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    Kerry Bone Covid 19 Presentation

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    Lukas
    The document discusses functional herbal therapy (FHT) approaches for COVID-19. It covers topics like what COVID-19 is and how it harms some patients, FHT core strategies for COVID-19 like supporting immune function and resolving inflammation, and some immune-boosting herbs like Echinacea, Andrographis, and medicinal mushrooms. It also discusses diaphoretic herbs that could help manage the acute phase and prevent cytokine storm, as well as the need for antiviral herbs to have in vitro and in vivo evidence of reducing viral loads and clinical trial data showing reduced loads and improved outcomes.

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    © All Rights Reserved
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    Kerry Bone Covid 19 Presentation

    Uploaded by

    Lukas
    21 views27 pages
    The document discusses functional herbal therapy (FHT) approaches for COVID-19. It covers topics like what COVID-19 is and how it harms some patients, FHT core strategies for COVID-19 like supporting immune function and resolving inflammation, and some immune-boosting herbs like Echinacea, Andrographis, and medicinal mushrooms. It also discusses diaphoretic herbs that could help manage the acute phase and prevent cytokine storm, as well as the need for antiviral herbs to have in vitro and in vivo evidence of reducing viral loads and clinical trial data showing reduced loads and improved outcomes.

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    Kerry-Bone-Covid-19-Presentation

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    The document discusses functional herbal therapy (FHT) approaches for COVID-19. It covers topics like what COVID-19 is and how it harms some patients, FHT core strategies for COVID-19 like supporting immune function and resolving inflammation, and some immune-boosting herbs like Echinacea, Andrographis, and medicinal mushrooms. It also discusses diaphoretic herbs that could help manage the acute phase and prevent cytokine storm, as well as the need for antiviral herbs to have in vitro and in vivo evidence of reducing viral loads and clinical trial data showing reduced loads and improved outcomes.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    21 views27 pages

    Kerry Bone Covid 19 Presentation

    Uploaded by

    Lukas
    The document discusses functional herbal therapy (FHT) approaches for COVID-19. It covers topics like what COVID-19 is and how it harms some patients, FHT core strategies for COVID-19 like supporting immune function and resolving inflammation, and some immune-boosting herbs like Echinacea, Andrographis, and medicinal mushrooms. It also discusses diaphoretic herbs that could help manage the acute phase and prevent cytokine storm, as well as the need for antiviral herbs to have in vitro and in vivo evidence of reducing viral loads and clinical trial data showing reduced loads and improved outcomes.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 27

    Functional Herbal

    Therapy in the Time


    of COVID-19

    Transforming global health


    2

    Disclaimer
    • This session with Simon Mills and Kerry Bone provides information
    exclusively to healthcare practitioners and offers the opportunity to
    hear the views, recommendations and experiences of other
    practitioners. Research discussed on COVID-19 and the application of
    herbs and other health-related information is not a substitute for
    individual medical advice and standard of care treatment.
    • Simon Mills and Kerry Bone make no warranty, expressed or implied,
    with respect to the information provided. As respected educators in the
    field, they are acting in their independent capacity as herbal clinicians
    to share their knowledge and experience with colleagues in a closed
    forum. The information discussed should not be construed as making
    claims for, or endorsing, specific herbal products.
    Transforming global health
    3

    Topics Covered
    • COVID-19, what it is, what it does, who is harmed by it
    • Functional Herbal Therapy (FHT)
    • FHT and COVID-19
    • Some clinically relevant herbs
    • Immune herbs and cytokine storm risk

    Transforming global health


    The structure of a coronavirus. Image credit: Scientificanimations.com / CC BY-SA 4.0
    Transforming global health
    Transforming global health
    Transforming global health
    Verity R, Okell LC, Dorigatti I et al. Estimates of the
    severity of coronavirus disease 2019: a model-
    based analysis. Lancet Infect Dis. 2020 Mar 30. pii:
    S1473-3099(20)30243-7. doi: 10.1016/S1473-
    3099(20)30243-7. PubMed
    Transforming PMID:
    global 32240634
    health
    Myers LC, Parodi SM, Escobar GJ, Liu VX. Characteristics
    of Hospitalized Adults With COVID-19 in an Integrated
    Health Care System in California. JAMA.2020 Apr 24. doi:
    10.1001/jama.2020.7202. [Epub ahead of print] PubMed
    PMID: 32329797

