How The Brain Works

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HOW
THE BRAIN
WORKS
CONTENTS
Editorial Consultant Contributors
Rita Carter Catherine Collin, Tamara Collin, Liam Drew,
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Illustrators
Mark Clifton, Project Editor
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Managing Art Editor Editors
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US Editor
Jacket Design
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Art Director
Karen Self
First American Edition, 2020

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BRAIN FUNCTIONS
AND THE SENSES
Sensing the World 64
Seeing 66
THE PHYSICAL BRAIN The Visual Cortex 68
How We See 70
Perception 72
What the Brain Does 10 The Limbic System 38
How We Hear 74
The Brain in the Body 12 Imaging the Brain 40
Perceiving Sound 76
Human and Animal 14 Monitoring the Brain 42
Brains Smell 78
Babies and Young 44
Protecting the Brain 16 Children Taste 80
Fueling the Brain 18 Older Children 46 Touch 82

and Teenagers
Brain Cells 20 Proprioception 84
The Adult Brain 48
Nerve Signals 22 Feeling Pain 86
The Aging Brain 50
Brain Chemicals 24 How to Use Your Brain 88
How to Slow the 52 to Manage Pain
Networks in the Brain 26 Effects of Aging
The Regulatory System 90
Brain Anatomy 28 Brain Food 54
Neuroendocrine System 92
The Cortex 30 Genetics and 56
Hunger and Thirst 94
Nuclei of the Brain 32 the Brain
Planning Movement 96
Hypothalamus, 34 Male and Female 58
Thalamus, and Brains Making a Move 98
Pituitary Gland Nature and Nurture 60 Unconscious 100
The Brain Stem 36 Movement
and Cerebellum
Mirror Neurons 102
COMMUNICATION CONSCIOUSNESS
AND THE SELF
Emotions 106
Fear and Anger 108 What Is Consciousness? 162

Conscious Emotion 110 Attention 164
Reward Centers 112 MEMORY, How to Focus 166
Your Attention
Sex and Love 114 LEARNING,
Expressions 116 Free Will and
AND THINKING the Unconscious 168
Body Language 118
Altered States 170
How to Tell if 120 What Is Memory? 134
Someone Is Lying Sleep and Dreams 172
How a Memory Forms 136
Morality 122 Time 174
Storing Memories 138
Learning a Language 124 What Is Personality? 176
Recalling a Memory 140
The Language Areas 126 The Self 178
How to Improve Your 142
Having a Conversation 128 Memory
Reading and Writing 130 Why We Forget 144
Memory Problems 146
Special Types 148

of Memories
Intelligence 150
Measuring 152
Intelligence
Creativity 154
How to Boost 156

Your Creativity
Belief 158
DISORDERS
Headache and Migraine 196 Seasonal Affective 207

Disorder
Head Injuries 197
Anxiety Disorders 208
Epilepsy 197
Phobias 208
THE BRAIN Meningitis and 198
Encephalitis Obsessive- 209
OF THE FUTURE Compulsive Disorder
Brain Abscess 198
Tourette’s Syndrome 209
Superhuman Senses 182 TIA 199
Somatic Symptom 210
Wiring the Brain 184 Stroke and Hemorrhage 199
Disorder
The Unexplored 186 Brain Tumors 200
Munchausen 210
Brain
Dementia 200 Syndrome
Artificial Intelligence 188
Parkinson’s Disease 201 Schizophrenia 211
The Expanded Brain 190
Huntington’s Disease 201 Addiction 212
The Global Brain 192
Multiple Sclerosis 202 Personality Disorder 213
Motor Neuron Disease 202 Eating Disorders 214

Paralysis 203 Learning Disabilities 215
and Difficulties
Down Syndrome 204
Attention Deficit 216
Cerebral Palsy 204
Hyperactivity Disorder
Hydrocephalus 205
Autism Spectrum 217
Narcolepsy 205 Disorders
Coma 206
Depression 206 INDEX 218
Bipolar Disorder 207 ACKNOWLEDGMENTS 224
THE
PHYSICAL
BRAIN
What the DO BRAINS
Brain Does
FEEL PAIN?
Despite the fact that it
registers pain from around
The brain is the body’s control center.
the body, brain tissue has
It coordinates the basic functions required no pain receptors and
for survival, controls body movements, and cannot feel pain itself.
processes sensory data. However, it also
encodes a lifetime of memories and creates
consciousness, imagination, and our sense of self.
The physical brain Weight Fat

On average, an adult The brain’s dry weight
At the largest scale, the human
human brain weighs is 60 percent fat. Much of
brain appears as a firm, pink-gray 2.6–3.1 lb (1.2–1.4 kg), this fat is present as
solid. It is made mostly from fats which is approximately sheaths coating the
2 percent of total body connections between
(about 60 percent) and has a
weight. neurons.
density just a little greater than
that of water. However, Water Volume
neuroscientists, the people who The brain is 73 percent The average volume of a
water, while the body as a human brain ranges from
study the form and function of
whole is closer to 60 69 to 77 cubic in (1,130 to
the brain, see the organ as being percent. The average 1,260 cubic cm), although
constituted from more than 300 brain contains around the volume decreases
35 fl oz (1 liter) of water. with age.
separate, although highly
interconnected, regions. On a much
Gray matter White matter
smaller scale, the brain is made About 40 percent of Around 60 percent of
from approximately 160 billion cells, the brain’s tissue is gray the brain’s tissue is white
half of which are neurons, or nerve matter, which is tightly matter. This is made
packed nerve-cell from long, wirelike
cells, and about half are glia, or bodies. extensions of nerve cells
support cells of one kind or another covered in sheaths of fat.
(see pp.20–21).
LEFT BRAIN VS. RIGHT BRAIN

It is often claimed that one side, or hemisphere, of
the brain dominates the other—and that this has an
impact on someone’s personality. For example, it is RIGHT HEMISPHERE
sometimes said that logical people use their left
brain hemisphere, while artistic (and less logical)
people rely on the right side. However, this is an
extreme oversimplification. While it is true that the
hemispheres are not identical in function—for LEFT HEMISPHERE
example, the speech centers are normally on the
left—most healthy mental tasks deploy regions on
both sides of the brain at the same time.
THE PHYSICAL BRAIN
What the Brain Does 10 11
Memory
The brain remembers a bank
of semantic knowledge, general
facts about the world, as well as a Movement
personal record of life history. The To contract, muscles rely on
function of memory is to aid the same kind of electrical
future survival by encoding impulses that carry nervous signals
useful information from through the brain and body. All
the past. muscle movement is caused by
nerve signals, but the conscious
brain has only limited
Emotions control over it.
Most theories of
emotion suggest that they
are preordained modes of
behavior that boost our survival
chances when we encounter
confusing or dangerous situations. What does the
Others suggest emotions are brain do?
animal instincts leaking Control
through into human
The relationship between the
The basic body systems, such
consciousness. body and brain has long been a as breathing, circulation,
subject of debate for scientists and digestion, and excretion, are all
philosophers. In ancient Egypt, the brain under the ultimate control of the
brain, which seeks to modify
was dismissed as a system for shedding their rates to suit the needs of
heat, and the heart was the seat of emotion the body.
and thought. Although our most significant
feelings are still described as heartfelt,
Communication neuroscience shows that the brain
A unique feature of the drives all body activities.
human brain is the speech
centers that control the
formulation of language and the
muscular execution of speech. The Thinking
brain also uses a predictive The brain is where thought
system to comprehend what and imagination take place.
someone else is saying. Thinking is a cognitive activity
that allows us to interpret the
world around us, while our
Sensory experience imagination helps us consider
Information arriving from all possibilities in the mind without
over the body is processed in the input from the senses.
brain to create a richly detailed
picture of the body’s surroundings.
The brain filters out a great deal
of sensory data deemed
irrelevant.
SMOOTHING OUT ALL THE WRINKLES OF THE

BRAIN’S OUTER LAYER WOULD COVER AN AREA
OF ABOUT 2½ SQUARE FT (2,300 SQUARE CM)
The Brain
in the Body
Skull provides
Permeating the body
protection
The nervous system extends
to brain
throughout the entire body.
It is so complex that all of a
The brain is the primary component of Brain body’s nerves joined end to
end could circle the world
the human body’s nervous system, which two and a half times.
coordinates the actions of the body with
the sensory information it receives.
Spinal cord
Spinal nerves of
The nervous system peripheral system
join spinal cord
The two main parts of the nervous system are the central of central system
nervous system (CNS) and the peripheral nervous system.
The CNS is made up of the brain and the spinal cord, a Spinal cord
thick bundle of nerve fibers that runs from the brain in the runs down
head to the pelvis. Branching out from this is the peripheral back, through
vertebrae of
system, a network of nerves that permeates the rest of the spinal column
body. It is divided according to function: the somatic
nervous system handles
voluntary movements Peripheral
of the body, while the nerves extend
through torso
autonomic nervous
SPINAL
CORD
and limbs to
system (see opposite) hands and feet
handles involuntary Motor Sensory
nerve nerve
functions.
VE
RT
E EB
ERV RA
Spinal nerves ALN
N
Most peripheral nerves SPI
connect to the CNS at the
spinal cord and split as they Bone
Sciatic nerve
connect. The rear branch carries vertebra
is largest and
sensory data to the brain; the protects
longest nerve
forward branch carries motor spinal cord
in body
signals back to the body. SPINAL COLUMN (REAR VIEW)
Sensory and
CRANIAL NERVES motor nerves are
often bundled
Within the peripheral system, Signals along together,
12 cranial nerves connect optic nerve separating at
travel directly their ends
directly to the brain rather
to brain
than the spinal cord. Most link
to the eyes, ears, nose, and KEY
tongue and are also involved
in facial movements, chewing, Central nervous
system (CNS)
and swallowing, but the vagus
nerve links directly to the heart, Spinal Peripheral
lungs, and digestive organs. cord nervous system
EYES EYES
The autonomic
nervous system
The involuntary, or autonomic,
system maintains the internal
conditions of the body by LUNGS LUNGS
controlling the involuntary
muscles in the digestive system
and elsewhere, as well as heart
and breathing rates, body
temperature, and metabolic ARTERIES ARTERIES
processes. The autonomic system
is divided into two parts. The
sympathetic system generally
acts to elevate body activity
and is involved in the so-called HEART HEART
“fight-or-flight” response. The
parasympathetic system works
in opposition to this, reducing
activity to return the body to
a “rest-and-digest” state. LIVER LIVER
STOMACH STOMACH
INTESTINES BLADDER
THE TOTAL LENGTH

OF THE SOMATIC BLADDER INTESTINES
NERVOUS SYSTEM
IS ABOUT 45 MILES Sympathetic Parasympathetic
These nerves emerge from the spinal Chiefly associated with the cranial
(72 KM) cord in the chest and abdominal nerves (see far left), this part of the
regions and connect to a chain of autonomous system works to
ganglia (nerve bundles) that run down reduce energy use when the body
either side of the spine. Nerves then is at rest. It is also involved in sexual
extend out from there to the body. arousal, crying, and defecation.
Human and
Animal Brains
KEY
Cerebellum Pituitary
gland
Optic lobe
Medulla
The human brain is one of the defining features of our Cerebrum
species. Comparing the human brain with the brains of Olfactory
bulb
other animals reveals connections between brain size and
Brain mass
intelligence and between an animal’s brain anatomy and
the way it lives. Brain mass as a
percentage of body mass
Brain sizes
The size of a brain indicates GO BU
its total processing power. For LD LL
example, a honeybee’s tiny brain
FI
FR
SH
OG
contains 1 million neurons, a Nile
crocodile’s has 80 million, while
a human brain has around 80–90
billion neurons. The link with
intelligence is clear. However,
with larger animals, it is important
to compare brain and body size to
give a more nuanced indication
of cognitive power.
Sizing up
There are two ways to compare brain sizes, 0.04 oz 0.04 oz
by total weight and as a percentage of body
weight. The largest brain, at 17 lb (7.8 kg), 0 0.004 oz (0.1g) 1g 0 0.04 oz (0.2g) 1g
belongs to the sperm whale, but that is a
minute fraction of its 44-ton (45-tonne) body. 0 0.16% 2 0 0.04% 2
Nerves branch Esophagus

Brain shapes out into head runs through
All brains are located in the head, and body from middle of
each ganglion brain
in close proximity to the primary
sense organs. However, it would be
a mistake to visualize animal brains
as rudimentary variations, in size
and structure, of the human brain.
All vertebrate brains follow the Doughnut-
same development plan, but shaped
anatomies vary widely to match brain
different sensory and behavioral Leech Octopus
needs. More variety can be seen in The 10,000 cells in a leech’s nervous system An octopus’s brain contains 500 million
are arranged in chains of cell clusters called neurons. Only a third are located in the head;
the brains of invertebrates, which ganglia. The brain is a big ganglia, with 350 the rest are in the arms and skin, where they
account for 95 percent of all animals. neurons, located at the front of the body. are devoted to sensory and motor controls.
THE PHYSICAL BRAIN
Human and Animal Brains 14 15
VARYING PROPORTIONS
All mammal brains contain the same Cerebrum
components, but they grow in different Cerebrum
proportions. A third of the volume of a rat’s
central nervous system (CNS) is made up of
the spinal cord, indicating its reliance on
reflex movements. By contrast, the spinal
cord is a tenth of a human CNS. Instead,
three-quarters is taken up by the cerebrum,
which is used for perception and cognition. RAT BRAIN HUMAN BRAIN
EUR DO
OP M HU
E ES
AN
M
TI
CC
AN
QU
AT
AIL
0.04 oz 1.76 oz 49.4 oz
0 0.03 oz (0.9g) 1 g 0 1.05 oz (30g) 50 g 0 47.6 oz (1,350g) 1,400 g
0 0.9% 2 0 0.9% 2 0 2% 2
Olfactory bulbs Cerebral cortex

sit behind is more folded
nares, which than that of
are nostril-like humans
openings that DO ALL ANIMALS
smell water
HAVE A BRAIN?
Sponges have no nerve
cells at all, while jellyfish
and corals have a netlike
nervous system but no
Shark Dolphin
The brain of a shark is Y-shaped due to the The hearing and vision centers of a dolphin’s central control point.
large olfactory bulbs that extend out on brain are larger and closer together than in a
either side. The sense of smell is the shark’s human brain. It is thought that this helps the
primary means of tracking prey. dolphin create a mental image using its sonar.
Protecting the Brain
The vital organs are safely secured in the body’s core, but
because the brain sits in the head at the top of the body,
Dural sinuses
it requires its own protection system. collect oxygen-
depleted blood
The cranium
The bones of the head are
collectively known as the skull
(2) FRO
but are more correctly divided AL
ET N
into the cranium and the mandible,
RI
TA
PA
SPHENOID (1)
L
or jawbone. It is supported by the
(1)
highest cervical vertebra and
the musculature of the neck. ETHMOID (1)
SUBARACHNOID
RAL (2)
PO
OC
The cranium forms a bony case IP EM

C
ITA
completely surrounding the brain.
T
L (1)
It is made of 22 bones that steadily
fuse together in the early years of
life to make a single, rigid structure.
SP
AC
Nevertheless, the cranium has
E
around 64 holes, known as Paired bones
foramina, through which nerves The brain is enclosed by eight large
and blood vessels pass, and eight bones, with a pair of parietal and
temporal bones forming each side of
air-filled voids, or sinuses, which the cranium. The remaining 14 cranial
reduce the weight of the skull. bones make up the facial skeleton.
Direction of flow
2 CSF flows from the
ventricles into the subarachnoid
space, where it then moves up
and over the front of the brain.
Cerebrospinal fluid
The brain does not come into direct
WHAT IS WATER
contact with the cranium. Instead it
ON THE BRAIN?
is suspended in cerebrospinal fluid
(CSF). This clear liquid circulating
CSF IS
Also called hydrocephalus,
inside the cranium creates a this condition arises when CONTINUALLY
cushion around the brain to protect
there is too much CSF in the PRODUCED,
it during impacts to the head. In
addition, the floating brain does cranium. This puts pressure AND ALL OF IT
not deform under its own weight, on the brain and affects IS REPLACED
which would otherwise restrict its function.
blood flow to the lower internal
EVERY 6–8
regions. The exact quantity of CSF HOURS
also varies to maintain optimal
Meninges and ventricles
pressure inside the cranium. The brain is surrounded by three membranes,
Reducing the volume of CSF or meninges: the pia mater, arachnoid mater, and
lowers the pressure, which in dura mater. The CSF fills cavities called ventricles
and circulates around the outside of the brain in
turn increases the ease with which the subarachnoid space, which lies between the
blood moves through the brain. pia and arachnoid mater.
16 17
Dura mater
The blood-brain barrier

Arachnoid mater
Infections from the rest of the
body do not ordinarily reach the
brain due to a system called the
Pia mater blood-brain barrier. As a general
Site of fluid production rule, blood capillaries in the rest of
1 CSF is made from plasma, the liquid the body leak fluid easily (and any
part of blood. Most of it is produced by the viruses and germs it contains) into
choroid plexus, a network of blood vessels
that runs throughout the ventricular system. surrounding tissues through gaps
between the cells that form the
CSF flows into Reabsorption blood vessel’s wall. In the brain,
ventricles
4 The CSF is reabsorbed these same cells have a much
into the circulatory system,
where it remixes with the tighter fit, and the flow of materials
blood. CSF is renewed at a rate between the brain is instead
NTRICLE
VE of three to four times a day. controlled by astrocytes that
LATER AL
surround the blood vessels.

CHOROID PLEXUS Substances pass Fat-soluble
out of vessel substances pass
through pore though cell
THIRD VENTRICLE
membranes
Water-soluble
FOURTH substances
VENTRICLE enter via pore NORMAL
CEREBELLUM between cells BLOOD VESSEL
Tight junction Some water-soluble

between cells substances enter brain
L
KUL
S
CSF travels
downward
at back of Astrocyte
spinal cord cells surround
blood vessels
Fat-soluble
substances BRAIN
3 Circulation
around move freely BLOOD VESSEL
spinal cord
SPINAL
As well as the brain, CSF KEY Selectively permeable

CENTR RD
surrounds the spinal Normal blood vessels allow fluid to pass

cord, flowing down Blood flow through easily. However, while oxygen,
CO
along the back of the fat-based hormones, and non-water-soluble

AL CAN
spinal cord, into the Flow of materials pass through the blood-brain
central canal, then up cerebrospinal fluid barrier unhindered, water-soluble items are
along the front. blocked so they don’t reach the CSF.
AL
Fueling DOES FOCUSED
CONCENTRATION USE
the Brain
MORE ENERGY?
The brain never stops
working, and the overall
The brain is an energy-hungry organ. Unlike energy consumption stays
other organs in the body, it is fueled solely more or less the same
on glucose, a simple sugar that is quick and 24 hours a day.
easy to metabolize.
Blood supply
The heart supplies blood to the whole body, but around a sixth
of its total effort is devoted to sending blood up to the brain.
Blood reaches the brain by two main arterial routes. The two
carotid arteries, one running up each side of the neck, deliver
Carotid artery
blood to the front of the brain (and the eyes, face, and scalp). The
back of the brain is fed by the vertebral arteries, which weave Vertebral
artery
upward through the spinal column. Deoxygenated blood then
accumulates in the cerebral sinuses, which are spaces created
by enlarged veins running through the brain. The blood there
drains out of the brain and down through the neck via the
internal jugular veins.
The vascular system delivers 26 fl oz (750 ml) of blood to the FROM THE
brain every minute, which is equivalent to 1.7 fl oz (50 ml) for HEART
every 3.5 oz (100 g) of brain tissue. If that volume drops below
about 0.7 fl oz (20 ml), the brain tissue stops working.
Crossing the blood-brain barrier Paracellular transport Diffusion

Water and water-soluble Cells are surrounded
The blood-brain barrier is a physical and metabolic materials, such as salts and ions by a fatty membrane, so
BLOOD VESSEL
barrier between the brain and its blood supply. It offers (charged atoms or molecules), fat-soluble substances,
extra protection against infections, which are hard to can cross through small gaps including oxygen and alcohol,
between capillary-wall cells. diffuse through the cell.
combat in the brain using the normal immune system,
and could make the brain malfunction in dangerous Water-soluble Fat-soluble
ways. There are six ways that materials can cross the substance substance
barrier. Other than that, nothing gets in or out.

BLOOD-BRAIN
Cellular wall
Tight junction
BARRIER
The physical blood-brain barrier is created by the Molecule

cells that make up the walls of capillaries in the brain. moves
Elsewhere in the body, these are loosely connected, through cell
leaving gaps, or loose junctions. In the brain, the
cells connect at tight junctions.
BRAIN
Astrocytes collect material from

blood and pass it to neurons
ASTROCYTE
THE PHYSICAL BRAIN
Fueling the Brain 18 19
Anterior
CI
GLUCOSE FUEL
RC
cerebral artery
LE
supplies front
OF
of brain The human brain makes up just 2
percent of the body’s total weight, but it
WI
Median Internal
consumes 20 percent of its energy. The
LLIS
cerebral artery carotid artery
supplies side large human brain is an expensive organ
of brain to run, but the benefits of a big, smart
Posterior cerebral
brain make it a good investment.
Direction of
blood flow artery supplies
back of brain
Arteries encircle
Basilar
stalk of pituitary Cerebellar
artery
gland, optic artery supplies
tracts, and basal cerebellum
hypothalamus
Vertebral
artery
BRAIN BRAIN’S ENERGY
UNDERSIDE SIZE: 2% NEEDS: 20%
OF BRAIN
The Circle of Willis

THE BODY’S ENTIRE
The carotid and vertebral supplies connect at the
base of the brain, via communicating arteries, to
SUPPLY OF BLOOD IS
create a vascular loop called the Circle of Willis. PUMPED THROUGH THE
This feature ensures cerebral blood flow is
maintained, even if one of the arteries is blocked. BRAIN EVERY 7 MINUTES
Protein transporters Receptors Transcytosis Active efflux

Glucose and other Hormones and similar Large proteins, which are When unwanted materials
essential molecules are substances are picked up by too big to pass through channels, diffuse through the blood-brain
actively moved across the receptors. They are enclosed are absorbed by the membrane barrier, they are removed by a
barrier through channels and in a vesicle (sac) of membrane and enclosed in a vesicle for its biochemical pumping system
gates in the membrane. for passage through the cell. journey through the cell. called efflux transporters.
Glucose Hormone reaches Protein molecule

receptor and enters enclosed in vesicle
vesicle Waste pumped
into blood vessel
Gates made
Vesicle merges with Unwanted
from protein
membrane to waste
release contents products
Brain Cells GRAY MATTER
The brain is divided into gray and white
The brain and the rest of the nervous system matter. Gray matter is made of neuron
contains a network of cells called neurons. The cell bodies, common in the surface
of the brain. White matter is made
role of neurons is to carry nerve signals through of these neurons’ myelinated axons
the brain and body as electrical pulses. bundled into tracts. They run through
the middle of the brain and down the
spinal cord.
Neurons
Most neurons have a distinctive branched shape with dozens of
filaments, only a few hundred thousandths of a foot thick, extending GR
from the cell body toward nearby cells. Branches called dendrites bring
AY
M
signals into the cell, while a single branch, called the axon, passes the WHITE
AT TER
signal to the next neuron. In most cases, there is no physical MATTER
connection between neurons. Instead, there is a tiny gap, called the
synapse, where electrical signals stop. Communication between cells
is carried out by the exchange of chemicals, called neurotransmitters
(see pp.22–23). However, some neurons are effectively physically
connected and do not need a neurotransmitter to exchange signals.
Types of neurons Dendrites act like antennae to

There are several types of neurons, with different collect signals from
combinations of axons and dendrites. Two common neighboring nerve cells
types, bipolar and multipolar neurons, are each Axons can
suited to particular tasks. Another type of neuron, be several
the unipolar neuron, appears only in embyros. Electrical pulse jumps centimeters long
from one myelin segment
to the next, speeding
up nerve signal
Connection to Dendrite receives signal
brain cells from sense organ
Axon
Dendrites are shorter than
axons, usually up to only
16 hundred thousandths
of a foot
Cell body
ON
Bipolar neuron
AX
This type of neuron has one dendrite and one
axon. It transmits specialized information
from the body’s major sense organs. Axon delivers
signal from
neighboring cell
Cell body
Synapse with
other cell Axon
Dendrite
THE HUMAN
Multipolar neuron
BRAIN CONTAINS
Most brain cells are multipolar. They APPROXIMATELY
have multiple dendrites connecting to
hundreds, even thousands, of other cells. 86 BILLION NEURONS
THE PHYSICAL BRAIN
Brain Cells 20 21
Chemicals crossing
from neighboring cell
create an electrical LIN Some neurons in
pulse in dendrite YE peripheral nervous
M
system have myelin-
producing Schwann cells
Neurofibrils
A
MEM XON
M BR A
YE NE
LIN
S HE A
TH
Myelin sheath is
Cell membrane coiled around axon
A single combined
conveys nerve
electrical signal is sent
impulses
out to the next cell
ELL BODY
VEC
ER Insulation
N
An axon may be covered in a

sheath of fat called myelin. This
works like insulation, preventing
DNA AXON electrical charges from leaking out
US
E
CL and thus speeding up the signal.
CELL NU
Glia
Golgi body The nervous system relies on a team of helper cells
packages Helper cells
Lysosomes destroy called glia. Astrocytes control what chemicals enter
chemicals There are eight main
waste chemicals the brain from the blood. Oligodendrocytes produce types of glia, but
Mitochondria myelin for brain cells, forming the white matter. only five are
process glucose Ependymal cells secrete the cerebrospinal fluid, while common in the
brain. They protect
microglia work as immune cells, clearing out waste the overall health of
cells. Radial cells are the progenitors of neurons. the nervous system.
Blood vessel
supported Myelin sheath
produced here
Developing
neuron
ASTROCYTES OLIGODENDROCYTES
Inside a neuron Cilia help move

A neuron contains broadly neurotransmitters Long,
the same set of organelles, straight cell
Damaged provides
or internal structures, as any
neurons support
other cell for releasing energy,
detected here
making proteins, and managing
genetic material. EPENDYMAL CELLS MICROGLIA RADIAL GLIA
Nerve Signals HOW DOES A
NERVE COMMUNICATE
DIFFERENT INFORMATION?
The brain and nervous system work by sending Receiving cells have different
signals through cells as pulses of electrical types of receptors, which respond
charge and between cells either by using to different neurotransmitters.
chemical messengers called neurotransmitters The “message” differs according
or by electric charge. to which neurotransmitters
are sent and received and
Action potential in what quantities.
Neurons signal by creating an action potential—a surge of
electricity created by sodium and potassium ions crossing
the cell’s membrane. It travels down the axon and
stimulates receptors on dendrites of neighboring cells.
The junction between cells is called a synapse. In many
neurons, the charge is carried over a minute gap between SOME NERVE IMPULSES
axon and dendrite by chemicals, called neurotransmitters, TRAVEL FASTER THAN
released from the tip of the axon. These junctions are
known as chemical synapses. The signal may cause the
330 FT (100 M) PER
neighboring neuron to fire, or it may stop it from firing. SECOND
Excess of positive ions on
outside of cell membrane
Membrane channels Excess of ions inside

open to let ions in produces a positive charge
CELL’S AXON MEMBRANE

FLUID INSIDE AXON
KEY
Direction of Positive ions
nerve impulse rush in
Flow of ions
Direction of nerve
impulse
Resting potential Depolarization

1 When the neuron is at rest, there are more positive 2 Chemical changes from the cell body
ions outside the membrane than inside. This causes a allow positive ions to flood into the cell
difference in polarization, or electrical potential, across through the membrane. That reverses the
the membrane called the resting potential. The difference polarization of the axon, making the
is about –70 millivolts, meaning the outside is positive. potential difference +30 millivolts.
THE PHYSICAL BRAIN
Nerve Signals 22 23
Synapses
NERVE AGENTS Some neurons do not share a physical connection. Instead they
meet at a cellular structure, called a synapse, where there is a
Chemical weapons, like novichok
gap of 40 billionths of a meter, known as the synaptic cleft,
and sarin, work by interfering with
how neurotransmitters behave at between the axon of one neuron (the presynaptic cell) and the
the synapse. Nerve agents can be dendrite of another (the postsynaptic cell). Any coded signal
inhaled or act on contact with skin. carried by electrical pulses is converted into a chemical message
They prevent the synapse from at the tip, or terminal, of the axon. The messages take the form
clearing away used acetylcholine, of one of several molecules called neurotransmitters (see p.24),
which is involved in the control which pass across the synaptic cleft to be received by the
of muscles. As a result, muscles,
dendrite. Other neurons have electrical synapses rather than
including those used by the heart
and lungs, are paralyzed. chemical synapses. These are effectively physically connected
and do not need a neurotransmitter to carry
electrical charge between them.
Synaptic
AX
Chemical store vesicle ON
1 Neurotransmitters are
TE
R M
manufactured in the cell body of the IN
AL
neuron. They travel along the axon to
the terminal, where they are parceled NA
SY
up into membranous sacs, or vesicles. PT
At this stage, the terminal’s membrane IC C
LEFT
PO
Neurotransmitter
carries the same electrical potential as TS
S
the rest of the axon. YN
AP Receptor for
TIC C neurotransmitter
Action potential ELL
arrives and
depolarizes
Signal received membrane
2 When an action potential
surges down the axon, its final
Calcium
destination is the terminal, where
ions flow in
it temporarily depolarizes the
membrane. This electrical change
has the effect of opening protein
channels in the membrane, which
Positive ions
allow positively charged calcium
pumped out
ions to flood into the cell.
Depolarization
causes voltage-
Calcium influx causes gated channels
synaptic vesicles to to open
release neurotransmitters
Releasing messages
3 The presence of calcium
within the cell sets off a complex
process that moves the vesicles Neurotransmitters
to the cell membrane. Once slot into
there, the vesicles release receptor sites
neurotransmitters into the cleft.
Repolarization Some diffuse across the gap to
3 The depolarization of a section of the be picked up by receptors on the
axon causes the neighboring section to dendrite. The neurotransmitters Channels open and
undergo the same process. Meanwhile, the may stimulate an action potential cause positive ions
cell pumps out positive ions to repolarize the to form in that dendrite, or they to flow in and
membrane back to the resting potential. may inhibit one from forming. polarize the cell
Brain IS TECHNOLOGY
ADDICTION THE SAME
Chemicals AS DRUG ADDICTION?

No, technology addiction
is more comparable to
While communication in the brain relies on
overeating. Release of
electric pulses flashing along wirelike nerve dopamine can increase by 75
cells, the activity of these cells—and the mental percent when playing video
and physical states they induce—are heavily games and by 350 percent
influenced by chemicals called neurotransmitters. when using cocaine.
Neurotransmitters Drugs
Neurotransmitters are active at the synapse, the Chemicals that change mental and physical states,
tiny gap between the axon of one cell and a dendrite both legal and illegal, generally act by interacting
of another (see p.23). Some neurotransmitters are with a neurotransmitter. For example, caffeine
excitatory, meaning that they help continue the blocks adenosine receptors, which has the effect of
transmission of an electrical nerve impulse to the increasing wakefulness. Alcohol stimulates GABA
receiving dendrite. Inhibitory neurotransmitters have receptors and inhibits glutamate, both inhibiting
the opposite effect. They create an elevated negative neural activity in general. Nicotine activates the
electrical charge, which stops the transmission of the receptors for acetylcholine, which has several
nerve impulse by preventing depolarization from taking effects, including an increase in attention as well as
place. Other neurotransmitters, called neuromodulators, elevated heart rate and blood pressure. Both alcohol
modulate the activity of other neurons in the brain. and nicotine have been linked to an elevation of
Neuromodulators spend more time at the synapse, dopamine in the brain, which is what leads to their
so they have more time to affect neurons. highly addictive qualities.
TYPES OF NEUROTRANSMITTERS TYPE OF DRUG EFFECTS
There are at least 100 neurotransmitters, some of which are listed A brain chemical that stimulates the
below. Whether a neurotransmitter is excitatory or inhibitory receptor associated with a particular
Agonist neurotransmitter, elevating its effects.
is determined by the presynaptic neuron that released it.
NEUROTRANSMITTER USUAL POSTSYNAPTIC A molecule that does the opposite

CHEMICAL NAME EFFECT of an agonist, by inhibiting the action
Antagonist of receptors associated with a
neurotransmitter.
Acetylcholine Mostly excitatory
A chemical that stops a
Gamma-aminobutyric acid (GABA) Inhibitory Reuptake neurotransmitter from being
inhibitor reabsorbed by the sending neuron,
thus causing an agonistic response.
Glutamate Excitatory
Dopamine Excitatory and inhibitory

BLACK WIDOW SPIDER VENOM
Noradrenaline Mostly excitatory INCREASES LEVELS OF THE
Serotonin Inhibitory
NEUROTRANSMITTER
ACETYLCHOLINE, WHICH
Histamine Excitatory
CAUSES MUSCLE SPASMS
THE PHYSICAL BRAIN
Brain Chemicals 24 25
THE LONG-TERM EFFECTS OF ALCOHOL KEY
Dopamine
Drinking large volumes of alcohol over a long Cocaine
period alters mood, arousal, behavior, and
neuropsychological functioning. Alcohol’s
depressant effect both excites GABA and inhibits
glutamate, decreasing brain activity. It also Dopamine and cocaine
triggers the brain’s reward centers by releasing The effects of cocaine are a
product of its effects on the
dopamine, in some cases leading to addiction.
neurotransmitter dopamine
at synapses in the brain.
Dopamine
held in vesicles Dopamine
inside sending VE released VE
neuron SIC SIC
LE LE
SENDING NEURO SENDING NEURO

N N
SY
S YN NA
APSE PSE
RE RE
CE CE
PTO PTO
R R
Once released, Unused dopamine Concentration Cocaine blocks
some dopamine sucked back into of dopamine dopamine’s path
bonds to receptors sending neuron in synapse back into
on receiving increases sending neuron
neuron
RE N RE N
CEIV CEIV
ING NEURO ING NEURO
Normal dopamine levels With use of cocaine

Dopamine is a neurotransmitter associated with feeling Cocaine molecules are reuptake inhibitors of dopamine. When
pleasure. It creates a drive to repeat certain behaviors that dopamine is released, it moves into the synapse and binds to
trigger feelings of reward, perhaps leading to addiction. While receptors on the receiving neuron as normal. However, the
some dopamine molecules bind to receptors on the receiving cocaine has blocked the reuptake pumps that recycle the
neuron, unused dopamine is recycled by being pumped back dopamine, so the neurotransmitter accumulates in a higher
into the sending neuron and parceled up again. concentration, increasing its effects on the receiving neuron.
Networks
in the Brain AXON
The patterns of nerve-cell connections in the SYNAPTIC CLEFT

human brain are believed to influence how
it processes sensory perceptions, performs
cognitive tasks, and stores memories. Calcium ions
facilitate signaling Axon releases
between neurons glutamate
Wiring the brain neurotransmitter
The dominant theory of how the brain remembers

Calcium unable
and learns can be summed up by the phrase “the to access channel Glutamate
cells that fire together, wire together.” It suggests neurotransmitter
binds to receptor,
that repeated communication between cells creates eventually causing
stronger connections between them, and a network channel to unblock
of cells emerges in the brain that is associated with
a specific mental process—such as a movement,
a thought, or even a memory (see pp.136–37). DENDRITE
Magnesium ion
Synaptic weight
blocks channel
KEY Little-used connections
Magnesium Channel have channels blocked
ion by magnesium ions. As the
strength of a connection
Calcium ion Glutamate between two neurons in Channel blocked
receptor a network increases, the 1 In a weak connection, magnesium ions block
Glutamate channel is unblocked, and the passage of calcium ions into the dendrite of a
neurotransmitter the number of receptors receiving neuron. A glutamate neurotransmitter
at the synapse increases. received from the axon will open that channel.
Neuroplasticity Strong Weak

The networks of the brain are not synapses synapses
fixed but seem to change and adapt

in accordance with mental and
physical processes. This means
WHAT IS THE BRAIN’S
that old circuits associated with
DEFAULT MODE NETWORK?
one memory or a skill that is no It is a group of brain regions
longer in use fade in strength as
that show low activity levels
the brain devotes attention to
another and forms a new network
when engaged in a task such
with other cells. Neuroscientists as paying attention but high
say the brain is plastic, meaning its activity levels when awake and
cells and the connections between not engaged in a specific
them can be reformed many times mental task.
over as required. Neuroplasticity
allows brains to recover abilities
lost due to brain damage. BRAIN PATHWAYS
THE PHYSICAL BRAIN
Networks in the Brain 26 27
More
neurotransmitters
received
Magnesium
ion removed Calcium ions
from channel pass freely
Extra glutamate
receptors
introduced
Channel open More receptors

2 With the channel open, calcium ions are 3 With more receptors active, the dendrite
now able to move from the synaptic cleft into the is able to pick up more neurotransmitters, and
dendrite. In response, the dendrite adds more so any signal sent from the neighboring axon
glutamate receptors to the surface of the dendrite. is received much more strongly.
Small-world networks
Brain cells are not connected in a regular
pattern, nor are they in a random network.
Instead, many of them exhibit a form of
small-world network, where cells are seldom
connected to their immediate neighbors but
to nearby ones. This way of networking
allows each cell to, on average, connect to
any other in the smallest number of steps.
Random Small-world Lattice
A random network Small-world networks By connecting every
IT IS ESTIMATED THAT is good at making
long-distance
have good local and
distance connections.
cell to its neighbors,
this network has
THE HUMAN BRAIN connections but poor
at linking nearby cells.
Every cell is more
closely linked than in
reduced scope to
make long-distance
CONTAINS 100 TRILLION the other two systems. connections.
CONNECTIONS BETWEEN
ITS 86 BILLION NEURONS
Brain Anatomy Surface layer of forebrain,
known as gray matter, is made
from unsheathed neurons
Tracts of white
matter—neurons
sheathed with
fatty myelin
The brain is a complex mass of soft tissue composed
almost entirely of neurons, glial cells (see
p.21), and blood vessels, which are
grouped into an outer layer, the cortex,
and other specialized structures. R TEX
CO
CEREB
Divisions of the brain RU
M
The brain is divided into three
unequal parts: the forebrain,
midbrain, and hindbrain. These
LLOSUM
divisions are based on how they S CA
ER
RPU
develop in the embryonic brain,
MATT
O
C
but they also reflect differences
S
EY
in function. In the human brain,
PU
GR
AM
the forebrain dominates, making C
O
up nearly 90 percent of the brain PP
HI
by weight. It is associated with AMYGDALA
sensory perception and higher
executive functions. The midbrain
US
and hindbrain below it are more
M
LA
MID
M
involved with the basic bodily THA LU
EL
EB
BR A
functions that determine survival, CE R
such as sleep and alertness.
IN
Midbrain
PO
The smallest brain section, this is associated with
NS
the sleep-wake cycle, thermoregulation (control
SPINAL NERVES
MED
of body temperature), and visual reflexes, such
as the rapid eye movements that scan complex
There are 31 pairs of spinal nerves scenes automatically. The substantia nigra, ULLA
BRA
that branch out from the spinal cord which is a region associated with planning
smooth muscle control, is in the midbrain.
above each vertebral bone, named
after the parts of the spine to which IN
SPIN
STEM
they connect. They relay signals
AL C
between the brain and sensory Hindbrain

Made up of the cerebellum at the lower
organs, muscles, and glands.
ORD
rear of the brain and the brain stem, which

connects to the spinal cord, the hindbrain
is the most primitive part of the brain.
The genes that control its development
Cervical
evolved around 560 million years ago.
nerves
Thoracic
nerves
Lumbar
nerves
Direct connections
Sacral to all three sections
nerves of brain are carried
in spinal cord
28 29
Parietal lobe governs perception Occipital lobe is mostly
of body position and other given over to vision
touch sensations
Hemispheres
The cerebrum forms in two
halves, or hemispheres, which
Brain handles are divided laterally by a gap
short-term memory called the longitudinal fissure.
in frontal lobe
Nevertheless, the hemispheres
BE share an extensive connection
LO
TAL via the corpus callosum. Each
ARIE
P
hemisphere is a mirror image of
the other, although not all functions
are performed by both sides (see
p.10). For example, speech centers
ITAL LOBE
OB E tend to be on the left side.
TAL L
ON
FR
OCCIP
SUM
LO
AL
White-matter
nerve tracts
C
US
form corpus
CORP
callosum
E
L OB Same layout
AL of four lobes
P OR
TEM on both sides
Communication
Temporal lobe is fibers from each
Forebrain
linked to language hemisphere switch
The forebrain is divided in
and emotion sides at base of
two. At its base is the thalamus,
which, along with the structures brain stem
around it, serves as a junction
box for sensory signals and Left side of body
movement impulses. The rest is controlled by
of the forebrain is the cerebrum, right hemisphere
which is dominated by the cerebral
cortex. This is where consciousness,
language, and memory are
processed, along with the brain’s
higher functions. The cortex is
further divided into four lobes.
18 in
(46 CM) THE LENGTH
Left and right
The brain and the body are connected
contralaterally, meaning that the left brain
hemisphere handles the sensations and
movements of the right side of the body
OF THE SPINAL CORD and vice versa.
The Cortex URF
AC
E
The cortex is the thin outer layer that forms the LS

IA
brain’s visible surface. It has several important
ED
M
functions, including handling sensory data and
language processing. It also works to generate
our conscious experience of the world.
A functional map
The cortex is a multilayered coating of neurons,
with their cell bodies at the top. Neuroscientists divide
it into areas where the cells appear to work together to
perform a particular function. There are different ways
to reveal this information: through the location of brain
damage linked to the loss of a brain function; tracking
the connections between cells; and through scans of
Areas related to
live brain activity. conscious emotional
responses and
decision-making
WHAT IS located in
orbitofrontal cortex Inferior temporal gyrus
PHRENOLOGY? is involved in face
Cingulate gyrus is fused to recognition
A 19th-century limbic area (pp.38–39)
pseudoscience, in which the
shape of the head was KEY
linked to brain structure, Memory Emotion Vision
specific abilities, and Audition Body sensation Olfaction
personality. Motor Gustation Cognition
Folds and grooves

The cerebral cortex is a feature of Gyrus
all mammal brains, but the human
brain is distinctive because of its
highly folded appearance. The
BE
many folds increase the total O BE
L LO
L
ETA
AL
surface area of the cortex, thereby RI Sulcus

NT
PA
BE
providing more room for larger

FRO
LO
cortical areas. The groove in a fold

PORAL LOBE
ITAL
is called a sulcus, and the ridge is TEM

CIP
called a gyrus. Every human brain Lobe divisions

OC
has the same pattern of gyri and The boundaries between the lobes of the
sulci, which neuroscientists cerebral cortex are set by deep grooves. The
frontal lobe meets the parietal lobe at the
employ to describe specific central sulcus, while the temporal lobe starts
locations in the cortex. next to a sulcus called the lateral fissure.
THE PHYSICAL BRAIN
The Cortex 30 31
CE
URFA
LS
ERA Somatosensory
T PRIMARY cortex processes
LA
MOTOR sensory
CORTEX information
PARIETAL
CORTEX Parietal cortex
combines
information
from senses to
orientate body
WERNICKE’S Wernicke’s area is

AREA involved in language
comprehension
ASSOCIATIVE
VISUAL
CORTEX
Vision-related Occipital lobe

Brodmann areas mainly devoted to
extend from visual processing
lateral surface to
medial surface
Broca’s area is associated Premotor cortex

with learning language plays a role in
(see pp.126–27) planning movement
THE CORTEX
Brodmann areas
This functional map of the brain is based on
CONTAINS
research carried out by neuroanatomist Korbinian
Brodmann, who linked cells by similarities in their
AROUND
size, shape, and connections. There are 52 regions 28 BILLION
in total, and each one can be associated with one
or more approximate functions. NEURONS
Layer 1 receives Molecular

Cell structure inputs from thalamus
The cells of the human cortex are Layer 2 contains a mass External granular
arranged in six layers, with a total of cortical neurons
thickness of 0.09 in (2.5 mm). Layer 3 receives inputs External pyramidal
Each layer contains different from other cortical areas
types of cortical neurons that Internal granular
Layer 4 is linked to
receive and send signals to other corpus callosum, brain
areas of the cortex and the rest stem, and thalamus Internal pyramidal
of the brain. The constant relaying
of data keeps all parts of the brain Layer 5 cells extend Multiform
aware of what is going on beneath cortex To opposite
hemisphere
elsewhere. Some of the more
primitive parts of the human To brain stem
Layer 6 sends signals and spinal cord To thalamus White matter
brain, such as the hippocampal back to thalamus
fold, have only three layers. CORTICAL LAYERS
Nuclei of
Globus Subthalamic
pallidus nucleus
Caudate
the Brain
nucleus
In brain anatomy, a nucleus is a cluster Central location

Most of the basal ganglia are
of nerve cells that have a discernible set positioned at the base of the forebrain
of functions and are connected to each around the thalamus. The nuclei sit
within a region filled with white-
other by tracts of white matter. matter tracts called the striatum. Substantia
nigra
The basal ganglia and other nuclei

An important group of nuclei collectively known
as the basal ganglia sit within the forebrain and
RE
AR
have strong links with the thalamus and brain SL
stem. They are associated with learning,
IC
E
motor control, and emotional responses. All WHITE
cranial nerves connect to the brain at a MATTER
nucleus (often two: one for sensory inputs
and another for motor outputs). Other
brain nuclei include the hypothalamus
(see p.34), hippocampus (see pp.38–39),
pons, and medulla (see p.36).
CAUDATE
CE
PU
T SLI NUCLEUS
TA
N
RO
MEN
GLOBUS
F
PALLIDUS
WHITE CAUDATE
MATTER NUCLEUS TAIL
AMYGDALA
SUBTHALAMIC CAUDATE
NUCLEUS NUCLEUS
P
GL LLIDUS
A
THALAMUS Each nucleus Nuclei of amygdala

