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PROSITE

PROSITE is a manually curated protein database that consists of entries describing protein families, domains, and functional sites, as well as amino acid patterns and profiles found within them. It identifies possible protein functions and predicts biochemical functions of unknown proteins based on similarities to well-studied genes. PROSITE offers tools for protein sequence analysis and motif detection to help determine protein function.

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80 views2 pages

PROSITE

PROSITE is a manually curated protein database that consists of entries describing protein families, domains, and functional sites, as well as amino acid patterns and profiles found within them. It identifies possible protein functions and predicts biochemical functions of unknown proteins based on similarities to well-studied genes. PROSITE offers tools for protein sequence analysis and motif detection to help determine protein function.

Uploaded by

william919
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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PROSITE

PROSITE is a protein database.[1][2] It consists of entries


PROSITE
describing the protein families, domains and functional sites as
well as amino acid patterns and profiles in them. These are
manually curated by a team of the Swiss Institute of Bioinformatics
and tightly integrated into Swiss-Prot protein annotation.
PROSITE was created in 1988 by Amos Bairoch, who directed
the group for more than 20 years. Since July 2018, the director of Content
PROSITE and Swiss-Prot is Alan Bridge.
Description PROSITE, a
PROSITE's uses include identifying possible functions of newly protein domain
discovered proteins and analysis of known proteins for previously database for
undetermined activity. Properties from well-studied genes can be functional
propagated to biologically related organisms, and for different or characterization
poorly known genes biochemical functions can be predicted from and annotation.
similarities. PROSITE offers tools for protein sequence analysis
and motif detection (see sequence motif, PROSITE patterns). It is Contact
part of the ExPASy proteomics analysis servers. Research center Swiss Institute of
Bioinformatics
The database ProRule builds on the domain descriptions of
Laboratory Structural
PROSITE.[3] It provides additional information about functionally
or structurally critical amino acids. The rules contain information Biology and
about biologically meaningful residues, like active sites, substrate- Bioinformatics
or co-factor-binding sites, posttranslational modification sites or Department
disulfide bonds, to help function determination. These can Primary citation PMID 19858104
automatically generate annotation based on PROSITE motifs. (https://pubmed.
ncbi.nlm.nih.gov/
Statistics 19858104)
Release date 1988
As of 26  February  2022, release 2022_01 has 1,902
documentation entries, 1,311 patterns, 1,336 profiles, and 1,352 Access
ProRules. Website prosite.expasy
.org (http://prosit
See also e.expasy.org/)

Uniprot — the universal protein database, a central resource on protein information -


PROSITE adds data to it.
InterPro — a centralized database, grouping data from databases of protein families,
domains and functional sites - part of the data come from PROSITE.
Protein subcellular localization prediction — another example of use of PROSITE.

References
1. De Castro E, Sigrist CJA, Gattiker A, Bulliard V, Langendijk-Genevaux PS, Gasteiger E,
Bairoch A, Hulo N (2006). "ScanProsite: detection of PROSITE signature matches and
ProRule-associated functional and structural residues in proteins" (https://www.ncbi.nlm.nih.
gov/pmc/articles/PMC1538847). Nucleic Acids Res. 34 (Web Server issue): W362–365.
doi:10.1093/nar/gkl124 (https://doi.org/10.1093%2Fnar%2Fgkl124). PMC 1538847 (https://w
ww.ncbi.nlm.nih.gov/pmc/articles/PMC1538847). PMID 16845026 (https://pubmed.ncbi.nlm.
nih.gov/16845026).
2. Hulo N, Bairoch A, Bulliard V, Cerutti L, Cuche B, De Castro E, Lachaize C, Langendijk-
Genevaux PS, Sigrist CJA (2007). "The 20 years of PROSITE" (https://www.ncbi.nlm.nih.go
v/pmc/articles/PMC2238851). Nucleic Acids Res. 36 (Database issue): D245–9.
doi:10.1093/nar/gkm977 (https://doi.org/10.1093%2Fnar%2Fgkm977). PMC 2238851 (http
s://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238851). PMID 18003654 (https://pubmed.ncbi.
nlm.nih.gov/18003654).
3. Sigrist CJ, De Castro E, Langendijk-Genevaux PS, Le Saux V, Bairoch A, Hulo N (2005).
"ProRule: a new database containing functional and structural information on PROSITE
profiles" (https://archive-ouverte.unige.ch/unige:36662/ATTACHMENT01). Bioinformatics.
21 (21): 4060–4066. doi:10.1093/bioinformatics/bti614 (https://doi.org/10.1093%2Fbioinform
atics%2Fbti614). PMID 16091411 (https://pubmed.ncbi.nlm.nih.gov/16091411).

External links
Official website (http://prosite.expasy.org/)
ProRule (http://prosite.expasy.org/prorule.html) — database of rules based on PROSITE
predictors

Retrieved from "https://en.wikipedia.org/w/index.php?title=PROSITE&oldid=1166578679"

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