Bioc192 2018 s2

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BIOC 192 S2 2018

13. Which statement about glycolysis is INCORRECT?

A) Glycolysis takes place in the cytoplasm in animal cells.


B) Red blood cells depend on glycolysis for ATP production.
C) Glycolysis uses two ATP but produces four ATP, resulting in a net gain of two
ATP molecules.
D) There are no redox reactions in the glycolytic pathway.

14. Energy from the breakdown of one glucose molecule in glycolysis is conserved
(captured) in:

A) two molecules of ATP and four molecules of ADP.


B) two molecules of pyruvate and two molecules of H2O.
C) two molecules of ATP and two molecules of NADH.
D) two molecules of NADH and two protons.

15. The pyruvate dehydrogenase reaction, shown below, is an example of:

A) a substrate-level phosphorylation.
B) an oxidative phosphorylation.
C) an oxidative decarboxylation.
D) none of the above.

16. The products of the complete oxidation of the fatty acid stearate (C18:0) through
β -oxidation are:

A) 9 acetyl-CoA + 8 NADH + 8 FADH2 + 8 H+


B) 7 acetyl-CoA + 8 NADH + 8 FADH2 + 8 H+
C) 9 acetyl-CoA + 8 NADH + 7 FADH2 + 6 H+
D) 18 acetyl-CoA + 9 NADH + 9 FADH2 + 9 H+

5 TURN OVER
BIOC 192 S2 2018
17. Which statement about the citric acid cycle is CORRECT?

A) Acetyl-CoA entering the citric acid cycle can come from the pyruvate
dehydrogenase reaction or β-oxidation.
B) All but one reaction in the citric acid cycle occurs in the mitochondrial matrix.
C) The second half of the citric acid cycle is involved in the removal of two carbons
from succinyl-CoA to regenerate the starting molecule, the 4 carbon oxaloacetate.
D) All of the above.

18. Below is the first reaction in the citric acid cycle. In this reaction the two carbon
atoms from acetyl-CoA are added to the four carbon oxaloacetate to produce a six
carbon citrate. The addition of the two carbon molecules in the form of acetyl-CoA
requires energy.

This energy is provided by:

A) the hydrolysis of ATP to ADP.


B) the cleavage of CoA from acetyl-CoA.
C) the citrate synthase enzyme.
D) the oxaloacetate.

19. The succinate dehydrogenase reaction is shared between:

A) the citric acid cycle and the electron transport chain.


B) the citric acid cycle and β-oxidation.
C) the electron transport chain and glycolysis.
D) β-oxidation and glycolysis.

20. The role of pyridoxal phosphate in aminotransferase reactions is to:

A) catalyse the reaction.


B) accept and amino group from an amino acid and transfer it to a keto acid.
C) provide oxidising power.
D) all of the above.

6 TURN OVER
Glycolysis
glucose
ATP
hexokinase
ADP

glucose 6-phosphate

glucosephosphate isomerase

fructose 6-phosphate

ATP
phosphofructokinase
ADP

fructose 1,6-bisphosphate

aldolase aldolase

dihydroxyacetone
glyceraldehyde 3-phosphate
phosphate triose
phosphate NAD++ Pi
isomerase glyceraldehyde-3-phosphate
dehydrogenase
NADH + H+

1,3-bisphophoglycerate
ADP
phosphoglycerate kinase
ATP

3-phosphoglycerate

phosphoglyceromutase

2-phosphoglycerate

enolase
H 2O

phosphoenolpyruvate
ADP
pyruvate kinase
ATP

pyruvate 27
Fates of pyruvate
NADH + H+ NAD+

pyruvate lactate
lactate
NAD+ + CoA-SH dehydrogenase

pyruvate dehydrogenase

NADH + H+ + CO2

acetyl-CoA

ATP synthase

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