OBU
SUBSTANTIA develops as a have been classified

NIGRA
S
mirrored pair, as part of basal

CAUDATE one in each ganglia by some
NUCLEUS TAIL hemisphere scientists
Nuclei structure
Nuclei are clusters of gray matter (nerve
cell bodies) situated within the brain’s white
Substantia nigra in matter (nerve axons). Most nuclei do not
midbrain linked with have a membrane so, to the naked eye,
fine motor control seem to blend into the surrounding tissues.
THE PHYSICAL BRAIN
Nuclei of the Brain 32 33
REGIONS OF THE BASAL GANGLIA
NUCLEUS FUNCTION
WHAT NUCLEI ARE
LOCATED IN THE Caudate A motor processing center that involves procedural
nucleus learning of movement patterns and conscious
BRAIN STEM? inhibition of reflex actions.
The brain stem contains 10 of Putamen A motor control center, associated with complex
learned procedures such as driving, typing,
the 12 pairs of cranial nuclei. or playing a musical instrument.
They provide motor and
Globus A voluntary motor control center that manages
sensory function to the pallidus movements at a subconscious level. When damaged,
tongue, larynx, facial it can create involuntary tremors.
muscles, and more. Subthalamic Although its precise function is not clear, this
nucleus structure is thought to be linked to selecting a specific
movement and inhibiting any competing options.
Substantia Plays a role in reward and movement. Symptoms

THE BRAIN HAS nigra of Parkinson’s disease (see p.201) are associated
MORE THAN 30 SETS with the death of dopamine neurons found here.
OF NUCLEI, MOSTLY Amygdala May play a part in integrating activity between

basal ganglia and limbic system, thereby considered
PAIRED LEFT AND RIGHT by some to be part of the basal ganglia.
Action selection
The basal ganglia have an
important role in filtering out the
noise of competing commands
coming from the cortex and
elsewhere in the forebrain. MOTOR LOOP PREFRONTAL LOOP LIMBIC LOOP
This process is called action
selection, and it occurs entirely
subconsciously through a series
SOURCE
Motor, premotor, Amygdala,
INPUT
of pathways through the basal Dorsolateral
somatosensory hippocampus,
prefrontal cortex
ganglia. Generally, these pathways cortex temporal cortex
block or inhibit a specific action
by having the thalamus loop the
ENTRY
POINT
signal back to the start point. Putamen Anterior caudate Ventral striatum
However, when the pathway
is silent, the action goes ahead.
POINT
Lateral globus Globus pallidus;

EXIT
Basal ganglia loops

pallidus, internal pars reticulata in Ventral pallidum
The route of the pathway depends on the
segment substantia nigra
source of the inputs from the cortex or
elsewhere in the forebrain. There are three
main pathways, and each one is able to
inhibit or select an action. The motor loop
THALAMUS
REGION
connects to the main movement control Ventral lateral and Mediodorsal and
Mediodorsal
center, the prefrontal loop carries input from ventral anterior ventral anterior
nucleus
executive regions of the brain, while the nuclei nuclei
limbic loop is governed by emotional stimuli.
Hypothalamus, Thalamus,
and Pituitary Gland
The thalamus and the structures around it sit at the center
of the brain. They act as relay stations between the forebrain
and the brain stem, also forming a link to the rest of the body.
The hypothalamus
This small region under the forward
region of the thalamus is the main
WHAT GLANDS
interface between the brain and the DOES THE PITUITARY
hormone, or endocrine, system. GLAND CONTROL?
It does this by releasing hormones The pituitary gland is a master
directly into the bloodstream, or by
gland that controls the thyroid
sending commands to the pituitary
gland to release them. The gland, adrenal gland, ovaries,
hypothalamus has a role in growth, and testes. However, it receives
homeostasis (maintaining optimal its instructions from the KEY
body conditions), and significant hypothalamus. Thalamus
behaviors such as eating and sex.
Hypothalamus
This makes it responsive to many
different stimuli. Pituitary gland
THE EPITHALAMUS RESPONSES OF THE HYPOTHALAMUS
STIMULUS RESPONSE
This small region covers the top
of the thalamus. It contains various Day length Helps maintain body rhythms after receiving signals about day
nerve tracts that form a connection length from the optical system.
between the forebrain and
midbrain. It is also the location Water When the blood’s water levels drop, releases vasopressin, also called
antidiuretic hormone, which reduces the volume of urine.
of the pineal gland—the source of
melatonin, a hormone central to the Eating When the stomach is full, releases leptin to reduce feelings of hunger.
sleep–wake cycle and body clock.
Lack of food When the stomach is empty, releases ghrelin to boost feelings
of hunger.
Infection Increases body temperature to help the immune system work faster
to fight off pathogens.
Stress Increases the production of cortisol, a hormone associated with

preparing the body for a period of physical activity.
Body activity Stimulates the production of thyroid hormones to boost the

metabolism, and somatostatin to reduce it.
Sexual activity Organizes the release of oxytocin, which helps the formation of
interpersonal bonds. The same hormone is released during childbirth.
34 35
Incoming signals for Nuclei separated by
Lateral nuclei
medial dorsal nuclei sheets of white matter The thalamus
are from prefrontal
AN The word “thalamus” is derived from
(pulvinar) cortex IAL T
MED BE LO E
send signals L O B the Greek word for “inner chamber,”
RI E
to visual
OR
cortex
and this thumb-sized mass of gray
matter sits in the middle of the brain,
between the cerebral cortex and
BE
L O
AL midbrain. It is formed from several
TER
LA bundles, or tracts, of nerves, which
Signals sent from send and receive signals in both
premotor cortex directions between the upper and
received in lateral
anterior nucleus lower regions of the brain, often in
Sense data from mouth feedback loops (see p.91). It is
transmitted to medial associated with the control of sleep,
ventral posterior nucleus
alertness, and consciousness. Signals
Thalamic nuclei from every sensory system, except
The thalamus is divided into three main lobes:
the medial, lateral, and anterior. They are each smell, are directed through the
further organized into zones, or nuclei, thalamus to the cortex for processing.
associated with particular sets of functions.
WEIGHING JUST 0.1 OZ (4 G),
AMUS
THE HYPOTHALAMUS IS
NOT MUCH LARGER THAN
L
THA
THE END SEGMENT
PO
Secretory cells in
HY
hypothalamus
OF A LITTLE FINGER release hormone
Stimulation
1 The hormones produced
The pituitary gland by the hypothalamus travel along
Weighing about 0.01 oz (0.5 g), the axons to the pituitary gland.
tiny pituitary gland produces many
of the body’s most significant Artery Posterior
hormones under the direction of the pituitary
Production Network lobe
hypothalamus. The hormones are 2 The chemicals from of veins
released into the blood supply via a the hypothalamus stimulate
network of tiny capillaries. Pituitary the pituitary gland to
release hormones.
hormones include those that control
PIT
growth, urination, the menstrual

U
Anterior
ITA
pituitary lobe
cycle, childbirth, and skin tanning.
RY
Release
Despite having the volume of a pea, 3
GLAND
The netlike
the gland is divided into two main portal system collects
lobes, the anterior and posterior, plus the hormones and releases
a small intermediate lobe. Each lobe them into the bloodstream.
is devoted to the production of a
Hormones pass
particular set of hormones. into bloodstream
Thalamus links brain
stem with forebrain,
relaying and
preprocessing sensory
and other information
HOW BIG IS
US
THE CEREBELLUM? L AM
THA
Most of the brain’s cells are
Midbrain is associated with
located in the cerebellum, control of state of arousal
although it makes up only and body temperature
around 10 percent of
the volume of the
whole brain.
M
ID
BR
Connecting the brain AI
N
The stalklike brain stem forms a link between
the thalamus, the base of the forebrain, and
the spinal cord, which connects to the rest Pons is a major
of the body. It is involved in many basic communication pathway
functions, including the sleep-wake cycle, that carries cranial nerves
eating, and regulating heart rate. used for breathing, hearing,
and eye movements
STEM
The brain stem
The brain stem is made up of three components, all of which have PONS
IN
an essential role in several of the human body’s most fundamental
BRA
functions. The midbrain is the start point of the reticular formation,
a series of brain nuclei (see pp.32–33) that run through the brain stem
and are linked to arousal and alertness and play a crucial role in
consciousness. The pons is another series of
nuclei that send and receive signals from
the cranial nerves associated with the
10 pairs of
face, ears, and eyes. The medulla
ME
cranial nerves
THALAMUS
DU
descends and narrows to merge with emerge from
LLA
the uppermost end of the spinal cord. brain stem
BR
It handles many of the autonomous CEREBELLUM

AIN
Cranial nerves
body functions, such as blood-pressure start and end
STEM
regulation, blushing, and vomiting. at nuclei in

brain stem
The Brain Stem Medulla is involved in

important reflexes
such as breathing rate
and Cerebellum
and swallowing
Spinal cord consists

The lower regions of the brain are the brain stem, of a bundle of nerve
SPINAL CORD
which connects directly to the spinal cord, and axons that connect
to peripheral
the cerebellum, located directly behind it. nervous system
THE PHYSICAL BRAIN
The Brain Stem and Cerebellum 36 37
RE
The little brain
Vermis controls
AR
The cerebellum, a term that
most basic motor
VI
means “little brain,” is a highly
EW
patterns, such as
folded region of the hindbrain
eye and limb
OF
that sits behind the brain stem.
movements
Like the cerebrum above it, the
CE
cerebellum is divided into two Outer layer
REB
lobes. These are divided laterally composed of
Anterior lobe of into functional zones. gray matter
SPINOCEREBELLUM
ELLUM
cerebellum receives
VERMIS
information about body
posture from spinal cord
ANTERIOR
Located on both
LOBE
Body movements sides of cerebellum,
are coordinated these zones are
in posterior lobe involved in planning LATERAL
sequences of ZONE
ANTERIOR movements
LOBE
Spinocerebellum compares
information about actual body
position to intended position of
planned movements and
modifies sequence as needed
The cerebellum
Although the cerebellum appears to play a part in maintaining
POSTERIOR attention and processing language, it is most associated with its
LOBE role in the regulation of body movement. Specifically, its role is
UM
to convert the broad executive motor requests into smooth and

ELL
B
coordinated muscle sequences, error-correcting all the while.

RE
It routes its outputs through the thalamus. At the microscopic

CE
LO
level, the cerebellum’s cells are arranged in layers. The purpose

IBU
of these layers is to lay down fixed neural pathways for all kinds
M
ST
LLU
VE
of learned movement patterns, such as walking, talking, and

keeping balance. Damage to the cerebellum does not result
BE
RE
CE in paralysis, but slow jerky movements.
THE CEREBELLUM AND NEURAL NETWORKS

Vestibulocerebellum is involved in
head control, eye movements, and Some artificial intelligences (AI)
maintaining balance through use a system inspired by the
information from the inner ear anatomy of the cerebellum.
AI programs itself by machine
KNOWLEDGE OF THE learning. It does this with a
processor called a neural
CEREBELLUM WAS network, where inputs find
their way by trial and error
ADVANCED BY through layers of connections,
STUDYING BRAIN- a setup that mirrors the way
the cerebellum lays down
INJURED SOLDIERS patterns for learned movements.
IN WWI
The Limbic THE S-SHAPED
HIPPOCAMPUS IS NAMED
System AFTER ITS RESEMBLANCE

TO A SEAHORSE
Sitting below the cortex and above Fornix is a bundle of nerve
tracts that connects
the brain stem, the limbic system is a hippocampus to thalamus
collection of structures associated with and lower brain beneath
emotion, memory, and basic instincts.
Location and function

The limbic system is a cluster of organs
S
situated in the center of the brain,
YRU
occupying parts of the medial surfaces G
E
of the cerebral cortex. Its major structures
AT
UL
form a group of modules that pass signals
CING
FORNIX
between the cortex and the bodies of the
X
lower brain. Nerve axons link all of its RNI
F FO
parts and connect them to other brain O
N
UM
areas. The limbic system mediates
COL
instinctive drives such as aggression,
fear, and appetite, with learning, memory,
and higher mental activities. MAMILLARY MIDBRAIN
BODIES
System parts
The limbic system’s components HYPOTHALAMUS
extend from the cerebrum inward
AM
and down to the brain stem.
It is usually understood to GD
Y
B ALA
include the structures
RY BUL
O
ACT
shown here.
OLF PARAHIPPOCAMPAL
GYRUS
L IES N ING
EL OR IO ON
M
IT
TI
M
SENSE OF S
R COND
RECOGNI
NEW ME
FEA
Smell, which is The small mamillary bodies The amygdala is most Involved in forming
processed in the act as relay stations for new associated with fear and retrieving memories
olfactory bulbs, is the memories formed in the conditioning, where associated with fresh
only sense handled by hypothalamus. Damage we learn to be afraid data from the senses,
the limbic system and leads to an inability to of something. It is also the parahippocampal
not sent through the sense direction, particularly involved in memory and gyrus helps us recognize
thalamus. with regards to location. emotional responses. and recall things.
THE PHYSICAL BRAIN
The Limbic System 38 39
WHAT DOES Reward and punishment
LIMBIC MEAN? The limbic system is closely linked to feelings of rage and
contentment. Both are due to the stimulation of reward or
The word “limbic” is derived punishment centers within the limbic system, particularly
from the Latin limbus, in the hypothalamus. Reward and punishment are crucial
meaning “border,” referring aspects of learning, in that they create a basic response to
to the system’s role as a kind experiences. Without this rating system, the brain would
of transition zone between simply ignore old sensory stimuli that it had already
experienced and pay attention only to new stimuli.
the cortex and lower
brain.
Pleasure Disgust Fear

Associated with the release This emotion is linked to the Fear is linked to specific
of dopamine, the brain sense of smell. Its primordial stimuli by the amygdala.
seeks to repeat behaviors role is to protect us from This can lead to a controlled
that create this feeling. infection. rage or fight response.
AMPUS
Cingulate gyrus helps

form memories
associated with Klüver-Bucy syndrome
C
SYMPTOM DESCRIPTION
PO
strong emotion This condition is caused by damage

P
HI Damage to the
to the limbic system and results in
hippocampus leads to
a spectrum of symptoms associated Amnesia the inability to form
with the loss of fear and impulse long-term memories.
control. First described in humans With little sensation
in 1975, this neural disorder is of reward for actions,
Docility sufferers lack
named after the 1930s investigators
motivation.
Heinrich Klüver and Paul Bucy, who
performed experiments that An urge to examine
objects by putting
EPISOD involved removing various brain Hyperorality them in the mouth.
IC
regions in live monkeys and noting
M
the effects.
EM
Eating compulsively,
In humans, the syndrome may
ORIES
including inedible
Pica substances like earth.
be caused by Alzheimer’s disease,
complications from herpes, or brain
damage. It was first documented in A high sex drive often
associated with
The hippocampus receives people who had undergone surgical Hypersexuality fetishes or atypical
and processes inputs from the removal of parts of the brain’s attractions.
cerebrum. It is involved in
creating episodic memories, temporal lobe. The condition can Losing the ability to
or memories about what you be treated with medication and recognize familiar
have done, and creating Agnosia objects or people.
assistance with daily tasks.
spatial awareness.
Imaging the Brain Layer of thermal
insulation keeps
liquid helium cold
Modern medicine and neuroscience can see through Liquid helium cools
electromagnet to
the skull to observe structures within the living brain. about –453°F (–270°C)
However, imaging this soft and intricate organ has
required the invention of advanced technology.
MRI scanners Superconducting

A magnetic resonance imaging (MRI) electromagnet generates IUM
extremely strong magnetic field ID HEL
machine gives the best general view U
LIQ
of the brain’s nervous tissue and is
most often deployed to search for Gradient magnets focus
magnetic field around area
tumors. MRI does not expose the to be scanned
brain to high-energy radiation, unlike
other scanning systems, which makes
Radiofrequency coil
it safe to use for long periods and emits and detects
multiples times. Two refinements radio waves
of MRI, called fMRI and DTI, are
also useful for monitoring brain
Patient lies inside body of
activity (see p.43). Although ideal as scanner during scanning
a tool for research and diagnosis, MRI
is expensive. With its liquid-helium LE
coolant system and superconducting Motorized D TAB
IZE
electromagnets, one machine also table moves O TOR
M
patient into
uses the power of six family homes. scanner
How MRI works

MRI makes use of the way that protons in
hydrogen atoms align to magnetic fields. Additional
Hydrogen is found in water and fats, Protons
south-facing
which are both common in the brain. aligned
INACTIVE proton
A scan takes about an hour, then the data randomly ACTIVE
is processed to create detailed images. ELECTROMAGNET ELECTROMAGNET
Proton faces
south
Magnetic
field line
INACTIVE ACTIVE Proton faces

ELECTROMAGNET ELECTROMAGNET north
THE ELECTROMAGNET
IN AN MRI SCANNER
CAN GENERATE A Protons unaligned Protons align to magnetic field
1 2
MAGNETIC FIELD Before the MRI machine is
activated, the protons in the brain’s
Activating the machine’s powerful magnetic
field forces all the protons to align with each other.
40,000 TIMES AS molecules are unaligned—the axes Approximately half face the field’s north pole, and
around which the particles are spinning half face south. However, one pole will always have
STRONG AS EARTH’S point in random directions. slightly more protons facing it than the other.
THE PHYSICAL BRAIN
Imaging the Brain 40 41
MR
I SC
AN
NER Person being X-ray
CT scans scanned detectors
Computer tomography (CT), or
computerized axial tomography
(CAT), takes a series of X-ray images
through the brain from different
angles. A computer then compares
the images to create a single cross
section of the brain. CT scans are X-ray source
quicker than MRI and are best for Rotating X-ray
The X-ray source shines through the
detecting strokes, skull fractures, brain, arcing around the patient to vary
and brain hemorrhages. the angle of each image.
OTHER TYPES OF SCANNING TECHNOLOGY

Imaging certain brain features require particular scanning techniques,
which may also be used if MRI or CT are dangerous or unsuitable.
IL
CO
N C Y ET
E TYPE OF SCAN TECHNOLOGY AND USES
QU GN
FRE MA T
ADIODIENT AGNE
R RA M PET (positron Used in order to image the blood flow through the brain and highlight
G R O
CT emission active regions. PET scans track the location of radioactive tracers
ELE tomography) injected into the blood.
An array of newer techniques that works by detecting how bright

DOI (diffuse
light or infrared rays penetrate into the brain. DOI provides a way
optical imaging)
of monitoring blood flow and brain activity.
A safe imaging technique that is based on the way ultrasonic waves

Cranial bounce off structures in the brain. Cranial ultrasound is mostly used
ultrasound on infants. It is used less often in adults because the images lack detail.
Flipped proton Computer

Radio-wave pulse realigns processes Image shows
signal data tissues in
RADIOFREQUENCY COIL RADIOFREQUENCY COIL cross section
COMPUTER
MONITOR
RADIOFREQUENCY COIL RADIOFREQUENCY COIL
Radiofrequency coil
Additional proton flips into Radio signal
detects signal and passes
different orientation emitted
it to computer
A pulse of radio waves Radio signal emitted Receiver creates image

3 With the magnetic field on, the MRI
4 Once the pulse is switched off, the
5 All the signal data is then processed by
machine’s radiofrequency coil sends a pulse unaligned protons flip back into alignment with computer to create two-dimensional “slices”
of radio waves through the brain. This input the magnetic field. This causes them to release of the brain. Protons in different body tissues
of extra energy makes the spare protons energy as a radio signal, which is detected by produce different signals, so scans can show
flip out of alignment. the machine. the tissues distinctly and in great detail.
Monitoring the Brain
Being able to collect information from a living brain
at work has revolutionized both our understanding
of how the brain functions and brain medicine. WHY DOES
THE BRAIN PRODUCE
EEG ELECTROMAGNETIC FIELDS?
The simplest brain monitor is the electroencephalograph (EEG). It uses
electrodes positioned all over the cranium to pick up an electrical field
Neurons use pulses of electric
created by the activity of neurons in the cerebral cortex. The varying charge to transmit messages.
levels may be displayed as waves (“ordinary EEG”) or colored areas The activity of billions of
(quantitative EEG, or QEEG). EEG can reveal evidence of seizure disorders, cells accumulates into
such as epilepsy, and signs of injury, inflammation, and tumors. The a constant field.
painless procedure is also used to assess brain activity in coma patients.
Types of EEG wave

High-frequency waves are
Neighboring cells in the cortex fire in
MMA WAVES packed tightly together
synchrony, creating wavelike changes in the
intensity of the electrical field. Characteristic
GA
wave patterns (named after letters of the MORE THAN Low-frequency waves
Greek alphabet) have been found to be 32 HZ are widely spaced
Amplitude
closely associated with certain brain states.
ES Time DE
AV LT
W These rhythms are associated with
A
TA
learning and complex problem- 0.1–4 HZ
W
Amplitude
14–32 HZ
BE
Amplitude
solving tasks. They may originate
AV
from the binding together of
ES
groups of neurons into
networks. Time
Time
Originating from both hemispheres These waves are typically seen
at the front of the brain, beta during some stages of sleep but
waves are associated with also when a person is
physical activity and with engaged in complex
states of concentration problem-solving
and anxiety. tasks.
ES TH
AV ET
W
A
A
PH
8–14 HZ 4–8 HZ
Amplitude
W
Amplitude
AL
AV
ES
Time Time
These typically originate from the Electrodes held close
back of the brain and are usually to skull by cap Usually seen in young children,
stronger in the dominant theta waves are also evident
hemisphere. They are seen Wire carries signal during states of relaxation,
during both relaxed to an amplifier creativity, and
and alert states. meditation.
THE PHYSICAL BRAIN
Monitoring the Brain 42 43
MEG Functional MRI and
In addition to making electrical activity, the brain produces a faint diffusion tensor imaging
magnetic field. This is detected by a magnetoencephalography MRI (see pp.40–41) can be extended
(MEG) machine and can be used to create a real-time account to collect information about what
of activity in the cerebral cortex. MEG is limited by the weakness the brain is doing. Functional MRI
of the brain’s magnetism, but the technique can detect rapid (fMRI) scanning tracks the flow of
fluctuations in brain activity, which take place over a few blood through the brain, specifically
thousandths of a second, better than other monitoring systems. showing where it is giving oxygen
to neurons and thus indicating
SQUID array in Cerebral Direction of Magnetic field which regions are active in real
form of skull cap cortex nerve pulse around nerve pulse time. Subjects are asked to carry out
mental and physical tasks while
monitored by fMRI to create a
How MEG works functional map of the brain and
MEG uses sensitive spinal cord that combines anatomy
detectors called with activity levels. Diffuse tensor
superconducting
quantum interference imaging (DTI) also uses MRI but
devices (SQUIDS) to tracks the natural movement of
pick up fleeting water through brain cells. It is used
magnetic fields made
by the electrical to build up a map of the white-
pulses of neurons. matter connections within the brain.
NEUROFEEDBACK Area of increased

activity
This form of cognitive therapy uses an EEG to create a feedback loop
between a person’s mental state and their brain activity. This makes
it easier for people to learn ways to control unwanted mental activity,
such as anxiety.
1
EEG charts
electrical activity
in the brain.
4 2 Computer
With practice, turns neural
the brain acquires patterns into
the habit of being in a dynamic display,
the rewarded state. such as an
interactive
game. Area of reduced
activity
3 Game gives
reward when the
required brain state Interpreting an fMRI image
is registered (for An fMRI scan begins with establishing a
example, low baseline of activity in the brain. The scan
anxiety). then shows up regions that fluctuate from
this baseline, allowing researchers to figure
out which areas are excited or inhibited
during particular tasks.
Brain development
The first nerve cells are produced just days after
conception. These cells form into a plate and then
curl to become a liquid-filled structure, called the
neural tube, which develops into the brain and
spinal cord. One end becomes a bulge and then
splits into distinct areas. Cerebrum
Cerebellum
KEY
Forebrain Hindbrain
Midbrain Spinal cord

Brain stem
Eye bud
Ear bud
Cranial The cerebrum enlarges, and the eyes

nerves and ears mature, moving into
position. Some parts of the
Ear bud
fetus’s body may respond
to touch.
Neural At week seven, the forebrain,
tube Eye midbrain, and hindbrain divide
Neural tube forms 11 WEEKS
bud into bulges that will become
the cerebrum, brain stem,
and cerebellum.
KS
Forebrain
Around week five, the neural EE
prominence
tube begins to form into 7W
Nerve cells develop, something recognizable as
migrating around the embryo a brain. The eye starts
to form the start of the
KS
to develop.
brain, spinal cord, and EE
nerve network. 5W
KS
EE
3W
Babies and RECOGNIZING FACES
Young Children
Babies prefer looking at face-like
images and learn about faces
rapidly. An area of the cortex called
the face recognition area (see p.68)
becomes specialized in identifying
The human brain begins to develop after conception faces. Chess champions also use this
and changes rapidly for the first few years of life, but area to recognize board layouts,
it takes more than 20 years for a brain to fully mature. suggesting that the most important
patterns in a person’s life are
decoded there.
Before birth
An embryo’s brain has a lot of development to do, going from just a few
nerve cells three weeks after conception to an organ with specialized
areas that is ready to start learning from birth. Genes control this process,
but the environment can affect it as well. Insufficient nutrition can change
brain development, and extreme stress on the mother during pregnancy FACELIKE NOT FACELIKE
can have an impact, too.
THE PHYSICAL BRAIN
Babies and Young Children 44 45
Cerebrum
Contours Prefrontal
Insula is found of cortex cortex
deep inside Prefrontal
Gyri lateral sulcus cortex
form
Amygdala
Frontal lobe Parietal
cortex
Reticular
formation
Hippocampus
Sulci
form Sensory and motor areas of the brain are well
Cerebellum connected and developed, but large areas,
Brain stem such as the prefrontal cortex, are still
immature. Changes in the hippocampus
In the last couple of months of gestation, the and amygdala allow long-term R
S
cerebral cortex grows and develops rapidly, memories to be retained. EA
and characteristic grooves appear. 3Y
Cerebellum Babies are born with as many
H
neurons as adults, but most
RT
The brain stem is mostly are not yet mature. BI
S/
mature and controls reflexes
such as blinking. Sleep and O NTH AT THE PEAK OF BRAIN
9M
wake cycles begin, and
the fetus responds to
DEVELOPMENT, ABOUT
loud noises.
TH 250,000 NEURONS
S
ON
5 M FORM EVERY MINUTE
Children’s brains
After birth, babies’ brains are like sponges; they are incredible
at taking in information from the world around them and trying
to make sense of it. During the first few years, the brain grows
and develops rapidly, with brain volume doubling in the first
WHY IS OUR
year of life. Synapses grow and form new connections quickly BRAIN WRINKLY?
and easily, a process called neuroplasticity. As human intelligence
evolved, our cortex expanded.
Building
connections But bigger heads would mean
Peak plasticity for that babies could not fit
each region of the
brain is different. through the birth canal.
Sensory areas build
synapses rapidly four
A folded cortex packs
to eight months after more tissue into a
birth, but prefrontal
areas do not reach smaller volume.
peak plasticity until
an infant is around
15 months old. NEWBORN 9 MONTHS 2 YEARS
Older Children
and Teenagers
Teenage brains undergo dramatic restructuring.
Unused connections are pruned, and insulating
myelin coats the most important connections,
making them more efficient.
Teenage behavior
Teenagers have a reputation for being
Risk-taking
impulsive, rebellious, self-centered, and Pleasure-seeking parts of
emotional. A lot of this is due to the changes teenagers’ brains are well
connected, but impulse-control
happening in adolescent brains. Human brains mechanisms are underdeveloped,
change and develop in set patterns, leaving which can lead to risk-taking.
teenagers with a mix of mature and immature
brain regions as they grow. The last area Frontal
to fully develop is the frontal cortex, which cortex
regulates the brain and controls impulses.

This area allows adults to exert self-control
over their emotions and desires, which is
something adolescents can struggle with.
Sleep cycles SYNAPTIC PRUNING

During our teenage years, we need plenty of sleep as our brain
continues to develop. But at this time, our circadian rhythms shift Synaptic pruning, which is when
as melatonin, the hormone that is released in the evening and unused neural connections die off,
makes us feel sleepy, begins to be released later than usual. This starts during childhood and
is why teenagers often want to go to bed later than children and continues through our teen years.
adults and may struggle to get up for school in the morning. Cortical areas are pruned from the
back to the front. Pruning makes
each area more efficient, so until it
is finished, that region cannot be
Onset of
KEY considered fully mature.
sleep in Adult sleep time
adults
Adolescent
sleep time
Teenagers
wake later
in morning Out of sync
than adults Waking teenagers early for
Onset of
school is like giving them
sleep occurs
constant jet lag. Studies
later in
have shown that starting
teenagers
school an hour later
than in adults
improved attendance and
grades. Fights and even car IMMATURE MATURE
Noon Midnight Noon accidents also decreased.
THE PHYSICAL BRAIN
Older Children and Teenagers 46 47
Clumsiness
During rapid growth
spurts, the brain’s body
maps can’t keep up. Brain and
body get out of sync, causing
clumsiness.
Motor
cortex
Extreme
emotions
The limbic system is
highly reactive in teenagers,
meaning they experience
heightened emotional responses,
feeling things more deeply.
Limbic
system
Peer pressure
Teenagers care deeply about
how their friends see them.
They take more risks with
peers, and being left out can
feel excruciating. Peer pressure
can be a strong influence on
them—for good or bad.
Mental health risks THE BRAIN REACHES ITS

Some of the brain areas that undergo the most dramatic
changes during adolescence have been linked with mental LARGEST PHYSICAL
ill-health. These changes can leave the brain vulnerable to SIZE BETWEEN
small issues becoming dysfunctions. This may explain why
so many mental health problems, from schizophrenia to AGES 11 AND 14
anxiety disorders, commonly appear during adolescence.
ADHD, conduct disorder Not all mental WHY ARE TEENS

illnesses will persist
into adulthood SELF-CONSCIOUS?
Anxiety disorders
When we think about being
Mood disorders embarrassed, a region of our
prefrontal cortex linked to
Disorders in adolescence
Some disorders from early Schizophrenia understanding mental states
childhood may disappear during is more active in teenagers
adolescence, while others can Substance abuse
emerge and persist into later life. than adults.
0 5 10 15 20 25
Age (years)
The Adult
PARENTHOOD
A new mother’s brain and body are awash with
Brain
hormones such as oxytocin, driving her to care for her
baby. Looking at her infant triggers the brain’s reward
pathways, and her amygdala becomes more active,
scanning for danger. Men’s brains are affected
Human brains continue to change and by parenthood, too, but only if they spend a
lot of time with their baby. The brains of
mature throughout early adulthood, as men who are primary caregivers of an
unused connections are pruned away. infant go through similar changes to
women’s, and these changes appear
This makes the brain more efficient to be very similar to falling in love.
but also less flexible.
HEA
LT
H
Corpus callosum is fully
developed to allow
information flow
between hemispheres
Last region to
fully mature is
frontal lobe
Adult life
A fully developed, mature
brain is equipped to handle
all the competing demands
and pressures of adult life, Amygdala is less
from work and finances emotionally reactive
to relationships and health.
Hippocampus
FAM continues to produce
ILY new brain cells
Mature brains
Full myelination (the sheathing of axons
FINA
NC in myelin) allows information to flow
freely, but the process is completed only
ES
in a person’s late 20s. The last brain

region to finish maturing is the frontal
lobe, which is responsible for judgment
and inhibition. Compared to children
and teenagers, adults are better able
to regulate their emotions and control
their impulses. They can use their
experiences to better predict the
outcomes of their actions and how
they may make other people feel.
THE VOLUME OF
THE PHYSICAL BRAIN
The Adult Brain 48 49
WHITE MATTER
Neurogenesis
IN A PERSON’S Neurogenesis is the development of new neurons by neural stem cells
BRAIN PEAKS (cells that can become other cells). In a range of mammals, neurogenesis
happens in the hippocampus and olfactory areas and continues
AROUND throughout life, with new neurons being produced regularly.
AGE 40 The same is thought to be true in humans, although the evidence is
mixed. Neurogenesis may also play a role in learning and memory.
New neurons
Neurons grow from stem
cells, dividing, specializing, Axons and Mature axons
and maturing into dendrites and dendrites
TY
ALI
functional brain cells. develop allow neuron
OR to integrate
with cell
M
network
EARLY LATE
TYPE 1 TYPE 2A TYPE 2B TYPE 3 IMMATURE IMMATURE MATURE
STEM CELL STEM CELL STEM CELL STEM CELL NEURON NEURON NEURON
Disrupting memories
New brain cells help store information, so boosting Memory storage
neurogenesis in the brain can improve learning into Due to the creation
of new brain cells,
adulthood. However, it also has a role to play in hippocampal memories
RE forgetting. Adding in new brain cells with new may degrade before
TU connections disrupts existing memory circuits they can be stored in
FU
the cortex. This might

by competing with them. This means there is explain why we are
an optimal level of neurogenesis, which balances unable to remember
learning ability with retaining older memories. our infancy.
Memory forms
in hippocampus
MEMORY PATH
NORMAL
Memory
K consolidated and
OR transferred to cortex Memory
retained
W
HIPPOCAMPUS CORTEX long-term

Consolidation
disrupted by new
MEMORY PATH
neurons
DISRUPTED
New neurons Memory

develop in poorly
hippocampus retained
The Aging
Normal size of Ventricles are
subarachnoid regular-sized
space hollow spaces
Brain
With age, some abilities decline as neurons
degenerate and the brain decreases in
volume. In those neurons that remain,
impulses may travel more slowly.
The shrinking brain

As we age, there is a natural reduction of neurons
as they degenerate, and the brain as a whole shrinks
5 to 10 percent in volume. This is partially due
to decreased blood flow to aging brains. The fatty White-matter Healthy basal
tracts are in ganglia free of
myelin that insulates the axons of neurons also decays good condition abnormalities
with age, leaving brain circuits less efficient at
transmitting information, which can lead to problems Young brain
Young brains look plump; the ridges
with memory recall and maintaining balance. covering the surface of the cortex
almost touch. The fluid-filled ventricles
in the center of the brain are small,
KEY and the subarachnoid space, which
Gray Basal surrounds and cushions the brain,
matter ganglia forms a thin layer.
White Ventricles
matter
Aging and happiness ALZHEIMER’S DISEASE

Aging might seem like a bad thing, but studies have
shown that as we get older, our feelings of happiness Alzheimer’s disease, the most common form of dementia
and well-being increase, while levels of stress and (see p.200), is linked to the buildup of proteins in the
worry decrease. Older adults’ brains seem to be better brain, which clump into plaques and tangles. Eventually,
at focusing on the positive. They are more likely to affected brain cells die, causing memory loss and other
remember happy than sad pictures and spend more symptoms. Scientists do not know yet whether the
time looking at happy faces than angry or upset ones. proteins cause the disease or are a symptom of it, and
drugs to break them down have not helped patients.
Enlarged ventricles
Ups and downs Severe

WELL-BEING
A study found younger cortical

and older people shrinkage
reported higher levels
of well-being than
those in middle age.
Happiness levels
rose steadily from HEALTHY BRAIN ALZHEIMER’S BRAIN
age 50 onward. AGE
THE PHYSICAL BRAIN
The Aging Brain 50 51
Subarachnoid space Loss of gray and
enlarges, reflecting loss white matter enlarges
in brain volume size of ventricles
CAN WE TREAT
ALZHEIMER’S?
Medication can slow down
the progression of the disease
and manage some of the
symptoms, but a cure for
Alzheimer’s has not yet
Decay of white matter Iron accumulates in
been found.
leads to inefficient basal ganglia, possibly
transmission of signals causing abnormalities
Old brain
As we age, brain cells die and spaces within
and around the brain enlarge. The cortex
thins, and areas like the hippocampus
shrink, often causing memory problems.
Both gray matter (neuron bodies)
and white matter (densely
packed axons) are lost. SUPER-AGERS’ BRAINS
STAY LOOKING YOUNG
FOR THEIR WHOLE LIVES
A slow decline? 60
Rapid response Vocabulary keeps
As we get older, our attention to stimuli is first skill increasing until
suffers, and our brains become less to decline old age
55
plastic. This makes learning harder,
although not impossible. In fact,
learning new things throughout 50
Average test scores
life boosts brain health and may

stave off cognitive decline by
45
strengthening neural synapses.
And with age come some benefits: At middle age,
KEY skills like spatial
on average, older adults are better 40 Inductive Numerical orientation stop
at extracting the big picture from reasoning ability improving
a situation and using their life Spatial Verbal
experience to solve problems. 35 orientation ability Numerical ability
requires working
Perceptual Verbal
memory, which often
Skills and abilities speed memory
30 declines with age
The Seattle Longitudinal Study followed
adults for 50 years. It found that skills like
vocabulary and general knowledge keep 25 32 39 46 53 60 67 74 81 88
improving for most of our lives. Age
As we get older, most of us notice Preventing decline Keep your mind stimulated. Any
a slight reduction in thinking speed We can take a variety of steps to mental challenge that involves
as well as a reduction in our safeguard our brain’s health. A diet learning—from home repairs to
working memory (see p.135). Some high in vegetables, fruit, “good” cooking to crossword puzzles—can
people experience severe decline or fats, and nutrients (see pp.54–55) stretch cognitive skills. Consider
even dementia (see p.200), but this keeps both brain and body healthy, learning a new language, as people
is by no means inevitable. In fact, as does moderate but regular who speak two or more languages
some cognitive capacities, such as physical activity. Jogging or other have stronger cognitive ability
our overall understanding of life, aerobic exercise can help delay than those who speak just one.
may even improve as we age. age-related declines both in To sum up, you can slow the
We inherit our basic level of memory and thinking speed. cognitive aging process by:
cognitive function from our parents, You can also protect your brain • Keeping your brain well supplied
but this genetic blueprint is also health by avoiding toxins, such as with oxygen and nutrients.
affected by our environment and alcohol and tobacco. Smoking has • Avoiding exposure to toxins
life experiences, including nutrition, been linked with damage to the such as alcohol and nicotine.
health, education, stress levels, and brain’s cortex. If you do drink • Exercising your body by building
relationships. Physically, socially, alcohol, keep within healthy activity into daily life.
and intellectually stimulating drinking limits and have at least • Exercising your mind by
activities also play a key role. two alcohol-free days per week. learning new skills.
How to Slow the

Effects of Aging
As we age, our thinking and short-term memory may
become less efficient. Nevertheless, we continue to
learn until we die, and we can take active measures
to keep our brain working well at any age.
52 53
Brain Food
Like any other organ, the human brain needs
a constant supply of water and nutrients to
maintain its health and to supply energy for
efficient functioning. D
2 , a nd
H 6, B1
FIS ins B
Feeding the brain LY tam
OI ids; vi
A healthy diet benefits both the ac CABBAGE
at ty
mind and the body. Complex 3f
a-
carbohydrates provide a steady eg SARDINES
m
O
flow of fuel; these are found in SALMON
whole grain bread, brown rice,
legumes, potatoes, and sweet CAULIFLOWER
potatoes. Healthy fats are essential AND
for maintaining brain cells, and BROCCOLI
these fats come from oily fish,
vegetable oils, and plant foods such ANCHOVIES
as avocados and flaxseeds. Proteins
supply amino acids. Fruits and MACKEREL
BRUSSELS
vegetables supply water, S
SPROUTS
R RIE
vitamins, and fiber. RASPBERRIES BE
L
MU
HYDRATION SWEET
BLUEBERRIES POTATOES
RIES OLIVE OIL
Brain cells need adequate STRAWBERRIES
hydration (water supply) in order
ER
KB
to function effectively. Studies have

AC
shown that dehydration can impair BL
our ability to concentrate and to
perform mental tasks and QUINOA
S
IE
negatively affect memory. Some R

ER
of our water intake comes from the G OJI B
food we consume, but it is helpful
to drink several glasses of water
An
CRANBERRIES
each day to maintain a healthy
tio
LEGUMES
xid
level of hydration.
BE ts, fib
an
RR er,
IE glu
S co
WHOLE GRAINS
se
PULSES
Sources of nutrients
Fresh fruits and vegetables, beans WH
and lentils, whole grains, healthy OLE
GR AINS & BLES
fats such as olive oil, and oily fish
such as salmon all supply vital
Com
p le x c a STARCHY VEGETA
rbohydrate er
nutrients for the brain. s, B vitamins, fib
THE BRAIN IS
THE PHYSICAL BRAIN
Brain Food 54 55
60 PERCENT FAT
Essential nutrients
AND NEEDS A Certain nutrients from food have been found to improve or
STEADY SUPPLY maintain particular brain functions. These substances include
vitamins and minerals, omega-3 and omega-6 fatty acids,
OF ENERGY antioxidants, and water. These essential nutrients help keep
brain cells healthy, enable the cells to transmit signals quickly
and effectively, reduce damage from inflammation and free
CR
U radicals (atoms that can damage cells, proteins, and DNA), and
& CIF
DA ER help the cells form new connections. They can also promote
An R
tio K O the production and function of neurotransmitters. As a result,
xid L
US AFY ber, n
a regularly eating foods that contain these nutrients can benefit

E s, fi
VE GR utrie
nt
memory, cognitive functions, concentration, and mood.

GE EEN nts
TA S
BL
ES
NUTRIENT BENEFIT SOURCE
KALE Omega-3 and Help maintain blood flow and cell Oily fish (such as salmon, sardines,
omega-6 fatty membranes in brain; support herring, mackerel)
acids memory and reduce risk of Flaxseed oil, rapeseed oil
depression, mood disorders, Walnuts, pine nuts, Brazil nuts
stroke, and dementia
SPINACH B vitamins Vitamins B6 and B12 and folic acid Eggs

support nervous-system function; Whole grains such as oatmeal,
choline helps production of brown rice, whole grain bread
neurotransmitters Cruciferous vegetables (cabbage,
broccoli, cauliflower, kale)
CHARD Kidney beans, soy beans
Amino acids Support production of Organic meat

neurotransmitters and aid Free-range poultry
memory and concentration Fish
Eggs
Dairy products
Nuts and seeds
OLIVES
Monounsaturated Help keep blood vessels healthy Olive oil
fats and support functions such as Peanuts, almonds, cashews,
memory hazelnuts, pecans, pistachios
VEGETABLE OIL Avocados
ts
d fa
ns a L S
Antioxidants Protect the brain cells from Dark chocolate (at least 70
ate
ou OI
inflammation damage due to the percent cocoa)

t ur
presence of free radicals; improve Berries

on LE
, m AB
cognitive functions and memory Pomegranates and juice

IL
in older people Ground coffee

T
/O
GE
Tea (especially green tea)

ED
SE
VE
6
Cruciferous vegetables
a-
X
eg
A
&
FL E Dark leafy greens

m
LIV nd o Soy beans and products

O -3 a
Nuts and seeds
a
eg Nut and seed butters, such
Om as peanut butter and tahini
Water Keeps brain hydrated to enable Tap water (especially “hard” water)
efficient chemical reactions Fruits and vegetables
EUS
NUCL
ELL Nonidentical
C sex chromosomes
(X and Y) indicating
a male
Chromosomes
We have around 20,000
ARE GENES
genes, which are grouped ALWAYS ACTIVE?
into chromosomes. Each
cell nucleus has 22 matched Every DNA-bearing cell has
pairs of chromosomes
(known as autosomes), plus a full set of genes, but many
a pair of sex chromosomes genes are normally active in
(identical XX chromosomes
in females, or a nonidentical only one part of the body, such
pair, XY, in males). as the brain, or at one stage of
life, such as babyhood.
Most
chromosomes
occur in
matched pairs
DNA and genes

The DNA molecule is a long, twisted
strand formed from pairs of chemicals
called bases—the “letters” of the genetic
code—with a sugar-phosphate backbone
at each edge. When cells divide, half of
What is a gene? the DNA goes into each new cell. In
addition, we inherit one chromosome in
Genes are sections of a long each pair from our mother and one from
molecule called deoxyribonucleic our father, so each parent contributes half
acid (DNA), which contains the of our genes.
code that governs how our bodies
develop and function. We inherit a Bases on one side of
strand are paired with
mixture of genes from our parents.
a complementary base
These genes produce proteins that on other side
shape physical traits, such as eye
color, or regulate processes such as
chemical reactions. Their action DNA helix is itself
turns these traits “on” or “off” or tightly coiled
makes them more or less intense.
Genetics
and the Brain
Outer edge of each
strand is made of sugar
and phosphate molecules
Genes govern the way our bodies, Four bases—adenine, Adenine (red)
including the brain, develop and function. thymine, guanine, and
cytosine—are arranged in a
always bonds with
thymine (yellow)
They work together with our environment particular sequence that
encodes our genetic
to shape us throughout our life, from information
conception to old age.
THE PHYSICAL BRAIN
Genetics and the Brain 56 57
How faulty genes affect the brain
MUTATION Genes do not directly control behavior; instead, they
govern the number and characteristics of nerve cells
When cells divide, the double-stranded DNA splits into
whose actions combine to produce our mental
single strands, and each base is matched with a new
complementary base to form two new copies of the functions. For example, some genes influence the
DNA. However, sometimes copying produces changes levels of neurotransmitters (see p.24), which in turn
in the sequence. These may cause a gene to produce an regulate functions such as memory, mood, behavior,
altered protein or stop it from working at all. Mutations and cognitive skills. A faulty gene may fail to produce
may arise during life or may be inherited from parents. a protein needed for healthy brain function or may
increase the risk of a disorder such as Alzheimer’s
Backbone Mutation occurs when disease. Some faults can be inherited from parents;
Base of DNA base pairs are changed
pair molecule during copying
two inheritance patterns are shown here.
AFFECTED UNAFFECTED
Autosomal dominant PARENT PARENT
In an autosomal dominant
disorder, such as Huntington’s
New DNA strand made disease, only one parent has
during cell copying ERROR to pass on the faulty gene for
it to cause the disease.
Faulty gene Normal
present gene only
AT LEAST ONE-THIRD
OF ALL OUR GENES
ARE ACTIVE PRIMARILY
IN THE BRAIN
AFFECTED UNAFFECTED
CHILDREN CHILDREN
Autosomal recessive CARRIER CARRIER

In an autosomal recessive PARENT PARENT
Guanine (blue) always bonds
disorder, such as Tay-Sachs
with cytosine (green)
disease, the disorder occurs
only if both parents pass on Parent has
a faulty copy of the gene. one faulty
Carriers have no disease and one
themselves but can pass on healthy gene
the faulty gene.
Affected child
has two copies
of faulty gene
Unaffected
child
Carrier children
have one faulty and
one healthy gene
ER IN MA
LARG LE
BR
AI
WHEN IS THE SEX
N
OF A FETUS FIXED? Thalamus
This area, the “relay station”
Chromosomal sex is between the cortex and deeper
brain structures, is larger in men
determined at the point of than in women. The two sides of
fertilization. Physical sexual the thalamus are more likely to
be connected in females, but
differentiation occurs seven the significance of this
to 12 weeks after feature is not known.
fertilization. GER IN FEMA
LAR LE
BR
A
Corpus
IN
callosum
The corpus callosum, which
Physical differences links the brain’s left and right
hemispheres, has been found to
Differences between males and females begin be larger in females. It has been
with the sex chromosomes at the moment of associated with greater cognitive
conception: XX for females and XY for males. skills in females, possibly because
brain functions are shared
In the uterus, the release of testosterone from between hemispheres,
the mother during gestation “masculinizes” but not in males. ALE BRAIN
a male fetus, triggering the growth of structural R IN M
GE
sex differences in both the brain and body. As AR
L
we grow and develop, these differences will Hippocampus
arise in many different brain structures (see right). Males have a larger anterior
Cognitive and skill differences between the sexes (front) hippocampus, which
governs acquiring and encoding
are present from childhood. Adult male brains are new spatio-visual information,
8 to 13 percent larger, on average, than adult while females have a larger
female brains. In addition, adult male brains also posterior hippocampus, which
governs retrieval of existing
tend to vary more, in volume and cortical spatio-visual knowledge.
thickness, than female brains.
Male and
Female Brains ALL HUMAN
EMBRYOS START
Scientists have found that male and female
brains show distinct physical differences. However,
LIFE WITH FEMALE
it is not always clear how these variations affect BRAINS—EXTRA
our attitudes, activities, and responses to our HORMONES
environment. Differences may arise from the way a ARE NEEDED TO
brain is used in life as well as from its physical form. CREATE A MALE
58 59
ALE BRAIN
R IN M Differences in function
GE
AR Male and female brains differ in
L
Hypothalamus function as well as structure. Male

Certain areas governing brains seem to be more “lateralized”
male-typical sexual behavior (with a greater difference in function
and responses to stress in the
hypothalamus are larger in between the left and right hemispheres).
heterosexual males than in Males also vary more than females in
females or homosexual males. cognitive ability. These variations are partly
due to the structure of the “connectome”—
ALE BRAIN
the network of neural connections between
R IN M parts of the brain (see below). They also
RGE
A result from the action of hormones, and
L
Amygdala external influences, throughout our life.

