANSPORT INFORMATION
The product is not covered by transport regulations.
15. REGULATORY INFORMATION
The product is not dangerous nor hazardous.
16. OTHER INFORMATION
As with most organic solids, dust from this material may pose an explosion of fire hazard,
if suspended in air and there is a source of ignition.

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SAFETY DATA SHEET ACCORDING TO 2001/58/EC

ISSUED DATE: September 1, 2008 Page 1 of 3

1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND OF THE

L-ARGININE MONOHYDROCHLORIDE (C6H14N4O2･HCl = 210.66)

4. FIRST AID MEASURES

5. FIRE FIGHTING MEASURES

6. ACCIDENTAL RELEASE MEASURES

7. STORAGE AND HANDLING

8. EXPOSURE CONTROLS / PERSONAL PROTECTION

9. PHYSICAL AND CHEMICAL PROPERTIES

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