    COPS2, Co-morbidity Point Score version 2; IQR, interquartile range global health
    Transforming
    Richardson S, Hirsch JS, Narasimhan M et al.
    Presenting Characteristics, Comorbidities, and
    Outcomes Among 5700 Patients Hospitalized With
    COVID-19 in the New York City Area. JAMA. 2020
    Apr 22. doi: 10.1001/jama.2020.6775. [Epub ahead
    of print] PubMed PMID: 32320003

    Transforming global health


    Du RH, Liang LR, Yang CQ et al. Predictors of Mortality for Patients with COVID-19 Pneumonia Caused by SARS-CoV-2: A Prospective
    Cohort Study. Eur Respir J. 2020 Apr 8. pii: 2000524. doi: 10.1183/13993003.00524-2020. [Epub ahead of print] PMID: 32269088

    Transforming global health


    The most common co-infections were rhinovirus/enterovirus (6.9%), respiratory
    syncytial virus (5.2%), and non–SARS-CoV-2 Coronaviridae (4.3%)

    Kim D, Quinn J, Pinsky B, Shah NH, Brown I. Rates of Co-infection Between SARS-CoV-2 and Other Respiratory Pathogens. JAMA.
    2020 Apr 15. doi:10.1001/jama.2020.6266. [Epub ahead of print] PubMed PMID: 32293646
    Transforming global health
    12

    The Elderly
    • The elderly are at increased risk of
    dying from RTI
    • Why?
    • Higher incidence of comorbidities
    and risk factors
    • Prior and concurrent viral infections
    • Reduced immunity
    (immunosenescence)
    • Chronic low grade inflammation
    (inflammageing)
    Transforming global health
    13

    Immunosenescence

    Grizzi F. DiCaro G et al. Immun Ageing 2013, 10:9. doi: 10.1186/1742-4933-10-9. PMID: 23496863 Transforming global health
    14

    Transforming global health


    Madjid M, Safavi-Naeini P et al. JAMA Cardiol 2020 Mar 27. doi: 10.1001/jamacardio.2020.1286. PMID: 32219363. [Epub ahead of print]
    5

    Functional Herbal Therapy


    • Functional herbal therapy (FHT): a system of modern
    prescribing for western herbal clinicians
    • Incorporates the defining characteristics of functional
    medicine
    • Applies these to the unique properties of medicinal plants
    • Embraces that contemporary western herbal therapeutics
    should draw heavily on its empirical roots

    Transforming global health


    6

    Functional Herbal Therapy


    Defining attributes
    1 Understanding diseases as disordered processes of normal physiology
    2 Embracing the complexity of mosaic diseases, where the individual story counts most