The amygdala, involved in In particular, our social environment and
emotional responses, making experiences continually shape our neural
decisions, and forming emotional
memories, is slightly larger in pathways, helping us perform male- or
males. However, differences in female-typical tasks.
functions such as responses to
negative versus positive
emotional stimuli, are Few connections Greater connectivity
more significant. cross hemispheres within hemispheres
Brain structures
There are several areas in which
quantifiable physical differences have
been identified between male and female
adult brains. The main regions are shown
here. How these differences can affect MALE
cognition and psychology are currently
the matter of ongoing scientific research.
Many connections Less connectivity
between hemispheres within hemispheres
NONBINARY BRAINS
Homosexual and transgender people
have been found to have certain
distinctive brain structures. For example, FEMALE
some parts of the hypothalamus (see
above) differ in homosexual and The connectome
heterosexual men, and the putamen One study, in which more than 900 brains were imaged,
(involved in learning and regulation of found that male brains have greater connectivity
within hemispheres, while female brains have denser
movement) has more gray matter in NONBINARY connections between hemispheres. The males were
trans women than in cisgendered men. SYMBOL found to be better at spatial processing, while the
females scored higher on attention and memory for
words and faces.
URE
NAT
MUSICAL BRAINS
Playing music involves multiple parts We inherit
ES
of the brain. Studies comparing the our chromosomes, which
CHROMOSOM
brains of professional musicians and contain our DNA, from our
parents (see pp.56–57). It’s the
amateurs revealed that professional chromosomes that, at the point of
musicians had a greater volume of fertilization, determine the
gray matter in brain areas related chromosomal sex of an embryo
to motor, auditory, and visual-spatial (XX for female and XY for male).
reasoning. The study’s findings show Chromosomal abnormalities
how the brain undergoes structural can also cause disease or
developmental
adaptations in response to the problems.
environment (dedicating hours
to repetitive rehearsals with
an instrument).
Some psychological
DNA
traits, such as the tendency to
develop depression, have been
THE HIPPOCAMPUS IN linked to particular genes—but they
usually involve dozens or even
AN ADULT BRAIN MAKES hundreds of the genes acting
together. The more of those genes
AN ESTIMATED 700 NEW a person inherits, the more
likely they are to develop
NEURONS EVERY DAY that trait.
Genes versus environment

People are born with a DNA “template” inherited from
their parents (see pp.56–57): this is the “nature”
element influencing the brain’s activities, such as WHEN DO
cognitive ability and behavior. Throughout a person’s EPIGENETIC CHANGES
life, though, their networks of neurons (see pp.26–27) HAPPEN?
can adapt and change in response to physical and
social experiences (“nurture”). Environmental Epigenetic changes can be
influences, if strong and sustained, can alter brain induced by environmental
structures and also influence the way that genes work— factors at any point in
a process known as epigenetic change (see opposite). a person’s life, from
development in
Nature
utero to old age.
and Nurture
The two fundamental influences on the brain, “nature”
and “nurture,” are sometimes seen as opposing forces.
However, there is a dynamic interplay between them
that goes on throughout a person’s life.
NURTU
RE PHY
THE PHYSICAL BRAIN
Nature and Nurture 60 61
S IC
AL
S
UR
Epigenetic changes
RO
Changes in the way genes are used (or expressed)
UN
Studies on children have
that occur during a person’s lifetime are called
D
found that growing up poor or
INGS
deprived can impair the epigenetic changes. They affect gene function,
development of areas related to
memory, language processing, rather than gene structure, and can be passed on
decision-making, and self-control. to a person’s children, although they may last for only
However, a safe, happy home, a few generations. In the brain, they can influence
with interesting things to do,
seems to reduce the harm. functions such as learning, memory, reward-seeking,
and response to stress. There are two main forms:
methylation, in which a compound joins on to the DNA;
STRE and histone modification, which alters how tightly the
SS
LE DNA is coiled.
VE
L
Chronic emotional S Methyl compound

attached to DNA base
stress in children can impair
development of the amygdala,
hippocampus, and frontal lobes,
leading to problems with memory,
emotion, and learning. It restricts the
action of genes regulating the
growth of networks of neurons.
However, moderate “positive”
stress (fun) can aid
learning. DNA methylation
In this process, a molecule of a methyl
compound attaches to one of the bases in Base pairs in most of
a gene’s DNA sequence. The effect is to stop
DIE sequence unchanged
T or restrict the activity of that gene.
A healthy diet (see pp.54–55)

rich in omega-3 fatty acids, B STUDYING TWINS
vitamins, and antioxidants keeps
blood vessels healthy, improving Studies of twins reveal how much of a specific trait, such
blood flow to the brain. These as intelligence quotient (IQ), is due to inheritance and
nutrients have also been linked to how much is due to environment. Most twins grow up
improving memory and
maintaining cognitive in the same home; however, identical twins share 100
functions in older people. percent of their genes, while nonidentical (fraternal)
twins share only 50 percent. If a trait is more evident
in identical twins than in fraternal ones, or appears in
SO identical twins who were separated at birth, it suggests
CIA
L that genetics has a stronger influence than environment.
N
ET
W
BIOLOGICAL PARENTS ADOPTIVE PARENTS

Loneliness has been
OR
found to alter the production of

KS
neurotransmitters, so people
perceive less reward from social
contact and are more likely to
misinterpret others’ attitudes as
threatening. However, maintaining
close social ties can support
memory and cognitive skills. NON-ADOPTED TWIN ADOPTED TWIN
BRAIN FUNCTIONS
AND THE SENSES
Sensing
the World Touch
Thought to be the
first sense to develop
To survive in our environment, in the womb, touch
neurons respond to pressure,
we must be able to react to, and temperature, vibration, pain, and
light touch. Touch is how
interact with, stimuli produced by humans make physical contact
physical, chemical, and biological with the environment and
with each other.
phenomena—sights, sounds, smells,
tastes, and touches. Sensors in the
body pick up these signals and send
them to the brain for deciphering.
Hearing
Sound waves in the
Senses air are collected by the
ear and transmitted into
Each sense has its own set of detectors. Most are the skull, where they are
localized in a specific area of the body, except for turned into electrical impulses
touch, which is spread all over the skin, as well as by the cochlea. Hearing is the
most developed of the senses RTEX
inside the body. Although the neurons and receptors L CO
at birth but is only UA
for each sense are largely dedicated to that sense complete by the end V IS
alone, they can sometimes overlap. Sensory information of the first year.
continuously bombards the brain, but only a fraction
of the input reaches consciousness. Even so, the
“unnoticed” information can still guide our actions,
particularly in the case of our sixth sense, Sight
Sight involves
proprioception, which relays information sensors at the back of
about the body’s position in space. the eye that turn light into
electrical signals. These are
transported to the back of the
brain, where they are converted
into colors, fine details, and
YOUR SENSE OF SMELL motion. We perceive objects
in as little as half a
IMPROVES WHEN YOU ARE HUNGRY second.
SYNESTHESIA
Synesthesia is a condition where a
stimulus may be interpreted by two
or more senses at the same time. In
its most common form, a person sees
a number or word as a color. Each
synesthete will have its own color
associations. Almost any combination
of senses can be affected. Combinations
of three or more senses are rare. Each note is associated
with a different color
BRAIN FUNCTIONS AND THE SENSES
Sensing the World 64 65
Proprioception
M The brain is constantly
SO CO OT
RT processing information
M
O X
AT from the joints and muscles that

R
E
CO OSE tell it where the body is in space.

R T NS It keeps us upright and allows us
EX
to make movements without
O
RY
conscious effort, such as

walking up stairs.
PRIMARY TASTE
AREA
AUDITORY Taste
CORTEX SECONDA Taste is important
RY TA
AREA STE in determining what
OLFACTO is safe and nutritious
CORTE RY to eat. Taste receptors pick up
X
only five basic tastes: sweet, salty,
bitter, sour, and umami
(savory). We need our sense
of smell to help identify
a taste.
Sense areas of the cortex

Inputs from the sense receptors map to different
Smell areas of the brain’s cortex. Although these areas
Despite having only are separate, they can often react to inputs from
400 smell receptors, another sense. For example, visual neurons will
humans can detect up to a respond better in low-light situations if they are
trillion different odors. Smell accompanied by sound.
is important for survival as it
warns us of hazardous
substances or events, such
as something burning. It also
plays a key role in taste.
HOW MANY
SENSES ARE THERE?
Including the six senses
described here, scientists
think there may be as many
as 20 senses, based on
the number of different
receptor types in
the body.
Seeing WHY DO MY EYES
The eye provides us with probably the most CLOSE WHEN I SNEEZE?
important of our five senses. It gathers the
light reflected by an object and delivers this When a nasal irritant triggers
the brain stem control center,
information to the brain via the optic nerve.
it causes widespread muscle
contractions, including those
The structure of the eye in the eyelids. This makes
The eyeball is roughly 1 in (2.5 cm) in diameter. At the back of the you blink momentarily.
eye is the retina, which contains light-sensitive cells that connect
via neurons to the optic nerve. The space inside the eyeball is filled
with a jellylike substance. The front of the eye contains a hole (the
pupil), which has a clear lens behind it. Surrounding the pupil is a Eyeball is encased Crossed-over rays
circle of colored muscle, the iris, which controls how much light by sclera produce an inverted
enters the eye. The cornea, a clear membrane, covers them and image on retina
merges into the white outer membrane called the sclera.
Light rays start to refract

(bend) as they pass from
air and into cornea
RE
TIN
Lens is like a bag of
jelly that changes
A
shape to help
LIGHT focusing
CORNEA
PUPIL
LENS
IRIS
Iris is a ring
of muscle
Seeing things
The eye is capable of providing the
D
brain with an enormous amount
of detail about what it is looking SC R OI
at. However, the image the brain
Cornea is a LE
RA C HO
transparent layer
receives is inverted, so it has to be covering front of eye
flipped before we can understand it. Choroid is a
blood-rich layer
that surrounds
retina
Light enters the eye Lens and focusing

1 Light passes through the cornea and 2 Behind the iris is the lens, where the
into the eye through the pupil. The pupil is light rays are bent so the image forms on the
surrounded by a ring of colored muscle, the retina. The lens is connected to muscles that
iris, which can make the pupil contract or allow it to change shape—it flattens for
dilate to vary the amount of light entering. distant objects and thickens for close objects.
Seeing 66 67
KEY
The purple arrows show RET
the direction of light INA Light ray travels
rays. Black and blue to back of retina
arrows are nerve signals
going to the optic nerve.
Rods work in grayscale,
responding to intensity
Light rays
of light; they enable us to
Black and see in dim conditions
white
Color
Cones send nerve

Signal for black signals in response
and white passes to green, red, or
from retina to blue light; they
optic nerve NERVE CEL LIGHT REC need bright light to
LS EPTOR produce a signal
CELLS
Ganglion OPTIC NER
cell V E
Signal for
color passes CHOROID
from retina to
optic nerve Wall of pigment
cells forming
Bipolar cell back of retina
The retina
3 The retina is made up Nerve signals to brain
of three layers. Light rays travel 4 The nerve signals trigger
through the first two layers, ganglion impulses in the ganglion and
and bipolar cells, and reach the third bipolar cells, which connect
layer, which contains light-sensitive directly to the optic nerve. The
rod and cone cells. These convert Optic nerve nerve signals travel along the
light rays into nerve signals. carries signals optic nerve to the brain.
from light sensors
to brain
VE
OP TIC NE R
THE BLIND SPOT

To connect to the brain, the nerve fibers
of the retina must pass through the Rods and cones
back of the eye to form the optic nerve. Blind spot
YOUR EYEBALLS This creates a “blind spot” that has no where nerve
photoreceptors. We don’t notice this
REMAIN THE SAME because each eye provides data about a
fibers leave eye
SIZE THROUGHOUT scene and the brain uses information from

the other eye to complete the picture. HUMAN EYE
YOUR LIFE
The Visual
Recognizing faces
3 Features that suggest a face are
sent to the face-recognition area and
amygdala, where they are searched
Cortex
for details that prompt recognition.
Nerve signals from the eye have to

travel all the way through the brain
before they reach the area dedicated Lateral geniculate
E
to decoding this information. This
OB
nucleus forwards
LL
signals from retina
area is called the visual cortex.
TA
to visual cortex
ON
Frontal lobe
LAMUS
FR
provides conscious A
The structure of the cortex recognition of faces TH
The visual cortex occurs in both Amygdala
brain hemispheres and is further
X
processes facial
TE
divided into eight main areas, each expressions
R
CO
of which has a different function AMYGDALA AL
I SU
(see table, opposite). Signals travel V
from the retina (see pp.66–67) via
the thalamus and lateral geniculate FACE
nucleus to the primary visual cortex OPTIC NERVE RECOGNITION
(V1). The raw data then passes AREA
Rods and cones in
through various vision areas, retina convert light Optic nerve carries
contributing different details about into nerve signals nerve signals to brain
shape, color, depth, and motion
From eyeball to visual cortex
before combining to form an image. 1 Data from the eyeball travels along the KEY
Some areas provide information that optic nerve until it reaches the optic chiasm (see Information from the eye
helps with immediate recognition of below), where some of the data is sent to the
opposite side of the brain. Signals then travel to
familiar objects, others with spatial the lateral geniculate nucleus, which forwards Face recognition pathway
orientation or visual-motor skills. data to the visual cortex for processing.
Lateral Half of signals travel

Stereoscopic vision geniculate to same hemisphere; View of object
Our ability to see in 3-D—known as stereoscopic nucleus LEFT HEMISPHER other half cross over from left eye
E
vision—is produced by having both of our eyes
looking straight ahead and moving together.
As the eyes are slightly apart, different views
are received from each, although they overlap
to a small extent. The brain computes the spatial LEFT VISUAL
CORTEX US
information from each eye to create an overall L AM
THA
image, using previous experience to speed RIGHT VISUA
L
up the processing time and fill in any gaps. CORTEX
Swapping sides
At a crossover point called the optic chiasm, Nerve axons split off
nerve axons from the left side of each retina after lateral geniculate E Optic nerves View of object
join and continue to the left visual cortex, nucleus and radiate to RIGHT HEMISPHER converge at from right eye
and likewise with nerve axons from the right. areas of visual cortex optic chiasm
RT
EX
The Visual Cortex 68 69
CO
R
O
V6
RI
TE
IN
V3A
V3D THE VISUAL CORTEX
V2 IS VERY THIN—
V1
JUST 0.08 IN (2 MM)
Some visual- V2
processing areas
curve around back of
V4V
brain into groove AREAS OF THE VISUAL CORTEX
between hemispheres VP V8
AREA FUNCTION
V1 Responds to visual stimuli.
R AIN
FB V2
Passes on information and responds
O to complex shapes.
CK
BA
V3A, V3D, Registers angles and symmetry and

V7
VP combines motion and direction.
Visual cortex,
located in V3A Responds to color, orientation, form,
V4D, V4V
occipital lobe and movement.
V3
V2 V5 Responds to movement.
V4D
Detects motion in periphery of
The visual cortex V6
2 Nerve signals progress
V1
visual field.
through the various layers of V7 Involved in perception of symmetry.

the cortex, each adding more
information to the image. It
takes half a second for the V8 Probably involved in processing of color.
image to be assessed and
become a conscious perception.
T E YE
OF LEF FIELDS OF VISION
UAL FIELD
VIS
Animals such as primates have
Image formed by brain a large field of stereoscopic
after it combines images
vision and can judge distances
VISUAL FIELD
BINOCULAR
from left and right eyes’

visual fields better than herbivores or most
birds. However, they have a
blind zone behind them that
can be seen only by turning the
head. Animals with eyes on the
sides and top of the head have
a wider field of 2-D vision and
greater all-around awareness. RABBIT HUMAN
VISUAL
FIELD O
F RIGHT Visual field of left eye Visual field of right eye Binocular visual field Blind zone
EY E
How We See
Seeing is both a conscious and an unconscious
NEWBORN BABIES
action. Each type follows its own pathway in the CAN SEE ONLY
brain. The conscious route helps recognize objects, BLACK, WHITE,
while the unconscious route guides movement. AND RED
Cell area V1 Cell area V2 Cell area V3

Signals from the eyes are first In the secondary visual cortex Visual area 3 (V3) is involved in
received in the primary visual (V2), some neurons improve on the analyzing angles, position, depth,
cortex (V1). Its neurons are sensitive images from V1, sharpening the lines and the orientation of shapes.
to basic visual signals, including the and edges of complex shapes. It also helps process the direction and
orientation and direction of Other neurons refine the initial speed of objects. A few cells are also
movement of objects and interpretation of the sensitive to color.
pattern recognition. color of objects.
VISUAL CORTEX PATHWAY
Visual pathway Parietal lobes judge

splits after cell location of object in
area V3 relation to observer
Following the path
As visual information is processed
by the layers of the visual cortex (see
pp.68–69), it splits into two pathways
known as the upper, or dorsal, route
and the lower, or ventral, route. There
is some uncertainty about where the V3
split occurs, but the dorsal route handles
our spatial awareness of where we are V2 V4
and how we move in relation to things V1 V5
around us, while the ventral route helps
us identify, categorize, and recognize
what we see. The dorsal route is
important in assessing significant Inferior temporal
situations, particularly if instant action KEY lobe involved
is required to avoid danger, such as in recognizing
Dorsal route objects
moving away from a flying object.
When this happens, the ventral route is
relegated to a secondary position since Ventral route
the information it carries is not critical.
How We See 70 71
Cell area V5 Parietal lobe

The middle temporal area (V5) The parietal lobe
judges the overall direction of gauges the depth and position
motion of an object rather than that of an object in relation to the
of its component parts. For example, observer. This allows the person
it processes the general direction of to take immediate action, such as
a flock of birds rather than the ducking from an object coming
movement of a single bird. It toward them rapidly.
also analyzes the motion
of our own body.
“WHERE” PATHWAY (DORSAL ROUTE)

Unconscious vision
The dorsal route carries visual
information to the parietal lobes,
passing through areas that calculate an
object’s location, timing, and motion
and make a plan in relation to it. All of
this happens without conscious thought.
Conscious vision
The ventral route adds more information to
the object, such as color and shape. The
information goes to the temporal lobe,
where it is matched to visual memories to
aid recognition. This is where the visual
stimulus becomes a conscious perception.
“WHAT” PATHWAY (VENTRAL ROUTE)
WHAT IS
PROSOPAGNOSIA?
Cell area V4 Inferior
Visual area 4 (V4) is involved in temporal lobe This is the inability to
the perception of color, texture, Signals are forwarded to the
orientation, form, and movement. fusiform gyrus of the inferior
recognize faces, even of close
This region contains the majority of temporal lobe, which is involved in family, usually due to damage
color-sensing neurons and is recognizing complex shapes, objects,
important in interpreting the space and faces. In conjunction with the to the inferior temporal lobe.
between objects. hippocampus, it helps with the Those affected have to learn
formation of new memories.
to recognize people in
other ways.
Perception Brain is so drawn
to faces that even
pictures are studied
Given that visual processing happens in microseconds,

it is not surprising that our brain sometimes struggles
to make sense of the information sent by our eyes and
so makes us doubt what we are seeing.
Processing a scene Openings are scanned,

When we look at a scene, we perhaps for possibility
of intruders
are not really taking it all in.
Instead, the eyes repeatedly scan a Pointing draws
attention to an object
sequence of thumbnail-sized areas and makes it worthy
that the brain considers points of of a look
interest. The rest of the scene blurs
until attention falls onto a new area.
Faces tend to be the main focus of a
scene—the brain is programmed to
look for faces, hence the tendency
to see them in the unlikeliest of
places, such as the scorch marks on
a slice of toast. While details of the
target objects are being scrutinized,
the conscious brain puts together
the story of the scene, complete Eye passes straight
across floor, pausing
with the context of each object. briefly at a potential
obstacle, but not
stopping long
enough to see it
Scanning for details
Looking at a complex picture, such as Brain looks for clues about
this café scene, activates processes that relationships by looking at
distinguish target objects, such as people, individual faces and interplay
from the background and then selects between characters
which bits of the target to focus on.
WHY DO WE
SEE FACES IN
INANIMATE OBJECTS?
Pareidolia (seeing faces where
there are none) may be a
survival instinct that ensures
we are vigilant for the
unfriendly features of an
enemy or predator.
Perception 72 73
Illusions
An illusion occurs when what the eye sees is interpreted by the
brain in a way that does not match up with the physical reality
of the actual image. With so many competing signals going to the
brain, it tends to look for familiar patterns. It also tries to predict
what will happen next to compensate for the slight time delay
between stimulus and perception. Both these facts can lead to our
brain misinterpreting visual stimuli. Illusions fall into three main
classes: physiological, cognitive, and physical.
HERMANN GRID KANIZSA’S TRIANGLE
Physiological Cognitive
Physiological illusions are thought to arise Cognitive illusions happen when the brain
from excessive or competing stimuli, such as makes assumptions about movement or
Direction of other brightness, color, movement, and position. perspective when viewing an object.
people’s eye gaze In this grid, gray spots seem to appear at the Sometimes these can lead to the brain
is followed intersections as your eyes flick over them but switching between two different images
vanish when you stare at them. or seeing a shape that is not there.
Light is refracted as
it leaves water
Brain directs eyes to
parts of the scene it
considers significant— Apparent
especially faces position of fish
Actual
position
of fish
REFRACTION
Physical
Physical illusions are caused by the optical
SOME MAMMALS
properties of the physical environment, AND BIRDS ARE
particularly water. The brain cannot take
account of the way that light bends as it ALSO FOOLED BY
passes between water and air, so it sees
the fish as further back than it actually is. OPTICAL ILLUSIONS
How We Hear
The world is full of noise. It travels as sound waves
through the air until it reaches our ears. There, they
are turned into electrical impulses and sent to the
brain for decoding into meaningful sounds.
Picking up sound
Hearing involves the conversion of a sound wave into an
electrical impulse that the brain can interpret. Sound waves
are carried from the outer to the middle ear, where they cause a
series of bones and membranes to vibrate. These vibrations then
reach the cochlea, where they become electrical impulses. These
are passed to the brain stem and thalamus, where direction,
frequency, and intensity are perceived. The data is then sent for
processing by the left and right sides of the auditory cortex. The
left side identifies the sound and gives it meaning, while the
right side assesses the quality of the sound.
EXTE
Vibrations make bones MALLEUS

RNAL EAR
rattle against each other (HAMMER) BONE

Sound waves travel
Sound waves
through air
vibrate eardrum
INCUS
(ANVIL) BONE
AL
RY CAN
AUDITO
OUTE
OSSICLES
(MIDDLE EAR BONES)
E AR D R
R EAR
STAPES
UM
(STIRRUP) BONE
The outer ear The auditory canal

1 Sound waves are caught 2 The sound waves travel along the
Oval window
by the outer ear, which funnels auditory canal to the eardrum. The auditory
ID
M
them inside the head via the canal is lined with tiny hairs that filter out Round window
auditory canal. foreign objects. DL
EE
AR
Eustachian tube connects

middle ear to nose and mouth
The eardrum Ossicles

3 The eardrum, or tympanic 4 Vibrations are passed through
membrane, is a thin layer of the eardrum to a set of connected
fibrous tissue that forms a bones called ossicles—the malleus,
barrier between the outer ear incus, and stapes bones. The stapes
and the middle ear. It vibrates bone pushes and pulls on another
when the sound waves traveling membrane, called the oval window.
up the auditory canal hit it. This transmits sound to the inner ear.
How We Hear 74 75
FILTERING OUT NOISE
On a busy street, there are lots of
conflicting sounds, yet you can still The primary
hear someone talking next to you. 9 auditory cortex
This is because the primary auditory Background After intermediate processing in
cortex can filter out unnecessary noise filtered the thalamus, the characteristics of
out each sound are interpreted by the
sounds and boost the signals it wants primary auditory cortex, which
to hear. It does this by dampening works with other cortical areas
the response to sustained sounds, to identify the type of sound.
such as traffic, while enhancing more
dynamic sounds, such as speech,
and actively listening to them.
Organ of Corti (central spiral

part of the cochlea) rests on a Primary auditory cortex
basilar membrane and contains processes sound
sensitive hair cells
LE A COCHL
CH E AR
CO NE THALAMUS
RV
E
Electrical signals
pass along
cochlear nerve
BRAI
Specialized cells at
top of brain stem
N
help determine
STEM
Vestibular canal
carries sound direction of sounds
L
vibrations
NA
AL
C AN
CA
R
A
UL The cochlear nerve
8 The thalamus
IC
I B 7
E ST The electrical signals are Signals are first received in
N
V
PA
transported from each hair cell the brain stem. From here, they travel
OR up to specialized neurons in the
M
GAN through cochlear nerve endings

OF CORTI TY that join together to form the thalamus for processing. These signals
cochlear nerve. This is responsible are then sent to the primary auditory
for transmitting signals to specialized cortex, which also feeds information
groups of neurons in the brain stem. back to the thalamus.
Vibrations return
INN E R E A R to round window
The cochlea The organ of Corti

5 The cochlea contains three fluid- 6 The movement of
filled ducts. Vibrations travel along the the basilar membrane bends
vestibular canal as wavelike movements
that are transferred to the basilar
sensitive hair cells in the organ
of Corti (see p.76), which is the
THE STAPES IS THE
membrane of the organ of Corti. main organ of hearing. The hair
cells convert this movement into
SMALLEST BONE
Residual vibrations return along the
tympanic canal to the round window. electrical signals. IN THE BODY
Perceiving Sound
Every sound is made up of a number of different This area receives
signals from low-
components. The brain has to take all the details frequency sounds
of its frequencies, intensity, and rhythm to Corresponds to

process, identify, and remember the sound. apex of cochlea
Y
AR
PRIM Y
AR
The auditory cortex O ND
SEC
The auditory cortex is the main RY
processing center for sound. It is E R TIA Corresponds to
T base of cochlea
located in the temporal lobe, just below
the temples on either side of the head.
Primary auditory cortex Receives signals from

identifies frequency and high-frequency sounds
intensity of sounds
Secondary auditory cortex

interprets complicated
sounds, such as language Hair cells are
disturbed when basilar
AUDITORY membrane vibrates
CORTEX
More flexible part
of basilar membrane
vibrates more easily
Base of cochlea
transmits low-
frequency sounds
1,00
z 0 Hz
Organ of Corti is main
H
Tertiary auditory cortex

500
organ of hearing
integrates hearing with
other sensory systems
BR A E
2,000 Hz
N
Apex of cochlea
transmits high-
frequency sounds
EM
M
Inside the auditory cortex BASIL AR
Signals from the thalamus (see p.75) are sent to
Hz
the primary auditory cortex, which is divided into 0

0
4,0
A
sections that respond to a range of frequencies. 16,00

LE
0 Hz 8,000 Hz
Some of these sections focus on intensity rather
Row of CH
hair cells CO
than frequency, while others pick up more complex
and distinctive sounds, such as whistles, bangs, or
animal noises. Signals then pass to the secondary The cochlea
auditory cortex, which is thought to focus on Areas along the curl of the cochlea respond
harmony, rhythm, and melody. The tertiary auditory to different frequencies of sound, from
high-pitched at the apex to low bass
cortex integrates all the signals to give an overall notes at the base. These are mirrored by
impression of the sounds picked up by the ears. corresponding areas in the auditory cortex.
Perceiving Sound 76 77
Music and the brain Mapping music
Music engages many areas of the brain. In Scans show that several areas of the brain
are active when listening to music, and even
addition to processing the sounds, listening more are involved when you are playing an
to music triggers the memory and emotion instrument or dancing. Processes touch sensations
centers in the brain, while recalling lyrics while dancing or playing
an instrument
involves the language centers. Performing Coordinates movement
while dancing or playing
music makes even greater demands: the an instrument
Places sounds
visual cortex is stimulated by reading music,
in context of
the frontal lobe is involved in planning memories and
actions, and the motor cortex coordinates
RT R
experience
CO OTO
EX
movement. Musicians are known to have a RY
SO E X
M
greater ability to use both hands because N RT
AL
SE
CO
music requires coordination of motor control,
RT T
CO RON
EX
somatosensory touch, and auditory PUS
COROSUM
PREF
LL
information. Unlike listeners, who process CA
music in the right hemisphere, professional
VIS
musicians use the left. They also have a ITORY COR UAL
AUD RTEX TE
thicker corpus callosum (the region linking CO X
US
the two hemispheres) and tend to have MP
HIPPOCA
larger auditory and motor cortices.
Involved in
planning and
30,000
controlling
expression CEREBELLUM
Activated by
reading music
Connects Amygdala (orange) or watching dance
THE NUMBER OF FIBERS hemispheres and nucleus accumbens
of brain (dark red) are both Involved in movement
THAT MAKE UP THE involved in emotional and emotional
reactions to music reaction to music
AUDITORY NERVE
HIGHS AND LOWS

Humans can detect a good range of
100 kHz
frequencies, but other animals can hear ELEPHANT
things far beyond our limits. Animals such 5 Hz–12 kHz
as bats and dolphins use high frequencies 10 kHz
in echolocation, while elephants and
hearing range
whales produce low rumbles that can

FREQUENCY
Human
travel long distances. Humans are most 1 kHz BAT

sensitive to frequencies between 2 kHz 2 kHz–120 kHz
and 5 kHz, which do not require great MOUSE
100 Hz 1 kHz–100 kHz
intensity to be heard. Young people have
the best hearing range, from 20 Hz to
20 kHz, but there is a gradual loss of 10 Hz HUMAN DOG DOLPHIN
higher frequencies with age, with older 20 Hz– 64 Hz–44 kHz 75 Hz–150 kHz
people having a limit of around 15 kHz. 20 kHz
0
ELIUM Inside the brain
EPITH Olfactory bulb 3 Signals then travel along the olfactory
ORY Olfactory bulb tract to the olfactory cortex. The cortex is
T located in the limbic system, which is responsible
C
processes signals
for emotions and memory. Signals are also sent
FA
before passing to
to the amygdala and orbitofrontal cortex.
OL
olfactory cortex
Dura Orbitofrontal cortex
mater involved in decision-
Nerve
making and emotions as Olfactory tract, a bundle Olfactory cortex
axon Bone
well as processing smells of nerves that carries further processes
signals from olfactory signals sent by
Mucus O bulb to olfactory cortex olfactory bulb
gland RB
IT
Receptor CO OF
Supporting cell RT RO
cell EX NT
AL
Mucus Cilia OLFACTORY
OLFACTORY BULB AMYGDALA CORTEX
Odor molecule
dissolving in mucus
TY
AVI
LC
Olfactory receptors Amygdala sends
SA
2 Each odor molecule activates Receptor cell nerve
A
warning messages if
N
a particular combination of olfactory axons detect odor and odor is associated
receptors. The activated receptor cells send send information to with danger
impulses up through nerve axons to the olfactory bulb
olfactory bulb for processing.
Smell enters the nose
1 Odor molecules are drawn up
through the nose and warmed to enhance
the scent. The molecules dissolve in mucus
produced by the olfactory epithelium and
stimulate cilia that are connected to Capturing a scent
receptor cells.
When we inhale, odor molecules drift into the nose and activate
Airborne odor receptor cells in the nasal cavity, triggering a reflex to breathe in
molecules enter nostril more deeply. In the nasal cavity, the odors dissolve in the mucus
that covers a sheet of neurons and supporting cells called olfactory
epithelium. The molecules spread through the mucus to hairlike
12 MILLION structures called cilia that are attached to receptor cells. These cells
THE NUMBER OF send signals to the olfactory bulb—a structure located in
the forebrain that forms part of the brain’s limbic
OLFACTORY CELLS system. Data is then sent to various parts of
IN THE HUMAN BODY the brain, particularly the olfactory cortex.
Smell WHY DO
SMELLS TRIGGER
Identifying a smell out of the many odors in the world MEMORIES?
around us involves the olfactory system, which isolates Unlike our other senses, smells
different chemicals and then passes signals on to the bypass the thalamus and go
brain to determine whether they are “good” or “bad.” straight to the limbic system.
Emotions and memories are
What makes a smell? processed and stored here,
How we identify smells is still a matter of debate. Research suggests especially in the amygdala.
that most odors fall into 10 groups—or primary odors—each of which
alerts us to something in the environment. Most smells are made up
of a combination of these groups. Smell is a key part of survival,
telling us whether something is safe or dangerous.
Fragrant Sweet
Light, natural scents such as Warm, rich, sugary smells with SMELLY OR SWEET?
flowers, grasses, and herbs, a touch of creaminess, including
chocolate, malt, and vanilla.
typically used in perfumery.
Dimethyl sulphide (DMS)
Minty is a very smelly compound.
Fruity
Typically includes warm, ripe fruits Cool, fresh, and invigorating, A whiff of the raw chemical
and other fresh scents that have a epitomized by mint, eucalyptus, can make you wonder
sense of smoothness on the nose. and camphor. whether something is
rotting or if a pungent
Toasted and nutty
Smell
Citrus cheese is in the room.

Separate from other fruits, citrus Slightly burned and caramelized However, flavor chemists
has fresh, clean, acidic aromas with warm and fatty overtones, such
as popcorn and peanut butter.
find it useful in creating
with a touch of sweetness.
all sorts of tastes. It
is used in meat,
Woody and resinous Pungent
Earthy, natural smells, such Often unpleasant smells such as seafood, milk, egg,
as compost, fungi, spices, manure or sour milk, also onions, wine, beer, vegetable,
cedar, pine, and mold. garlic, and pickles. and fruit flavorings,
usually at
78 79
Chemical Decayed minuscule

Includes synthetic, medicinal, solvent, Beyond pungent are the odors of concentrations.
and gasoline odors that are easily rotting food, sewage, household gas,
identifiable. and other “sickening” substances.
Taste The five basic tastes
Taste is an evolutionary adaptation for survival.
Fueling the body requires the intake of nourishing Being able to determine whether something
is nutritious or potentially poisonous before
foods and liquids. Choosing what is safe to eat is taking it into the body is enormously important.
largely influenced by our senses of taste and smell. So far, only five basic tastes have been
discovered, although there may be others.
Picking up taste Sweet

Signals the presence of
Taste is actually a limited sense; there are only five basic tastes
carbohydrates, which are
that can be detected (see right). Like smell, taste is a chemosense. sources of vital sugars.
Chemical substances in food are picked up by the taste buds,
Salty
which are mainly found on the tongue. Receptor cells, housed
Detects chemical salts and
in structures called microvilli within the taste bud, detect minerals that are needed
these chemicals and send signals to the brain for processing. by the body.
Sour
Warns against foods that may be
unripe or going bad.
Tongue
1 The tongue is a strong, Bitter
flexible muscle. It is used to push Poisons and other toxins are often
food around the mouth and for bitter or unpalatable.
speech. Its upper surface is
covered in tiny projections called
papillae. Most of the papillae are Umami
filiform, or threadlike, structures Detects glutamate salts and amino
and contain no taste buds. They acids, which are found in meat,
help grip and wear down food cheese, and other aged or
while it is being chewed. fermented foods.
Surface of Circumvallate Taste Nerve Microvilli contain receptor proteins,

tongue papilla pore fiber which bind with chemicals in food
Food
Filiform molecule
papilla
Taste
bud Neuron
Supporting Gustatory
cell receptor
cell
Papillae Taste buds Taste bud cells
2 In addition to filiform papillae, the
3 A taste bud is a collection of 50–100
4 When food molecules hit the cells,
tongue has fungiform (mushroomlike), cells that are clustered together like they interact with either receptor proteins or
foliate (leaflike), and circumvallate (wall-like) segments in an orange. They are located porelike proteins called ion channels. This
papillae, which all contain taste buds. Most in the walls of papillae. One end of each causes electrical changes in the cell, which
taste buds are found in the foliate papillae cell protrudes out of the bud, where it gets prompt neurons at the base of the cell to
on the back and sides of the tongue. washed with saliva containing food molecules. send signals to the brain.
Y
S OR
EN
TOS E X
A T
Signals travel to secondary Signals sent to Signals travel to M COR
O
taste area, located in primary taste tongue area of
S
TEX AL
orbitofrontal cortex area, located somatosensory cortex
COR RONT
in insula
Taste and smell
F
Detecting flavors depends as much on the
ITO
Signals from olfactory
nose as on the taste buds. The nose picks
ORB
cortex sent to
up external odors from food (see pp.78–79), orbitofrontal cortex
but this is increased significantly by food-
particle odors carried up into the nasal cavity
by expired air from the lungs (retronasal
THALAMUS
olfaction). Some smell receptors have also Olfactory cortex
OLFAC
been found in the taste buds. The brain TORY
BULB
combines the information from the nose A
AL
and taste buds to perceive all the NAS YGD
AL
C AM
different flavors in the food. These are AV Amygdala assigns
IT
not the only sensations that contribute Y positive or negative
to the taste experience—the values to taste and
smell
somatosensory cortex detects
the texture and temperature of
food, adding context to the flavor.
MEDULLA
Smell from food particles
that have been swallowed
are sent for processing by
olfactory bulb
The taste pathway Food particle

Information from the taste buds travels to
the brain via cranial nerves in the jaw and
throat. Impulses travel up the brain stem
to the thalamus and are forwarded to the
taste regions of the frontal cortex and Trigeminal and
insula, a fold of cortex deep in the brain. glossopharyngeal
cranial nerves carry
signals to medulla Expired air from
in brain stem lungs pushes
food particles
WHY DON’T from mouth into
BABIES LIKE nasal cavity
BITTER FOODS?
KEY
Babies have many more
Taste signals
taste buds than adults so they
Retronasal smell
taste bitter foods more
intensely. They instinctively Expired air
refuse foods that aren’t

as sweet or fatty
as breast milk.
THE AVERAGE ADULT

HAS BETWEEN 2,000
AND 8,000 TASTE BUDS
LIGHT BREEZE TEMPERATURE CHANGE BRUSH OF A FEATHER
TOP, DEAD LAYER OF EPIDERMIS

EPIDERMIS
SPINOUS LAYER
BASA
LL
AYER
Net of nerve fiber

AFT
endings wrapped
DERMIS (DEEP LAYER OF SKIN)
HAIR SH
around base of shaft
Hair movement
triggers nerve Well-defined
impulse Free nerve endings borders make
extend into skin’s Merkel’s disks
surface layer sensitive to
shapes and
edges
Root hair plexus Free nerve endings Merkel’s disks

Nerves wrapped around the base of a hair Extending up into the spinous layer of Found slightly lower than free nerve
shaft are triggered by things that have not the epidermis, these bare, rootlike nerve endings, Merkel’s disks are particularly
touched the skin, such as air currents or endings are sensitive to cold, heat, light dense in the lips and fingertips. They
objects that brush against the hair. touch, and pain. respond to light touch.
Touch
TYPES OF RECEPTORS FUNCTION
Mechanoreceptors Sensory receptors that respond to

mechanical pressure or distortion.
This can range from a light touch
to deep pressure.
The skin is the biggest organ of the body
and also the largest sense organ. Packed Proprioceptors Receptors that receive stimuli from
within the body, particularly in
with sensors, it enables us to experience relation to position and movement.
a wide variety of sensations, as well as

Nociceptors Sensory neurons that respond
an awareness of where we are. to damaging stimuli by sending
“possible threat” signals to the
spinal cord and the brain.
Receptors in the skin
Skin sensors consist of receptors connected by axons. Thermoreceptors Specialized nerve cells that are able
Found at various levels in the skin, there are around to detect differences in temperature.
They are found all over the skin and
20 types that respond to different sorts of stimuli. The
in some internal areas.
receptors register mechanical, thermal, and, in some cases,
chemical stimuli and convert them into electrical signals. Chemoreceptors Extensions of the peripheral nervous
These travel up peripheral nerves to the spinal cord, then system that respond to changes in
blood concentrations to maintain
to the brain stem, and finally to the somatosensory cortex, homeostasis (see pp.90–91).
where they are translated into a touch.
GENTLE TOUCH
FIRM MASSAGE VIBRATION
Enlarged,
encapsulated
receptor
Fluid-filled
receptors
extend into
upper dermis Large, covered
receptor at
base of dermis
Meissner corpuscles Ruffini endings Pacinian corpuscle

These receptors are rapidly adapting, Also known as bulbous corpuscles, these The deepest and largest type of
meaning that they respond quickly to soft, capsulelike cells—located deep in the touch receptor, these rapidly acting
stimulation but stop firing if the stimulus dermis—respond if the skin or joints are mechanoreceptors respond to sustained
continues. This gives precise information. stretched or distorted by pressure. pressure as well as vibration.
The somatosensory cortex Touch map

All information from touch receptors is processed Areas of the body rich in touch
receptors, such as the hands, require
in the somatosensory cortex. This area sits across
TRUN
more processing than others, so they
LEG
the top of the brain like a hair band. Data from the
HEA
take up a greater proportion of the
somatosensory cortex.
K
right side of the body travels to the left side of the
AR
brain, and vice versa. Each part of the body maps D

M
to its own area of the cortex.

HA
ND
FOOT
AXON
TOES
E YE GENITALS
Myelinated FACE
Signal travels through sheath RIGHT HAND
nerve bundle
LIPS
SPINAL
CORD TONGUE
LEFT SIDE
OF BRAIN
PERIPHERAL NERVE
Proprioception
Nerve signal from
proprioceptors
The body has its own sense of where it is Stretch receptors

in skin, muscles,
and how it is moving in space. This process and joints send
information about
happens almost unconsciously, making it, position of body parts
in essence, the body’s sixth sense.
Body position sense Knowing your place

Physical self-awareness comes from a
UMN
Inside muscles, tendons, and joints are Signals travel
combination of proprioception with other along spinal
movement receptors called proprioceptors. sensations: a sense of force, a sense of
L COL
column to brain
Every time we move, these receptors measure effort or weight, sight, and information
changes in length, tension, and pressure that from the balance organs in the ears.
SPINA
relate to that movement and send impulses to
the brain. The information is processed and
a decision is made to stop moving or change
position. Messages are then relayed back to Parietal lobe
the muscles to carry out the decision. All of this

happens without us having to think about it. Inner ear sends
information about
rotation, acceleration,
and gravity
Types of proprioception
Most of the information our brain
receives about body position is Parietal lobe Eyes send visual
processed unconsciously, such as information about
position
how we are constantly adjusting
the position of our body to maintain
balance. However, proprioceptive
information can become conscious Input from
if it requires us to make a decision— pressure and tension
sensors in arms
for example, refining muscle Thalamus
movement to make a voluntary,
skilled movement.
Cerebellum
Proprioception pathways
Conscious proprioception signals travel up
the brain stem to the thalamus and end at the Unconscious Conscious
parietal lobe, which is part of the cerebral pathway pathway
cortex. The unconscious pathway loops back
to the cerebellum, which controls movement.
Proprioception 84 85
GROWTH SPURTS
Types of proprioceptors CAN CONFUSE
The body contains a variety of proprioceptors, and the combined THE BRAIN
information from these receptors helps the brain construct an overall
picture of the body’s position. There are three main types of AS IT CANNOT
proprioceptors: muscle spindle fibers, which are embedded in our KEEP UP WITH
muscles; Golgi tendon organs, which are located at the junction
between tendons and muscles; and joint receptors, which attach to our
CHANGES IN LIMB
joints. Special receptors in the skin can also detect stretch (see p.83). DIMENSIONS
Bone
Muscle
Muscle
Golgi tendon organ senses

changes in muscle tension
Muscle spindle
Touch-sensitive fibers
nerves Bone
Ligament receptors
Signal travels up
nerve axon
Ligament
Tendon
Joint receptors Tendon receptors Muscle receptors

Nerve endings within our joints detect the Golgi tendon organs are found within Muscles have position sensors called spindle
joints’ position. The receptors help prevent the tendons at the ends of muscles. They fibers within them. As they stretch, the
damage through overextension as well as monitor muscle tension to ensure we do spindles send information to the brain
detecting position in normal motion. not overstretch the muscles. about the positions of the muscles.
THE PINOCCHIO ILLUSION

Sometimes proprioception can be confused, making Brain thinks
hand has
the body feel like something is happening when it is not. Hand touching
moved away
One such effect is called the Pinocchio illusion. A vibrator nose
from face
is fixed to a person’s bicep. If the person holds her nose
Vibrator Vibrator
while the vibrator is turned on, she will feel as though switched on
her arm is moving away from her nose. It happens
because the vibrator stimulates the muscle spindle
Before stimulation During stimulation
fibers in the biceps in the same way as if the muscle
At rest, the brain is aware that the Vibrations tell the brain that the
was stretching. Because the fingers are still touching the fingers are touching the nose, but arm is moving, creating a sensation
nose, it feels as if the nose is growing out from the face. there is no movement of the arm. that the nose is growing outward.
Feeling Pain WHO FEELS
THE MOST PAIN?
Although unpleasant, pain is a useful warning Women feel pain more
sign that something isn’t right with the body and intensely than men
that we need to act quickly to avoid further injury. because they have
more nerve receptors
Pain signals in their bodies.
Pain receptors are located all over the body and respond to
heat, cold, overstretching, vibration, and chemicals released
by wounds. Electrical signals are sent from the site of injury
to the spinal cord, where they cross over and travel to the SPINAL C
ORD
SIG
opposite side of the brain to the injury. If sudden, NA
L
strong pain is experienced, a reflex
reaction occurs (see p.101) within
Slow C-fiber
the spinal cord to make the
limb pull away from Nerve bundle
whatever is causing the contains multiple
pain, even before we axons, or nerve fibers
are aware of it.

LE
UND
EB PAIN SIGNAL
ERV
N
Slow C-fibers Fast A-fiber Pain signals travel up nerve bundles
are widespread 2 Signals from the injury site travel along
in skin nerve bundles toward the spinal cord. The
A-fiber signals get there within milliseconds
and trigger a withdrawal reflex away from
the source of the pain.
Axon
Nerve cell
Pain receptors
1 activated
Injury prompts the
release of chemicals
called prostaglandins
from damaged cells.
These trigger the nerve
Fast A-fiber axons to send impulses
covered by to the brain. Prostaglandin
myelin sheath molecule
Pain fibers released by cell
There are two types of nerve fibers, or axons.
Fast A-fibers carry sharp, localized pain from Damaged cell
an injury such as a cut. Slower C-fibers carry
the more persistent dull feelings from the
area around the injury.
SKIN SE
BRUI CUT
Feeling Pain 86 87
Frontal cortex plays Somatosensory cortex
role in anticipating identifies intensity, location,
and controlling pain and type of pain
NATURAL PAIN RELIEF
Limbic system
is responsible for
emotional and The body releases its own chemicals,
behavioral called endorphins and enkephalins,
reaction to pain to dampen the pain signals. They
bind to receptors on the nerve
endings, preventing further
transmission of pain signals.
Reticular Transmission of signal Receiving

formation neuron
modulates Sending
pain signals neuron
Thalamus relays signals

to different areas of brain Nerve fibers
descending from
Pain signals processed brain intercept and Pain
4 The signal continues modify ascending signal
to the thalamus, which pain signals
PAIN SIGNAL TRANSMITTED
distributes impulses to the
cortex and other areas Endorphin blocks
responsible for emotion, Alleviating pain pain signal reaching
attention, and assessing the 5 Descending signals receiving neuron
significance of the pain. travel back down from the
brain to intercept the pain
signals (see box, right).
Pain signals These trigger the release of
travel up natural painkillers by the
spinal cord brain stem and spinal cord
that reduce pain signals.
Spinal cord signal

bypasses brain BLOCKED PAIN SIGNAL
SPINAL CORD
DORSAL
HORN
Pain signals reach

3 the spinal column
The nerve bundle enters the spinal cord
through the dorsal horn. Pain signals pass Most nerve bundles
across to the other side of the spinal cord enter at back of spine,
for their onward journey to the brain. known as dorsal horn
How to Use Your Brain
to Manage Pain
When we are in pain, the usual courses of action involve
medical treatment or painkillers. However, we can also
help control pain ourselves by regulating our mental
response—both to the pain and to the stress it causes.
Pain is an emotional as well as effects, including stomach ulcers a big ball of energy outside your
physical response to injury or and liver disease. Your body may body, and “shrink” it in your mind.
disease. Intense fear or anxiety also build up a tolerance to a drug Cognitive behavioral therapy (CBT)
are vital immediate reactions that so that you derive less benefit from uses a similar approach, by training
cause you to avoid sources of pain it as time goes on. you to replace negative thoughts
whenever possible. Sometimes, like “This pain is unbearable,” or “I
however, pain persists even when Mind-body therapies can’t stop this pain,” with positive
the injury or disease is no longer In addition to medication, you can ones such as, “This pain is only
present. A painful sensation can use mind-body techniques such temporary.”
become associated with constant as relaxation and visualization to Practicing mindfulness reduces
stress, recurring unpleasant reduce or help control pain—with stress, making you better able to
memories of what caused the no risk of side effects. Most use cope with pain. In this practice,
pain, or the constant fear that it relaxation and deep, controlled adapted from Buddhist teachings,
will persist or recur. breathing to reduce the tension you merely acknowledge the pain—
These feelings can be powerful that comes with pain and often instead of allowing it to dominate
and unsettling. Although you makes it worse. Try lying quietly in your thoughts or exhausting
should always seek medical advice a darkened room; breathe in deeply yourself by actively fighting it.
if pain is severe or prolonged, you while counting to 10, hold the To sum up, your brain can be a
can also use several techniques to breath for a moment, then exhale powerful tool for pain control if you:
regulate it by training your mind. slowly for a count of 10. Continue • Practice relaxation and deep
this for 10–20 minutes. breathing techniques to reduce
The painkiller problem Shifting your attention often stress levels.
Medication is often essential to reduces pain’s severity. Try turning • Employ mental exercises to shift
control pain in the short term, but your attention away from the attention away from pain.
taking painkillers for an extended painful area, focusing instead on • Use CBT techniques to focus on
period can lead to issues such as a nonpainful part of your body. positive thoughts.
addiction or serious physical side Alternatively, imagine the pain as • Practice mindfulness.
The Regulatory GENERAL ANESTHETICS
System
A vital part of modern surgery, how
general anesthetics work is not fully
understood. What is known is that they
act on the reticular activating system
The human body is a cooperative of 38 trillion (comprising the reticular formation
and its connections) to suppress
cells organized into different systems. Keeping awareness and on the hippocampus to
them functioning at their best is a system of temporarily suspend memory formation.
Anesthetics also affect the nuclei of the
feedback mechanisms controlled by the brain. thalamus, preventing the flow of sensory
information from the body to the brain.
Maintaining stability
The process of maintaining a stable internal environment is called
homeostasis. Key functions, such as breathing, heart rate, pH,
temperature, and ion balances have to be kept within strict
operating limits to prevent us from becoming ill. As the body works,
its systems are constantly being moved away from their balance or
set point (the value at which a system works best). When the change
becomes too great, the body initiates a feedback loop that
returns the system to its ideal level. Many of these
Signals travel to various
functions are controlled by a part of the
areas of cerebral cortex
brain stem called the reticular formation.
Signals forwarded
3 Signals are then sent directly
to the thalamus and hypothalamus,
as well as to the appropriate areas
of the cerebral cortex for a decision
and response to the stimulus.
Hypothalamus
THALAMUS regulates sleep,
Excitatory area of reticular hunger, and body
formation amplifies temperature
important signals
Thalamus relays
sensory signals
to cerebral cortex
Signals processed
2
LLA
In the reticular formation,

WHAT IS THE unwanted signals are suppressed in
DU
RETICULAR FORMATION? the inhibitory area, while others are

ME
amplified in the excitatory area.

The reticular formation
Inhibitory area of reticular
consists of more than 100
L CORD
formation dampens
nuclei that project to the unwanted signals
SPINA
forebrain, cerebellum, and

Signals travel up
brain stem, controlling 1 the spinal column
many of the body’s Impulses travel Incoming sensory signals
up spinal cord from all over the body travel
vital functions. to the reticular formation.
The Regulatory System 90 91
SENSOR
STIMULUS
Stretch receptors
RESULT The fetus exerts
are stimulated and
Baby is born. pressure on
send signals to the
the cervix.
hypothalamus.
Positive feedback system

The less common of the two feedback systems, positive
feedback systems are more unstable because they have
the potential to have a knock-on effect on other systems,
creating a “runaway” process. An example of a positive
feedback system is the increase in strength and frequency
of labor contractions, which stop when the baby is born
and the cervix is no longer being stretched.
CONTROL
EFFECTOR The hypothalamus
Feedback loops Oxytocin stimulates the
Biological systems operate on a mechanism promotes more posterior pituitary
of inputs and outputs, each caused by, and contractions. gland, which releases
oxytocin.
causing, a certain event. Feedback loops
either amplify the output of a system
(positive feedback) or inhibit the output of
the system (negative feedback). Feedback
loops are important because they allow
living organisms to maintain homeostasis.
STIMULUS SENSOR
RESULT Thermoreceptors
Normal body The body’s
temperature in the skin sense this
temperature is temperature
achieved. changes.
change.
Negative feedback system

Most systems use negative feedback loops,
which are very stable and act to reverse the
direction of change to restore the system to
normal. They include regulation of blood
glucose and body temperature.
EFFECTOR CONTROL
The hypothalamus
95˚F (35˚C)
If too hot, the
brain induces compares to
sweating. If too cold, temperature set
the brain initiates point (98.6°F/ 37°C).
THE BODY TEMPERATURE AT shivering.
WHICH HYPOTHERMIA SETS IN

Synthesizes oxytocin,
vasopressin, and
somatostatin Regulates blood pressure
AMUS and heart rate
Nuclei in the hypothalamus THAL
NUCL ICULAR
Most of the nuclei have distinct PO Initiates intake of
functions. They secrete hormones E HY DORSAL water and food
TH
HYPOTHALAMIC
EUS
that act on the pituitary gland,
R
E AREA
VENT
stimulating it to produce hormones D Involved
SI
that will help achieve homeostasis in memory,
IN
in the required part of the body.
PARA
arousal, sleep,
NUCL EOPTIC
NU ERIOR
DORSOMEDIAL
and energy
C
US
LATERAL NUCLEUS
ARE LAMI
balance
CLE
EUS
OTH AL
PREOPTIC
NUCL OR
T
EUS
AL PR
POS
HYP LATER
NUCLEUS
A
A
RI
Inhibits eating and
EU AL
ANTE
CL EDI
reduces food intake
MEDI
S
NU OM
Y
R
AR
NT
ILL
VE
M DY
Controls thermoregulation AM BO
M
Body’s “clock”—controls SUPRACHIASMATIC SUPRAOPTIC LATERAL
R
VE TO
circadian rhythms NUCLEUS NUCLEUS TUBERAL
ER O
NUCLEI
N OM
30
L
CU
O
GLAN Y
TAR
D
HORMONES ARE
PITUI
PRODUCED BY THE
ENDOCRINE SYSTEM
Neuroendocrine OUT OF BALANCE
System When homeostasis is disrupted,

it can lead to disease, as well as to
our cells malfunctioning. The body
tries to correct the problem but
Maintaining homeostasis (see p.90) requires the may make it worse, depending on
brain and body to communicate. This is achieved what is influencing the imbalance.
Genetics, lifestyle, and toxins can
using chemical messengers called hormones. all impact homeostasis.
The hypothalamus
At the center of the brain’s homeostasis system is the hypothalamus
(see p.34). It contains clusters of neurons, called nuclei, that perform
specific functions and has connections to the autonomic nervous system
(see p.13), through which it sends messages to control heart rate, digestion,
and breathing. When the hypothalamus receives a signal from the nervous
system, it secretes neurohormones, which in turn stimulate the pituitary
gland to secrete hormones. These affect organs all over the body and
prompt them to increase or suppress their own hormone production.
Neuroendocrine System 92 93
Hormone producers Hypothalamus links nervous
Hormones are used for two types of system to endocrine system
communications. The first is between
two endocrine glands, where a
Pineal gland releases melatonin
hormone is released to stimulate a
in response to light levels—
target gland to alter the amount of
melatonin governs body’s
hormone it is secreting. The second is
circadian rhythm and regulates
between a gland and a target organ,
some reproductive hormones
such as the release of insulin from the
pancreas prompting muscle cells to
take up glucose. Controlled by the hypothalamus,
pituitary gland acts as “master gland”;
it secretes its own hormones that
control other glands
Thyroid gland and
parathyroid glands
regulate metabolism,
PARATHYROID GLAND
blood calcium levels,
and heart rate THYROID
GLAND
Produces cortisol
(regulates metabolism, Produces white blood
immune response, and cells that defend against
energy conversion), THYMUS viruses and infections
aldosterone (controls
blood pressure and salt
balance), and adrenaline
(fight-or-flight hormone)
Releases hunger-
inducing hormone
ghrelin and hormone
gastrin, which
Secretes renin and stimulates acid
angiotensin, which STOMACH production
ADRENAL
control blood
GLAND
pressure, as well as
erythropoietin, which
stimulates production KIDNEY
of red blood cells KIDNEY
Secretes insulin, glucagon, and somatostatin
to control blood sugar; gastrin, which
stimulates stomach cells to produce acid;
Producing hormones PANCREAS and a hormone that controls water secretion
The endocrine system is made up of and absorption in intestines
glands that are dedicated specifically to
secreting hormones, as well as organs—
such as the stomach—that are not glands Produces female reproductive hormones
themselves but are able to produce, store, estrogen and progesterone, which
prepare uterus for menstruation or
and release hormones. Both types react to pregnancy
signals from the brain by increasing or
decreasing the production of hormones,
which then travel, via the bloodstream, OVARY
Produce testosterone, which is essential
to a target organ, where they lock onto in sperm production, maintaining
specialized receptors on the surfaces of muscle mass and strength, libido, and
bone density
cells. This triggers a physiological change
that restores homeostasis. TESTES
Hunger 5 Feeling full
Signals that
leptin and insulin
Hypothalamus
acts as regulator
and Thirst
levels are increasing
stimulate the US
M
hypothalamus to
LA
HA
produce the hormone
melanocortin, which
OT
makes us feel full.
Food and drink are essential
H YP
to human survival. Prompts by Rising levels of
ghrelin tell
hormones to take in nutrients hypothalamus
and water are experienced by stomach is empty
the body as hunger and thirst.

Signals from
Hunger 4 adipose tissue Insulin levels tell
There are two types of hunger. Hedonic To prevent us from hypothalamus
hunger involves eating food—particularly overeating, adipose tissue whether body
cells release a hunger- has enough
foods high in fat, sugar, and salt—when we inhibiting hormone called energy
are already full, while homeostatic hunger leptin, which travels to
(see right) is a response to our energy the hypothalamus.
stores depleting. Once food has passed
through the stomach and intestines, the
now-empty stomach releases a hormone
called ghrelin. This acts on neurons in Signals from pancreas
3 After we have eaten, the
Decreased levels
the hypothalamus to tell us that we are small intestine releases the hormone
of leptin inform
hungry, prompting us to eat. A hunger- hypothalamus of
incretin. This, combined with the
low energy stores;
inhibiting hormone called leptin is stomach stretching and increased
increased leptin
glucose in the blood, causes the
then released by adipose (fat-bearing) pancreas to release insulin.
levels help inhibit
tissue to stop us from overeating. appetite
Urge to eat
Feeling hungry 2 Rising levels of ghrelin
The brain, digestive system, and fat stores form
instruct the hypothalamus to release
an interconnected system that regulates our
a chemical signal called neuropeptide
feelings of hunger. The sensation of hunger
Y, which stimulates our appetite.
can be caused by internal factors, such as our
stomach being empty or our blood sugar
levels falling, or by external triggers, such as Incretin produced by
seeing or smelling food. intestines triggers
insulin production
KEY
DEHYDRATION Ghrelin
Stretch receptors
detect expansion
AFFECTS OUR Insulin
of stomach
SHORT-TERM Leptin
STOMACH
ADIPOSE
MEMORY, PANCREAS
SMALL INTESTINE
Incretin Pancreas (FAT)

produces insulin
CONCENTRATION, Vagus
Empty stomach
TISSUE
AND ANXIETY LEVELS

nerve signal 1 Once the stomach has been empty
Movement for around two hours, levels of sugar and
of food insulin in the blood decrease. This causes the
stomach to produce the hormone ghrelin.
Hunger and Thirst 94 95
Lamina Organum vasculosum
Thirst terminalis (LT) of the lamina terminalis (OVLT)
When water levels in the body drop, salt
levels in the blood increase. Thirst areas Subfornical organ (SFO)
in the brain detect rising salt levels and
signal to the body to increase water levels Thirst areas of the brain
by reducing urine output and taking in Two structures, the organum
more fluids. After drinking, it takes around vasculosum of the lamina
terminalis (OVLT) and the
15 minutes before salt concentration levels subfornical organ (SFO)—both
in the blood return to normal. It is thought linked to the hypothalamus—help
that the gulping action of the throat when create the sensation of thirst.
Hypothalamus They lack a blood-brain barrier so
swallowing liquids sends signals to Pituitary are thought to be able to detect
stop drinking. gland salt levels in the blood.
Heart and kidney The SFO and The hypothalamus

1 receptors detect 2 OVLT also 3 passes these
decreases in blood receive signals about signals to the pituitary
volume and increases in blood volume and salt gland, which then
salt concentration. They concentration. They signal produces antidiuretic
alert the brain. to the hypothalamus. hormone (ADH).
High levels of
4 ADH tell the
kidneys to retain water
and secrete renin. This in
turn forms the hormone
angiotensin II.
Inhibitory neurons The hypothalamus The SFO detects

7 in the LT are 6 creates the 5 angiotensin II
triggered by gulping sensation of thirst, and stimulates the
movements in the throat. prompting the urge hypothalamus to
These neurons stop to drink so as to restore prompt the formation
further intake of water. water levels. of more ADH.
ARE YOU DEHYDRATED?

HOW LONG CAN VERY
The most obvious symptoms HYDRATED
YOU SURVIVE WITHOUT of dehydration are a dry mouth
FOOD OR WATER? and eyes, and perhaps a slight HYDRATED
headache. Another good way
Three to four days is the to tell is by the color of your
urine. It should be pale yellow MODERATELY
average without water, but DEHYDRATED
at full hydration. A darker
you can go up to two months amber color shows severe
VERY
without food in certain dehydration. Adults should DEHYDRATED
circumstances. take in around 31 ⁄ 2 –4 pints
(2–2.5 liters) of fluids a day. DANGEROUSLY
DEHYDRATED
Putamen feeds stored Posterior parietal cortex receives
READINESS POTENTIAL information to posterior information from putamen and also
parietal cortex assesses body’s position in relation
to surroundings
When we prepare for a voluntary action, a buildup of
electrical activity, called the readiness potential, occurs. AL X
T ER TE PO
It begins in the SMA and is intensified by activity in the R PA STE
LA O
PMA. Activity in the SMA starts up to 2 seconds before R SO AL C CO RIE RIO
D O ON
T RT TA R
we become consciously aware of our decision to move— EX L
F R
which may suggest that we are less in control of our
actions than we might believe (see p.168).
BASAL
TH GANGLIA
Activity in PUTA ALA
MEN MU
SMA Time of actual S VISUAL
Activity in movement CORTEX
Activity
PMA
0
Sensory information is sent
–3 –2 –1 0 1 from visual cortex via thalamus
Time (seconds) to dorsolateral frontal cortex
Gathering information
1
SPINAL CORD
Sensory areas, such as the visual
THE CEREBELLUM CONTAINS cortex, send signals to the frontal cortex.
The putamen, which stores learned actions,
MORE THAN 50 PERCENT sends information to the parietal cortex,
which assesses whether these learned
OF THE BRAIN’S NEURONS actions could be used in this new situation.
Planning Movement
Conscious movements are those that we deliberately decide
to make. They involve several regions of our brain and include
processes that lie outside our conscious awareness.
The planning process WHY DON’T WE

There are several stages involved in carrying out a movement—from
FORGET HOW TO RIDE
initial perception of the environment, to planning, to adjustments
A BICYCLE?
during the movement. These stages involve different areas of the
brain working together to produce a response. The area that prompts Nerve cells in the putamen
the movement is the motor cortex. Different sections of the motor encode the sequence of muscle
cortex send signals to different parts of the body (see p.98). However,
movements into our long-term
before an action begins, an action plan is created by the dorsolateral
frontal cortex and the posterior parietal cortex and is passed through
memory storage so that
two areas of the motor cortex: the supplementary motor area (SMA) they are easily accessible
and the premotor area (PMA). The cerebellum coordinates the even years later.
movement as it is happening. The steps above show the brain areas
involved and the sequence of signals in a typical movement.
Planning Movement 96 97
Posterior parietal cortex Brain stem passes Primary motor area has
signals conscious intention to information back to command-feedback links with
move via basal ganglia primary motor cerebellum and basal ganglia
area once it is
A
A
SM fine-tuned
TOR Y
AL X
ARE
MO RIMAR
PO
ER TE
T
A OR PA STE
OL L C CO RIE RIO
PMA
S
P
R TA RT TA R
D O ON EX L
F R
BASAL
BASAL GANGLIA
THALAMUS GANGLIA
PUT
A MEN
Dorsolateral
frontal cortex
sends signals to
basal ganglia CE R
E BE
BR
Command for action LLU
M
AI
Thalamus relays signals sent via spinal
N
from basal ganglia to cord to muscles
ST
PMA and SMA
EM
Basal ganglia
Deciding how to move Getting ready for action
2 strengthen or
3
SPINAL CORD
SPINAL CORD
The dorsolateral frontal cortex weaken signals Signals travel to the primary
and parietal cortex work together to Information exchanged
motor area, which forwards instructions
plan the movement. This information between cerebellum
to the cerebellum and brain stem to be
is sent via the basal ganglia (see pp.32–33) and brain stem
fine-tuned. Signals from these areas return
to the PMA and SMA, which specify the to the primary motor area, which sends the
sequence of muscle contractions needed. signal for action to the spinal cord.
Putamen receives Dentate nucleus

N Once signals have signals from frontal makes subtle
TIO been regulated, thalamus and parietal areas N adjustments to
C IO motor plans
forwards to PMA and SMA
CT
SE
SE
SS
CRO
OSS
PU
TA
SIDE CR
THA
FRONT
ME
L
DENTATE
N
BR
AMU
Substantia
US NUCLEUS
AI
nigra controls
L OB DUS
N
G LLI
S
strength of
ST
PA
EM
actions
Cerebellar
AR
L
cortex EL X
coordinates E RE B R TE
C CO
Globus pallidus timing
Subthalamic inhibits unwanted
nucleus involved movements
in impulse control
KEY
Regulating movement Making adjustments Signals to
The basal ganglia are a group of nuclei that Signals from the primary motor area are cerebellum
are linked to the thalamus. Signals from frontal sent to the cerebellum, which plays a role
and parietal areas are processed by circuits in in measuring time. It also makes real-time Signals from
the basal ganglia that amplify or inhibit adjustments to movements in response to cerebellum
movement signals. our environment.
SIMPLE AND COMPLEX MOVEMENTS
Making a Move A motor homunculus shows
Once our brain has planned a movement (see pp.96–97), which areas of the motor
cortex control which areas of
it sends signals to the appropriate muscles in the body, the body. Areas for adjacent PR
IM
body parts—such as the arm A
via the nervous system, to turn intention into action.
RY
and hand—are generally

M
grouped together. The body

OT
From brain to spine

OR
Signals from the motor and parietal areas of the cortex are sent along the parts are shown in proportion;
A
those areas that make complex

axons of neurons, through the brain stem, to communicate with motor
REA
movements, such as the face

neurons in the spinal cord. Most of the axons form part of a bundle called and the hand, take up more
the lateral corticospinal tract, which crosses over at the base of the brain space in the cortex than those
stem so that axons from one brain hemisphere connect to motor nerves for making simple movements,
the opposite side of the body. Other nerve tracts originate in different parts such as the foot. MOTOR HOMUNCULUS
of the midbrain and perform specific movement functions.
T S LEFT
SID
US
KEY AC EO
M
TR
A
Lateral corticospinal
L
FB
PRIMARY
AL
tract
RA
INA
Red MOTOR
IN
TH
PA
SP
Rubrospinal tract nucleus AREA CO RIE
RT TA
Vestibulospinal EX L
Reticular Lateral corticospinal Most signals
tract
formation tract begins in originate in
Reticulospinal cortex and runs primary
tract Axons cross to through thalamus motor area
opposite side
Motor-nerve axon of body in Rubrospinal
midbrain tract aids fine
PONS motor control
Axons cross MIDBRAIN
over to opposite
Nerve tracts side of body CEREBELLUM
1 The Vestibulospinal tract,
axons of just below
which originates in
the lateral corticospinal brain stem
brain stem, helps Axons collect in
tract send signals to
regulate balance midbrain and join
muscles that connect to Reticulospinal
and body spinal cord
S
the skeleton to produce tract helps

P
orientation
voluntary limb movements. coordinate Neurons from brain (upper
INA
Other groups of axons are movement motor neurons) pass

responsible for the body’s signals down spinal cord
L CO
involuntary responses, such

RD
as balance, as well as for

SPINAL CORD
fine-tuning movements.
NEUROM Muscle contracts
and moves joint,
USC
N
AL
UL
causing arm to E
IN
RV
AR
Direction bend NE Lower motor neurons
RM O
of signal AL
JU
TE AX
DI pass signals from
N
RA
C
spinal cord to muscles
TIO
N
Receptor for
acetylcholine Acetylcholine
Upper motor
SYNAPTIC CLEFT neurons
Lower motor
SP
neurons WHITE
IN
MUSCLE FIBER MATTER

A
LE
SC
At the neuromuscular junction, the end GRAY
L CO
MU
3 of the axon releases acetylcholine, a MATTER
RD
neurotransmitter (see p.24). The acetylcholine VENTRAL

binds to receptors in the muscle cell HORN
membrane. This triggers chemical
reactions that make the muscle
fiber contract.
The upper and lower motor neurons meet
2 in the ventral horn of the spinal cord.
The outer part of the ventral horn carries
nerves that run to the hands and feet;
the central part carries nerves to
the upper arms and thighs.
RM
Executing movement
T A
Nerve signals make a muscle
contract and pull on the associated
GH
RI
joint to move the part of the limb
just beyond it. Muscles used in fine
movements have more nerve endings
HOW LONG DOES IT
than those used for simple movements. TAKE FOR A SIGNAL
TO TRAVEL FROM
Making a Move
BRAIN TO MUSCLE?
From spine to muscle
Inside the spinal cord, the axons of the corticospinal tract, which are Signals can travel
covered with a myelin sheath, form the white matter. The gray matter at from the brain to our
the center of the spinal cord consists of the cell bodies of motor neurons.
muscles at a speed of up
The ends of the corticospinal axons (known as upper motor neurons)
synapse on to motor neurons (known as lower motor neurons) in the to 395 ft (120 m)
ventral horn of the gray matter. The axons of the lower neurons exit the per second.
98 99
spine through gaps in the vertebrae (see p.12) and extend to the muscle
fibers. The point where the nerve endings activate the muscle fibers to
complete the movement is called the neuromuscular junction.
Unconscious WHY DOES BEING
Movement
TIRED SLOW DOWN
OUR REACTION TIME?
When we are tired, neurons
We perform many voluntary actions without having in our brain slow down,
to think about them because they are so familiar. affecting our visual
Another kind of unconscious movement is the perception and memory.
reflex action—an instinctive response to danger. This means we respond to
events more slowly.
Reaction pathways
Visual information is vital in helping us
plan our movements. Information from the UPPER
visual cortex follows two routes in the brain (DORSAL)
ROUTE Visual pathways in the brain
(see pp.70–71). The upper (or dorsal) route,
The dorsal route carries information
which leads to the parietal lobe, guides LOWER on the position of the body and other
our actions in real time. Meanwhile, the (VENTRAL) objects, while the ventral route draws
lower (or ventral) route, which ends at ROUTE on perception and memory for
CORTEX
VISUAL
identifying objects. The brain uses this

the temporal lobe, triggers stored visual information to judge the strength and
experiences to help us interpret what we direction required for a movement.
see and respond accordingly.
Attention focused on Body readies

what the player can see, itself to
Coordinated actions such as opposing player respond
Any sequence of actions demands
coordination between different
parts of the brain—first to focus
attention on the task, then to
integrate sensory information and Thalamus Frontal lobe Putamen stores
focuses inhibits learned actions,
memory to create a plan, then
attention on distracting such as how to
to engage the motor area to act. opponent thoughts return a ball
Acquiring a new skill, such as
driving or playing a sport, involves
learning and practicing movement
FR LOB
ON E
sequences so that they become PARIETAL

TA
almost unconscious. When we learn CORTEX

L
THALAMUS PUTAMEN
a skill, our brain cells form new
connections. By the time we have
mastered a skill (see box, right),
there is far less cortical activity
associated with performing that
Attention Memory
task than there was when we were 1 To prepare for action, the 2 Visual cues trigger the parietal
a novice. As a result, the actions thalamus directs attention to the area cortex to call up memories of action
of a skilled person—such as a where the activity will occur (such as the sequences from the putamen. The
opposing player), while the frontal lobes parietal cortex uses this information
professional tennis player—are block distracting thoughts so the player to assess the context and create an
more rapid, precise, and subtle. can concentrate on the visual cues. internal model for the action.
Unconscious Movement 100 101
Reflex actions Additional relay
KEY
Reflexes are split-second responses neurons send
signal to brain Motor neuron Signals to spinal cord
to danger that we do not have to learn sends signal Signals to muscle
or even think about; the body reacts to muscle
Signals to brain
automatically. Reflex actions involve the to contract
same muscles that are used in voluntary 5

4
SPINAL
CORD
movements, but the initial, instantaneous Receptors in
response does not involve the brain.
skin detect heat 1
Instead, the signal from the sensory
3 MU
from flame
SC
nerves travels to the spinal cord, which LE
triggers a response that travels along the 2
motor nerves. Additional signals are sent
Relay neurons Sensory neurons
to the brain afterward, to encode the in spinal cord send signal to
memory in case the danger recurs. generate response spinal cord STIMULUS
Bypassing the brain

OUR NEURONS AND Reflexes involve a simple neural
response called the reflex arc.
NERVE PATHWAYS CHANGE Receptors in the skin and muscles
send a danger signal along sensory
CONSTANTLY IN RESPONSE neurons to the spinal cord; there, relay
neurons synapse with motor neurons
TO EXPERIENCES to trigger a fast response.
DEVELOPING COMPETENCE
Anyone learning a new skill passes
through several stages. Beginners have
Movement Ball coming
to work hard to acquire competence.
sequence toward player
begins
With practice, neural pathways
develop until the learner can perform
Primary motor area plans well without thinking about it.
and executes movement
Unconscious
Premotor competence
area plans Performing skill
movement is automatic
MOTOR Conscious
CORTEX competence
VISUAL Able to use skill,
CORTEX but only with effort
Conscious
incompetence
Aware of skill needed
but lacking proficiency
Planning Conscious action
3 The brain combines real-time 4 By the time the player becomes Unconscious
visual information and stored programs conscious of acting, the movement incompetence
for movement sequences to create a sequence is well underway. The action Unaware of skill needed
plan of action. This is first rehearsed in is most likely to be effective if the and lack of proficiency
the premotor area and then sent to the person has sufficient skill, stored
primary motor cortex. knowledge, and information.
Mirror Mirroring movement
Neurons
Some scientists suggest that mirror neurons may play
a role in learning how to imitate movement. In this
theory, information on the purpose of an action is
passed to mirror neurons from brain areas such as the
Learning does not just involve prefrontal cortex, which is responsible for analysis.
practicing a new skill—we also Mirror neurons in various motor areas then encode a
simulation of that action, which becomes part of our
learn by watching others. This
own motor programming. We can then go on to use this
kind of learning is thought to “program” if we need to carry out the action ourselves.
involve nerve cells in the brain
Observing an action
called mirror neurons that allow Mirror neurons respond differently to various actions of the
us to experience actions without face and limbs. In particular, neurons in different brain areas
are activated for movements of the body itself, such as chewing,
actually performing them. and those focused on a visible object, such as biting a fruit.
What are mirror neurons?

Mirror neurons are brain cells that fire both when
we perform an action and when we see someone
else performing that action. They were first
discovered in monkeys but have since been found
in humans, too. Most studies have used functional
magnetic resonance imaging (fMRI; see p.43),
but one study involved people who had electrodes
implanted into their brains. In this instance, mirror Various motor areas
neuron cells were detected in the supplementary activated, including
motor area, where movement sequences are those linked to
controlling mouth
planned, as well as in the hippocampus, and jaw movements
which governs memory and navigation.
OBSERVER
Where are they?
Mirror neurons Part of parietal
have been found lobe activated by
in several cortical sight of action
areas as well as in targeted at object
structures deeper
within the brain,
such as the
hippocampus.
KEY
Parts of premotor
Premotor area Primary motor area area and Broca’s area
(which plays a role in
Part of Broca’s area Somatosensory area understanding another
person’s movement)
Inferior frontal gyrus Inferior parietal area activated
Supplementary motor area

OBSERVER
Mirror Neurons 102 103
DO OTHER YAWNING
ANIMALS HAVE
Mirror neurons may play a role
MIRROR NEURONS? in “contagious yawning”—the
impulse to yawn when we see
Mirror neurons were first
someone else yawning. FMRI
discovered in macaque scans of people who watched
monkeys. They have also videos of someone else yawning
showed activity in the right
been found in some birds,
inferior frontal gyrus, an area
such as songbirds, and associated with mirror neurons.
more recently in rats.
Understanding intention
Mirror neurons are activated in different ways
when we see others performing particular actions,
Watching a body movement
suggesting they could play a role in decoding
1 Watching a person perform an intention. Watching similar actions observed in
action not linked to an object, such as different contexts—such as watching someone
chewing, activates the premotor area
in the observer. This is an area that is
pick up a cup either to drink from it or to clean it
linked to rehearsing planned up—triggers different levels of neural activity in
sequences of action. It also the inferior frontal gyrus; an area of the brain that
activates areas in the primary
motor area associated with
directs our attention to objects in our environment.
mouth and jaw movements.
0.7
Strong
0.6 response from
0.5 mirror neurons
ACTION WITH 0.4
Neural activity
DRINKING
NO OBJECT 0.3
0.2
CLEANING
0.1
0
Weak response
–0.1
from mirror
Watching action –0.2
2 on an object –0.3
neurons
Watching an action directed Time

at an object, such as a person
biting into a fruit, activates Intention and brain activity
similar areas of the motor cortex. Activity in the brain is greater when a person watches someone
However, mirror neurons also lift a cup to drink rather than when they watch someone pick it
fire in an additional area, the up to clear it away. Some scientists suggest this may be because
parietal cortex, which is involved drinking has a greater biological function than cleaning.
in interpreting sensory
input as well as providing
information about the
body’s position.
THE BRAIN WAVES OF
MUSICIANS COME INTO
ACTION WITH
AN OBJECT
SYNC WHEN THEY
PLAY TOGETHER
COMMUNICATION
Emotions
Emotions are physiological responses to HORMONES THAT TRIGGER
external events, shaped by experience, EMOTIONAL RESPONSES ARE
that are accompanied by distinctive ABSORBED IN 6 SECONDS
feelings. They evolved to push us away
t a n ce Aw
e
from danger and toward reward. ep
c
Ac
Basic emotions ty t io n
e ni ira
er m
Research suggests that there are four
Ad
physiologically distinct conscious feelings:
lief
anger, fear, happiness, and sadness. t io n Re
is fa c
Aspects of these combine and allow
t
Sa
us to feel a range of emotions. Broadly,
emotions are positive or negative usion u st
experiences, which vary in intensity. nf isg
Co
D
Different emotional states are associated p ation
ici
with particular physiological changes
t
ie t y
An
nx
that affect how a person behaves and
A
thinks. For example, we view the world
e
differently when we are relaxed and pr i s
ur
when we are afraid. This coordination
S
of physiology, behavior, and thought Joy
with feeling is what makes us adapt FE
R A
our behavior in response to events. GE
R
AN
Emotions
Other emotional experiences stem from the four
key ones. A recent study found there may be 27
types of emotional experiences, some of which are
shown here. Certain emotions lie along gradients,
such as moving from anxiety to fear to horror.
WHY DO WE CRY?
Only humans cry, and nobody is certain
why we do it—especially given that both
sadness and joy can evoke tears. Crying
serves an interpersonal function,
signaling that we are in emotional
distress to evoke appropriate
social responses. It is also
cathartic, enabling full
emotional engagement
and processing that is
SS
good for mental health.

SAD
E
PIN
NE
SS
AP
COMMUNICATION
Emotions 106 107
The anatomy of emotion Low levels
Brain produces
In response to a stimulus, the brain initiates hormonal majority of of serotonin
changes that, in turn, trigger physiological changes SEROTONIN hormones in brain
that prime us to respond in appropriate ways to the relating to
happiness
current emotional state. Heart rate changes, altered Mildly increased
blood flow to the muscles, and sweating are associated bodily feelings
Heart rate around neck
with heightened emotions. These changes can be felt
decreases and chest
consciously, increasing the emotional intensity.
Low levels
of serotonin
Happiness and sadness Large amount produced
Serotonin, dopamine, of serotonin
oxytocin, and endorphins produced by
are hormones that affect large intestine
WHAT IS THE PURPOSE our happiness profoundly.
OF LAUGHTER? Emotions are felt across
Feeling of
Sensations
the body, with different of decreased
emotions felt in different well-being
The relaxation that results reported all
limb activity
places. The effects of
from a bout of laughter serotonin are shown here. over body
inhibits the biological fight-

or-flight response. KEY
Positive feelings reported
Negative feelings reported

HAPPINESS SADNESS
Unconscious emotions
For primitive automatic responses, such as the
fight-or-flight reflex, speed is critical. Emotionally Sensory
cortex Hippocampus
charged stimuli presented too fast to be consciously Sensory information The hippocampus
perceived can evoke emotional responses and transmitted to the processes consciously
sensory cortex is extensively perceived information to
activate the amygdala. These initial responses form memories. It also
processed toward conscious
shape how the cortex processes information. The perception and integrated compares incoming signals
amygdala is involved in emotional memory that with stored information. to previous memories to
This takes time. adjust emotional
may be automatically activated in the future. responses.
SLOW AND ACCURATE ROUTE

Two routes
Conscious processing
of emotions involves
integrating sensory
Thalamus Amygdala information with stored
Hypothalamus
Incoming The amygdala memories and reasoned
Signals from the
information is relayed instantly assesses the evaluations of a situation—
amygdala trigger
to the amygdala for quick emotional importance of this is the “slow and
hormonal changes and
assessment and action and incoming information accurate route.” In contrast,
output to the autonomic
also to cortical areas where content and rapidly sends unconscious responses, via
nervous system to prime the
it enters conscious signals to other areas for the “quick and dirty route,”
body to respond to
awareness. QUICK immediate bodily action. happen much faster. The
emotional stimuli.
AND DIRTY prefrontal cortex is
ROUTE important in conscious
emotional regulation.
Hypothalamus
Fear and Anger
Thalamus
Fear and anger trigger the release of hormones in the body
that prepare us to deal with threats. In the modern world,
however, long-term anxiety can cause overactivation of the
Amygdala
sympathetic nervous system and lead to health problems.
Visual cortex
Fight or flight
When we see a possible threat, visual Responding to danger
information travels to our amygdala, Signals travel to the thalamus and amygdala,
which triggers the hypothalamus to produce
a tiny part of the brain that processes fight-or-flight hormones. A slower, conscious
emotion. The amygdala sends a signal pathway involving the cortex also assesses the
to the hypothalamus, which activates situation (see p.107).
the sympathetic nervous system,
preparing the body to react to danger
(see p.13). The hypothalamus also sends
signals to the pituitary and adrenal
glands, which secrete hormones such
as cortisol and adrenaline. The combined Saliva production Pupils dilate
effect of these pathways is to initiate our reduces Our pupils enlarge,
Saliva secretion letting in more light
fight-or-flight reflex, which prepares our slows down when so we can see the
bodies to attack or run away. we are afraid. This threat more clearly.
causes a dry mouth.
Muscles tense Digestion slows Breathing rate rises Heart rate Sweating increases Blood vessels
The muscles in our To avoid wasting This oxygenates our increases Our sweat glands constrict
arms, legs, and energy, digestive muscles, preparing Our heart beats faster are triggered, and Blood flow is
shoulders prepare activity falls. In them for action. But to pump oxygen- we begin to sweat, directed away from
themselves for action. extreme cases, we it can also cause and-nutrient-rich ensuring we remain the surface of the
We may feel tense may vomit to eject symptoms of blood to where it is cool if physical skin, so we may
or “wound up.” undigested food. hyperventilation. needed in the body. exertion is needed. appear pale.
Immune system Blood sugar spikes Blood flows Bladder
4 PERCENT
activity reduced Sugar stores are to muscles muscles relax OF PEOPLE
In the moment, released from the Blood carries This causes us to
dealing with liver to provide the nutrients and need to urinate, WORLDWIDE HAVE
infections is not muscles with the oxygen to the which rids the
crucial, so the energy they need to muscles, readying body of excess ARACHNOPHOBIA,
immune system shuts work. Fat stores are them to fight or weight and makes
down to save energy. also mobilized. flee from danger. us faster and lighter. A FEAR OF SPIDERS
Angry or afraid? Panic attacks

The bodily reactions to fear and anger are similar. Panic attacks are physical reactions to fear or anxiety. Symptoms include
It is mainly the way we interpret the sensations we a pounding heart; chest pain; rapid, shallow breathing; and sweating.
experience that determines whether we feel afraid Initially, sufferers can think they are having a heart attack. The first step to
or angry. One theory suggests that if we know why a break the cycle is to recognize that you are experiencing a panic attack.
negative event happened, and who was responsible for
it, we will feel angry. If we are unable to figure out Panic attack The trigger
Left unchecked, this can Panic attacks can have a single
the cause, or it is out of our control, we will feel fear. spiral into a full-blown trigger, like a phobia, or
panic attack. Sufferers
6 1 begin without warning,
Context is key may even fear they as stress and anxiety
Whether we react with fear or are dying. build up.
anger to a particular stimulus is
often conditioned by its context. Interpreting
Symptoms
danger
increase
Your brain
You live alone Without being More hormones
construes the
so know there able to figure are released,
Fear and Anger
COMMUNICATION
Fight-or- feelings as
should not be out the cause, and symptoms 5 The panic
flight reflex
YOU LIVE ALONE
cycle
2 danger and
is triggered anyone here. you feel afraid. get worse,
releases fight-or-
increasing
flight hormones.
You are woken anxiety further.
by loud noises
downstairs in Anxiety builds Physical effect
the middle of Unaware of the Physical sensations,
the night. triggers and unsure such as an increase in
You recall your Sensations are why this is happening, 4 3 heart rate, occur in
roommate interpreted as your anxiety increases. response to the hormones.
108 109
was out and anger about

realize she has inconsiderate
LIVE WITH ROOMMATE
come back. behavior.