    3 Matching treatment energetics with the patient’s condition


    4 Complex interventions (network pharmacology) for multifactorial disorders (mosaic diseases)

    5 Therapy based on twelve core strategic targets


    6 Modular treatments and pulsed dosing used as key strategies where appropriate

    7 The key overriding consideration is to support the affected tissues

    Transforming global health


    7

    FHT Core Strategies and COVID-19


    • Support HPA axis
    • Reduce pathogens (viral focus)
    • Enhance mitochondrial function and biogenesis
    • Boost macrocirculatory, microcirculatory and endothelial health;
    improve blood quality
    • Optimise immune function
    • Resolve inflammation
    • Enhance natural barriers
    • Address metabolic imbalances
    • Support the affected tissues
    Transforming global health
    Key Immune Herbs
    Major immune herbs
    • Echinacea
    • Andrographis
    • Medicinal mushrooms
    Other immune herbs
    • Holy Basil
    • Pelargonium
    • Commiphora
    • Adaptogenic/tonic herbs
    but especially Astragalus, Eleuthero and Tinospora
    Transforming global health
    Quotes from Ellingwood
    • “In pleuritis, in bronchitis, in peritonitis, especially pelvic
    peritonitis from sepsis; in hepatitis and nephritis and cystitis
    always at the beginning of the acute stage before much structural
    change has occurred, it may be given, and will retard and often
    throw off the attack.”
    • “It is perfectly safe to give echinacea in massive doses—from two
    drams to half an ounce every two or three hours—for a time at
    least…”
    • “In septic peritonitis it (Bryonia) may be given alternately with
    aconite, or aconite and echinacea, the latter remedy directly
    controlling the sepsis.”
    Transforming global health 19
    Mushrooms and Immunity
    • Research suggests branched chain beta-glucan polymers found in
    the fruiting bodies of various mushrooms are particularly adapted
    to heightening immune vigilance against potential pathogens1
    • Innate immune cell responses are augmented by binding of beta-
    glucans to dectin-1 expressed by macrophages or dendritic cells
    • Interaction of mushroom beta-glucans with the dectin-1 receptor
    may even be able to “train” the innate immune response (as per
    BCG vaccine) via epigenetic changes2
    1: Taylor PR, Tsoni SV, Willment JA et al. Dectin-1 is required for beta-glucan recognition and control of fungal infection.
    Nat Immunol. 2007 Jan; 8(1):31-38. PMID: 17159984
    2: van der Meer JW, Joosten LA et al. Trained immunity: A smart way to enhance innate immune defence. Mol Immunol.
    2015 Nov; 68(1): 40-44. doi: 10.1016/j.molimm.2015.06.019. PMID: 26597205

    Transforming global health


    Two-stage Model for Immune Activity

    Wasser SP. Medicinal Mushrooms in Human Clinical


    Studies. Part I. Anticancer, Oncoimmunological, and
    Immunomodulatory Activities: A Review. Int J Med
    Mushrooms. 2017; 19(4): 279-317. doi:
    10.1615/IntJMedMushrooms.v19.i4.10. PMID: 28605319

    Transforming global health 21


    2

    Diaphoretic Herbs
    • Diaphoretic herbs: often overlooked when discussing herbs for
    managing acute viral infections
    • Their appropriate use could be critical in managing acute phase and
    preventing CS
    • Include Mentha x piperita (peppermint), Achillea (yarrow),
    Sambucus (elderflower), Matricaria (chamomile), Tilia (lime flowers)
    and Asclepias tuberosa (pleurisy root)
    • Were central to the Eclectic strategy during the Spanish Flu
    pandemic

    Transforming global health


    3

    Clinically Relevant Antiviral Activity


    • Activity in vitro, preferably broad-based AND
    • Identified active phytochemicals (or metabolites) with known
    bioavailability (or can be enhanced) AND
    • In vivo activity demonstrating reduced viral loads AND
    • Clinical trial activity demonstrating reduced viral loads and
    improved clinical outcomes; BUT EVEN THEN
    • Should ALWAYS be combined with immune herbs

    Transforming global health


    4

    Microcirculation Diet
    Diet Individual Components Microcirculation Hypertension
    1 Berries 85 to 115g per day

    2 Cocoa (90% chocolate, 20g/day)

    3 Garlic as 1-2 fresh, crushed raw cloves per day

    4 Beets as juice or supplement plus sunlight

    5 Green tea – several cups per day

    6 OR Green tea and hibiscus tea – several cups per day of each

    7 Introduce the key elements of the DASH guidelines:


    High in fruit, vegetables, whole grains, low-fat dairy products,
    fish, chicken and lean meats

    8 Fibre, especially 30g/day of freshly milled/ground flaxseeds

    9 Reduce salt to 3g/day (approx. ½ teaspoon) and increase


    potassium
    If hypertension is present points 6,7,8 and 9 Transforming
    are added global health
    Immune Herbs and
    Cytokine Storm Risk

    Transforming global health


    Immune Herbs and Cytokine Storm
    • Echinacea, medicinal mushrooms and elder berry should be
    avoided because they increase the risk of an inflammatory
    response by elevating cytokines
    • Andrew Weil website and Center for Integrative medicine
    • Herbs have been identified as having a counter-productive effect
    on the body’s natural defenses against the coronavirus including
    willow bark and other herbal anti-inflammatories, such
    Echinacea, turmeric and Boswellia and Commiphora
    • ANSES (French Agency for Food, Environmental and
    Occupational Health & Safety)
    Transforming global health
    Acknowledgement

    • Many thanks to my colleague Berris Burgoyne for assistance


    with some of these slides

    Transforming global health

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