ONS CONS
ESSI CIO
US
PR FA
EX
CI
L
CIA
AL
Feelings
E
X FA
Ongoing feelings are
XP
shaped by the senses, MOT
OR
RES
COR OR MOT EX
REFLE
disposition, memories, TEX T

COR
SIONS
body signals, and
EMOTIONAL attention.
CENTER
OF BRAIN
Conscious
Signals intervention
Bodily signals such Analysis of situations
as heart rate, sweating, by the frontal cortex
muscle tension or shapes expectations
relaxation, and and adjusts emotional
trembling all help processing.
shape feelings.
Expressions
Facial expressions
REFLEX SMILE CONSCIOUS SMILE
are both products
and influencers of
emotion—smiling, for
example, elevates
mood.
Motor Motor
neuron neuron
Reflex facial expressions Conscious facial expressions
Emotions generate facial expressions After we have started to experience
without our control. For example, an emotion, we can change our
when we hear good news, we facial expressions to hide or
automatically smile. The amygdala and reinforce our true emotions. Such
other parts of the limbic system initiate action involves conscious
these reflex actions. engagement of the motor cortex.
Conscious
How emotions form
Both reflex and conscious expressions are mediated
by the motor cortex, but reflex ones are signaled to
the motor area directly from the limbic system rather
Emotion
than via the frontal lobes. We can also consciously
modify our physical responses to emotions.
Emotions are felt consciously, and Forming emotions

Emotional responses are complex and dynamic. They
whether they are positive or negative, arise when rapid innate responses to stimuli interact
changeable or constant, they have with detailed analysis. Innate responses evolved as the
major effects on our quality of life. most beneficial reactions to key stimuli. Once such
stimuli have caught a person’s attention, reasoned
Conscious feelings ceaselessly interact
assessment follows. Then, how a person’s emotions
with the unconscious processes that change is shaped by their disposition, past experience,
also shape our emotions. and how they assess multiple streams of information.
COMMUNICATION
Conscious Emotion 110 111
Emotional reactions
Emotional responses evolve over time,
KEY SEROTONIN
Amygdala
from initial protective responses to more
Primary visual cortex Alongside dopamine and
considered responses. Imagine a friend
Frontal cortex
noradrenaline, serotonin is
leaping out on you: first, you feel shock a neurotransmitter that plays
or fear, but as the brain processes what is Fusiform gyrus (face a key role in regulating mood.
happening, you transition to calm. The recognition area)
Although it is not as simple as
first stage involves attention being grabbed Motor cortex high serotonin equals happiness
and the amygdala responding early to and low equals sad, decreases in
Parietal cortex this molecule are associated with
prime the conscious brain to “expect”
depression and anxiety.
an important perception.
Many antidepressant
Signal travels medications act
Less than 100 milliseconds to motor and by increasing
Sensory information goes to parietal cortex
brain levels
the amygdala, which sends
signals to the parietal cortex and then
of serotonin.
Signal travels
to the motor cortex to produce fast to amygdala
Exercise can
reactions to emotional stimulus, such help, too—for
as when fleeing from danger. example, taking
Signal from a brisk walk
sensory areas
or dancing can
100–200 milliseconds raise serotonin levels.
The information then arrives
in the frontal lobes, where it Recognition
becomes conscious and appropriate pathway
action is planned.
Information
registers in EMOTIONS ARE
frontal cortex
CONTAGIOUS—
350 milliseconds Signal from
frontal lobe to
HUMANS MIMIC
Considered reactions are
then conveyed back to motor cortex EACH OTHER’S
the motor cortex, which signals
appropriate bodily responses. EXPRESSIONS
Emotions versus moods ADAPTIVE BEHAVIORS

Emotions are usually transient— EMOTION POSSIBLE STIMULUS ADAPTIVE BEHAVIOR
arising from thoughts, activities, or
Challenging behavior from “Fight” reaction prompts dominant and
events that act as cues for adaptive Anger another person threatening stance or action
behaviors. Moods last for hours,
Threat from stronger or “Flight” to avoid threat; or act to socially
days, or even months. For example, Fear dominant person appease the threatening person
emotion might be experiencing a
Backward-looking state of mind and
sudden rush of joy at seeing a Sadness Loss of loved one
passivity, to avoid additional challenge
friend waiting to greet you
Unwholesome object (e.g., rotting Aversion behavior—remove oneself from
compared to a lingering mood of Disgust food or unclean surroundings) the unhealthy environment
sadness or worry after losing a job.
Emotions tend to be expressed in Surprise Novel or unexpected event
Attention on object of surprise maximizes
sensory input that guides reaction
the moment, while moods are not.
Reward Centers Rush of dopamine tells
brain to repeat activity
The brain’s reward system evolved because it helped
us seek out things that are important for our survival. Attention
focused on
Dopamine neurons
activated and project
But if this system is hijacked, it can lead to addiction. activity to other brain areas
Reward pathways
When we do something that is important for our survival,
X
TE
such as eating when hungry, or having sex, neurons that
OR
NUCLEUS
FRONTAL C
trigger the release of the neurotransmitter dopamine are ACCUMBENS
activated in the ventral tegmental area (VTA). These send
signals to an area called the nucleus accumbens—a rush in
dopamine here tells the brain this is a behavior that should SUBSTANTIA
NIGRA
be repeated. Neurons also send signals to the frontal cortex, VTA
which focuses attention on the beneficial activity. TEM
SYS
E YE BIC
ER S LIM
T ENT
LIGH
Stimulus
1 The initial stimulus can originate Route to reward
outside the body, such as the sight of Sensory The reward system starts in the VTA in the
food, or from within, such as falling information midbrain, then passes to the nucleus
glucose levels. registers in accumbens in the basal ganglia and then the
limbic system frontal cortex. Dopamine also travels from
the substantia nigra to the basal ganglia.
This pathway affects motor control.
Urge Desire
2 Dopamine released from the
3 The urge may be registered as
VTA to the nucleus accumbens drives us a conscious desire in the cortex, but
to seek out and work for the reward sometimes it goes undetected, or even
that is linked to the stimulus. opposes our conscious desires.
Reward Learning
5 The reward triggers parts of the
6 If the reward is better than
brain known as “hedonic hot spots” to expected, the brain releases more
release opioid-like neurotransmitters, dopamine, strengthening the connection
giving a sense of pleasure. between stimulus and reward.
Action
4 A region of the frontal cortex
weighs the inputs and decides whether
to seek the reward. The body then
acts to reach it.
COMMUNICATION
Reward Centers 112 113
Addiction
Most drugs of abuse cause huge amounts of dopamine to build up UP TO 60%
in the reward system—far more than natural rewards like food or
sex. This creates a powerful drive to seek out more of the drug. It
OF ADDICTION
also causes the brain to reduce the number of dopamine receptors, RISK STEMS
so natural rewards no longer give the same sensation. This means FROM GENETIC
the user loses the urge to seek out things like food and social
engagement. Instead, drug cues become powerful triggers for FACTORS
dopamine release, causing intense cravings, even when the user
consciously wants to stop and no longer enjoys the drug.
E
ONS Normal
ES
P Vesicles in nerve
CE dopamine
cell release N release
PRESYNAPTIC
R
RA
neurotransmitters PRESYNAPTIC
AL
NEURON
LE
NEURON
RM
TO
Dopamine
NO
Dopamine
SYNAPSE SYNAPSE
RE
CE RE
PTO CEP
RS TORS
Many receptors Not many receptors
POSTSYNAPTIC POSTSYNAPTIC
NEURON NEURON
Flooded with dopamine Under tolerance

Some drugs of abuse increase dopamine release, while Over time, the brain reduces the number of dopamine
others stop it from being recycled. The buildup in the synapse receptors to counteract the excess. Now, when normal
produces a large response in the brain, triggering the drive amounts of dopamine are released, they have little effect.
to seek out more of the drug. Environmental cues become The user may need bigger and bigger doses of the drug to
linked with the drug and can trigger cravings in the future. feel its effect, and their desire for other rewards decreases.
WANTING VERSUS LIKING

WHY IS JUNK
FOOD SO TASTY? The reward pathway is often called
a “pleasure pathway,” and dopamine
Most junk food contains a “pleasure chemical,” but this is not
lots of sugar, salt, and fat, accurate. Dopamine in the nucleus
accumbens drives “wanting” of a
which trigger our reward
reward, but it is common for addicts
system. This would have to experience strong cravings without
helped us survive when liking the effects of the drug. Pleasure
is likely to be caused by other
food was scarce.
neurotransmitters such as opioids
or endocannabinoids.
Sex and Love
Sexual reproduction is fundamental
to passing on our genes. Multiple
emotions evolved that accompany and DOPAMINE
facilitate this process, which together

can create the feeling of love.
Brain
Love and attraction produces
dopamine
The scientific study of love and sexual
Reward
behavior has identified three primary pathway in
components: attraction, attachment, and lust. brain triggered
Feelings of
These states all occur on different timescales excitement
and involve different regions of the brain and euphoria
producing an array of chemical messengers— SEROTONIN

neurotransmitters and hormones. Lust and
attraction are closely interlinked, and both are
transient, passing in a relatively short time.
Brain
For relationships to last, these states must produces
yield profound attachment, which involves Serotonin
less serotonin
long-term changes to the brain. levels
reduced
Loss of
appetite,
KEY insomnia,
feelings of ADRENALINE
Prefrontal cortex obsession NOR
Hypothalmus
Pituitary gland
Brain produces
noradrenaline
Brain areas
The hypothalamus and pituitary gland control early Noradrenaline
hormone-led phases of bonding. The prefrontal cortex then levels increased Energy levels
mediates the emotional control involved in attachment. increased,
heart races,
appetite
THE LOVE DRUG decreased,
insomnia
Oxytocin, which is released by the hypothalamus,

has long been known as the hormone that
induces labor in mammals.
It was then found to be
crucial for mother-offspring
bonding and later to
be central to forming Attraction
long-term attachments Surges of the chemical messengers dopamine
in sexual and social and noradrenaline combine with reduced levels
relationships. of serotonin to produce urgent feelings of
attraction. In an energized state—with racing
heart, sweaty palms, and little appetite—we think
constantly about our lover, craving their company.
114 115
OXYTOCIN REDUCES Facial symmetry
A person’s face is key to how
ACTIVITY IN THE attractive others find them.
BRAIN’S FEAR CENTER Humans and monkeys prefer
symmetrical faces—symmetry
is an indicator of good health
and genetics. Many species also
OX Y TOCIN favor sexually dimorphic faces,
males preferring feminine faces
and vice versa. These factors
interact: higher facial symmetry
Brain increases a face’s perceived
produces femininity or masculinity.
oxytocin
Oxytocin ORMONES
levels SEX H KEY
increased Feelings of Symmetrical Asymmetrical
bonding and face face
contentment
FEMALE MALE
Hypothalamus Percentage of
triggers people who
production of Increased levels 69% found face 85%
sex hormones of testosterone sex-typical
by testes or and estrogen
ovaries
Increased
Brain libido
produces 31% 15%
vasopressin
Vasopressin
Feelings of European
levels
bonding and When shown composite faces with high
increased
attentiveness or low symmetry, European observers
judged high-symmetry faces to appear
more feminine or masculine.
62% 60%
VASOPRESSIN
Percentage of
37% people who 39%
found face
sex-typical
Attachment Lust
The hormones oxytocin and vasopressin Lust is the primeval urge to engage in
have multiple effects—including making sexual relationships, driven by the sex Hadza
us feel more protective of our object of hormones testosterone and estrogen. Similar results were found in the Hadza
attraction and attentive to their needs. While they increase libido in men and people, an indigenous Tanzanian ethnic
They stimulate long-term bond formation women respectively, they alone do group. This suggests that the link between
but can increase distrust of others. not induce lasting connections. symmetry and attractiveness is universal.
Early stages of
forming an angry or
disgusted expression
are similar S
R ST S
GE GU NE
AN
D
S
SA
DI
Nose Raised
Brows lowered wrinkled inner brows
Lowered
Lips pressed together Upper lip raised mouth
Anger causes the brows to lower, the Disgust is associated with a wrinkled A sad person turns down the corners of
lips to be pressed together, and the eyes nose with the cheeks and upper lip their lips while raising their inner brows
to bulge. An observer would be wary being raised. The wrinkled nose stops and lowering the outer brow. This
of the person signaling anger. the person from inhaling offensive odors. expression might evoke sympathy.
Universal expressions
Psychologists have found that there are six universal emotions: anger, MICRO EXPRESSIONS
disgust, sadness, happiness, fear, and surprise. Like primary colors,
Micro expressions are tiny,
they combine to give rise to the many emotions we experience. Each
involuntary, and often barely
one is linked to a distinctive facial expression that is similar in every perceptible facial expressions.
culture. Expressions are part biologically and part socially driven. When They last half a second or less,
surprised or fearful, for example, widening the eyes takes in more and the person making them
light to better survey the situation. But other aspects of expressions may be unaware that this form
evolved to convey social signals to members of the same species. of “emotional leakage” is
revealing their true feelings.
Expressions
Expressions are extensions of emotions. They allow
us to communicate our feelings to others and to
infer the thoughts and feelings of people around us.
Psychologists believe there are six basic emotions,
each with an associated expression.
COMMUNICATION
Expressions 116 117
SS ISE
NE AR PR
PI
FE
R
P
SU
HA
Raised cheeks Raised brows
Eye widening and

other features are
common to early
stages of expressing Jaw dropped
fear or surprise
When we are happy, we raise the The distinctive fearful expression In surprise, people quickly open their
corners of our mouths and also raise includes raised eyebrows, wide eyes, eyes wide and arch their brows, while
our cheeks—the skin under the eyes and the mouth falling open. This signals their lower jaw drops, leaving the
wrinkle, and the eyes are said to sparkle. others to be on high alert. mouth agape.
Motor cortex Motor cortex

Smiling
Frontal cortex
A smile can either be a genuine
expression of positive mood or a
conscious, socially motivated action.
Genuine smiles are unconscious Amygdala
acts that involve different muscle
groups to social smiles. While both
involve a stretched mouth with lips
Signal causes muscles
upturned at the corners, the genuine around mouth to contract
smiling person constricts muscles and pull lips sideways in
that raise the cheeks, producing both types of smiles
“crow’s feet” around the eyes.
Signal causes small muscles
Conscious smiles vary in their exact around eye socket to contract
structure and are used in an array
of social interactions—they can be Genuine smile Conscious smile
socially bonding but also used to The muscular contractions involved in genuine Conscious control of social smiling involves
smiles are triggered by signals from the brain’s activation of the frontal cortex and signals
signal dominance, and people may emotional centers, such as the amygdala, from the motor cortex. The mouth muscles
also smile to mask embarrassment. usually operating without our awareness. contract, but we can’t control the eye muscles.
Body From a resting
HAPPY
Language
point, pupils can
shrink or expand
Body language is nonverbal NORMAL

communication, in which our Iris muscles
contract to
thoughts, intentions, or feelings are enlarge pupil
expressed by physical behaviors
such as body posture, gestures, eye
movements, and facial expressions. DILATED
Nonconscious communication Eye signals

Pupils frequently shift size and can
Social interactions between people involve signal various things. A dilated
complex streams of nonverbal communication pupil may indicate surprise or E
that are processed in parallel to speech. Many attraction. Constricted
SSIV
pupils are associated E
aspects of body language arise instinctively— with negative G GR
eye movements, facial expressions, and emotions such A
posture, for example, all change without as anger.
conscious control. These movements can MORE THAN 50 PERCENT
therefore reveal unspoken intentions. Body OF COMMUNICATION
language is also used to signal social intentions
overtly, such as when blowing a kiss. The IS BASED ON OUR
richness of this communication involves the BODY LANGUAGE
whole body and our brains are attuned to it.
Superior temporal Orbitofrontal

gyrus cortex
DO GESTURES
HAVE THE SAME
MEANING AROUND
THE WORLD?
No, many gestures are
culturally specific. A simple
hand gesture can have
different meanings for
Amygdala different societies.
Brain processes
Processing body language involves areas like the amygdala,
which receives emotional content; part of the superior
temporal gyrus, which responds to seeing human
movement; and the orbitofrontal cortex, which analyzes
meaning. Special cells, called mirror neurons (see pp.102–
103), are also activated when you see someone else moving.
COMMUNICATION
Body Language 118 119
SAD
Gestures
Most body language is performed unconsciously, but
we have more conscious control over our gestures, which
are movements of the body used to convey meaning.
There are four categories of gestures: symbolic (or
Facial expressions
Facial expressions reveal much about emblematic); deictic (or indexical); motor (or beat); and
a person’s emotions (see pp.116–117). lexical (or iconic). They might be used instead of speech
The eyes and the mouth, in particular, or alongside it for emphasis. Some scientists believe
automatically respond to strong feelings,
although people can consciously change that increasingly complex gestures evolved as the
their expressions to mask emotions. forerunners of speech, which now defines our species.
Symbolic
These are gestures that can be literally translated into
words—for example, waving hello or making the “okay” sign.
They are widely recognized in a given culture but may
DE not be recognized beyond that culture.
FE
Deictic
N
SI
Deictic gestures involve pointing or otherwise

VE
TYPES OF GESTURES
indicating a concrete object, person, or more intangible

item. Used with or without speech, they act like pronouns,
Posture meaning “this” or “that.”
An aggressive posture tends to inflate a person’s
size. It may involve extending the arms, setting
the feet far apart, and protruding the chest. Motor
The same postures may be used to invade This type of gesture is short and tied to speech patterns,
others’ personal space. In contrast, defensive such as moving the hand in time with speech, and is used for
postures are closed—folded arms, for example, emphasis. Motor gestures contain no inherent meaning and
are a classic indicator. are meaningless without accompanying vocalization.
Lexical
These gestures depict actions, people, or objects, such as
miming throwing when telling a story about throwing a ball,
or using your hands to depict an object’s size. They usually
accompany speech but contain meaning independently.
SIGN LANGUAGE
Sign language may appear to Broca’s Motor cortex
be a sophisticated type of area
body language, but it has
more in common with speech.
Studies show that when
people sign, the same brain
areas (see right) light up
as when they speak. Sign
language has grammar, and
each gesture has a specific
meaning, while body language
is interpreted broadly. Auditory area Wernicke’s area
How to Tell if
Someone Is Lying
Separating truth from falsehood depends partly
on knowing a person, so you can judge whether they
are behaving differently from usual. With a confident
and persuasive talker, especially someone you don’t
know, how easy is it to spot a lie?
120 121
The short answer is, it is difficult. Clues from speech person’s total cooperation. Certain
Traditional telltale signs of lying Speech can be slightly more reliable. parts of the brain are more active
are shifting gaze to avoid eye Hesitation, repeated words or when lying and show up together
contact, folding and unfolding arms, phrases, breaking up sentences, on screen. These include the
shrugging shoulders, and fidgety a change in tone or in speaking prefrontal, parietal, and anterior
hands and feet. However, scientific speed, vagueness, and describing cingulate cortices and the caudate
studies do not support these beliefs. trivial details while avoiding the nucleus, thalamus, and amygdala.
Some honest people are generally main topic—are all strategies to In summary:
nervous and squirmy. In others, give the brain “time to think” and • Be very aware of judging
these signs show someone is figure out which falsehood might be someone you don’t know well.
concentrating on being trustworthy. most believable. This is especially • Don’t rely on time-honored
Polygraph, or “lie detector,” true for persistent liars, who must signs such as fidgeting and
machines—which record pulse and access memory so as not to lack of eye contact.
breathing rates, blood pressure, and contradict themselves as their • Clues from speech, such
sweating—have a dubious history. multiple deceptions become ever as hesitation and repetition,
This is partly due to the stress of more tangled. can be slightly more reliable.
using them. Innocent but anxious A more reliable method involves • In many tests, a simple “gut
people can show up as deceitful, the use of fMRI (see p.43), a feeling” was as successful
while calm, skilled liars pass easily. brain scan that requires the as most other methods.
Morality
Most people living in normal environments develop instinctive
senses of right and wrong. Morality seems to be in part hardwired,
arising from the conjunction of rationality and emotion.
Where do right and wrong come from?

Social norms based on shared morals exist across all cultures, Moral judgment
enabling social cohesion. When making moral decisions, two When we make decisions,
brain systems come into play: a “rational” system that effortfully our emotions play a vital role. KEY
In order to weigh moral
and explicitly weighs the pros and cons of possible actions; and matters, brain areas that
Rational
circuit
a system that rapidly generates emotional, intuitive feelings of are involved in emotional
right and wrong. Interactions between rationality and emotion experience coordinate with Emotional
areas that register facts and circuit
are complex, but studying brain activity while people grapple consider possible actions
with moral dilemmas has identified the key areas involved. and consequences.
Parietal lobe Dorsolateral

Involved in working memory prefrontal cortex
and cognitive control, this area This area integrates rational and
of the cortex provides information emotional information. It may
needed to help us perceive social also counteract the ventromedial
signals, to figure out others’ beliefs area to suppress emotional drives
and intentions—such as whether when dealing with complex moral
an act was aggressive or how a dilemmas that favor cognitive
social context should solutions using memories
affect behavior. Amygdala or other data.
Posterior superior Ventromedial

temporal sulcus prefrontal cortex
This part of the cortex functions EXTERNAL VIEW This area is an important
with the parietal lobe, providing structure for allowing emotional
information to guide moral responses to influence rationalized
intuition and attributing beliefs to moral decisions. In psychopaths,
others and integrating this data connections between this region
with the potential outcomes of and both the amygdala and
actions. It also helps assess Temporal pole reward pathways are
whether a person is The temporal pole functions disrupted.
lying. in both social processing, such
as face recognition and figuring
out the mental states of others,
and in emotional processing. It
may also help combine complex
perceptual inputs with
intuitive emotional
responses.
COMMUNICATION
Morality 122 123
Altruism
Altruism—when a person acts to benefit another PSYCHOPATHY
at personal cost or risk—involves empathizing
Psychopaths can understand
with another’s distress then acting to help.
morality and can, therefore,
It involves distinct processes. mimic normal social
Brain scans show that acting interactions. This means
altruistically activates the that while they behave
reward pathways (see pp.112– heinously, they remain
113), reinforcing the behavior hard to identify. The
and quelling emotional underlying cause may
be a disconnect between
discomfort. Selflessness is
brain regions linking logical
a distinguishing feature of decision-making and
human behavior and an emotion, leaving them
evolutionary enigma unable to grasp the fallout MIMICKING
given dangers to the altruist. from their behavior. EMOTIONS
Posterior Medial
cingulate cortex frontal gyrus
This region is active when our This region of the brain
environment changes and when is important for decision-
we are thinking about ourselves. It Nucleus making and for choosing
may help assess the seriousness of accumbens between alternative potential
offenses and the appropriate actions. This is especially
response by acting as a hub for the case when there is
integrating intuitions about conflict between
the mental states of multiple options.
others.
INTERNAL VIEW
CAN BRAIN
DAMAGE AFFECT
SEEING SOMEONE MORALITY?
HURT BY ACCIDENT Orbitofrontal
It depends on the area
PRODUCES SIMILAR prefrontal cortex
Activated by watching morally affected. For example, damage
BRAIN ACTIVITY charged scenes, this area
processes emotional stimuli. It aids to regions that link emotion to
AS IF THE VIEWER in representing just rewards and
punishments for observed
moral choice can cause people
WAS HURT behavior and in making to make “coldhearted”
emotionally driven moral decisions.
THEMSELVES choices.
Learning Learning to talk
a Language Our innate preference for looking at faces helps

newborns focus attention on people talking to them.
Later, making eye contact and following gaze allows
Unlike other species, humans have them to connect the words they hear with what is
a brain with regions dedicated being talked about. As they learn new words, infants
make “overextension” errors by using a single word
to language. Babies are born ready
to label multiple things, for example, by using the
to learn language, acquiring it word “fly” to refer to anything small and dark.
through an interplay between these
specialized areas of the brain and
Timeline of speech
their own unique experiences. The exact timescale for mastering language varies
To learn language, we also have from child to child, but all children progress through
the main stages in a similar order—from cooing and
to interact with other people. babbling to first words and, ultimately, full sentences.
First consonants:
c and g Intonation
SPEAKING
added to sounds,
Cooing (vowels Laughter begins Babbling, e.g., plus more First true
only) from “ba-ba,” “ga-ga” consonants, e.g., spoken words
6 weeks (true syllables) “ma-ma,” “da-da”
(not words)
UNDERSTANDING
Understands 10–12 months

Can distinguish
Prefers sound some common Understands
between vowel Responds to
of mother’s words for simple
sounds and own name
voice objects or instructions, e.g.,
consonants
people “give me the ball”
Throat anatomy Babies start to

changes to make follow their
PREPARING
speech sounds caregiver’s gaze 10–12 months

Prefers looking Begins to Left hemisphere
possible (before and begin to link
at faces understand of brain becomes
this, the need to the words they
(from birth) pointing specialized for
breathe while hear with the
breastfeeding object they are speech
prevents this) looking at
PREBIRTH UP TO 4 4 5 AROUND 6 BY 6–8 9–10 10–11

MONTHS 10–12
COMMUNICATION
Learning a Language 124 125
The bilingual brain White
ALCOHOL AND LANGUAGE
In the brain of a bilingual speaker, matter
preserved
languages “compete” for attention. in older One study of second-language learners
This provides unconscious practice bilingual looked at whether alcoholic drinks would
RIGHT adults
in ignoring irrelevant information, HEMISPHERE improve speaking and pronunciation by
and studies show that bilinguals reducing self-consciousness. It worked
are better at this than monolinguals. up to a point—but after too many drinks,
Activated
The ability to learn a second region
performance rapidly deteriorated.
language like a native speaker is of gray
matter
usually lost after around four years LEFT BONJOUR, BHLEES
of age, especially with pronunciation. HEMISPHERE ÇA VA? CHIDEVSSSS
The brains of elderly bilinguals Bilingualism areas
show better preservation of white Areas of gray matter (shown in
blue) are activated in bilingual
matter, which may protect them speakers when they switch
from the effects of cognitive decline. between languages.
“Telegraphic”
Multiword, Vocabulary
stage of
sentence-like commonly
One-word stage: Two-word stage utterances of
speech begins: around 3,000
can use single begins, e.g., more than two
e.g., “shoe all words and
words for “mommy eat,” words. Also
wet.” Also use of growing. Also
familiar objects, “daddy bad,” begins to use
“where,” “why,” increasing use
e.g., milk, cat, “big teddy” question words,
and inversion, of grammar, e.g.,
cup (e.g., “where my
e.g., “where did plurals, past
book?”) and Full use
you go?” tenses
negatives (e.g., of language—
“no doing it”) although many
subtleties of
meaning remain
to be mastered
May understand
Can understand
around 50
around five
words. Becomes
times as many
specialized in
words as in
hearing speech
speech
sounds within
vocabulary
own language
AT AROUND 18 MONTHS,
Start to point for
THERE IS A VOCABULARY
themselves,
effectively
EXPLOSION—THE WORD
“asking” for
word names
LEARNING RATE CLIMBS
TO ABOUT 40 A WEEK
AROUND 12 FROM 12 12–18 18 MONTHS 2 YEARS 2–21 ⁄2 3 ONWARD 5

YEARS
The Language
Areas
The human brain, unlike that of any other animal,
Motor cortex
has areas dedicated specifically to language, usually The motor cortex enables the
located in its left hemisphere. The unique ability of physical movements required to
produce language—for example,
humans to communicate using language is thought moving your tongue, lips, and jaw.
The motor cortex is activated when
to be an evolutionary advantage. words that are semantically related to
body parts are heard or spoken. For
example, the word “dance” might
be related to your feet.
Broca’s and Wernicke’s areas
The two main language areas are Broca’s and Wernicke’s areas.
Broca’s area is associated with moving the mouth to articulate
words. When learning new languages, separate parts of Broca’s
area are activated when we speak either our native or non-native
tongue. In Wernicke’s area, words that we hear or read are Speech travels through
understood and selected for articulation as speech. Damage to air as sound waves
this part of the brain can lead people to speak in peculiar ways,
creating sentences that do not make sense.
BRAIN DAMAGE AND

LANGUAGE CHANGES HELLO
There have been cases in which SHWMAE BONJOUR
patients with brain injury appeared
to wake up speaking a different ASALAAM ALAIKUM
language or with a different accent.
Foreign accent syndrome is one
example of such a medical
condition. These cases are rare, and
GUTEN TAG
there have not been sufficient PRIVET OLÁ
scientific studies carried out to
understand them in any detail.
KONNICHIWA
# & @ å HOLA CIAO
ž ø ï ¿ œ
» § ë Speaking and understanding
Processing language is a complex task.
Articulating or decoding even a simple
greeting, such as “hello,” requires several
different areas of the brain to work together.
COMMUNICATION
The Language Areas 126 127
Aphasia
Aphasia is a medical condition
Supramarginal in which people are unable to
gyrus
Although it is not considered comprehend or produce language,
EX one of the main language areas, read, or write due to damage
RT
the supramarginal gyrus caused to the brain—for example,

CO
works with the angular gyrus

as the result of a trauma, stroke,
R
to perceive and process

TO
language in order to give or tumor. The condition can be

MO
words their meaning.

AL relatively mild or severe. There are
GIN
many types of aphasia (for some
AR S
R AM YRU A examples, see table below). Some
G
BROCA’S UP
N
are named after the brain area
GU
AREA
S
LA
that is affected or the type of
RG
EX E ’S speech produced. However,

RT
YRUS
Y CO ICK aphasia can affect language,

R N
ITO ER E A
AUD W AR reading, and writing in many
different ways, and some of these
difficulties may not fit into one
specific type or category.
TYPES OF APHASIA
Angular gyrus
TYPE SYMPTOMS
The angular gyrus is associated
with complex language.
Global The most severe form of aphasia,
It coordinates auditory, sensual,
causing general deficits in
and visual information to help
comprehension, understanding,
us understand words and concepts.
and production of language.
The angular gyrus allows the
association of particular words
with different images, ideas, Broca’s Speech production is affected
and can be reduced to just a few
or sensations.
words, which may be halting or
Auditory cortex “nonfluent” in their nature.
The auditory cortex is part of
the temporal lobe at the side of Wernicke’s An inability to understand the
the brain. This area processes meaning of words. Speech
auditory information in humans production is unaffected, but
and other vertebrates to enable irrelevant words may be used,
information to be heard. The auditory forming nonsensical phrases.
cortex is divided into sections (see
p.76), which allows humans Anomic Difficulty finding words during
to hear complex sounds, speaking or writing. This can
such as words in lead to vague language, causing
a conversation. significant frustration.
Primary Language capabilities become

progressive slowly, progressively impaired.
This form can be caused by
diseases such as dementia.
THERE ARE AROUND
Conduction A rare form of aphasia that
6,500 DIFFERENT causes difficulty repeating
LANGUAGES SPOKEN phrases, particularly if phrases or

sentences are long and complex.
AROUND THE WORLD
Facial expressions
We constantly use facial expressions
during conversation. As speakers, we
raise eyebrows to emphasize a point
or indicate a question, and as listeners,
we use expressions to show interest
in what is being said. One study looked
at the top reasons for using facial FACIAL SHRUG THINKING EMPHASIS EMPATHIC
expressions in conversation.
KEY
Speaker Both
Listener
QUESTION RETELLING PERSONAL I’M LISTENING
REACTION
ER
E AK
E SP
TH 1 Message idea
The starting point of
a conversation is an idea the
speaker wants to express and
the intention to express it. NO,
THANKS
Formulation
2 The speaker selects the
words with the right meaning TURN TAKING
(semantics) and then puts them
into the right form and order
(syntax) to make sense. For LIKE
example, “Would you like a drink?” WOULD
is a question; “You would like a WOULD YOU
drink” is a statement; and “Like LIKE
you drink a would” is nonsense. YOU
Broca’s area (see p.126) is crucial SEMANTICS SYNTAX
to these two processes.
Articulation
3 To say the message, the
speaker moves the mouth, tongue,
lips, and throat, controlled by the
motor cortex, to form the speech
sounds with the right intonation.
GARDEN PATH SENTENCES

We can be misled if the first part of a message suggests
an idea that is contradicted by the later part. For example:
“The car stopped at the crash scene was soon surrounded
by police.” We initially understand “stopped” to mean
WOULD
something the car did; but when we hear “was soon,” it
becomes clear that the car was stopped by police. We
YOU LIKE
have to revisit the start of the message to make sense of A DRINK?
it. This type of statement is called a garden path sentence.
COMMUNICATION
Having a Conversation 128 129
Having a Beyond words

We constantly use nonverbal
Conversation
signals alongside speech in
conversation. In addition to adding
emphasis (via facial expressions)
or visual effect (via gestures),
A conversation is a shared endeavor between such signals allow the person
speaker and listener, which involves more than not speaking to have a role in
the conversation partnership,
producing and understanding words. We take turns, encouraging the speaker without
signal understanding, and align our thoughts. interrupting or taking over.
THE ELEMENTS OF CONVERSATION

LIS
TE
NE Looking
Response
R Listeners look at their conversation
4 Now the listener can reply partner much more than speakers
and take their turn as speaker. do. They do this to show interest—
as without this, speakers often
falter. In contrast, speakers look
Message interpretation
3 Usually, listeners add their
intermittently at the listener.
own experience to understand

the message. For example, if we Gestures
are asked “Would you like a We use many types of hand gestures
drink?” at 9 a.m., we may expect (see p.119), including conventional
coffee, but at 9 p.m. it is likely the signs—such as “thumbs up,” pointing,
offer is a different type of drink. and expressive hand movements—to
add emphasis to the message.
Message decoding
2 The listener recognizes words and
makes sense of the message structure “I’m listening” signals
WORD PARSING by analyzing the syntax (parsing). Parsing Listeners use nonverbal sounds and
RECOGNITION includes extracting meaning from the gestures, such as saying “mmm” or
order of the words. For example, “dog nodding, to show they are engaged in
bites man” has the same words but the conversation while not speaking.
different meaning to “man bites dog.”
Wernicke’s area (see p.126) is crucial in
comprehending speech. Turn taking
Conversation requires taking turns,
and we start learning this from
Hearing speech sounds infancy. Conversation partners
1 The speaker’s speech rarely talk over each other, even
sounds are heard via the auditory though the average gap between
pathway in the listener’s brain. turns is only a few tenths of
a second.
Speaking and listening

Speaker and listener swap roles many times in a
conversation—and as speakers, we also monitor our own PEOPLE TALK
speech output. Although both roles involve multiple steps,
it can all happen fast—taking from 0.25 seconds between OVER EACH
having an idea to saying it, and from 0.5 seconds for OTHER LESS
comprehension. Hesitation occurs when speakers need
time to “catch up” with the complex speech planning
THAN 5% OF
and production process. CONSERVATION TIME
BIRT
H AG
Learning to ON
W
E3
+
read and write A
RD
The ability to read and write Children may
is something that most people start to recognize
start to learn at a young age. symbols when
playing
As our brains develop, we learn
Babies imitate
important reading and writing sounds that
skills. By the time we reach adults make
adulthood, we can read on average
200 words per minute. Reading
requires several areas of the
brain and body to work together.
For example, when you read, your
eyes need to recognize the word
on a page and your brain then
processes what that word says. Making sounds Recognizing symbols
1 Babies make sounds that imitate 2 Children begin to understand what
Writing uses the brain’s language adults but often aren’t recognizable as words. symbols mean when they are in text. They
areas (see pp.126–127), visual areas, This is the foundation for learning to develop use the visual cortex and memory to
and motor areas concerned with language skills. Babies see and process facial translate symbols that they see into sounds.
expressions using the visual cortex and other As children grow, they connect these sounds
manual dexterity to make the areas. They then learn to associate sounds with the meanings of words and start to
necessary hand movements. and facial expressions with things in the world. relate language to written text.
Reading WHAT CAUSES

DYSLEXIA?
and Writing Research suggests that children

with dyslexia have problems
understanding the sounds
Our brains are hardwired for speech, but the
letters make, but dyslexia is
ability to read and write is not innate. We have
also found in cultures where
to start training our brains as babies to develop
symbols represent an idea
these complex skills. rather than a sound.
DYSGRAPHIA
Dysgraphia is the inability to write SPEED READERS
tHisIsaS eNT E
clearly. It can be the symptom of ncEw
riT
ARE ABLE TO
some brain conditions, such as
Parkinson’s disease, that affect fine tENbY
sOMEonEwItHdYs READ MORE
GRap
motor skills. Writing may be wobbly
and indistinct or completely mangled.
HiA THAN 700
WORDS PER
MINUTE
COMMUNICATION
Reading and Writing 130 131
AG AG AG
E5 E1 E1
+ 1+ 3+
As fine motor
skills advance,
Reading writing becomes
We increasingly
to a child more fluent
read text on
helps them
screens and type
relate sounds
words on
and text
keyboards
Beginning to read Expanding vocabulary Continuing to learn

3 Reading aloud can improve a child’s 4 As we grow older, we experience 5 As adults, we continue to learn and
reading ability. Listening to a story activates more of the world around us so we learn and practice our reading and writing skills. Our
the auditory cortex to hear the words, which see new things, adding to our vocabulary. vocabulary is constantly being extended.
are then processed by the frontal lobe. Comprehension, the ability to understand Learning to read and write is just the start
Picture books help children practice relating how to use words, requires every lobe of of the story. The whole brain is required to
words to images, and asking them to join in the brain (see p.30) and the cerebellum to maintain language skills, and good brain
reading builds vocabulary and comprehension. successfully comprehend and use language. health is vital to both reading and writing.
Dyslexia ALPHABETIC PRINCIPLE

Dyslexia takes various forms,
affecting people’s ability to read or The alphabetic principle is the idea
write, or both. It is thought that up that individual letters or groups of
to one in five people have dyslexia. letters represent sounds when they
A full neurological explanation of are spoken aloud. The alphabetic
Nondyslexic brain reading principle has two parts:
the causes of dyslexia has not yet Broca’s area helps form and articulate
been achieved. Studies have speech. The parietal-temporal cortex works
1. Alphabetic understanding
suggested that particular to analyze and understand new words. The
occipital-temporal area forms words and aids Learning that words are made
structures of the brain function in meaning, spelling, and pronunciation. up of letters that represent the
differently in dyslexia (see right). sounds made when speaking
As children with dyslexia typically Increased Less these letters aloud.
struggle with their reading abilities, activity activity
it is difficult to determine whether 2. Phonological recoding
the developing brain impacts the Understanding how strings of
letters in written words combine
dyslexia or if the dyslexia itself has
to make sounds, which enables
an impact on the developing brain. spelling and pronunciation.
Dyslexic brain reading

KEY
Broca’s area is activated to form and articulate
Parietal-temporal Inferior frontal words, but the parietal-temporal and occipital–
gyrus (Broca’s temporal areas are less active. Broca’s area
Occipital-temporal area) can be overactivated to compensate for the
lack of stimulation of the other regions.
MEMORY,
LEARNING,
AND THINKING
What Is Memory?
Our memory allows us to learn from experience and shapes us as
individuals. Memory is not a single discrete brain function; there
are several types, involving different brain areas and processes.
Memory in the brain Types of memories

Memory includes instinctive processes that you are unaware of, as To better understand how it works,
well as the more obvious parts that allow you to remember what you scientists break memory down into
had for lunch yesterday or your boss’s name. Each type of memory a number of types. Many of these
uses a range of different brain areas. Scientists used to think the rely on different networks within
hippocampus was vital for all new memories to form, but now it the brain, although there is also
is thought this is the case only for episodic memories. Other types a lot of overlap between the brain
of memories use other areas, which are spread all around the brain. areas involved in each category.
Caudate nucleus Frontal lobe is Cingulate cortex may Putamen

is associated with involved in working be involved in is involved
memories of and episodic memory memory retrieval in learning
instinctive skills procedural skills
Parietal lobe is
Mammillary body important for
is involved in spatial memory
episodic memory
Thalamus helps
Short-term
Olfactory bulb links direct attention
memory
to the amygdala Short-term memory is very
so smells are Hippocampus
turns experience limited—storing only around 5–9
potent triggers for items, but this varies between
emotional memories into episodic
memory individuals and for different types
of information. To keep something
Temporal lobe in short-term memory, we often
Brain areas holds general repeat it to ourselves, but if we
Memory areas often relate to the knowledge are distracted, we instantly
information stored. Memories of forget it.
movement, for example, use the Amygdala is vital for Cerebellum is
motor cortex. Limbic areas, linked to forming emotional vital for “muscle
emotion, are also involved in memory. memories memories”
Nonassociative Simple classical Priming and

learning conditioning perceptual learning
When you are repeatedly exposed Made famous by the Russian In priming experiments, you are
to the same stimulus, such as a light, physiologist Ivan Pavlov and his shown a word or picture so quickly
a sound, or a sensation, your response dogs, in classical conditioning, you don’t consciously “see” it—but
changes. For example, when you come repetition causes something neutral to it can still affect your behavior.
home, you smell dinner cooking, but be linked with a response. An example For example, someone primed with
gradually the smell seems to fade. is your mouth watering as you enter the word “dog” will recognize the
This is known as habituation, one a cinema lobby, as you have word “cat” faster than a
form of nonassociative learned to expect popcorn in completely unrelated word
learning. that environment. such as “tap.”
MEMORY, LEARNING, AND THINKING
What Is Memory? 134 135
WORKING MEMORY
Memory systems To multiply 50 x 20, you must

manipulate the numbers stored 50 x 20
Memory is split into two main
types: short- and long-term in short-term memory. This
TO DO
memory. Short-term memories are uses a process called working
fleeting, but important information memory. Working memory
can be passed over to long-term ability is one of the best 5 x 20 = 100
memory for storage. Long-term 100 x 10 =
memories may last a whole lifetime predictors of success in
school for young children. 1,000
and are further divided into
several different types WORKING
of memories.
Long-term
memory
Our long-term memory allows us
to store a—theoretically—almost
infinite number of memories for most
of our life. Long-term memories are
stored as distributed networks of
neurons spread out across the outer
layer of the brain, the cortex.
Recalling the memory sparks
the network to fire again.
Nondeclarative Declarative
(implicit) (explicit)
Nondeclarative memories are Declarative memories can be told
unconscious so cannot be passed to someone else. They are conscious
from person to person using words. and sometimes learned through
You might try, for example, to explain repetition and effort, although others
to someone how to tie their shoe can be stored without awareness of
laces or ride a bike, but they would the process. They include memories
probably still fail or fall off of events that have happened
the first time they attempted in your life (episodic) and
to do it for themselves. facts (semantic).
Procedural Episodic Semantic

Skills or abilities, such as riding Episodic memories might be Semantic memories are
a bike or dancing, are termed recalling a big event like your 18th factual—meaning they are things
procedural memories. When first birthday or something mundane like that you know rather than things
learned, they require concentration yesterday’s breakfast. These are things that you remember. For example,
and conscious effort but over time you actually remember happening: these might include recalling the
they become habit. Often called recalling an episodic memory capital of France or the first three
“muscle memory,” procedural is almost like reliving the event. digits of Pi. Semantic memory relies
memories are actually stored The hippocampus is vital for on a large network of brain areas
in a brain network involving storing new episodic and may not involve the
the cerebellum. memories. hippocampus at all.
How a
Memory Forms MEMORY TRACES
Scientists have recently been able to
pinpoint a precise memory trace in
When networks of neurons in the brain are someone’s brain. In general, memories
repeatedly activated, changes in the cells tend to be stored near the area of the
strengthen their connections, making it easier brain that relates to how they were
formed. For example, memories for
for each to activate the next (see pp.26–27). This voices would be near the language
process is known as long-term potentiation. centers, and things that you have
seen are stored, at least partly,
near the visual cortex.
Strengthening connections
When you repeatedly activate a group of neurons—by practicing a
skill or revising facts, for example—they begin to change. This is how AUDITORY
we form long-term memories (see p.135) in a process called long-term CORTEX
potentiation, which depends on various mechanisms taking place
in brain cells. The first (presynaptic) neuron makes more VISUAL
neurotransmitters release when the signal reaches it, and the second CORTEX
inserts more receptors into its membrane. This speeds up transmission
Memories of sounds
at the synapse. Something like driving a car, which seems complex are stored partly in or
when you start, can become effortless as the neural pathways involved near auditory cortex
become more efficient. If this paired activation is repeated enough, new
dendrites can grow, linking the two neurons via new synapses, giving
the message alternative pathways and helping it travel even faster. NG
NI
AR
Electrical signal
LE travels along axon
MORE THAN 100 DIFFERENT of sending neuron
RE
FO
NEUROTRANSMITTERS
BE
HAVE BEEN IDENTIFIED

AX
Nerve cell in ON
hippocampus fires a
signal to a receiving cell Action potential
triggers release of
neurotransmitter
SY
NA
PS
E
Second Vesicle containing

NERVE CELL nerve cell neurotransmitters
BODY DE
ND
AX
RI
TE
ON
SYNAPSE
Firing together
Long-term potentiation
occurs across the brain but
has been best studied in the Before learning, only a weak connection exists between
hippocampus. Electrical signals 1 neurons. One action potential (pulse of electrical current)
travel along a neuron’s axon to from the first cell releases only a small amount of neurotransmitters,
the synapse, where chemical and this may or may not be enough to activate the next neuron,
messengers are released. which has just a few receptors.
How a Memory Forms 136 137
Emotional memories
When something strongly emotional happens, whether that is good or bad,
KEY
stress chemicals such as adrenaline and noradrenaline are released. These
Neurotransmitter
make it easier for long-term potentiation to occur with fewer repetitions.
This explains why emotionally arousing memories are stored more rapidly Phosphate
in the brain and why they are easier to recall than nonemotional memories.
Action potential in
Changes presynaptic neuron triggers
triggered in neurotransmitter release
hippocampal
neurons Neurotransmitter
released
Noradrenaline
released by neurons Phosphates guide
in locus coeruleus, receptors to insert
located in pons themselves next to synapse
HIPPOCAMPUS
LOCUS
Hormone released Strong connection
1 Noradrenaline released
COERULEUS 2 An enzyme adds
Neuron is
primed for
PO
by neurons originating in the phosphate groups to receptors

connection
NS
locus coeruleus triggers a cascade in the postsynaptic neuron. This

of changes within cells in makes it easier for more receptors
the hippocampus. to be inserted in the cell membrane,
so the connection is strengthened Action potential
and the memory forms easily. triggered easily
NG NG
RNI Repeated activation causes NI More neurotransmitters
EA more neurotransmitters
AR produced and
to be released released
E
L
RL
G
RIN
TE
AF
DU
More Strong
receptors connection
move to allows
membrane signal to
surface pass quickly
More receptors
on receiving
cell
Action potential
triggered in
second neuron
Both neurons firing repeatedly at the same time causes a Now, a single action potential causes the release of
2 chemical cascade within the second cell (see p.26), which 3 more neurotransmitters, carrying the message quickly
makes it more sensitive to the neurotransmitter, and causes extra and efficiently across the synapse, where it is received by
receptors to migrate to the edge of the synapse. A signal travels many receptors. This makes it easier for the second neuron
back to the first cell, telling it to produce more neurotransmitters. to be activated, sending its electrical signal onward.
Storing Memories CO
R TEX
After being encoded by the hippocampus, memories are

consolidated and transferred to the cortex for long-term
storage. These memories are formed by strengthening
connections, a process called long-term potentiation
X
TE
(see pp.136–137).
OR
LC
TA
Storage in the cortex WHY DO I
ON
To transfer memories for long-term
FR
FORGET WHERE I
PRE
storage, the hippocampus repeatedly LEFT MY KEYS?
activates a network of connections
in the cortex. Each activation Often, things we “forget”
strengthens connections until they actually weren’t stored
are secure enough to store the as memories in the first
memory. It was thought that place, because we weren’t
memories formed first in the
paying attention when
hippocampus, with the cortical
memory trace forming later, but we did them.
recent research in mice suggests
that they may form simultaneously,
although the cortical memory is Memory bank
initially unstable. Repeated Memories are stored as networks
reactivation of the network of connections in the cortex. The
number of neurons here creates
somehow “matures” the cortical a near infinite amount of possible
memory, meaning we can use it. combinations—in theory, long-
term memory is virtually unlimited.
N
ATIO
ING OLID
Consolidation ARN NS
LE CO
This storage process, known as Study Sleep
consolidation, happens mainly 1 When you learn something new, 2 While you sleep, new
while we sleep. During this time, your brain takes in that information and information is consolidated. The
forms new connections, or strengthens memory becomes less reliant on
your brain is not processing synapses that already exist. the hippocampus and less likely
information from the outside to be affected by interference
world so it can carry out these from other inputs or brain injury.
housekeeping tasks. Memories
are sorted, prioritized, and the
gist extracted. They are also
linked with older memories,
already in storage. This makes
it easier to retrieve important
memories in the future. Studies
have shown it is better to take a
nap after learning something
new than it is to keep studying!
Storing Memories 138 139
A certain combination of
Memory stored in cortex neurons fires repeatedly
2 Networks across the cortex to consolidate memory
store memories for things that M
happened less recently. Different
EM
types of memories might be stored
OR
in various combinations of regions.
Y TR
X
E
ACE
RT
CO
RY
SON
SE
ATO
SOM
AUDITORY
CORTEX
Synapses strengthen,
storing memory as
a trace
US
AMP
HIPP
OC HIPPOCAMPAL
INJURY CAN MAKE
CO AL
Memory encoded by hippocampus

EX
1 FORMING NEW
SU
RT
Experiences are registered by the

VI
hippocampus, and some of them—those that are

destined to become memories—are encoded LONG-TERM
there. Long-term potentiation alters connections
between neurons in the hippocampus to create
MEMORIES
a memory. This area is vital for new memories. IMPOSSIBLE
L
RIE
VA PRACTICE MAKES PERFECT
T
RE
Remember If you learn something just once, over time that memory
3 When you wake up, the memory trace will fade as the connections weaken. The more times
of what you learned is stored more you practice or revise something, the stronger those
securely. It has also been linked to other connections between neurons become and the more likely
facts, making it easier to recall, and you you are to remember it in the future.
may find that you
understand the
underlying KEY
Strength of memory trace
concepts better.
Rest
Study
Time
Recalling a Memory
Recalling a memory is not the passive process we once
thought, like playing back a recording on your phone.
Instead, our brain actively reconstructs our experience from
the information it has stored. This introduces the opportunity
for mistakes, meaning our memories can change over time. Nerve-cell connection
activated during recall
Memory in the cortex

1 Each time we recall a
long-term memory, the network of
cortical neurons storing it is activated.
This strengthens the connections
between the cells, so it is less likely Neuron in cortex
to be forgotten in the future.
Nerve-cell connection
strengthens
Strong emotions
make it easier for Cortex
connections to
strengthen
RY
MEMO
ED
Strong connections OR
2 If we do not recall a memory ST
frequently, the connections between
the cells will weaken and the memory
HOME DATES
will fade. Memories associated with LIF
strong emotions, however, are less
E
likely to decay with time.
Reactivating a memory
When we recall a memory, we activate
the same network of neurons that
fired during the original experience, IONSHIP TRIPS
bringing it back to mind. While being LAT S
RE
recalled, the memory enters a flexible,
or labile, state. This means that once
we have finished thinking about that
memory, it must be reconsolidated Stored memories
Most memories are stored
and stored again. If new information long-term in the cortex, but
is presented while the memory is you can’t point to the area for
labile, it can be stored alongside old your 18th birthday, for example.
Each memory is represented
information. This allows memories to by a network of neurons,
be changed and updated. spread across the brain.
Recalling a Memory 140 141
False memories
When a memory is reconsolidated,
True memory
new information is stored with old. 1 Scientists asked participants to watch
But when we next recall the memory, clips of car accidents. After each clip, they had
it is impossible to tell which is which. to describe what happened and answer
questions. This meant they were recalling
This means we can end up with and reactivating
false memories. Just talking about the memory.
an event can change our memory of
it, so in legal cases, witnesses must
be questioned carefully, to avoid
contaminating their memories.
WHAT IS 2 New information

Some participants were asked about the cars’
DÉJÀ VU? speed when they “contacted” each other, while
others were asked about the speed when
The feeling of déjà vu the cars “smashed.” The first group
might arise because we rated the cars as slower than
the second group.
recognize something in
an environment but cannot
recall what. This gives
a vague feeling
of familiarity. NEW INFORMATION
STORED WITH OLD
TIME LATER
ATI
VAC ONS False memory recalled
3 One week later, subjects recalled the video again
and were asked whether there was any broken glass (there
was not). Significantly more people in the “smashed”
group “remembered” broken glass. The
words used had changed their
memory of the event.
HD
BIRT AYS
RECALL VERSUS RECOGNITION

It is much easier to recognize something
as familiar when we are shown it than it
is to recall the details without any input.
For example, we all know what a quarter
looks like, but could you draw one
from memory?
How to Improve
Your Memory
Once we understand learning and recall, research
shows that we can find ways to boost these
processes and improve our memories. Some of the
best memory techniques, such as the memory
palace, are actually some of the oldest.
Often, when we “forget” external—such as the scent of
something, we haven’t stored it freesias taking you back to your
properly in the first place. To avoid wedding day. The memory palace
this, we must process information technique uses associations and
deeply—paying full attention to triggers to help recall long lists
what we are learning, thinking of information in order.
about it, and seeing how it links Probably the most important
to other things we already know. thing we can do for our memories
Once stored, we need to make is get enough sleep. If we are tired,
sure the information stays put, by our focus and attention suffer, and
practicing or repeating whatever the brain just isn’t in the right state
we are trying to learn. The more to learn. Sleep is also vital after
often we activate pairs of neurons learning for memories to be
together, the stronger that consolidated, sorted, and stored.
connection becomes and the more Here is a quick recap of how
likely we are to remember it in the to boost your memory:
future. The spacing of repetitions is • Process the information deeply.
important, too—it is better to revise • Rehearse it regularly.
for 10 minutes a day for six days • Use cues and associations.
than one hour on a single day. • Get plenty of sleep.
The power of cues and rest

There are techniques we can use to
help recall information, and many
Using a memory palace
of them rely on cues. These triggers Imagine you are walking through somewhere
can be internal, such as mnemonics, familiar, such as your house. At strategic points,
which provide the first letters of a visualize objects relating to the words you
hope to remember, such as the items on a
list of items, cuing recall of the shopping list. To recall the list, simply “walk”
items themselves. Or they can be the route again – the objects act as triggers.
142 143
Why We Forget
There are many theories to explain why we forget things.
Some scientists think that all our memories remain in our Memory trace
brains but that we sometimes lose the ability to access them. exists in brain;
often, blockage is
Our memories may also interfere with one another. later released and
memory can
be recalled
Forgetting in the brain Y Y
OR OR
There are many conditions that
M
M
ME
ME
cause us to forget (see pp.146–147).
Broadly, there are two possibilities
for what happens in the brain when
we do. The simplest idea is that
over time memories fade away;
information is lost as the trace that
was formed is no longer there. But
evidence for this is hard to come by, Memory cannot
as other factors could be involved. be accessed or
brought to mind,
Most of us have experienced the
perhaps giving
struggle to remember information a “tip of the
that later pops into your head for no L tongue” feeling
CAL
reason—this suggests memories RE
Y
can still exist but be inaccessible.
OR
This could be because other similar

MEM
memories are interfering with them,

or because there is no cue in our
environment to prompt that recall.
It is not known whether the
nerve-cell connections of a memory
disappear or if they still exist but
we are unable to access them.
WHY DO I FORGET
WHAT I WENT
UPSTAIRS FOR?
Leaving a room changes the
environmental cues that help
us remember. When you Memory retrieved Failure to retrieve
When we recall If recall is unsuccessful, it
go back to where you were, something, we must may be that the memory
the memory often reactivate the network is still in the cortex,
of neurons that stores it. we are just unable to
reactivates. If this is successful, access it (above). Or
we remember the connections may have
fact or event. been lost (see right).
Why We Forget 144 145
Interfering memories
Our brains experience interference, particularly when information ACTIVE FORGETTING
is similar. Learning new information can block recall for old, and
old information can also affect new. These problems might arise Forgetting seems passive,
but you can choose to forget.
because the wrong memory trace is activated when you go to recall
In one study, subjects’
the information, blocking access to the right one. Or it may be that prefrontal cortices—involved
old information can disrupt consolidation of new, and if successful, in suppression—were activated
the new memory may actually replace the old one. when they were told to forget
a specific word.
Proactive
interference
Old memories may
disrupt new ones. BONJOUR, HOLA,
For example, when ÇA VA? ¿CÓMO
starting to learn ESTÁS? Prefrontal
Spanish, you may cortex
experience interference
from French words
learned as a child.
WE MAY BE LESS
LIKELY TO RECALL
Retroactive INFORMATION WE
interference
If you later went to BONJOUR, HOLA, CAN FIND EASILY
speak French and ÇA VA? ¿CÓMO ESTÁS?
instead spoke Spanish, ONLINE; THIS IS THE
that would be new
memories disrupting GOOGLE EFFECT
the recall of old ones.
S S S
NTH AR ADE
O YE C
DE
M
Storage Memory fades Losing a memory

1 Long-term memories are stored 2 If months or years pass before you 3 One theory for forgetting is that
in the cortex as networks of connections. recall a memory, it may begin to fade. synapses that are not in use become weaker
These form and strengthen over weeks or Without reactivation, connections between and are eventually pruned away, taking that
months. Recalling a memory activates it, nerve cells are not strengthened. Specific memory with them. The longer a memory
strengthening the synapses and making details about special events, such as the food is inactive, the more likely it is to be lost
the memory easier to retrieve later. you ate at your wedding, may be forgotten. through this process.
Memory
Problems
Retrograde amnesia
People often forget moments before
an accident, but they can lose weeks,
or even years. Some memories,
especially older ones, return slowly.
Memory problems increase with age, and dementia
affects one in six people over 80. Sometimes, brain Anterograde amnesia
People with anterograde amnesia are
damage, stress, or other factors can cause us to unable to form new memories. They
remember who they are and retain
experience an inability to remember (amnesia). memories from before the damage.
Transient global amnesia

Amnesia This is a sudden episode of memory
If someone suffers a brain injury that damages the hippocampus and loss, typically lasting a few hours.
There are no other symptoms or
surrounding areas, it can cause amnesia. There are two main types, obvious cause.
depending on whether the patient forgets memories they had stored
Infantile amnesia
before the incident (retrograde amnesia) or is unable to form new
Infantile amnesia refers to the fact
memories (anterograde amnesia). There are also cases of amnesia that people usually cannot retrieve
without any obvious signs of damage, for example, after experiencing memories of situations or events
before the age of two to four years.
a psychological trauma. Drugs and alcohol can cause temporary
amnesia, although this can become permanent if large amounts are Dissociative amnesia
used over a long period. It is also possible to suffer anterograde and This can be triggered by stress or
psychological trauma. Patients forget
retrograde amnesia at once, particularly if there is significant damage days or weeks around the trauma or,
to the hippocampus. This condition is called global amnesia. in rare “fugue states,” who they are.
Aging and memory

As we age, it is normal to experience memory
BY THE TIME PEOPLE
lapses and encounter more difficulty learning new REACH THEIR 80s, THEY
things. Focusing attention and ignoring distractions
becomes harder, and you may forget everyday
MAY HAVE LOST AS MUCH
things, such as why you went upstairs, more often. AS 20 PERCENT OF THE
These experiences differ from the symptoms of NERVE CONNECTIONS
dementia (see p.200), which can include getting lost
in your own house or forgetting a partner’s name. IN THEIR HIPPOCAMPUS
Losing trust in memory Using memory less Memory getting worse

1 Older adults often begin 2 Brain abilities are like muscles, getting 3 Not exercising your memory can cause a
doubting their memories, seeing normal stronger with use. Writing things down or vicious cycle of cognitive decline. Encouraging
lapses as a sign of worsening abilities. looking them up instead of exercising your older adults to use their memory, by providing
This can lead them to rely on it less. memory could make it worse. feedback showing it still functions well, may help.
Memory Problems 146 147
A curious case
Henry Molaison (1926–2008) was
an American assembly line worker WHAT IS
suffering from severe epileptic
seizures. In 1953, he underwent FRON
“SHELL SHOCK”?
surgery to remove sections of his TA
L
medial temporal lobe, including The expression was coined
LO
both hippocampi, to treat severe during World War I to describe
B E
epilepsy. This controlled his
seizures, but he forgot several an effect thought to be caused
years before the surgery
and developed anterograde
by the sound of exploding
MPUS
amnesia. He could retain new shells. Soldiers were, in fact,
declarative memories (see
suffering from PTSD, brought
CA
p.135) only for a few seconds O
but could learn new skills. HIPP on by the trauma of war.
CE
Large areas
RE
of medial temporal lobe BE

LLU
removed from brain M
in each hemisphere
VIEW FROM BELOW
Other memory problems

Many things affect memory, from short-term stress to life events, POST-TRAUMATIC STRESS
such as having children. Memory changes can be linked to changes
DISORDER
in our neurochemistry. For example, cortisol is released when we
worry and hormones surge in a pregnant woman around the time Normally when we store memories, the
of birth. Lifestyle changes such as sleep deprivation also play a role. emotion fades over time, so we recall past
events without reliving them. In post-
CAUSE EXPLANATION traumatic stress disorder (PTSD), sufferers
Stress Moderate, short-term stress can make it easier to form fail to dissociate memory from emotion,
memories, but it becomes harder to recall facts you have and intrusive memories bring the fear
already learned. This may explain why the feeling of “going flooding back. These memories can be
blank” during an examination is so common.
activated by sights or sounds, and often
Anxiety Long-term or chronic stress, such as is experienced the patient is unaware of their triggers.
by people with anxiety disorders, can damage the
hippocampus and other memory structures of the brain,
causing memory problems.
Depression Depression can impact the short-term memory and cause

people to have difficulty recalling details of events they have
experienced. Healthy people tend to remember positives
better than negatives. In depression, this is reversed.
“Baby brain” Pregnant women may experience mild decline in a range of

cognitive abilities, although these are likely to be noticeable
only to the women themselves. After the baby is born, sleep
deprivation can worsen memory problems.
Special Types
of Memories Posterior hippocampus,
involved in spatial navigation
Although a few children exhibit remarkable skills,

most people with exceptional memory are not born
that way. Instead, they use special techniques and
lots of practice, sometimes leading to physical
changes in their brains.
Training exceptional memories

Scientists studying trainee London taxi drivers as they
learned “the Knowledge” (a huge network of roads and Hippocampal
Anterior
structures
landmarks) found that the volume of the subjects’ Our two hippocampi—
hippocampus
posterior hippocampi increased as their ability to one on each side of
navigate improved. This could occur due to the birth the brain—are vital for
learning and memory.
of new neurons or the growth of existing dendrites (see They can be divided
p.20). However, the taxi drivers performed worse than into posterior (back)
control subjects in memory tests not involving London and anterior (front),
with the posterior portion
landmarks. This suggests memory is finite, and particularly important for
improving one area may come at the expense of others. spatial navigation.
S
NT
Savant syndrome VA FLASHBULB MEMORIES
SA
People with mental disabilities 10%

ALL
sometimes demonstrate incredible People often remember where

ACQUIRED
abilities in one specific area, often they were when receiving
related to memory. This is called emotional news, and the memory
CONGENITAL
savant syndrome. Many savants are 90%
seems extremely vivid and
autistic, but the syndrome can also detailed. These are called flashbulb
be triggered by severe head trauma. memories. However, studies have
shown that we are as likely to be
Some savants can calculate the day
TS mistaken about these snapshots as
of the week for any given date. AN we are about any other memories.
AV
Others remember everything they
S
CON NITAL
read or can paint detailed pictures 21%

of scenes they have seen only once.
GE
FEMALE
Scientists think these talents may
develop because of savants’
MALE
extreme focus and interest in one 79%
area. There is also evidence they
see the world as building blocks, By genetics and gender
not whole pictures, by accessing One database of savants, as reported by their
parents or caregivers, found that the vast
perceptual information most of us majority (90 percent) are born with the
are not consciously aware of. condition, and of these, most were male.
Special Types of Memories 148 149
KEY
Taxi driver’s Taxi driver’s posterior Posterior hippocampus
Posterior hippocampus
hippocampus hippocampus returns to original size
increases in volume
Before training, taxi drivers

have hippocampi with
regions of normal size
Same size Changing anatomy Returning to normal
1 At the start of the study, scientists
2 The trainee taxi drivers who passed
3 The brains of retired taxi drivers look
scanned the brains of the participants to “the Knowledge” had larger posterior much more like those of the control group.
measure the size of their hippocampi. There hippocampi than the control group, or the This suggests that the changes to the
were no differences between the trainee taxi trainees who failed. Some studies found that hippocampus revert once taxi drivers stop
drivers and the control group. the front of their hippocampi was smaller. using “the Knowledge” on a daily basis.
“Photographic” memory
There is no such thing as photographic memory—no one can literally CAN PEOPLE
recall pages of text or images as if they were really in front of them. The REMEMBER
closest is eidetic memory, which occurs in 2–10 percent of children. After EVERYTHING?
looking at an image, “eidetikers” continue to “see” it in their visual field,
until it gradually fades or disappears as they blink.
A perfect memory does
not exist, but a few people
Picture imperfect
Studies have shown that eidetic images are not have superior autobiographical
perfect. Children may not manage to remember memory, giving them
all the letters in a word they were shown, or
they may invent details, for example, “recalling” exceptional recall for
something in a picture that was not really there. events during
their lives.
MEMORY
PEOPLE WITH
Sometimes, people
with an eidetic memory INCREDIBLE RECALL
vividly recall details that
were not present in the FOR FACES ARE
original scene, such as
the color of this roof CALLED SUPER
PHOTOGRAPH CHILD RECOGNIZERS
Intelligence Network implicated
in hypothesis testing—an
integral component
of intelligence
There are many theories about how intelligence
evolved, what it actually constitutes, and which
factors are key to high intelligence.
What is intelligence? 1 Acquire

Intelligence is our ability to acquire Information
is gathered through
information from our surroundings, various experiences,
incorporate that information into understood, and
a knowledge base, and then apply retained for
processing.
it to new situations and contexts.
While there are many models for
how human intelligence evolved,
language and social living
undoubtedly played a role as this 2 Process
New
enabled knowledge to be passed
information is
on from generation to generation. critically analyzed,
The evolution of human intelligence compared with
existing knowledge Frontal lobe houses
has led to our success as a species,
and placed in context. large-scale networks
enabling us to adapt to and inhabit associated with
almost all environments on Earth. intelligence
THERE ARE OVER Theories of intelligence

1,000 HUMAN 3 Apply
Existing
Some studies suggest that connectivity
between the prefrontal and parietal cortices
GENES THAT knowledge is applied
to a new situation or
and small areas of neurons (networks) is the
key to high intelligence (above). Other
HAVE BEEN LINKED problem, as opposed explanations (right) have also been put
to being repeated forward, suggesting that intelligence is related
TO INTELLIGENCE from memory. to connectivity across the brain as a whole.
Types of intelligences Naturalist Existential

Recognizes features of plants Uses observations, insight,
Intelligence is often spoken of in a
and animals and infers insights and knowledge to explain the
broad sense, but there is a theory based on what is known about external world and the role
that multiple intelligences exist. the natural world. of humans in it.
It recognizes that people may have
the capacity to acquire and apply
Musical Interpersonal
knowledge in specific areas. For Sensitive to rhythm, pitch, Sensitive to people’s moods,
example, someone may struggle tone, melody, and timbre and feelings, and motivations.
with solving math problems but applies this to playing and Applies this to relationships
composing music. and helping groups function.
can reproduce a piece of music after
hearing it only once. Some argue
this theory supports a more Logical–mathematical Bodily–kinesthetic
realistic definition of intelligence, Quick with numbers and easily Uses heightened body
quantifies things. Figures out awareness, coordination,
while critics claim that these problems systematically and and timing to master physical
“intelligences” are merely aptitudes. thinks critically about issues. activities such as sports.
Intelligence 150 151
Arcuate fasciculus Gamma and beta waves
is an important are neural oscillations
connection between
brain regions implicated
Brain waves
in intelligence
When gamma waves
and beta waves occur
together, neural
communication is
efficient and less
prone to distraction.
Network
implicated Whole brain
in components is involved
of intelligence, in intelligence
including
abstraction
Network
neuroscience
theory
Intelligence is less
about particular
regions but rather
how the whole brain
communicates.
Plasticity is brain’s
ability to reorganize
Plasticity
Higher intelligence is
Parietal lobe has numerous related to the ability
functions associated with to make alternate and
intelligence, including additional connections
spatial awareness within the brain.
Linguistic
Has a way with words and INTELLIGENCE IS INHERITED
uses this understanding to
craft stories, convey complex
concepts, and learn languages. Physical features are not
the only traits passed from
one generation to the next. In
Intrapersonal fact, intelligence is thought to
A deep understanding of self be one of the most heritable
that can be used to predict behavioral traits in humans. It
one’s own reactions and is estimated that between 50
emotions to new situations.
and 85 percent of the
differences in adult
intelligence can be MOTHER FATHER
Visual–spatial
Able to easily judge distance,
explained by genetics.
recognize fine details, and
solve spatial problems by CHILD
visualizing the world in 3-D.
Measuring Intelligence
Measures of intelligence have been used for well over
a century, but the methods used and the way the results IQ scores are standardized
are put to use remain hotly debated, even today. so the curve is always
centered on a score of 100
Normal distribution
When scores from IQ tests are AN INDIVIDUAL’S
plotted on a frequency graph,
the result is a bell curve, or IQ SCORE CAN VARY
normal distribution, in which
most people’s scores cluster
BY 20 POINTS OR
symmetrically around the
average. For every 100 people,
MORE DEPENDING
68 will have an IQ score
between 85 and 115. At both
ON THE TEST USED
the upper and lower ends of
the scale, the frequency falls
away rapidly.
DOES A PERSON’S
IQ STAY THE SAME?
A child’s IQ score can be quite
variable with potentially
FREQUENCY
dramatic changes in score over

relatively short periods of time.
IQ scores tend to stabilize
as adults. IQ
Intelligence quotient (IQ) is a total score
derived from a standardized test that
measures aspects of intelligence, including
analytical thinking and spatial recognition.
There are more than a dozen tests that
Following a US court ruling in provide an IQ score, and they have been
2002, prisoners with an IQ lower used to stream students and recruit to
than 70 cannot be considered for
capital punishment
professions such as the military. Although
IQ tests are statistically reliable, it has
been argued that they are biased toward
the cultures from which they originate.
0.1% 2.1% 13.6% 34.1% 34.1%

CATEGORY
55 70 85 100 115
LOWER EXTREME WELL BELOW LOW AVERAGE AVERAGE HIGH

AVERAGE AVERAGE
IQ
152 153
Alternatives to IQ
IQ is not the only measure of intelligence. There are RECORD IQS
several alternatives, many of which are more visually
based, with pictures, illusions, or pattern sequences Claims of exceptional IQs (including scores over
at their core. Psychometric testing is an approach often 200) are often made but rarely verified. The
American Marilyn vos Savant held the IQ record
used in job recruitment to assess a person’s aptitudes—
(228) in the Guinness World Records from 1986
for example, to evaluate empathy when selecting a to 1989, after which Guinness retired the
carer. People who score well on IQ tests are also likely category because it concluded the tests were
to score well on other tests. This probably indicates not reliable enough.
a high level of overall cognitive ability, sometimes Attempts have also been
referred to as general intelligence factor (g). made to measure the
IQs of people who can
no longer be tested.
General intelligence
The ability to do well
Albert Einstein, for
across several specific example, is estimated
areas of intelligence to have had an IQ
is indicated by of over 160.
the general MECHANICAL
intelligence factor.
Is IQ on the rise?
There is evidence for a widespread increase in
GENERAL
VERBAL INTELLIGENCE SPATIAL
IQ. When IQ tests are revised every 10–20 years,
(g) the test-takers who are used to standardize
the new test are asked to take the previous test
as well, and they consistently score higher on
the old test. In other words, if American adults
today took an IQ test from the 1920s, the vast
majority would score in the upper extreme,
NUMERICAL above 130. This is supported by evidence from
around the world, although the rate of increase
is most rapid in developing countries. Recent
evidence suggests that this rise, known as the
Flynn effect, has started to plateau.
30 The Flynn effect

Members of the organization
Mensa have an IQ of about
In the US, there has been an average
132 or more
25 increase of 3 points per decade in IQ
scores since the mid-20th century.
Gain in IQ points
20
13.6% 2.1% 0.1% 15
130 145 10
WELL ABOVE UPPER EXTREME 5

AVERAGE
0
1940 1950 1960 1970 1980 1990 2000 2010
Creativity T W
OR
K
This network
We all get a creative spark from time E
activates when
N E
the mind wanders
to time, but what makes some of us
OD
DEFAULT M
more creative than others is linked
to our connections and coordination
between three different brain networks.
The science of creativity

Creativity—our ability to come up with new
and useful ideas—is linked to three distinct brain
networks: the default mode network, the salience
network, and the central executive network. While Daydreaming
these networks are linked, they are not typically 1 When the mind wanders,
active at the same time. However, fMRI studies the default mode network is active.
This network includes brain regions
of people asked to perform specific tasks show that involved with self-reflection,
people who can switch quickly between these thinking of others, and considering
networks at suitable moments have more creative the past or future—all things we
think about when we daydream.
responses to the task. The correlation is so strong,
in fact, that a person’s creativity can be predicted
based on the strength of the connection between
these networks.
JAPANESE INVENTOR
SHUNPEI YAMAZAKI
HAS A REPORTED 5,255
PATENTS TO HIS NAME
The creative brain

While genetics plays a role in creativity, other factors
are also significant. Low levels of noradrenaline may
support creativity as this neurotransmitter diverts inward-
focused attention to external stimuli. While this might
help our fight-or-flight response, creative ideas generally
emerge from internal sources. Creativity may also require
a strong knowledge base—composers, for example, tend
to write their best work after decades of compositions.
Creativity 154 155
WORK
Recruits other E NE T Regions activated
K IV
OR networks based UT to maintain
W on information attention on
EC
ET
EX
received particular task
EN
AL
C
SALIEN
CENTR
Switching Focusing
2 The salience network 3 The central executive network
detects sensory information to engages the conscious brain to think
determine whether the central and maintain focus on a task. Studies
executive network should engage. have shown that the default mode
For example, when hearing your network is reengaged within a fraction
name while daydreaming, the of a second of the task being completed.
salience network triggers a switch.
THE BRAIN ON JAZZ

Activity in the lateral Deactivation in lateral
WHY DO IDEAS
In one study, jazz musicians OFTEN FLOW WHEN
prefrontal cortex prefrontal cortex
were asked to play the piano
while in an fMRI machine. WE ARE NOT FOCUSED
Their brain activity was ON A TASK?
recorded as they switched
from playing memorized The brain is particularly good
music to improvised jazz. The at reconfiguring and
results showed that brain connecting information
areas responsible for the
evaluation of our own actions when it is not in a task-
and inhibition were less active orientated mode.
during improvisation. MEMORIZED MUSIC IMPROVISED MUSIC
How to Boost
Your Creativity
Just as exercise builds muscles and improves
cardiovascular fitness, there are activities that
can improve your creative conditioning by getting
areas of the brain to work together in new ways.
To boost creativity, you must first Creativity-friendly activities create mental distance from it. Imagine
remove barriers to it. Stress, time new neural connections. Learning how someone from another country,
constraints, and lack of sleep or to play a musical instrument, for time period, or age group would
exercise are known creativity example, opens and strengthens deal with the issue.
killers. People tend to be creative links between different brain areas. Allow yourself to disconnect.
when they are rested, happy, and Simply varying your routine can If you are stuck in a line, don’t
can let their thoughts wander freely. also foster creativity, so pick a more default to your phone to check
Many people claim to have their interesting route to work, a color emails or social media; instead,
best ideas during their morning you don’t usually wear, or a new zone out and let the ideas flow.
shower or walk to work. It seems recipe to cook. Surround yourself The next time you are stuck for
that ideas flow most freely around with like-minded, creative people ideas, try one of the following:
our brains when they are not in a as much as possible. Whether it is • Get enough rest, destress,
task-orientated state but instead in in a gallery or a garden shed, new and exercise.
a condition called the resting state. input stimulates new ideas. • Learn a new skill. Spend time
Unsolvable challenges encourage with other creative people.
Cultivate new connections novel ways of thought. How many • Think outside the box. Think
Routines help regulate our daily things can you think of to do with of new ways to solve old problems.
lives, but they also reinforce a paper clip, for instance? If you are • Switch off from digital devices
existing neural pathways. stuck on a problem, get some to give your brain some downtime.
156 157
Belief
Our brains can distill complex information, taking
unexplainable observations and evaluating and
categorizing them. From this, we form propositions—
true or not—that guide us in life.
How do our beliefs form?

Knowledge Events
Our beliefs develop out of what we hear, see, What you know Positive and negative
and experience, from our interactions with impacts on beliefs and events both shape how
others and with our environment. They are challenges those held. you view the world.
entwined with our emotions, which is why an

emotional response is often evoked when those Future vision Environment
How you imagine life Where, how, and who
beliefs are challenged. Beliefs are accepted as raised you underpins
to be is intricately
truth, whether there is proof or not. Our beliefs linked to your beliefs. many beliefs.
then become a filter, where information that
does not support those beliefs is rejected, Facets of belief
Past results
potentially limiting our perceptions of the world. We process information from many
Successes and failures
aspects of life in order to form our
Beliefs are not static, though—each of us has beliefs. Equally, our beliefs also shape
shape your beliefs
about what is possible.
the power to choose and change our beliefs. how we process this information.
Ventromedial
prefrontal cortex
activated in belief
Insula registers
disbelief
Bad behavior Brain areas

1 The human brain is exceptional at 2 Regions of the brain involved in
spotting patterns in even random phenomena. emotions are important in establishing
Before humans understood what lightning beliefs. The biochemical basis of beliefs is an
was, for example, they looked for patterns, active area of research as evidence, including
and many cultures around the world the placebo effect, suggests that beliefs
believed it coincided with bad behavior. trigger biochemical responses in the body.
158 159
The layers of belief
WHY DO SOME The deepest layer of beliefs, core beliefs, are the
PEOPLE HAVE principles that guide our actions (processes). It is our
EXTREME BELIEFS? actions that then determine what our outcomes are.
People with extreme beliefs When we are looking to make changes in our life, we
often focus on outcomes as these are the easiest to
may not transition easily
change in the short term. However, to foster long-
from one concept to lasting change, we need to change our habits, and
another—a way of thinking to do this, we may need to examine our core beliefs.
known as cognitive
Core beliefs
inflexibility. Your core beliefs are intertwined with
how you view yourself and the world
around you and are therefore the most
tightly held and inflexible.
OUT
CO
ME
S
PRO
CE
SS
CORE BELIEFS
ARE FORMED BY CORE B
EL
I
AROUND AGE 7
EF
REASONING BELIEFS
There are three types of beliefs: factual, preference, and
ideology. If two people are debating factual beliefs, only
one of them can be right, whereas both people can be
right in the case of preference. Ideological beliefs draw
elements from both fact and preference. Preschoolers
can differentiate between these types of beliefs and
recognize that, in some cases, two people can be right.
PREFERENCE PREFERENCE
Orange is the Green is the
prettiest color prettiest color
FACTUAL FACTUAL
2+2=4 2+2=5
Supernatural explanation
3 As well as spotting patterns,
the human brain favors intention over IDEOLOGY IDEOLOGY
randomness. The idea that lightning was There is only There is
intentionally wielded by gods to punish bad one God no God
behavior was therefore more satisfying than
it being a random natural event.
CONSCIOUSNESS
AND THE SELF
What Is
Consciousness?
Consciousness is our awareness of external
stimuli (such as our surroundings) and internal
events (such as our thoughts and feelings). We can
identify the brain activity that generates conscious
awareness, but how this phenomenon arises
from a physical organ remains a mystery.
Locating consciousness
Our thoughts, feelings, and ideas are all activities
of the brain—products with a neurological basis.
However, it is unclear whether it is the neurological Monism
activity itself that forms consciousness (or the “mind”) According to monism, every
thought, feeling, and idea is a
or whether it is merely linked to consciousness. This product of the brain activity that
is the fundamental difference between two theories occurs as the result of a stimulus.
of consciousness. The first, monism, equates the This brain activity is itself the
conscious perception of the object.
mind with the brain, while the second, dualism, In other words, the brain is the mind
sees the mind as separate from the brain and body. and vice versa.
MONISM
LISM
DUA
HT
LIG
Where is the mind?

When we see an object, it is the result of our
brain perceiving a light stimulus. However,
whether this activity in our brain directly leads
to consciousness, or whether the activity links
to an external mind, is debated.
VIRTUAL REALITY BRAIN STEM DEATH

Virtual and augmented In some parts of the world, the legal definition of death
realities are no longer is brain stem death. Irreversible damage to the brain
restricted to the plots of stem (see p.36) prevents it from regulating the
science fiction. Computers automatic functions essential to life. These may be
are now used to simulate continued with the help of medical equipment, but
external stimuli—such as the person will never regain consciousness.
sights or sounds—that
provide the brain with
an alternative reality.
CONSCIOUSNESS AND THE SELF
What Is Consciousness? 162 163
COULD ARTIFICIAL
Dualism
The dualist theory argues that the mind INTELLIGENCE
(which is nonphysical) exists outside of BECOME CONSCIOUS?
the brain (which is physical) but that the
two interact. The brain activity that Some scientists do believe that
happens as a result of the stimulus is
associated with conscious perception, artificial intelligence could be
but the mind itself is separate. programmed to be conscious;
others believe consciousness
is not something that
machines could
ever learn.
The requirements of consciousness

The neural basis of consciousness remains an area of research, which is
directed at identifying the structures and processes in the brain that are
necessary to produce a conscious experience. The process of consciousness
is believed to be at the level of individual neurons rather than at the level of
individual molecules or atoms. It is likely that for consciousness to arise, the
four factors below must be present.
S G
TE IN
A
IR
GR
SF
OU
RIN
SYNCHRON
HIGH FI
BETA BRAIN WAVES
A normal state of consciousness occurs Consciousness may depend on the

when neurons fire at fairly high rates. synchronicity of neurons. Clusters
Beta waves (see p.42) occur when of neurons firing in unison “bind”
neurons fire at a high rate, and individual perceptions—such as
indicate alertness and sight, sound, and smell—to
logical, analytical create one perception.
thinking.
IN 1 OR 2
OF EVERY
Y
1,000 G
IT
IN
TIV
TIM
MEDICAL
AC
FRONTAL
PROCEDURES
INVOLVING GENERAL
It can take half a second for the The frontal lobes may play an
ANESTHESIA, unconscious brain to process stimuli important role in aspects of
into conscious perceptions—but consciousness, including feelings
A PATIENT MAY our brain is capable of making of reflection, as well as
us think that we experience
BECOME CONSCIOUS things immediately.
coordinating levels of
consciousness.
Parietal lobe Frontal lobe
holds spatial contains frontal
Paying attention maps eye field
Attention directs our consciousness
(see pp.162–163) to focus more
OPTIC NERVE
intently on a particular sensory
input, such as a sight or sound, and
to tune out competing information. Superior colliculus acts
The process of paying attention as a tracking system,
begins with the sensory organs, directing head and eyes
to follow an object
which activate various areas of the
brain, including the frontal and
parietal lobes. The parietal lobe
processes spatial information, Attention areas
directing attention to an area of Key to paying attention to visual stimuli
is the frontal eye field, located in the frontal
space, while the frontal lobe directs lobe, and the superior colliculus. Together,
the eyes to focus on specific objects. they instruct our eyes to focus on an object.
Attention
Attention is the process of concentrating or
focusing on specific information. The brain is the
RESEARCH SUGGESTS
main organ that processes both behavioral and THAT THE AVERAGE
cognitive information, although other parts of the HUMAN ATTENTION
body, such as the eyes and ears, are also required. SPAN IS JUST 8 SECONDS
ATTENTION DEFICIT
HYPERACTIVITY DISORDER
Attention deficit hyperactivity disorder (ADHD) ARE OUR ATTENTION
is a behavioral disorder (see p.216) that includes
symptoms such as inattentiveness and hyperactivity.
SPANS SHRINKING?
The exact cause of ADHD is not yet fully understood. There is no evidence that our
Research suggests that there
may be an imbalance of individual attention spans are
neurotransmitters or a genetic shrinking, but a recent study
cause. Any potential genetic suggests that our collective
cause of ADHD, however, is
thought to be complex and is attention span—how long as a
unlikely to be caused by society we focus on a news
a single gene. story or trending topic, for
example—is decreasing.
Attention 164 165
INED ATTENT
USTA ION
S
E ATTENT
ECTIV
Sustained attention is the
ability to concentrate on a specific EL ION
S
task, such as reading a book, for a long
period of time. Brain imaging studies have
shown that the frontal and parietal cortical Selective attention is the
areas, particularly in the process of focusing intently on
right hemisphere of the something specific, such as an object or
brain, are associated with sound, while tuning out our environment.
sustained attention. Ignoring the sound of a car while paying
attention to a phone
is an example of
selective attention.
TING ATTEN
ERNA TIO
Types of attention AL
T N
There are various types of
IDED ATTENTIO
DIV
attention, and the sort of attention Alternating attention is the
ability to switch attention quickly
N
that is required depends on the between tasks that require a very
circumstances that we are in. different cognitive response. Cooking Divided attention is used so
Both sustained and selective dinner while periodically that we are able to perform two
checking a recipe in a or more activities at the same
attention are used when we book is an example of time—for example, riding
need to focus fully on one stimulus. alternating attention a bicycle while listening
Alternating and divided attention between different tasks. to music. This type of
are used when there are multiple attention is sometimes
called multitasking.
inputs that we need to focus on
at the same time. Attention is
not an unlimited resource and the
process of focusing our attention on
something can be tiring, as it needs
a significant amount of energy.
Distractions During periods

The brain is not able to focus our attention of distraction, brain
constantly. Instead, it cycles rapidly between two scans environment
different states: attention and distraction. During
periods of distraction, the brain scans the
Looking for trouble
environment to check that there is nothing more Even when we think we
important to which it should be paying attention. are focused on a task,
This cycle is thought to give an evolutionary our brain is checking
the environment so
advantage to humans, allowing us to respond that attention can be
quickly to either new opportunities or threats. diverted if necessary.
166 167
How to Focus
Your Attention
Focusing your attention requires your brain to process specific
information. Learning how to accomplish this in a world where
there are plenty of distractions is crucial to allow you to learn,
understand, and function properly.
Attention is a limited resource, external and internal distractions. responses, and the retrieval of
and focusing it has to be carefully While you are reading this book, long-term memories.
managed if you are to be able to you will hopefully be focusing your Research suggests that once
limit distractions and concentrate attention on the words written your attention is distracted from
on specific tasks. The ability to in the text. However, your brain completing a task, it can take an
focus attention varies between will be bombarded with a range average of 25 minutes to return
people. It is influenced by both your of distractions. These can emanate to the original exercise. So the
interest in the task at hand and the from a variety of external sources. next time you are being distracted,
number of distractions that you For example, the television may try one of the following to focus
encounter. If you are really be on in the background or people your attention:
interested in something, you may may be having a conversation • Keep potential distractions away.
not even notice other distractions around you. Turn off any electronic devices
that occur in the environment You might also be faced with and move to a quiet place.
around you. This is simply because internal distractions. Hunger may • If the task at hand is unavoidably
it is easier to focus your attention motivate you to start thinking monotonous, it can help to remind
on something if you are engaged about what you are having for yourself why you are doing it.
with it. So how can you increase dinner. You might suddenly • Imagine the sense of
your ability to focus your attention? remember an important task that accomplishment you will feel
had slipped your mind. These types upon completing the task. This
Distractions, of internal thoughts are driven by can provide additional motivation.
distractions, distractions an area of the brain called the • Gradually and slowly increase
Focusing your attention involves medial prefrontal cortex (see the time that you try to focus your
concentrating on something pp.30–31), which is associated attention. This can improve your
specific, while tuning out both with decision-making, emotional attentional focus.
Free Will and CAN YOUR
the Unconscious
UNCONSCIOUS HELP
YOU SOLVE A PROBLEM?
If you are stuck on a problem,
Many activities in everyday life—from our letting your mind wander can
movements to our emotions—are not controlled allow the brain to collect
consciously. Instead, unconscious activity in the information from your
brain is behind a lot of our actions, thoughts, unconscious and potentially
and behaviors. provide a solution.
Free will
The ability to choose a course of action without restriction is
called free will, and it may seem that we use our conscious mind Benjamin Libet’s experiment
to make these decisions. However, research suggests that we Scientist Benjamin Libet instructed his
may have less conscious control over our actions than we think. subjects to note down when they became
conscious of their decision to raise a finger.
Experiments have shown that our brain begins to plan a movement At the same time, their brain waves and
one-fifth of a second before we consciously decide to make a move. muscle movements were recorded.
Brain Conscious
1 activity
2 thought 3 Finger
raised
An electroencephalogram The subject records the An electromyograph (EMG),
(EEG, see p.42) shows brain exact time when they become an instrument that measures
activity increasing one-fifth of a aware that they want to raise muscle movement, records
second before conscious thought. their finger. the moment the subject
raises a finger.
Subject at rest, Unconscious Moment subject EMG records

with finger flat brain activity makes conscious muscle movement
on table plans finger decision to from finger
movement move finger being raised
Point at which
unconscious brain
G
N
DI
activity signals to
muscles to raise finger A
RE
G
EE Planned action EMG
READING
–500 –200 0
Time (milliseconds)
Free Will and the Unconscious 168 169
Levels of consciousness
In the early 20th century, neurologist Sigmund Freud
popularized the idea that the mind is divided into
three levels of consciousness: the conscious mind
(mental processes we are aware of), the preconscious
(processes we are not aware of but can be brought Introspection Normal consciousness
into the conscious), and the unconscious (inaccessible We examine our thoughts, We have a sense of agency—we
mental processes that influence our behavior). More actions, and emotions—for believe that we control our
example, we may brood over thoughts and that they
modern thinking suggests that there are several levels an action we have taken. influence what we do.
of consciousness, ranging from intense self-reflection
to the deepest sleep.
95 PERCENT
OF OUR DECISIONS Unconscious knowledge
We can perform complex tasks,
Lack of consciousness
Asleep, we neither perceive
ARE MADE BY OUR though may not have a memory the world around us nor have
of doing so—for example, not the sense of self to experience
UNCONSCIOUS MIND remembering the drive home. things such as time passing.
MAKING DECISIONS
Ironic process theory
If we are asked not to think of a white bear, we will probably think of In 2006, two Dutch researchers
a white bear. This is because a deliberate attempt to suppress a thought asked subjects to make a complex
makes it more likely to occur. This phenomenon is explained by an idea decision under one of three
known as ironic process theory. The idea is that the brain unconsciously conditions: with little time for
monitors itself for occurrences of the unwanted thought—which, ironically, consideration; with ample time;
then makes us aware of the thought. This or with ample time but distractions
that prevented conscious thought
is partly why quitting smoking is difficult
about the decision. In all cases, the
or why trying to forget a bad memory distracted subjects performed best.
rarely works—the unconscious reminds The findings suggest that people
us of the things we are trying to forget. can make better decisions
unconsciously than consciously—
although the experiment suggested
this is true only when we are
making complicated decisions.
Altered States Physical and physiological
Extreme environmental
An altered state of consciousness is any condition conditions, such as high altitudes
that differs significantly from our normal state of or weaker gravity in space, can
induce altered states, as can
consciousness (see pp.162–163). It is almost always extended fasting and breath
manipulation.
temporary and always reversible.
Types of altered states

Altered states can be grouped into Psychological
categories based on how they are An altered state can be induced
induced. However, all altered states through certain cultural or
disrupt brain function in some way. religious practices, such as
meditation or trances brought on
through dancing or drumming.
Other examples are sensory
deprivation and hypnosis.
Disease-induced
Spontaneous Disease and illness can alter the
Spontaneously induced altered conscious experience to different
states include drowsiness, degrees. Examples include
daydreaming, near-death psychotic disorders such as
experiences, and the state of schizophrenia (see p.211), as well
consciousness that happens just as epileptic seizures and coma.
before you fall asleep (known
as a hypnagogic state).
Pharmacological
Psychoactive (mind-altering)
drugs, such as alcohol, cannabis,
or opioids, disrupt how the brain’s
neurotransmitters function,
altering the user’s awareness and
consciousness levels.
IS A NEAR-DEATH What is an altered state?

When we are in a normal state of consciousness,
EXPERIENCE AN
we are aware of external stimuli (such as our
ALTERED STATE?
surroundings) and internal events (such as our
This is highly debated, but those thoughts). However, the brain can produce a much
who have had such experiences wider range of conscious experiences, including
altered states. Whenever we enter an altered state,
describe elements, such as
our brain patterns change. This disruption in brain
a sense of timelessness, function can be caused in different ways, including
common to other changes in blood flow and oxygen to the brain or
altered states. interference with neurotransmitter function.
Altered States 170 171
Controlled and Self-control

automatic processes We may have difficulty
The way we are able to perform controlling our actions and
controlled processes (tasks that movements, for example walking
require our full awareness, such as a straight line while intoxicated.
solving a puzzle) and automatic It may also be difficult to restrain
processes (tasks that require emotions, often resulting in
relatively little attention, such outbursts of crying
as reading a book) or aggression.
is compromised.
Identifying an
altered state
Level of awareness Consciousness is a spectrum from Emotional awareness
In an altered state, our level highly alert to total lack of Often in an altered state we
of awareness of events going on will have less emotional
around us—as well as internally—
awareness, with a “normal” state awareness (the experience of
may be increased or decreased somewhere in the middle. Altered emotions), as well as finding it
compared with normal waking states, meanwhile, can be on either difficult to control those emotions.
consciousness. More often, our This can make us more or less
level of awareness is lowered in
side of the scale, with greater or affectionate, aggressive,
an altered state. lesser awareness than normal. An or anxious.
altered state can be identified
using different criteria.
382
Perceptual and Time orientation
cognitive distortions In an altered state, our
Perception may be altered. sense of time (see pp.174–175)
DAYS Normal processes for storing

and retrieving memories may
be more fragmented or less
can become distorted; time
may appear to slow down or
speed up. This is because there
THE LONGEST accurate. Thought processes
may be disorganized and
is less awareness of time
passing, just as we are unaware
RECORDED FAST less logical. of time while we sleep.
FROM SOLID FOOD
Altered states in the brain Decrease in activity in Altered activity in

frontal lobe reduces parietal lobe distorts
Altered states can lead to a range
ability to reason and spatial judgments and
of experiences, from feelings of make decisions time perception
bliss to a sense of terror. These
experiences are generated by a Thalamus—which acts
as gateway between Changes in temporal
similarly diverse range of neural lobe function lead to
limbic system and
activity in various parts of the brain. frontal cortex— unexplainable experiences
Alterations to normal brain function can be inhibited such as hallucinations
can result in our brain distorting
incoming information, leading to Locating altered states
In an altered state, activity in different Signals from reticular formation,
auditory or visual hallucinations, areas of the brain may increase or decrease, which plays important role in
memory distortion, or delusions. distorting how we perceive the world. consciousness, can be reduced
Sleep and Dreams HOW MANY
When we are asleep, it may seem like our brains are quietly HOURS OF SLEEP
DO WE NEED A NIGHT?
resting, but they are actually busy processing and storing
information that we have learned throughout the day. Most adults need
7–9 hours of sleep a night,
The stages of sleep but teenagers and children
During the night, we cycle through different sleep stages, moving from (especially babies)
light to deep sleep then to rapid eye movement (REM) sleep. Our brain need more.
waves, produced by the electrical activity of neurons in the cortex (see
p.42), change in each stage. As sleep becomes deeper, the waves
become slower (with lower frequency) and more organized. We repeat Period of wakefulness
during night
this sleep cycle every few hours, but the proportions shift; we have
more slow-wave sleep at the start of the night and more REM If woken during REM sleep,
sleep in the early morning. we are more likely to
3AM remember our dreams
2AM 4AM
A not-so-silent night
There are four distinct stages
of sleep, and we pass through M
each stage several times a 1A 5A
night. During light sleep, Level 1 is M
we are easily woken. lightest stage
It is much harder of sleep
to wake from
deep sleep. AM
12
6A
In REM sleep, body

M
is paralyzed, but
eyes dart about
under eyelids
PM
Longest periods of
11
deep sleep are at
beginning of night During level 2 sleep,
ess
7A
heart rate and breathing

M
a renAKE
become even
ke
s aw AW
wa n
HT
e
ive
ciou
s to a f b r a i M
LIG EP
act ep;
e
SLE
s
wn
Cons
pat
do L 2
wav tern o RE
r
L
l a
w
wav t sl L 1
i
o
ar
m
sl EVE
Si
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LEV
brain Ligh LEVE

aves EP
d re e s a r e
SLE
n
EP
a
DE
Br ai
Brain w
slow n wav EL 3
Cleaning the brain
SLEEP DISORDERS During the day, our brain
activity produces by-products
Problems like sleepwalking, sleep THE
that can become toxic if GL
talking, and paralysis occur when YM
they build up. Recent studies Debris swept away by
the brain fails to make a clean cerebrospinal fluid
PH
shift between sleep states. This using mice have shown
AT
leaves part of our brain awake that sleep gives the brain Astrocytes shrink,
IC
allowing fluid through

S
while other parts are sound a chance to clean these

asleep. When a person
YST
by-products away. It seems

sleepwalks, the motor areas of likely that something similar
EM
the brain are awake and active,

happens in humans, which BLOOD LYMPHATIC
but the conscious awareness and VESSEL DUCT
memory areas are asleep. People may explain some of the
can even perform complex tasks negative effects sleep
such as driving while fast asleep. deprivation can have on our
ability to learn, remember, Flow of Neurons
cerebrospinal fluid produce debris
and manage our emotions.
There is evidence to suggest that while we sleep, some
of our brain cells shrink, allowing cerebrospinal
fluid to flow more easily between them. The
THE LONGEST fluid carries away any waste that has
accumulated to the lymphatic ducts,
RECORDED ATTEMPT TO where it is removed from
STAY AWAKE IS 264 HOURS the body.
Thalamus delivers
The dreaming brain Areas of prefrontal signals to cortex
cortex are inactive, Parietal cortex,
Scientists do not know why we dream, but so reason not which controls
Sleep and Dreams
they have theories. Dreams might help us applied to dreams awareness of

process information and emotions encountered oneself, is inactive
Amygdala generates
during the day and store them in our long-term emotions
Hippocampus sends
memory (see pp.138–139). A dream might also
new memories to cortex
be like a rehearsal—our brain is trying out
KEY
responses to extreme events in safety so we
Active Inactive Visual cortex
would be prepared if the event happened in generates
real life. This might explain why dreams are imagery
often stressful or negative. Another idea is that Activity during REM sleep
172 173
Emotional brain regions are very active during REM Reticular formation
dreams are merely “screen savers” for the sleep, as is much of the cortex. The frontal lobes, switches between
mind, with no real purpose at all. involved in rational thinking, are much less active. sleep and wakefulness
Time
We can measure time objectively—by hours, minutes,
and seconds—with clocks, but our brain also helps us
Direction of
keep track of time passing. Our internal clocks are all set dopamine flow
at different speeds and even change within our lifetime.
The timekeeper brain

Our concept of time is linked to a neural network Anterior part
involved in memory and attention. Neurons in the of prefrontal
cortex
network fire, or “oscillate,” and the brain uses this to
keep time. The more oscillations in a measured second,
the more we think that time is lasting longer. Events The dopamine clock
(such as near-death experiences), state of mind (such as Another one of the brain’s Basal ganglia
depression), stimulants (such as caffeine), and disease clocks is formed of the oscillation,
or cycle, of dopamine flowing between
(such as Parkinson’s disease) can all affect the rate at the substantia nigra, basal ganglia, and Substantia nigra
which the neurons fire, skewing our perception of time. prefrontal cortex.
FRAME 1 FRAME 2 FRAME 3 FRAME 4
Frames 1 and 2 seen Frames 3 and 4

as one packet, so we are in separate
see only one event packets, so
movements seen
as two events
Packets of time
One cycle of a brain
clock equals one
“packet” of time, which
we register as a single
event. Just as a camera
with a higher frame rate
will capture more details Dopamine cycle
in a sequence of events, doubles in speed
faster rates of neuronal
firing will create more
TIME PACKET 1 TIME PACKET 2 TIME PACKET 3
time packets, registering
more events. 0.1 Time (seconds) 0.2 0.25 0.3
TIME ILLUSIONS
Distance can skew our perception “B” flashes 10
of time. If three lights flash one after seconds after “A”
another at equal time intervals (of
10 seconds, for example) but the
distance between lights “B” and “C” is “C” flashes 10
greater than the distance between “A” seconds after “B”
and “B,” it will create the illusion that
the time between “B” and “C” flashing
was longer than 10 seconds. A B C
4 IN (10 CM) 8 IN (20 CM)
Time 174 175
Time and age
It can feel like time speeds up as we get older—
a trip that felt like an eternity as a child passes quickly
as an adult. Part of the reason for this is that
our perception of time develops as we age. As infants,
we live in the moment—we cry if we are not fed on time,
but we are not aware of the passage of time. As
toddlers, we are taught to become aware of time, and
we learn how long it takes to perform everyday tasks,
such as brushing our teeth. By the time we are six years
old, we can estimate time, applying our knowledge
of how long something takes to new situations.
Factors affecting time perception

As adults, we are more conscious of time, as we have
responsibilities and schedules. These routines of
moving from one event to the next can speed
up our perception of time.
However, there are also HOW DO DRUGS
biological, proportional, AFFECT TIME PERCEPTION?
and perceptual theories as
to why time seems
to speed up
Dopamine is the main
with age. neurotransmitter involved in
time processing. Some drugs,
such as methamphetamines,
activate dopamine receptors,
speeding up the perception
Metabolism
of time.
In a 24-hour period, a four-year-old’s
heart will have done 125 percent of the beats
of an adult heart. Other biological markers, such
as breathing, are also faster. This means children take
in more information, so time appears to move slowly.
PERCEPTION OF TIME
Proportional theory
As we age, time intervals constitute smaller fractions IS SUSPENDED WHEN
of our lives as a whole. For example, one year is 10 percent
of a 10-year-old’s life but only 2 percent WE ARE ASLEEP
of a 50-year-old’s life.
Perceptual theory
The more information we absorb and process, the slower we
perceive time to be. Children, who are experiencing many
things for the first time, pay more attention to details that
adults dismiss, which may stretch out time.
Pathways in the brain

As we age, the pathways in our brain grow more complex, so
signals take longer to travel along them. This means older
people view fewer images in the same amount of objective
time, so time seems to pass more quickly.
What Is Personality?
Our personality makes us who we are. It is a set of behavioral
characteristics that shape the choices we make in life and how
we react to the world. Various systems have been invented to
assess and classify personality.
Changeable personality
From the moment we are conceived, DNA begins to shape our personality,
leading us to produce more of a certain neurotransmitter than another, for
example, or making us less sensitive to a hormone compared to other
people. This affects our underlying temperament, and even our final CHILD
FRIENDS
personality to some extent. However, as well as our genetics, who we
are is also shaped by our experiences and environment.
Becoming you Closed body

As we grow, our brains mature along language may
PARENTS
SCHOOL
set patterns and change through suggest shy
experience. Regularly used neural personality
pathways become stronger, and we
may become more or less reactive Developing
to neurotransmitters and hormones. 2 a personality
This changes our personality. Throughout childhood,
our brains change
rapidly, and experiences
HOME
affect our personality.

Home life has a large
BABY impact, as do friends
and interactions at day
care or school.
DAY CARE
FAMILY
DN
A
DO IDENTICAL
TWINS HAVE THE SAME
PERSONALITY?
Identical twins, with the same
DNA, have more similar
personalities than nonidentical
Early temperament
twins. But there are also
1 As a result of the role genetics plays in differences, due
forming personalities, even newborn babies
behave differently from each other. For
to their individual
example, some seem very sensitive to noise experiences.
or disruption—by contrast, others hardly
notice them.
What Is Personality? 176 177
PERSONALITY IN THE BRAIN
Crossed arms may
indicate defensiveness Scientists have tried to link different personality types
or insecurity to brain structures, but the results have been mixed. We
do know that brain damage, particularly to frontal areas,
can have an impact on someone’s personality, and
studies have linked certain traits to differences in brain
Fashion choices structure or activity. So far, however, the
used to reflect
complexities of both the human brain
personality
and our behavior have made the links
ADULT hard to unravel.
Adult personality
3 As well as environmental
factors, such as school or
friends, our personality alters
due to the fact that our brains
do not finish maturing until
Assessing personality
our early 20s. Our personality The most common personality assessment,
goes on to change subtly the Big Five test, identifies how a person scores in
throughout adulthood.
terms of five traits: openness, conscientiousness,
extroversion, agreeableness, and neuroticism.
A person is placed along scales for each trait,
with one end being the least likely to exhibit
this trait, and the other the most.
TRAITS OF LOW SCORERS TRAITS OF HIGH SCORERS

Openness is the
Practical; inflexible; Curious; creative;
tendency to appreciate
prefers routine; adventurous;
new ideas, feelings,
conventional, focused unpredictable
and behaviors.
OPENNESS
Conscientiousness
Impulsive; disorganized;
relates to traits such as Dependable; hardworking;
dislikes structure;
following rules and organized; stubborn
flexible, spontaneous
being hardworking.
CONSCIENTIOUSNESS
Extroversion is the
Quiet; withdrawn; Outgoing; articulate;
tendency toward being
reserved; prefers dominant; friendly;
sociable, assertive, and
solitude talkative
expressive.
EXTROVERSION
Critical; suspicious; Agreeableness concerns Helpful; empathetic;

uncooperative; insulting; being cooperative, trusting; caring; polite;
manipulative trustworthy, and kind. amiable; meek
AGREEABLENESS
Neuroticism relates to
Anxious; easily upset;
Calm; secure; emotionally emotional stability and
unhappy; stressed;
stable; relaxed tendency toward
moody
negative emotions.
NEUROTICISM
The Self
The self is an accumulation of concepts of who
we are, who we were, and who we want to be. We
Detects physical Detects sensations from
derive our sense of self in different ways, through interactions; confirms body; gives repeated
awareness of ourselves as physical beings, as body’s boundaries reminders of physical self
agents of our actions, and as a part of society.

Maps body and
its relationship
What is the self? to outside world
The self is our internal sense of who we are, which SOMATOSENSORY
develops through our evaluation of our experiences MOTOR CORTEX
PA OR
of the world. It is formed of two aspects: the ANTERIOR CORTEX
C
RI TEX
AL CINGULATE CIN
ET
physical self (who we are as tangible beings)
L
GU PO
PREFRONT
MEDIA
AL
CORTEX
CORTEX
LA S
and a mental self (which can be seen as our T
TE CORTEX
E
autobiographical memory). There are several
RIOR
linked areas of the brain that contribute to
our sense of self. Our physical sense of self
is created by areas that tell us how our
body occupies space, while areas that
allow us to reflect on our mental state
and retrieve memories contribute
Monitors
to our mental self. our actions
Enables consciousness of
mental state and character
Active in personal memory
retrieval and awareness of
social interactions
The mirror test

To determine whether a human (or animal)
Adult understands has the ability to recognize itself in a mirror, a
reflection is herself test called the mirror test is used. A mark is
so points to her drawn on the face of a subject to see whether
own nose they will wipe it off; if they do, it indicates that
they have a sense of self. This ability develops
at about two years old in humans.
Baby does not recognize

reflection as himself, so
points to “other” baby
with mark on his nose
The Self 178 179
The actual and ideal self SELF AND IDENTITY
There can sometimes be a difference between who we believe we are (our
actual self) and who we aspire to be (our ideal self). How we perceive our The self is a first-person
actual self shifts in response to feedback and challenges from the social account of how we perceive
environment. Some psychologists believe that when our actual self is close and evaluate ourself. Identity
to our ideal self, we are more able to live a balanced, happy life. involves the specific beliefs
and characteristics that can be
Congruence used to define a person and
When the difference between our Small overlap indicates our Large overlap suggests distinguish them from others.
actual self and ideal self is small, we actual self does not reflect our actual self is similar
are said to be “congruent.” who we aspire to be to who we aspire to be
Actual self Ideal self Actual self Ideal self
INCONGRUENCE CONGRUENCE
The development of self

The concept of self begins as soon as we are able
to recognize that we are an individual being that is DO DOGS RECOGNIZE
Am I
distinct from other objects and people. This basic liked? THEMSELVES IN
sense of self happens shortly after birth, but it is A MIRROR?
not until our second year of life that we begin to
develop a more complicated view of who we are. Dogs fail the mirror test, but
some scientists have argued
that the test might not work
I am 3.
for animals that do not rely
I am good.
on sight as their
primary sense.
60 PERCENT OF
SOCIAL MEDIA
USERS SAY IT
2 YEARS OLD 3–4 YEARS OLD 6 YEARS OLD NEGATIVELY
Self-description Categorical sense of self Defining self against peers
IMPACTS
By two years old, toddlers
begin to refer to themselves
Young children define
themselves in terms of
By school age, children start
comparing themselves to
HOW THEY
as “me.” They often describe properties and categories— their peers. Many beliefs FEEL ABOUT
themselves as they may be these are usually concrete, about their self stem from
perceived by other people. such as age or hair color. how others react to them. THEMSELVES
THE BRAIN OF
THE FUTURE
Superhuman RETINAL IMPLA
NT
Senses
The latest electronic devices almost rival our
eyes and other sense organs. Future versions
may not only restore lost sensory function
Implanted
but even expand our range of sensations. retinal array of
microelectrodes
Transmitting sight and sound

Cochlear implants were introduced in the 1970s and Data transmitted to implant
TEX ORY
retinal implants first appeared in 2011 to help people
3 The relay sends wireless signals
COR SENS
to the antenna of a prosthesis on the
with severe hearing and sight problems, respectively. side of the eyeball. The antenna passes
ATO
Video cameras and microphones “catch” light and the signals along wires to a retinal array
SOM
sound and convert them into signals that travel to implanted inside the eye.
a processing unit. This creates a digital “map,”
which is relayed via wireless signals to an implant. Electrodes stimulate
The implant sends the data via nerve impulses VIDE olfactory bulb
O C AM
to our relevant sensory region of the brain. ER A AUDITORY CORTEX
Camera
captures
images A
TENN
ESP Wire travels
to electrodes
AN
Some people report that they implanted in RETINAL

receive information or awareness nostril IMPLANT
that could not have originated from
known sensory inputs. Such
NECTS TO ELECTRODE
occurrences can be labeled ON
EC Electrosniffers
extrasensory perception (ESP) but
IR
Some “electronic noses”

W
can usually be explained by sudden

feature copied human
recall of forgotten experience or proteins that work as
coincidence. Future research may receptors, creating electric Optic nerve carries Relay transmitter
also reveal natural human abilities pulses that travel along a impulses from sends signals
to detect magnetic fields and other wire when contacted by deeper retinal cells wirelessly to
phenomena. a certain substance. to visual cortex antenna on eyeball
Scans show Video camera Video data

more right
1 One or two small video 2 The smartphone-sized
hemisphere cameras worn on glasses form VPU, worn on the body but
activity in images from incoming light rays. potentially implantable,
reported ESP The images are converted to converts the camera’s video
Airborne odor and
electrical signals and sent along signals into a digital “map”
flavor molecules
wires to a portable video of spots or pixels. It sends this
enter nasal cavity
processing unit (VPU). along wires to a receiver-
transmitter relay mounted
on the glasses.
THE BRAIN OF THE FUTURE
Superhuman Senses 182 183
Implant sends data to brain
4 The retinal array is an electronic ARTIFICIAL SKIN
grid that sends signals to the deeper
layers of cells in the retina, bypassing
Evolving forms of artificial skin contain graphene sheets with domed
its faulty light-detecting cells. These
deeper cells create nerve impulses electronic sensors. Physical changes such as temperature and pressure
that travel to the visual cortex. stretch or squash these sensors to generate electrical signals that are
then transmitted to the somatosensory cortex in the brain.
Protective
Dead high-grip
epidermis surface
Microsensors Moving
Touch area of electrical
in upper
brain receives charge
layer detect
signals from
light touch Graphene
artificial skin
and pain sheet with
Auditory area Microsensors domed
of brain receives in lower sensors
signals from layer detect Moving
cochlear implant pressure and electrical
temperature charge
VISU
FINGERTIP SKIN ELECTRONIC SKIN

AL CO
RTEX
RECEIVER
Camera signals
travel to VPU
TRANSMITTER Signals from transmitter
pass wirelessly to receiver
inside skull
Signals from receiver

travel along wire to
cochlea
COCHLEAR
W
Microphone
IR
NERVE
E
converts
sound waves
to electrical
signals
EAR CANAL
EA
HL
C
Signals travel CO
along wires from Electrodes directly
body-worn VPU stimulate cochlear
nerve fibers
ELECTROSNIFFERS
DETECT SCENTS WITH Cochlear implant
Many designs of cochlear implant bypass damaged
AROUND 97 PERCENT parts of the outer and middle ear and the sensory cells
of the inner ear’s cochlea. They work by supplying tiny
ACCURACY electrical signals directly to cochlear nerve fibers.
1 Motor cortex
The brain’s
Wiring the Brain
movement center formulates
patterns of motor nerve impulses
Until recently, only the brain controlled the body’s
that naturally coordinate dozens of muscles and glands. But next-generation electrical,
muscles to move the arm and hand.
mechanical, and robotic devices—often developed
Motor cortex after limb loss—are extending its abilities.
Somatosensory
cortex
Bionic limbs
Motorized bionic limbs now exist that react to activity in
the brain’s motor cortex, responding to instructions sent
as tiny electrical impulses along motor nerves. These
increasingly powerful prostheses can also provide sensory
Spinal cord feedback so that the brain’s control systems can provide
links to arm
nerves
delicate ongoing control, more closely mimicking the
natural limb or other body part.
Wires carry digital
signals to servos in hand
Bionic hand
2 Sending impulses
3 Microprocessor 4 Up to 10 servos
Motor nerve impulses Microchips change
travel from the brain via the spinal the nerve impulses into digital (small, lightweight motors) drive
cord along peripheral nerves to the signals understood by the circuits movements of the hand and fingers,
arm and hand. and motors of the bionic part. pivoting at self-sensing joints.
Impulses converted Hand receives

to digital signals processed signals
and converts
them to
movement
Pattern of nerve
activity
Median, radial,
and ulnar nerves
Two-way communication
The motor cortex masterminds
movements of the bionic part. As
with a natural limb, these are
continually modified by interchange
with the somatosensory cortex.
Mindful Sensory data

6 awareness 5 Receptors in the
Further processing converts Motor impulses hand’s motors, joints, and
the sensory signals to more to bionic hand artificial skin generate responses.
natural forms that can be
interpreted by the brain’s touch
center, the somatosensory cortex.
Feedback signals
Electrical Sensory signals produced by robotic
pulses from bionic hand hand in digital form
Wiring the Brain 184 185
Deep brain stimulation (DBS)
In DBS, electrode wires are implanted in various parts
of the brain (see below) to treat a range of disorders.
These send pulses of electricity from a generator and THE BATTERIES USED IN PULSE
battery in the chest, connected to the electrodes. GENERATORS FOR DEEP BRAIN
A remote controller adjusts the pulses. In adaptive
DBS, the electrodes have sensors and the generator
STIMULATION LAST UP TO
automatically responds to the brain’s electrical activity. ABOUT NINE YEARS
Thalamus Globus Subcallosal Orbitofrontal Fornix

pallidus cingulate cortex
WHEN WAS THE

FIRST BIONIC LIMB
CREATED?
Subthalamic Caudate
In 1993, a team of bioengineers
nucleus nucleus at the Margaret Rose Hospital
Movement disorders Psychiatric disorders Cognitive disorders in Edinburgh created the first
DBS is well established DBS may be used in Research explores DBS bionic arm for amputee
to treat movement severe anxiety, depression, for problems such as
problems, such as the and obsessive-compulsive Alzheimer’s disease, Robert Campbell Aird.
tremors and “freezing” disorder, where other targeting specific
of Parkinson’s disease treatments such as drug structures involved in
and the spasms and medication have not memory and cognitive
contractions of dystonia. proved effective. neural networks.
Vagus nerve stimulation

The vagus nerve, one of the Brain releases
neurotransmitters
cranial nerves (see p.12) connects when stimulated
the brain with organs in the chest
and abdomen. In vagus nerve
stimulation (VNS), a small signal VAGU
SPIN
generator in the chest, similar to

a heart pacemaker, is connected
S NERV
AL C
by wires to electrodes around the

RD O
left vagus nerve in the neck. The

E
Cable carries
nerve’s sensory fibers are stimulated
CAROTID pulse to stimulate
to send impulses into the brain, where SHEATH nerve
they are distributed along various
neural pathways. VNS is
SPINAL CORD
mainly used to treat forms

of epilepsy and depression.
Signal generator Electrodes
sends pulses wrap around
SIGNAL GENERATOR along cable nerve
The Unexplored Brain
New research is revealing that some well-known
parts of the brain have unexpected functions. This is
especially true of the “lower brain” areas, such as the
brain stem and thalamus—areas once thought to be
largely passive and to perform only automated roles.
Discovering potential
Cutting-edge scanning methods can probe areas of the brain beneath
the cortex to understand their contributions to conscious thoughts
and behaviors. These techniques include magnetoencephalography
(MEG), which detects magnetic fields generated by neurons (see p.43),
and fMRI and near-infrared spectroscopy (NIRS), which monitor brain
activity by detecting changes in local blood flow and oxygenation.
The brain stem and emotion

Far from being a routine life-support region, the
brain stem (see pp.36–37) is active in our behavior,
especially emotions. Moods and feelings are even
being localized to specific nuclei (clusters of nerve EM
cells). These areas may be manipulated by ST
N
electrodes or chemicals to treat problems such DORSAL

AI
RAPHE
BR
as depression, anxiety, and panic attacks.
BRAIN
Dorsal raphe MID
This nucleus is a major source of
serotonin. Problems here can lead
to worry, anxiety, and low mood.
PEDUNCULOPONTINE
PERIAQUEDUCTAL NUCLEUS
Locus coeruleus
Malfunction of this major producer GRAY
LOCUS
of noradrenaline may cause intense
COERULEUS
emotions, stress, and poor memory.
CEREBELLUM
NS
TUM
PO
L
Pedunculopontine nucleus
VENTRA
TEGMEN
This has roles in focused attention

and concentration as well as in
physical tasks, such as moving limbs. A
LL
DU
Periaqueductal gray
ME
Wrapped around the cerebral

aqueduct channel, this nucleus is a
major part of the pain-coping system.
Ventral tegmentum
This nucleus has a central function in
motivation, learning, and reward and is
implicated in conditions such as ADHD.
The Unexplored Brain 186 187
US
ALAM
TH The brain’s relay station
It is already well known that the
Nuclei of anterior lobe, concerned
with learning and memory thalamus acts as a relay station
Medial dorsal nucleus,
for all incoming sensory
involved in memory information (except smell), but
Internal medullary lamina,
more is now being discovered
a layer of white matter about how it preprocesses this
information in a complex and
Lateral nuclei
(pulvinar), crucial selective manner before it travels
for visual to sensory zones in the cortex.
cognition
The thalamus is also central for
the regulation of arousal, and,
Medial geniculate with its links to the hippocampus,
nucleus involved it plays an important role in
in hearing
memory. Deep brain stimulation
Ventral anterior
nucleus, involved in (see p.185) of the thalamus has
voluntary movement been used to treat conditions
including tremors.
Lateral geniculate Intralaminar nuclei, involved
nucleus involved in consciousness, alertness,
in vision and feelings of pain
Thalamic nuclei
Investigations into lesser-known nuclei are revealing DESPITE ITS BODY-WIDE
lots of surprises. For example, the pulvinar nucleus
helps the vision centers map out and measure EFFECTS, THE SCN
a scene and how we reach
out to objects there. CONTAINS ONLY 20,000
NEURONS AND IS
SMALLER THAN
THIS LETTER O
THE SCN
HAVE ALL THE Located in the hypothalamus, the
BRAIN’S PARTS tiny suprachiasmatic nucleus (SCN) SCN
BEEN DISCOVERED? sets the body’s circadian rhythm—

our 24-hour sleep-wake cycle. Heart
Not yet. In 2018, improved This biological clock drives vital
microscopes uncovered a small homeostatic functions, including Liver
body temperature, feeding, and
region at the brain–spinal cord hormone levels. The SCN also Stomach
junction, which was named coordinates the activities of many
the endorestiform organs. Microscopic electrodes or
lasers could one day adjust these Ovary
nucleus. cycles and patterns.
Artificial Intelligence
As computers become more sophisticated, the ultimate Delivering dropout
Many electronic neural networks analyze
goal is to develop a machine that passes the Turing and process in stages. In dropout, the
Test, in which a person in conversation with the machine probability is assessed that a particular
item of information will or will not be
cannot tell that they are not talking to another person. useful. If it is not, it is removed.
Artificial
Mimicking the brain neuron STANDARD NEURAL NETWORK
Computer programs called neural
networks attempt to copy the way
the brain works by using artificial
neurons arranged in layers.
Inspired by the way people learn,
neural networks can adapt and
change their responses over time
(see right), a feature known as
machine learning. To more closely
replicate the human brain’s highly
adaptive, generalized intelligence,
a more advanced approach involves
querying, modifying, and deleting
data, a technique called adaptive
forgetting. For example, data that is INPUTS HIDDEN LAYERS OUTPUTS
little used further along a network,
as shown by feedback through the Input layer Hidden layers Output layer
1 The network receives 2 The hidden layers 3 Once it has been
system, can be trimmed or deleted. inputs in the form of numbers, process the data they receive processed, data passes
This is called dropout. Reducing or values. For example, in an from the input layer. Over to the output layer. In the
this redundant data produces a image-recognition system, an time, the network “learns,” image-recognition system,
input might be the brightness modifying its results by the output would be the
system that is faster and more of an individual pixel in a applying different weights application’s “guess” for
compact and responsive. digital image. to the values. what the image shows.
DROPOUT SYSTEM
WILL ROBOTS TAKE

OVER THE WORLD? RELEVANT
DATA
An “AI takeover” sounds like KEPT
science fiction, but it is
hypothetically possible. A lot UNUSED
DATA
depends on friendly computers REMOVED
preventing self-evolving
ones from advancing
beyond humans.
INPUTS HIDDEN LAYERS OUTPUTS
Artificial Intelligence 188 189
Forming memory circuits
Modeling digital electronic circuits on the brain
KEY IN 2019, AN
means storing and recalling information. In the brain,
remembering involves the repeated use of particular Large AI PROGRAM
resistance
pathways between neurons that strengthen their CALLED PLURIBUS
junctions (synapses) to form a “memory circuit.” In Small
electronics, a device in development known as the resistance BEAT 5 ELITE HUMAN
memory resistor or memristor offers a similar function. POKER PLAYERS
Random
NEURONS MEMRISTORS resting inputs
Resting state Resting state
INPUT
1 Nerve impulses
Random resting 1 A set of
inputs
pass randomly between electrical memristors
a group of neurons— NEURON receive equal inputs
only three are shown NEURON and allow through
here, but there could signals as and when
be thousands. Some they arrive. Like the MEMRISTORS
synaptic junctions send neurons, there is no
them on easily, others Synapses overall pattern and the
NEURON
less so. There is no pass on circuits hardly change. MEMRISTOR Large
overall pattern and occasional resistance
no definite outcome. impulses Irregular activity
continues Output current
is same as input
Organized, more frequent inputs RESTING OUTPUT Organized inputs RESTING OUTPUT
INPUT
Memory pathway Increased use Memristor
2 Recurring, more strengthens 2 pathway
frequent impulses in specific synapses Stronger inputs arrive
patterns represent a at certain memristors,
movement or fact being which alter their
committed to memory. The electrical resistance—
repeatedly used synapses the electronic MEMRISTORS
boost their connections over equivalent of LTP. Over
time, a characteristic called time, a recognized pattern Increased
long-term potentiation develops as the signals inputs
(LTP; see pp.26–27 and strengthen this pathway. reduce
pp.136–137). resistance
Output current is
Continued use Continued use greater than input
strengthens pathways INCREASED OUTPUT strengthens pathways INCREASED OUTPUT
ELECTRONIC TELEPATHY
Telepathy is the hypothetical direct Block
communication between brains, EEG ROTATE rotated
bypassing senses such as sight.
In an experiment using a block-based
computer game, instructions to rotate
blocks were collected from two players’ TMS
brains in the form of EEG readings and
then communicated, via a transcranial COMPUTER
magnetic simulation (TMS) cap, to a GAME
third player to make the moves. SENDER 1 SENDER 2 RECEIVER
The Expanded Brain
Medicine uses electrode implants, magnetic
fields, radio waves, and chemicals to treat
brain problems. These technologies could also TMS WAND
potentially enhance normal brain functions.
Wand positioned close to
IC FIELD
Boosting the brain (but not touching)
patient’s skull
“Overclocking” is the speeding
IS IT SAFE
up of a computer’s internal clock,
MAGNET
TO SPEED UP
which coordinates all its circuits,
YOUR BRAIN?
to push components to work faster
and harder. Like computers, the So far, the evidence suggests
brain uses tiny electrical signals
EX
that tDCS is safe. Thousands
in the form of nerve impulses,
RT
of healthy people have taken
CO
which raises the possibility that
part in experiments using tDCS,
AL
it might be similarly overclocked.
and no adverse effects
CEREBR
Depending on the region
Negatively charged
stimulated, this might improve have been noted. electrode can inhibit
attention and focus, information neural activity
processing, and memory.
Cathode
NANO NEUROBOTS
Transcranial direct
Researchers are developing almost current stimulation
molecule-sized, robotlike implants, In transcranial direct current stimulation
to deliver medical drugs, for example. (tDCS), a direct electric current is passed
Next-generation neurobots that are at a constant low strength through the
specialized to deliver programmed brain, between padlike electrodes attached
electronic signals might also accelerate to the skin. Sessions of tDCS have helped
both the way neurons work and how
treat depression and relieve pain. The ability
they process their nerve impulses.
of tDCS to enhance a range of cognitive
functions, from creativity to logical reasoning,
is being researched. Here, tDCS is shown in
use at the same time as TMS,
although the techniques
Wires form
are not actually used complete circuit
simultaneously.
Inhibiting the brain
During cathodal tDCS, the
current is negative with respect
A HIPPOCAMPAL PROSTHESIS to the brain’s own electrical
activity. This has the effect of
CAN IMPROVE MEMORY slowing or inhibiting nerve cells,
for example, to reduce
PERFORMANCE BY AS hyperactivity.
MUCH AS 37 PERCENT
The Expanded Brain 190 191
Wire coil
TEX
Activated neurons
enclosed in
plastic case COR
E Transcranial magnetic stimulation
TH
In transcranial magnetic stimulation (TMS), pulses of
DE
electric current pass through a coil and generate magnetism
INSI
that penetrates the skull to influence brain cells and their

impulses. The coil’s position and motion, and pulse strength
and timing, are adjusted to modify particular brain regions.
TMS is being tried for many kinds of brain and behavioral
conditions and also possibly to heighten thinking and other
mental processes.
Magnetic pulse
Magnetic When in use, the magnetic coils change polarity and
field produce magnetic pulses, which penetrate the scalp.
This produces electrical activity in surrounding neurons.
Resting neurons
Area of brain
being stimulated
RK Radio waves
T WO provide power
Positively charged NE
electrode can N Neurograins on cortex
I
RA
stimulate neural surface form connections

OG
activity in brain with neurons

NEUR
Skin patch for wireless

power and monitoring
Implanted
Anode neural grains,
webs, or chains
ARTIFICIAL
HIPPOCAMPUS
Neurograins
Scientists are developing a
technique in which tens of
thousands of “neurograins”
each independently interface
with a single neuron and Embedded
send data to an electronic microprocessor
patch on the scalp. and memory chips
Constant electrical current

supplied from battery
Memory chips
The abilities of electronic devices can be extended by
Stimulating the brain adding more memory, often in the form of microchips.
Anodal tDCS uses a positive The brain could be similarly upgraded. Microdevices
current to speed up nerve cell
activity. The positions of the skin to receive, store, and send data are being shaped like
electrodes determine which ultrafine webs, chains, and grains. Implanted on or
brain regions are aroused. Tests in the cerebral cortex, they could develop connections
show that effects can persist
even after the current ceases. with individual nerve cells and assist them in thinking
and memory. Already, chips can advance hippocampus
memory tasks such as long-term recall.
The Global
Brain
Public use of the World Wide Web dates
from 1991. Now, the development of
a system that may allow our brains to
interface with the Cloud is a possibility.
Brain/Cloud interface
Technology is racing to connect
human brains into the gigantic
electronic network of the Cloud “Farms” containing
using a brain/Cloud interface (B/CI). racks of servers are
A person may eventually be able bigger than many towns
to access a vast bank of human and

electronic knowledge, but many
challenges must be overcome. For
The Cloud
example, the speed of data transfer 1 The Cloud includes giant databases,
must be controlled, or incoming server farms, megaprocessors, and
information could be so excessive supercomputers. These work together
in real time to receive, store, manage, and
that it totally overloads our send information to millions of individual
consciousness. And from the start, computers and other devices linked to them.
fully safeguarding each human DATA CENTER
brain is essential.
Design challenges
Attempting to design a B/CI involves many
key elements: a connection to the human
brain itself, a method of wirelessly
transmitting the brain’s neural activity into
a local computer network, and establishing
how this network interacts with the Cloud.
The use of personal

WHAT IS computers may fade
THE CLOUD? as personal brain/Cloud
interfaces take over
The Cloud is an immense,
worldwide, interwoven
network of major electronic 2 Communicating with the Cloud
Computers and smart devices, which
equipment. Through it, can connect with each other and with the
software and services can internet, communicate with the Cloud.
The number of smart devices linked to
run on the internet instead the internet is now more than double the
of on your computer. number of people in the world. If human
brains are also able to join the Cloud, it
will become an even busier place.
The Global Brain 192 193
ACCESS TO THE CLOUD
Deciding which human brains should join the
Cloud raises many social and economic issues.
Future applications may include facilitating the
accuracy of medical diagnoses. But the question
of who will be able to use the technology first will
have to be considered. Will it be those who need
it, those who can best develop it, or those who
can pay for it?
NE
UR
OB
OT
S
Retractable arms
work as aerials
Cerebral nanobots
Neurobots implanted in the cerebral cortex, or
traveling through its blood vessels with the
help of their own micro-positioning
guides, act as go-between
transmitter-receivers.
Implants may link NE

brain regions as well UR
as to the interface Scalp skin
AL
LA
CE
Neural implants Cerebral cortex Implanted lace

3 Several technologies are competing unfolds
to enable early forms of B/CIs. They include Cortical intraweb
neural lace, various types of nanobots, and Neural lace is an ultrafine mesh of
subnanosize particles known as neural electrodes that forms a data-collecting
dust. Neural dust would allow wireless and dispersing area. It also works
communication to the brain through as a wireless antenna.
microscopic implantable devices inside the
body, which are powered by ultrasound.
DISORDERS
Headache and migraine Signals are passed
onward from
Cortex receives pain
impulses, resulting in the
hypothalamus and sensation of pain
A dull ache or a sharp or throbbing pain, a headache may appear thalamus to cortex
gradually or suddenly and last from less than an hour to several CE R
days. Migraine sufferers have episodes of severe headaches often EB
RA
LC
accompanied by sensory disturbances, nausea, and vomiting. O
RT
EX
A headache is a symptom with a typically consists of up to
range of possible causes. Probably four stages, which vary
the most common form of headache in intensity and duration THALAMUS
is tension headache, in which the (see panel, below). The
pain tends to be constant, in the underlying cause is not HYPOTHALAMUS
forehead or more generally over known, but research
the head. It may be accompanied suggests it may be due to a surge
by a feeling of pressure behind the of neuronal activity in the brain,
eyes and/or tightness around the eventually stimulating the sensory
head. It is typically brought on by cortex, resulting in the sensation of
stress, which causes tension in the pain. Triggers for a migraine
muscles of the neck and scalp. This, include emotional shock or stress;
Pain signals from MEDULLA
in turn, is thought to stimulate pain tiredness or lack of sleep; missed meninges are
receptors in these areas, which send meals, dehydration, and certain received in medulla
pain signals to the sensory cortex, foods, such as cheese or chocolate; Migraine pathway
resulting in a headache. Another hormonal changes (for many When a migraine attack is in progress, pain
form of headache is cluster women, migraines are associated signals originating in the meninges are
transferred to a nucleus in the meninges and
headache, which involves relatively with menstruation); and changes in then relayed, via the hypothalamus and
short attacks of severe pain. the weather or a stuffy atmosphere. thalamus, to various regions of the cortex.
Migraine headache MIGRAINE ATTACKS

A migraine usually occurs over one
eye or temple or on one side of the An attack may begin with an early stage, the prodrome, with symptoms
head, although the area of pain can such as anxiety, mood changes, and tiredness or excessive energy. This is
move during an attack. A migraine sometimes followed by aura, a warning stage that can include flashing
lights and other visual distortions; stiffness, tingling, or numbness;
difficulty speaking; and poor coordination. The main stage includes a
severe throbbing
headache made worse
ARE MIGRAINES by movement, nausea 1. Prodrome stage may last hours or days
A GENETIC DISORDER? and/or vomiting, and
dislike of bright light or
Migraines often run in the loud noise. This is
family. Certain genes combine often followed by a 3. Headache
Intensity
to increase predisposition to postdrome stage of may last hours

tiredness, poor 2. Aura typically or days
migraines, but environmental concentration, and lasts an hour
factors such as stress persistence of 4. Postdrome
or hormones are increased sensitivity. may last hours
or days
also involved.
Time
DISORDERS 196 197
Head injuries
Minor bumps to the head or injuries to the scalp alone
have no long-term consequences. However, injury to the
BRAIN
brain is potentially extremely serious and can be fatal.
SKULL
Direct damage to the brain may days. Postconcussive amnesia can Rapid movement
1 When a person is moving rapidly—for
occur if both the scalp and the skull also occur. Repeated concussions
example, on a bike or in a car—the skull and
are penetrated. Indirect damage lead to detectable brain damage, brain are moving at the same speed.
occurs as a result of a blow to the such as impaired cognitive abilities,
head that does not damage the tremors, and epilepsy.
skull. In both cases, head injuries Severe head injury may produce Brain Blow to
impact 2 head
can rupture blood vessels, causing unconsciousness or coma and
a brain hemorrhage. Minor head usually brain damage. In nonfatal
injuries typically produce only mild, cases, the effects of brain damage Brain
short-lived symptoms, such as a may include weakness, paralysis, impact 1
bruise. In some cases, concussion poor memory and/or concentration,
Stopping suddenly
may follow, and this may cause intellectual impairment, and even 2 On impact, the brain smashes into the
confusion, dizziness, and blurred personality changes. Such effects front of the skull, rebounds, and sustains
vision, which may last for several can be long-term or permanent. further injury as it hits the back of the skull.
Epilepsy
THERE ARE ABOUT
Ranging from mild to life-threatening, epilepsy is a brain function
disorder in which there are recurrent seizures or periods of altered 60 TYPES OF
consciousness, caused by abnormal electrical activity in the brain. EPILEPTIC SEIZURES
Often the cause of epilepsy is partial, depending on how much of movements of the limbs and
unknown, but in some cases, it may the brain is affected by abnormal body begin, lasting up to several
be due to a brain condition such as electrical activity. There are several minutes. In absence (petit mal)
tumor or abscess, a head injury, types of seizures. In a tonic-clonic seizures, the victim loses
stroke, or a chemical imbalance. (grand mal) seizure, the body consciousness, although muscle
Seizures (fits) may be generalized or stiffens before uncontrolled is retained.
Most or all of the

brain is affected
Partial seizure
may become
generalized
Partial seizure Generalized seizure

The person remains conscious, The person may become
their head and eyes may turn to Only part of the unaware or unconscious. Fits
one side, and one hand, arm, brain is affected are brief but may reoccur
and cheek may tingle or twitch. rapidly or several times a day.
Meningitis and encephalitis
Meningitis and encephalitis are inflammatory diseases caused
1 MILLION
mainly by infection. Both can produce symptoms such as sudden THE NUMBER OF PEOPLE
fever, a stiff neck, light sensitivity, headaches, drowsiness, vomiting, WORLDWIDE AFFECTED
confusion, and seizures.
BY MENINGITIS
Meningitis is an infection of the such as anesthetics, contain
EACH YEAR
meninges—the membranes that substances that can also irritate
protect the brain and spinal cord the meninges, triggering meningitis.
and contain the cerebrospinal fluid
that flows throughout the entire Encephalitis Dura mater
nervous system. When infection Encephalitis is an inflammation of
causes these membranes to swell, the brain itself, due to an infection
SC
the inflammation can ultimately or to the immune system attacking AL
P
SK
impact every part of the body. the brain in error. A person of any AR U L
Pia mater
AC L
Young children whose immune age can contract encephalitis, HN
OI
systems are not fully developed are which can cause serious symptoms D
M
AT
most at risk, although the disease such as muscle weakness, sudden ER
can strike people of any age. dementia, loss of consciousness,
The main cause of meningitis is seizures, and even death.
germs entering the body, whether
in the form of bacteria—which Sites of infection
The meninges are the outer dura mater, the
BRAIN
can also lead to septicemia, or
middle arachnoid, and inner pia mater. In all
blood poisoning—viruses, or fungal forms of meningitis, they become inflamed
infections. However, certain drugs, and impair brain function.
Brain abscess
Also known as cerebral abscesses, brain abscesses are pus-filled swellings
in the brain, which often form after an infection or severe head injury CONGENITAL
that have allowed bacteria or fungi to enter the brain tissue. HEART DEFECT
A brain abscess can also be a
The symptoms of a brain abscess part of the skull such as an ear rare complication of a group of
may develop slowly or quickly. They infection or sinusitis; an infection conditions known as cyanotic
can include symptoms such as a in another part of the body—for heart disease, which are congenital
localized headache that cannot be example, a pneumonia infection (present at birth). These cause
relieved by painkillers, neurological spreading via the blood; or trauma, abnormal blood flow through the
heart and lungs, allowing poorly
problems such as muscle weakness such as a severe head injury that
oxygenated blood to be pumped
and slurred speech, changes in cracks open the skull. around the body. This oxygen-
mental state, high temperature, Assessment and diagnoses of deprived blood gives affected
seizures, nausea, stiff neck, and brain abscesses are made via blood children’s skin a blue, or cyanotic,
changes in vision. tests and a CT or MRI scan. color and severely limits their
Brain abscesses are usually Medication and surgery are the physical activity.
caused by an infection in another most common forms of treatment.
DISORDERS 198 199
TIA 1 Temporary
blockage
A transient ischemic attack, or TIA, is similar to a stroke Blockage A blood clot is caused
when certain blood
(see below), which occurs when the blood supply to the components coagulate.
Blocked
brain is interrupted. Unlike a stroke, however, a TIA lasts blood flow
Triggers include head
only briefly. injury, altitude, or lifestyle.
A TIA is often termed a “mini headache with no known cause.

stroke” and may serve as a Depending on the area of the Carotid artery
warning sign. Indications of a TIA brain involved, symptoms may supplies blood
usually disappear within an hour be similar or different. to brain
and resemble those found early in Axillary artery
a stroke. Symptoms include the Seeking treatment Blood flow
sudden onset of weakness, TIAs most often occur hours or resumes
paralysis, or numbness in the face, days before a stroke, so it is vital to
arm, or leg, typically on one side of seek medical attention immediately
Dispersal
the body; slurred speech and after a TIA. Roughly one in three 2 of blockage
difficulty understanding others; people who have a TIA will Medication to thin the
blindness or double vision; experience a stroke, and around blood, or surgery to
remove the clot, can
dizziness or loss of balance or half of these will take place within Blockage alleviate a blockage, so
coordination; and a sudden severe a year of the initial TIA. disperses blood flows normally.
Stroke and hemorrhage IN THE US

A stroke is a life-threatening condition that occurs when the SOMEONE
blood supply to the brain is cut off. There are two main types
of strokes: ischemic and hemorrhagic, and each affects the HAS A STROKE
brain in different ways. EVERY 40 SECONDS
Arachnoid mater If the blood supply to the brain is one or both eyes; and a sudden,
Pia mater reduced or interrupted, brain tissue severe headache, dizziness, and
is deprived of oxygen and nutrients. loss of coordination.
When this happens, brain cells
begin to die within minutes. Blood in the brain
A stroke can be caused by a Brain hemorrhages can be caused
SK LP
T
A
L
blockage, usually a blood clot by weak spots in blood vessels that

UL
SC
Dura
CL
mater (ischemic), or when blood spills into form an aneurysm, or swelling,

D
OO
BRAIN the brain or its surrounding tissues which bursts, often due to high
BL
(hemorrhagic), often as the result blood pressure. If this occurs

of a ruptured blood vessel or artery. between the two inner membranes
Symptoms can include slurred surrounding the brain, it is called
speech; paralysis (drooping) or a subarachnoid hemorrhage.
Subdural hematoma (hemorrhage) numbness of the face, arm, or leg, Causes of bleeding within brain
Bleeding between the brain’s protective
outer layers, the meninges, forms a clot that which often occurs on just one side tissue (intracerebral hemorrhage)
puts pressure on the brain, causing a stroke. of the body; trouble seeing with include injury, tumors, or drug use.
Brain tumors
A brain tumor is caused by cells that multiply in an abnormal way. It can
BRAIN Tumor occur in any part of the brain, from the intracranial space between the
brain and the skull to deep within the brain itself. Tumors may be benign
or malignant, and treatment varies accordingly.
There are approximately 130 percent start in the meninges—

NASAL
types of brain tumors, and they the membranes that surround
CAVITY
are classified according to the kind and protect the brain and spinal
of tumor or the area of the brain cord. These tend to be easier to
EN
in which they grow. Some take treat, if found early. Around 10

DO
years to develop, while others are percent of brain tumors occur

SC
PE much faster growing and more in the pituitary gland or pineal

O
aggressive. Brain tumors can occur glands, which are surrounded by

in people at any age or stage of life. brain tissue.
In children, the picture is slightly
Transnasal brain surgery Locations and types different. Approximately 60 percent
Surgeons can now operate on some brain The most common types of brain of childhood tumors occur in the
tumors through the nose. The procedure is
much less invasive than a craniotomy, where tumors in adults are found in the cerebellum or brain stem. Only 40
the skull is opened and the brain exposed. cerebrum (see pp.28–29). About 24 percent arise in the cerebrum.
Dementia COMMON CAUSES OF DEMENTIA

Dementia is a term applied to a group of diseases associated with a decline Dementia can be caused by various disorders.
in mental function that occurs most often in adults aged over 65. There are Some of the most common are listed here.
many different types of dementia. Alzheimer’s disease
A progressive condition in which bodies of
proteins, called plaques, damage the brain.
Whether due to reduced blood language difficulties, and need help
flowing to the brain, a buildup of with basic activities such as Vascular dementia
Impaired blood flow to the brain, such as that
protein deposits, or other forms of feeding or dressing themselves. caused by stroke, leads to a decline in function.
damage, dementia in all its forms
is a progressive disorder. Symptoms Diagnosis Lewy body dementia
typically include mild forgetfulness, While there is no cure for dementia, Protein deposits in the brain’s nerve cells affect
thinking, memory, and motor control.
which may evolve into apathy or early diagnosis and treatment can
depression, reduced socialization, slow the rate of mental decline. Frontotemporal dementia
and loss of emotional control. Brain scans highlight the areas A form that occurs in the front and sides of the
brain, affecting behavior and language.
In later stages, a person with of the brain most affected in an
dementia may lose the ability to be individual, and treatment can be Parkinson’s disease
compassionate or feel empathy, or tailored accordingly. The area most Most Parkinson’s sufferers develop dementia
to organize day-to-day activities. affected in Alzheimer’s disease, thought to be related to Lewy bodies.
People with dementia often become for example, is the cortex. This
Creutzfeldt-Jakob disease (CJD)
very confused, not recognizing part of the brain includes the Rare, rapid, and fatal, this is caused by an
loved ones or knowing where they hippocampus, where new infectious protein called a prion.
are. They might hallucinate, have memories are formed.
DISORDERS 200 201
Parkinson’s disease
The second-most common degenerative disease after Alzheimer’s
(see p.50), Parkinson’s disease is a neurological disorder that affects Average
movement and mobility by destroying dopamine-producing cells in the number of
substantia nigra, which is located in the uppermost part of the brain stem. pigmented
neurons
HEALTHY
Symptoms manifest gradually, BRAIN
sometimes starting as a mild tremor
CAN SURGERY in one hand. Other signs include
BE USED TO TREAT muscle stiffness, slurred speech,
PARKINSON’S DISEASE? and a general slowing of mobility. Marked
Early stages of the disease usually decrease in
Deep-brain stimulation (DBS) affect one side of the body, but pigmented
neurons
involves surgical implantation when 80 percent of the substantia
of electrodes in the brain that nigra dies, severe disablement DISEASED
occurs. Late-stage sufferers require BRAIN
can control, but not cure,
assistance with all daily tasks. Changes in the substantia nigra
the motor symptoms Parkinson’s mainly strikes adults Parkinson’s affects nerve cells in the
of Parkinson’s. substantia nigra, which produce the
aged 60 or over and affects more neurotransmitter dopamine. As the cells die,
men than women. dopamine levels fall, disrupting motor control.
Huntington’s disease AFFECTED UNAFFECTED

PARENT PARENT
Huntington’s is a progressive brain disorder caused by a genetic mutation.
Early signs include irritability, depression, involuntary movements, poor
coordination, and trouble with decision-making or learning new information.
Adult-onset Huntington’s is the with this condition. Juvenile

Huntington’s Normal
most common form of the disease, Huntington’s disease tends to gene present gene only
and it usually appears in people in progress rapidly.
their 30s and 40s. It affects three
to seven out of 100,000 people of Huntington’s chorea
European origin. Less frequently, it Many people with Huntington’s
begins in childhood or adolescence, develop involuntary twitching
where it causes mobility problems movements known as chorea, which
and mental and emotional changes. become more pronounced as the
Additional symptoms of juvenile disease progresses. They may
Huntington’s include slow have difficulty walking, speaking,
movements, clumsiness, frequent and swallowing, and may also
AFFECTED UNAFFECTED
falling, rigidity, slurred speech, and experience personality changes and CHILDREN CHILDREN
drooling. Thinking and reasoning a decline in thought processing.
abilities are impaired, which affects Prognosis for people with adult- Patterns of inheritance
Huntington’s is classed as an inherited
performance in school. Seizures onset Huntington’s is a life span of condition. It occurs when a single defective
occur in 30 to 50 percent of children 15 to 20 years after symptoms begin. gene is passed on from an affected parent.
Multiple sclerosis
Multiple sclerosis, or MS, is a condition that affects both the brain Cell
body
and the spinal cord. It is believed to be caused when the body’s
immune system mistakenly damages protective nerve sheaths.
Macrophage
Demyelinated
Myelin cells, made of proteins and leaves behind disrupt impulses Myelin
area
fats, surround neurons in the normally transmitted along nerve sheath
central nervous system, enabling fibers or axons. Neural messages
Nerve Scar
messages to travel quickly and slow down, become distorted, or axon tissue
smoothly between the brain and are simply not delivered at all.
the rest of the body. When MS MS may occur at any age but
develops, the immune system, is usually diagnosed in a person’s
which normally fights infection and 20s or 30s. Early symptoms include EARLY STAGE LATE STAGE
inflammation, seems to mistake dizziness, vision changes, and Macrophage numbers and MS stages
myelin for a foreign body and muscle weakness. In later stages, When MS begins, macrophage cells remove
attacks it with macrophage cells, speech, mobility, and cognition may damaged tissue but also help repair it. In
later stages, however, their numbers increase
damaging it and stripping it away. be affected. The progressive form and actually accelerate myelin loss,
The scars, or plaques, this action of the disease results in disability. increasing the severity of symptoms.
Motor neuron disease PHYSICIST

Motor neuron disease, or MND, is an umbrella term used to describe STEPHEN
a group of conditions that affect motor neurons—the nerves in the
brain and spinal cord that tell all the muscles in the body what to do.
HAWKING LIVED FOR
55 YEARS AFTER BEING
Genetic, environmental, and Whatever their cause, most forms DIAGNOSED WITH MND
lifestyle factors are thought to of MND cause symptoms that
contribute to the development of include general muscle weakness
Nerves in dorsal (back)
MND. Exposure to heavy metals or and wasting, cramps,
horns carry sensory
agricultural chemicals, an electrical difficulty swallowing, signals from body
or mechanical trauma, military a progressive loss to brain
service, or excessive exercise have of speech, and
Nerves in lateral (side)
all been investigated as possible limb weakness.
horns control internal
causes, with conflicting results. Diagnosis includes organs
Some types of MND, however, do MRI scans, muscle
Nerves in ventral (front)
have a genetic basis. Progressive biopsies, and blood
horns control skeletal
bulbar atrophy, also known as and urine tests. muscles
Kennedy disease, results from a Although there is
mutated gene and affects mainly currently no cure for
KEY
men. Kennedy disease specifically MND, symptoms,
Ascending tracts
damages the bulb-shaped lower can be managed Spinal cord bundles carry sensory signals
brain stem, where neurons that to give sufferers Different forms of MND involve
different tracts of neurons, Descending tracts
control muscles in the face and the best possible located in the dorsal, lateral, and control torso and limbs
throat are found. quality of life. ventral horns of the spinal cord.
DISORDERS 202 203
Paralysis
The main symptom of paralysis is loss of voluntary control of movement
in part of the body. It is classified by the areas of the body affected.
Sometimes only one muscle or a small muscle group is affected, but
paralysis can also be total, resulting in complete loss of motor function. WHAT IS THE
It can be intermittent or permanently disabling. MOST COMMON
CAUSE OF
Paralysis may affect any part of the or transient ischemic attack (see PARALYSIS?
body, including the face, the hands, p.199) can lead to sudden weakness
In the US, the most common
one arm or leg (monoplegia), one on one side of the face, weakness
side of the body (hemiplegia), both in one arm, or slurred speech. Bell’s
trigger is stroke, followed by
legs (paraplegia), and both arms Palsy is an abrupt weakness that spinal-cord injuries and
and legs (tetraplegia or quadriplegia). affects one side of the face, along multiple sclerosis.
The body may also become stiff with earache or face pain.
or rigid (spastic paralysis) with In addition, severe head or
occasional muscle spasms, or floppy spinal-cord injury can trigger
(flaccid paralysis). paralysis, while multiple sclerosis
or myasthenia gravis—a disease tumors, Guillain-Barré syndrome,
Main causes of paralysis that affects the junction between cerebral palsy, and spina bifida.
Paralysis can result from an injury, nerves and skeletal muscles—can Tick-borne Lyme disease causes
or be caused by many different cause weakness in the face, arms, paralysis that may begin weeks,
disorders, each of which requires or legs that comes and goes. Other months, or years after the initial
specialist assessment. A stroke causes of paralysis include brain tick bite.
OVERHEAD
VIEW Cervical
vertebra 4
Thoracic
vertebra 1 Cervical
vertebra 7
Front
of brain
Lumbar
Motor cortex vertebra 1
affected
Opposite side of
body paralyzed
Hemiplegia Paraplegia Quadriplegia

Paralysis affects one side of the body, Paralysis affects the legs, and sometimes Also known as tetraplegia, both arms
often seen as a result of stroke or part of the trunk, usually due to a spinal and legs are partially or completely
brain tumor affecting the motor injury, but it can arise from traumatic paralyzed, as is the body from the
cortex. Hemiplegia may also be brain damage or a medical condition such neck down, usually as a result of a
caused by a brain trauma. as a spinal or brain tumor or spina bifida. break to the lower part of the neck.
Down syndrome SCREENING TESTS
Down syndrome, which affects both physical and mental development,
results when an extra copy of a chromosome is made randomly due to Prenatal screening tests such as
abnormal cell division. Babies born with this disorder have identifiable facial blood tests and ultrasounds help
characteristics and developmental delays evident from early infancy. predict whether a child might be
at risk of Down syndrome.
If the risk is high, these can be
Down syndrome is also known Everyone born with it has some followed by two diagnostic tests:
as trisomy 21, because it creates level of learning disability. Certain chorionic villus sampling and
amniocentesis, which analyze fetal
a third copy of chromosome 21. health conditions, such as heart
cells and amniotic fluid to detect
Experiments conducted on mice conditions and hearing and vision chromosome abnormalities.
have shown that the presence of problems, are more common in
this extra chromosome disrupts the people with Down syndrome.
function of brain circuits involved in
memory and learning, mainly in the
area of the hippocampus.
The chances of Down syndrome
occurring in a child increase with
the mother’s age at pregnancy.
Normal and trisomy 21 chromosome sets

Two karyotypes, or photographs of a full set
of chromosomes, show a normal male with
two copies of chromosome 21 and a male
with Down syndrome, who has three. NORMAL CHROMOSOME SET TRISOMY 21 CHROMOSOME SET
Cerebral palsy
Cerebral palsy, or CP, refers to a group of disorders that impair movement, TYPES OF CEREBRAL PALSY
coordination, and cognition. CP is the most common childhood motor
disability and is broadly defined as being either congenital or acquired. CP is categorized by the movement disorder
involved. A few types are listed below.
Spastic (or diplegic) CP

Most children are diagnosed with Symptoms and severity vary People with this type are very stiff and cannot
congenital CP, which occurs either enormously and become more relax their limbs and muscles. They may walk
on their toes or with legs turned inward.
before or during birth as a result of evident as a baby develops. Many
brain injury, such as a difficult signs of CP are often not even Athetoid (or dyskinetic) CP
delivery that deprives the brain People with this form cannot control various
noticeable in newborns.
parts of their body and make involuntary
of oxygen. Brain infections or a Some children with CP have writhing or jerking movements.
serious head injury, however, can impaired mobility, speech, and
Ataxic cerebral palsy
also cause acquired CP more than intellectual abilities and may require Balance and coordination are affected, and
28 days after birth. a wheelchair or need support with there is often loss of voluntary muscle control
The nature of CP symptoms daily activities. Others may be when using fine motor skills such as writing.
depends on the location of the floppy or rigid, have weak limbs, or Mixed cerebral palsy
brain damage, but the damage have trouble walking. Depending Mixed cerebral palsy involves a combination
is typically located in the motor on CP type and treatment, affected of symptoms of CP types, due to several
damaged motor-control centers in the brain.
cortex, which controls movement. people live for 30 to 70 years.
DISORDERS 204 205
Hydrocephalus Skull
Hydrocephalus is a buildup of fluid on the brain, which can damage Choroid

plexus Lateral ventricle
brain tissue. It is caused by excess cerebrospinal fluid or by fluid not
draining away normally. Acquired and normal-pressure hydrocephalus
are the two adult-onset forms, but it can also occur in children.
Acquired hydrocephalus is caused The main symptoms are usually

by damage to the brain after stroke, headache, nausea, blurred
hemorrhage, a brain tumor, or vision, and confusion.
meningitis. Enlarged brain cavities In children, hydrocephalus can Third
fill with excess cerebrospinal fluid develop after a premature birth, ventricle
Cerebral
(CSF) or block areas where fluid is bleeding on the brain, or in cases of
aqueduct
reabsorbed into the bloodstream. spina bifida. In babies and young
Fourth ventricle Cerebellum
children, symptoms include a
Causes of other forms swollen head, but in older children,
The cause of normal-pressure the disorder might show up as
hydrocephalus is often unknown, severe headaches. Damage caused Fluid on the brain
but it might be due to underlying by the pressure can lead to loss of CSF is created by the choroid plexus, a
cellular membrane lining brain ventricles, or
health conditions such as heart developmental skills, such as cavities. If it isn’t reabsorbed, it pressurizes
disease or high cholesterol. walking and talking. the brain, causing hydrocephalus symptoms.
Narcolepsy
Narcolepsy is a rare, long-term neurological disorder
characterized by sudden bouts of sleep. Sufferers are
unable to regulate normal sleeping and waking patterns. Locus
coeruleus
Hypocretin release
Narcolepsy usually starts around

puberty and affects both sexes Hypothalamus
equally. Symptoms include
The hypocretin system
excessive daytime sleepiness, Narcolepsy may be caused by
falling asleep suddenly, and unusually low levels of a brain chemical
sometimes performing tasks but hypocretin, which is excreted by cells Raphe
in the hypothalamus. Once released, nuclei
having no memory of doing so. hypocretin signals neurons in the brain
Hypocretin
The condition can include sleep that control wakefulness.
release
paralysis—a temporary inability to
move or speak, accompanied by A cataplexic person experiences
terrifying nightmares. Sleep weakness in muscle control in CATAPLEXY CAN
deprivation is a common side effect. response to strong emotions such
as humor, anger, or pain. There BE TRIGGERED BY
Cataplexy is no loss of consciousness, but AN EMOTIONAL
Around 60 percent of sufferers sufferers may collapse as a result of
are classed as Type 1, which loss of muscle tone and are usually
REACTION SUCH
means they also have cataplexy. unable to speak or move. AS LAUGHTER
DISORDERS OF UNCONSCIOUSNESS Coma
There are several types of comas, some A coma is a prolonged state of deep unconsciousness, whether due to injury
of which are described here. Some other
disorders also show similarities to comas. or induced to treat a medical condition. Coma patients are unresponsive
and may look like they are asleep. Unlike in deep sleep, however, a person
Anoxic brain injury in a coma cannot be awakened by any stimulation, including pain.
In anoxia, the brain is starved of oxygen. This
leads to confusion, agitation or drowsiness,
cyanosis (blue-tinged skin, due to low blood
Comas are caused mainly by head for example, when blood-sugar
oxygen), and loss of consciousness or coma.
injuries that damage the brain. levels remain either extremely
Medically induced coma They often result in swelling, which high or far too low. More than
A drug-induced coma causes a state of
deep unconsciousness, which allows the in turn leads to increased pressure 50 percent of comas are related
brain to recover from swelling due to stroke on the brain and damages the to head traumas or disturbances
or injury. reticular activating system—that in the brain’s circulatory system.
Locked-in syndrome part of the brain responsible for
Someone with locked-in syndrome is arousal and awareness. Treatment
conscious, but brain damage has caused
Bleeding in the brain, a loss of The treatment for coma depends
almost complete paralysis. The person almost
always communicates using eye movements. oxygen, infections, an overdose, on the specific cause but in general
chemical imbalances, or a buildup involves supportive measures.
Vegetative state
A person in a vegetative state does not show of toxins can also trigger a coma, Coma patients are placed in an
any meaningful emotional responses, follow as can the side effects of various intensive care unit and may often
objects with their eyes, or respond to voices. conditions. A temporary and require full life support until their
Recovery is usually highly unlikely.
reversible coma occurs in diabetes, situation improves.
Depression EXTERNAL CAUSES
More than simply feeling unhappy, depression consists
Poverty
& debt
of persistent feelings of sadness, hopelessness, and apathy,
Re pro
accompanied by sleep disorders, fatigue, and appetite changes.

la bl
ss
t io e m
re
ns s
St
hi
p
Depression acts on people in fatigue, insomnia INTERNAL

different ways and to varying or excessive sleeping, Pregna CAUSES
l
nc
childbir y & • Personality traits Alcoho
degrees. Symptoms can be mild to weight loss or gain, th & dr u g
s
• Childhood experiences
severe—the latter is sometimes loss of sex drive, and
• Family history
referred to as “clinical depression”— physical pain.
• Long-term health B
and range from constantly feeling Although it has e re
e ss problems av
unhappy, tearfulness, and a loss multiple causes, e lin em
o n en
L t
of interest in normal activities to depression is a genuine
pro
g
Wo ems
lyin
an inability to perform daily tasks illness that can impact all

bl
rk
and thoughts of suicide. aspects of a person’s life. One

B ul
in 10 people have depression at

Physical symptoms some point in their lives, and it can
Depression and anxiety often affect children and adolescents.
go hand in hand. The disorder Depending on its severity, Causes of depression
Stressful life events can act as external
may also bring about physical treatment may include medication triggers for depression. These interact with
symptoms, such as persistent and psychotherapy. internal causes that include a family history.
DISORDERS 206 207
Bipolar disorder
Formerly known as manic depression, bipolar disorder is a Bipolar phases
mental condition marked by alternating periods of exaggerated People often experience a manic or
hypomanic period of feeling high, then a
elation and depression, in which a person’s mood swings balanced stage of calm followed by episodes
suddenly from one extreme to another. of feeling mildly or extremely depressed.
Bipolar mood swings vary Mania Mania symptoms include

enormously, and individuals with euphoria, rapid speech, short
the disorder may also have “normal” attention span, loss of sleep or
appetite, and occasionally psychosis.
moods. The patterns are not always
the same, however; some people Hypomania This is a milder version
may experience rapid cycling from of mania that lasts a few days, often
with agitation and reckless social
high to low, or a kind of mixed state. or financial behavior.
Treating bipolar disorder involves
reducing the severity and number of Balanced mood Euthymia is the
term used to describe the relatively
opposing episodes to give sufferers stable mood state where a person
as normal a life as possible. is neither manic nor depressed.
Medicines such as mood stabilizers,
Mild depression Symptoms may
a recognition of triggers and include feeling sad, hopeless, or
warning signs, psychological irritable; a lack of energy; difficulty
treatment such as cognitive concentrating; and feelings of guilt.
behavioral therapy, and lifestyle Depression Emotionally painful,
advice are all used to treat bipolar this phase may be marked by flat
patients. When effective, episodes mood, misuse of drugs and alcohol,
self-harm, and suicidal thoughts.
usually improve within months.
RN
Seasonal affective disorder T TE SPRING
A
P
Seasonal affective disorder, or SAD, is a depression that comes

AD
and goes in a seasonal pattern. It is sometimes known as “winter

RS
depression,” as that is when symptoms are usually more severe.

WINTE
WINTER
SUMMER
The exact cause of SAD is not Other possible causes include
fully understood, but for those who a malfunctioning “body clock,”
suffer from winter SAD—where which regulates sleep patterns, or
the onset of cold weather triggers abnormally high levels of melatonin.
symptoms—it is often linked to Symptoms include depression,
reduced exposure to sunlight, a loss of pleasure in everyday
which limits the functioning of activities, irritability, feelings of FALL
the hypothalamus. This is the part despair, guilt, or worthlessness, and Winter pattern Summer pattern
of the brain that controls mood. a lack of energy. Tracking symptoms Symptoms begin at Symptoms reduce
Some people, however, experience in a diary, exercise, light therapy, the change of fall to or disappear in early
winter, marked by spring. There is a
symptoms when warmer weather and support groups are some low energy levels and return of energy and
begins—known as summer SAD. self-help methods used by sufferers. poor mood. normal sleep patterns.
Anxiety disorders 1 In response
to stress,
the hypothalamus
Anxiety disorders are a group of mental illnesses characterized HYPOTHALAMUS stimulates the
by strong feelings of threat and fear, including panic attacks and pituitary gland
an inaccurate appraisal of danger. Although there are many to produce
adrenocorticotropic
types of anxiety disorders, they usually share similar symptoms. hormone (ACTH).
ANTERIOR
PITUITARY GLAND
Common anxiety disorders include People with social anxiety disorder
generalized anxiety disorder (GAD), are worried, have an excessively
social anxiety disorder, panic negative self-image, and feel
disorder, and post-traumatic stress continually observed and judged. Adrenal
ACTH
disorder (PTSD). As well as feelings PTSD sufferers have feelings of
gland 2 stimulates
of fear, physical symptoms are being threatened and constantly production of
adrenaline and
brought on by excessive levels of on edge, triggered by experiencing KIDNEY cortisol by the
stress hormones such as cortisol or witnessing a traumatic event. adrenal glands.
and adrenaline. Symptoms include
trembling; sleep problems; cold, Contributing factors
sweaty, numb, or tingling hands or Many factors influence anxiety
feet; shortness of breath; heart disorders, including environmental Adrenaline
3 and cortisol
palpitations; nausea; and dizziness. stress and genetic predisposition; trigger various
Those with GAD are prone to if disorders run in families, they physiological
feelings of intense worry, while may also be learned. Some may responses, such as
a more rapid heart
panic disorder arises from an be linked to changes in brain areas ADRENALINE rate and increased
extreme bodily response to stress. that control fear and other emotions. AND CORTISOL muscle tension.
COMMON PHOBIAS Phobias

PHOBIA DESCRIPTION An overwhelming, debilitating fear of an object, place, situation,
Arachnophobia Fear of spiders
feeling, or animal is known as a phobia. Phobias provoke extreme
reactions and involve an unrealistic, intense sense of danger.
Aviophobia Fear of flying
A phobia is a type of anxiety around a particular object, animal,
Claustrophobia Fear of enclosed disorder characterized by an situation, or activity. Examples
spaces
excessive reaction to a specific include acrophobia (fear of heights)
Coulrophobia Fear of clowns trigger. In some cases, just thinking and hemophobia (fear of blood).
about the threat can make a person Common animal triggers for
Mysophobia Fear of contamination feel anxious, a condition known as phobias are snakes (ophidiophobia)
by germs anticipatory anxiety. Symptoms and spiders (arachnophobia).
Necrophobia Fear of death
include dizziness, nausea or Simple phobias often begin during
ordead things vomiting, sweating, palpitations, childhood or adolescence but tend
breathlessness, and trembling. to decrease in severity over time.
Nosophobia Fear of developing
a specific disease Phobias can generally be divided Complex phobias, however, are
into two main types: specific or more disabling. These include
Trypanophobia Fear of injections
or medical needles
simple phobias; and complex social phobia or social anxiety
phobias. Specific phobias center disorder—a fear of social situations.
DISORDERS 208 209
Obsessive-compulsive disorder
Obsessive-compulsive disorder (OCD) is a common mental-health
condition that affects men, women, and children. A person with OCD
experiences repeated intrusive thoughts coupled with a need to perform
specific actions over and over in order to relieve any associated anxiety.
Anxiety
OCD can strike at any age but the intolerable anxiety brought
typically develops during early on by the obsession. Both
Co
adulthood. It can often be traced medication and cognitive
session
mpulsion
to a traumatic event or situation behavioral therapy (CBT) can
that occurred in childhood or be used to manage symptoms.
adolescence and may stem from TAKES UP AT LEAST
Ob
an out-of-proportion sense of fear, Genetic factors 1 HOUR PER DAY
guilt, and responsibility linked to About a quarter of OCD sufferers
a particular incident. have a family member with the Te
mp ie f
The obsessive part of OCD is disorder, and studies involving orary rel
an unwanted and unpleasant fear, twins suggest that a genetic link is
thought, image, or urge called an likely. It is also believed that OCD
intrusion, which triggers feelings disrupts communication in brain Losing time to OCD
of anxiety, disgust, or unease. areas, including the orbitofrontal An overwhelming desire to carry out rituals
The compulsion aspect involves cortex, linked to feelings of reward, is triggered by anxiety caused by an intrusive
thought. This urgent need to count or check
a repetitive behavior or mental and the anterior cingulate cortex, objects, wash hands, or repeat thought
routine that temporarily relieves linked to error detection. sequences can use up many hours every day.
Tourette’s syndrome
Tourette’s syndrome is a complex neurological condition that causes
a person to make involuntary sounds and movements called tics. It Basal ganglia Frontal cortex
almost always develops during childhood, usually after the age of two. implements is involved in
movement routines self-control
Tourette’s generally appears in Tics can cause pain due to muscle

early childhood, but before age 15, strain, and they often increase
and is much more likely to affect when a person is stressed, anxious,
males than females. Physical tics or tired. Symptoms can change
range from simple blinking, eye and may improve over time,
rolling, scowling, and shrugging to sometimes resolving completely.
jumping, spinning, or bending. Tourette’s tics are often preceded
The most publicized vocal tic by powerful sensations, like an itch Thalamus filters
and relays signals
is inappropriate swearing, although or urge to sneeze. With practice, to cortex
in reality this is rare and only some sufferers learn to use these Implicated brain areas
affects around one in 10 of those cues to control symptoms while in Tourette’s tics are thought to result from an
with the disorder. The most usual social situations such as school. overproduction of the neurotransmitter
dopamine, as well as dysfunction in brain
verbal tics involve making grunting, People with Tourette’s may also areas linked to movement, such as the
coughing, or animal sounds. have OCD or learning difficulties. frontal cortex, basal ganglia, and thalamus.
RELATED CONDITIONS Somatic symptom disorder
Illness anxiety disorder Somatic symptom disorder (SSD) is characterized by an extreme focus on
Also known as health anxiety or hypochondria, physical symptoms that may or may not be related to an actual diagnosed
people with illness anxiety disorder are
preoccupied with having or contracting
medical condition. People with SSD, however, truly believe they are ill, and
disease. They may have no physical symptoms their distress is experienced as bodily, or “somatic” symptoms.
but view normal experiences as serious illness
indicators, constantly monitoring themselves
and seeking reassurance due to anxiety. SSD is closely linked to anxiety and the physical problems they
depression. Physical manifestations describe. If a diagnosis is found,
Conversion disorder often include pain, weakness, and SSD sufferers are so focused on
In conversion disorder, neurological
symptoms such as paralysis, numb limbs,
fatigue; shortness of breath is their conditions that they are often
visual problems, and motor issues arise as a another common complaint. unable to function normally.
result of psychological stress. The condition is Those affected worry excessively Treatment includes
most common in people with early or lifelong
experience of trauma. Therapy and lifestyle
about their health and focus on one antidepressants as well as
change usually result in recovery. or several symptoms, even when a therapies such as cognitive
medical cause cannot be found for behavioral therapy (CBT).
Munchausen syndrome
Munchausen syndrome is caused by severe emotional distress. It is
classed as a factitious disorder—a mental-health condition in which a MUNCHAUSEN
person acts mentally or physically ill, purposefully fabricating symptoms. SYNDROME BY PROXY
Munchausen by proxy is a type of
Munchausen syndrome is a rare factitious disorder in which carers
COMMON SYMPTOMS fabricate or physically induce
psychological illness and tends OF FACTITIOUS DISORDERS
to occur in people who have had symptoms of illness or injury in
Here are some of the symptoms commonly those under their control. Also
traumatic early life events, such
seen in patients with Munchausen syndrome considered a type of physical and
as emotional abuse or illness, who and other factitious disorders. mental abuse, it is usually inflicted
have a personality disorder, or on young children by a parent, but
A long medical history, often including
who harbor resentment toward sometimes on other vulnerable
frequent hospitalization at different locations
authority figures. It is believed to and visits to several doctors. people under the control of a
be an extreme form of attention- caregiver, such as an elderly
seeking behavior. Those affected Extensive textbook knowledge of the parent being looked after by a son
disease reported, as well as of medical or daughter.
may tell stories of dramatic practice in general.
occurrences, lie about symptoms,
A willingness to submit to medical tests,
?
make symptoms worse by investigations, and even surgery.
deliberately aggravating wounds
or ingesting toxins, and even alter An unwillingness to allow medical staff to
contact friends and family, or having few
test results and falsify records. visitors when hospitalized.
A new form of the disorder has
been termed Munchausen by Many surgical scars or evidence of
numerous procedures.
internet, in which a person
pretends to have a specific illness Conditions that get worse for no apparent
reason, or which don’t respond as expected
and joins an online support group
to standard therapies.
for real sufferers of the disease.
DISORDERS 210 211
Schizophrenia
Schizophrenia is a mental-health disorder whose symptoms may include
delusions and visual or auditory hallucinations. It is a type of psychosis, DO PEOPLE WITH
meaning those affected may not be able to distinguish fantasy from reality. SCHIZOPHRENIA HAVE
A SPLIT PERSONALITY?
Schizophrenia can be a difficult Frontal lobe malfunction The word schizophrenia means
disorder to assess. Diagnosis leads to hallucinations
“split mind.” People with this
involves examining emotional
disorder do not have multiple
and cognitive behavior and is
confirmed by the presence of two or personalities but instead
more symptoms that last longer than are cut off from
30 days. These include disorganized what is real.
speech or behavior, catatonia,
delusions or hallucinations, and
1.1%
“negative symptoms,” such as a lack
of emotion or speech. Abnormalities
may occur in
There are many types of
temporal lobes
schizophrenia, each with varying
Hippocampus
symptoms. Paranoid schizophrenics
are overly suspicious of others’
is usually disrupted
THE APPROXIMATE
motives and believe they are being Structural abnormalities
The brains of people with schizophrenia
PERCENTAGE OF
conspired against. A catatonic
schizophrenic may withdraw
show structural difference in specific areas,
such as the frontal and temporal lobes. They
ADULTS WITH
emotionally to the point of also contain less gray matter than normal, SCHIZOPHRENIA
and this impacts on emotional regulation,
seeming to be paralyzed, while
motor control, and sensory perception. WORLDWIDE
disorganized schizophrenia
includes flat or inappropriate CAUSES OF SCHIZOPHRENIA
responses and an inability to
Despite years of research, the causes of schizophrenia remain unclear. It may be linked to genetics,
complete everyday tasks.
brain chemistry, life experiences, drug use, prenatal or birth trauma, or a combination of these.
Ventricles enlarged due Genetics Brain abnormality

to brain-tissue reduction About 80 percent of people MRI studies of the brain show
with schizophrenia show a reduced gray matter in several
hereditary predisposition to regions, including the
the disorder. However, genes prefrontal cortex. This area is
are not the sole cause, as important for emotion
environmental factors and regulation, decision-making,
family history are also and complex cognitive tasks
considered relevant. such as efficient planning.
Brain chemistry Environment

Two brain chemicals, A predisposition to
HEALTHY BRAIN BRAIN WITH
glutamate and dopamine, developing schizophrenia can
SCHIZOPHRENIA
are linked to schizophrenia. be triggered by fetal exposure
Elevated dopamine levels may to a virus, birth trauma, or
cause hallucinations. Low malnutrition. Environmental
Tissue loss
glutamate levels may trigger triggers include extreme
Some schizophrenia patients have enlarged
psychotic episodes, while high stress, family relationships, or
ventricles (the fluid-filled cavities within the
levels damage brain cells. use of mind-altering drugs.
brain) as a result of a reduction in brain
tissue in surrounding areas.
Addiction TO WHAT
EXTENT IS ADDICTION
Addiction stems from a chronic dysfunction of a brain system that INHERITED?
regulates reward, motivation, and memory. A person suffering
from an addiction craves a substance or behavior, often with Studies involving twins
no concern at the time about the consequences of pursuing it. and adopted individuals show
that about 40–60 percent
An addiction involves the repeated to achieve the same amount of of susceptibility to
use of, or engagement with, a pleasurable reward. Removal of the an addiction is
substance or activity for feelings addiction source causes reactions inherited.
of pleasure. Psychological and such as sweating, trembling,
social symptoms include many vomiting, and behavioral changes.
behaviors, such as lack of self-
control, obsession, and risk-taking. Chemical pleasure Why people are susceptible to
Common physical symptoms are Addiction affects the brain’s addiction is not fully understood,
changes in appetite, appearance structure as well as how it but evidence suggests that genetic
changes, sleeplessness, injury or functions. Humans feel excitement makeup may be a factor in some
disease caused by substance abuse, and pleasure when the brain cases. Genes, after all, dictate not
and increased tolerance to the releases neurotransmitters like just how we respond to substances
source of the addiction so that dopamine, followed by a feeling of but what reactions occur when
more and more of it is required intense satisfaction from hormones those substances are withdrawn.
such as endorphins. Endorphins This may explain why some people
Normal amount
relieve stress and pain in ways become more readily dependent on
of dopamine
receptors similar to drugs such as cocaine. alcohol, for example, than others.
For many people, creative or Evaluating individuals for a
physical activities, such as playing suspected addiction includes the
a musical instrument or exercising, use of diagnostic tests as well as
release enough neurotransmitters psychological assessments. They
to provide pleasure and satisfaction. are then referred to specialists for
For others, however, certain drugs, treatment and rehabilitation.
alcohol, and risk-taking activities
Areas of greatest gray
HEALTHY BRAIN such as gambling induce a quicker matter reduction
Fewer available and much more extreme form
dopamine receptors
of pleasure before eventually
disrupting and damaging normal
neurotransmitter circuitry.
Such artificial stimuli flood the
brain with dopamine then create
feelings of intense satisfaction once
endorphins are released. The
resulting “high” is registered by
COCAINE USER the hippocampus as a long-term
Cocaine use and dopamine memory, which leads to an urge
Using cocaine reduces the availability to repeat the experience. Once this Gray matter and methamphetamine
of receptors for the neurotransmitter desire overrides normal behavior The use of methamphetamine shrinks the
dopamine. The result is that, over time, the amount of gray matter in the brain’s frontal
user has to consume more of the drug to and the ability to function, it is cortex, among other areas, leading to a
achieve the same sensation of reward. classed as an addiction. decline in mental function.
DISORDERS 212 213
Personality disorder
Individuals who display persistent inappropriate, inflexible, or extraordinary
behaviors, or have problems relating to others, have a personality disorder,
or PD. There are several PD types, ranging from antisocial (BPD) to schizotypal,
but some sufferers can manage their lives without medical help.
A personality disorder involves

a consistent pattern of behavior
that deviates noticeably from that
thinking, impulsive behavior, and
problems controlling emotions.
The anxious cluster includes
75 PERCENT
which is considered acceptable by avoidance personality disorder, OF PEOPLE
society. Symptoms usually appear which is characterized by feelings DIAGNOSED
by adolescence and can lead to of inadequacy and extreme
long-term difficulties for sufferers, sensitivity to negative criticism and
WITH BPD
in terms of navigating relationships rejection. Unsurprisingly, people ARE WOMEN
and simply functioning effectively who have this type of PD also
in social situations. experience severe social anxiety.
The many types of PDs are which also helps control emotions,
broadly grouped into three groups The PD brain is often reduced in the brain of
or “clusters”: suspicious; emotional Some people affected by PDs have individuals with PDs.
and impulsive; and anxious (see an unusual amygdala, part of the People with PDs usually find that
box, below). Each type has its own limbic system—the most primitive talking therapies help them gain a
symptoms. For example, a person part of the brain that regulates fear better understanding of their
with a suspicious personality and aggression. People who have thoughts, feelings, and behaviors.
disorder is typically antisocial, PDs involving excessive levels of Therapeutic communities, a form
easily frustrated, and has difficulty fear generally have smaller of group-therapy treatment, can
controlling anger. Borderline amygdalae than those who do not, also be effective but require a high
personality disorder (BPD)—a type and the smaller the amygdala, the level of commitment. Medication
of emotional and impulsive PD—is more overactive it seems to be. may also be used in some cases
associated with disturbed ways of In addition, the hippocampus, to control depression and anxiety.
PERSONALITY DISORDER CLUSTERS
CLUSTER A: SUSPICIOUS CLUSTER B: EMOTIONAL CLUSTER C: ANXIOUS

People with these PDs tend to be considered AND IMPULSIVE The most fearful cluster of PDs. Those in this
odd or “eccentric.” They fear social situations and These PD types are characterized by a lack of group are generally anxious, submissive to
have problems relating to other people, whom emotional control. Cluster B individuals often others, and have difficulty coping with life on
they view with a great deal of suspicion. Some bully or manipulate others, are self-centered, their own. They tend to be oversensitive,
sufferers appear detached, others introverted. and are prone to dramatic, excessive displays, inhibited, extremely shy, or perfectionists.
forming intense but short-lived relationships.
Paranoid Antisocial Avoidant
Schizoid Borderline Dependent
Schizotypal Histrionic Obsessive-compulsive
Narcissistic
Eating disorders 1. The person eats
Eating disorders are emotional mental-health problems that large amounts of food
rapidly, often in secret, and
include an extreme relationship with food. Most revolve may go into a kind of dazed
around an obsessive focus on weight and body shape, state while doing so.
which can damage health and may even be life-threatening. 6. Need to 2. Anxiety drops
binge-eat becomes as eating temporarily
urgent; the person often numbs stressful, sad,
Although they can occur at any life activities, eating very buys special food for or angry feelings.
stage, eating disorders usually little or overeating the purpose.
develop among adolescent and then purging
young-adult age groups. The three (self-induced 5. Thoughts of food 3. Low mood returns,
most common types are anorexia vomiting), extreme become more and more bringing with it self-loathing
dominant, as distressing and disgust, due to guilt
nervosa (or simply anorexia), use of laxatives, and
feelings increase. and shame associated
bulimia nervosa (bulimia), and exercising too much. with bingeing.
binge-eating disorder (BED; see Sufferers may also have
4. Anxiety rises
panel, below). Diagnosis involves stomach problems, an as eating provides only
psychological evaluation as well as abnormal weight for short-term relief from
physical examinations, such as their age and height, menstrual psychological pain.
Depression sets in.
blood tests and measuring the problems or disruption, dental
person’s body mass index (BMI). issues, sensitivity to cold, fatigue,
Anorexia always involves weight or dizziness. The bingeing cycle
loss, and a very low BMI is usually Those with a binge-eating disorder use
food to numb emotional pain instead
flagged in diagnosis. Those Underlying factors of addressing its psychological cause
affected by both bulimia and BED The causes of eating disorders are positively. The result is a destructive cycle.
do not tend to have a low BMI not fully understood, but those
and may be slightly overweight. affected are more likely to have a being slim, are likely to have a
Eating-disorder symptoms include family member with a history of higher number of people with
a preoccupation with weight and eating disorders, depression, eating disorders than other
body shape, avoiding food-based substance misuse, or addiction. professions. People with eating
Social pressure and criticism may disorders may also suffer from
TYPES OF EATING DISORDERS contribute to a focus on eating anxiety, low self-esteem,
habits, body shape, or weight. perfectionism, and sexual abuse.
DISORDER DESCRIPTION Some occupations, such as ballet- Treatment includes nutritional
Anorexia Mainly affects young women. dancing, acting, sports, or education, psychological or talking
nervosa Involves an obsessive desire modeling, where there is a focus on therapies, and group programs.
to maintain a low body
weight by eating little and
overexercising.
FEMALE BIAS
Bulimia Bingeing and purging occur
nervosa in this disorder. The body
In the US, and many other
weight is often normal, but KEY
bulimics possess a severely
countries, more women than Men
negative self-image. men are diagnosed with
eating disorders. However, Women
Binge- Regular excessive eating, the prevalence in men may Women Women
eating usually planned and be underestimated because 64% 75%
disorder consumed rapidly and in they are less likely than
secret, is followed by
women to seek help. BULIMIA ANOREXIA
intense guilt and shame.
DISORDERS 214 215
Learning disabilities and difficulties
A learning disability is a sign of impaired cognitive abilities and is
HOW COMMON
reflected in a person’s general intelligence or IQ. Learning difficulties do
ARE LEARNING
not affect IQ levels but make information-processing harder. Both affect
DISABILITIES?
how a person acquires knowledge, masters new skills, and communicates.
An estimated 1–3 percent
An intellectual or learning disability conditions have no identifiable of the world’s population
occurs when brain development is cause. No two learning disabilities has some form of learning
affected in some way, whether are the same, and they can include disability, and people in low-
through injury or a genetic a wide variety of symptoms. income countries are the
abnormality. Learning disabilities Some people with learning
most affected.
range from mild and moderate to disabilities can talk easily and care
severe and profound. The most for themselves but may take longer
severe may even mean that an than usual to learn new things.
affected person will face problems Others may not be able to Learning difficulties
coping with independent life skills. communicate at all. Some may also Distinguishing some learning
Specific causes include genetic face mobility problems, heart disabilities from learning
mutations such as in Down defects, or epilepsy, which can difficulties can be challenging.
syndrome, or fetal head injuries, shorten life expectancy. Generally, however, learning
maternal illness, a lack of adequate Affected people may also have difficulties do not affect intellectual
oxygen to the brain before or associated learning difficulties— ability or aptitude but instead
during birth, or brain damage from for example, someone with cerebral impact on how the brain processes
a childhood illness or injury. Some palsy (see p.204) may have data. Someone with dyslexia, for
impaired cognitive function and example, which makes reading,
Left
dyspraxia, or a person on the writing, and spelling difficult, often
temporoparietal
junction autistic spectrum may have a has dyspraxia, which affects fine
severe form of developmental delay. motor skills and coordination.
Left inferior SOME COMMON LEARNING DISABILITIES AND DIFFICULTIES

temporal
cortex NAME DESCRIPTION
NORMAL READERS Dyslexia Impaired ability to learn to read and/or write. In addition to poor
reading and spelling skills, dyslexics may have problems with
Left inferior sequences, such as date order, or difficulties organizing their thoughts.
frontal gyrus
Dyscalculia Difficulty processing numbers, learning arithmetical concepts such as
counting, and performing mathematical calculations. Dyscalculia
often occurs alongside dyslexia or other learning difficulties.
Amusia Literally meaning “lack of music,” amusia is sometimes known as tone

deafness and means that a person with normal hearing is unable to
recognize musical tones or rhythms or reproduce them.
DYSLEXIC READERS
Dyspraxia The inability to make skilled movements with accuracy, dyspraxia is
The dyslexic brain (developmental often first noticed in childhood as “clumsiness.” It can cause problems
Areas of the brain activated during reading coordination disorder) with establishing spatial relationships, such as positioning objects.
differ hugely in normal readers and dyslexics.
Only the left inferior frontal gyrus activates Specific language Indicated by a delay in acquiring language skills where no
in dyslexics, but this is paired with increased impairment developmental delay or hearing loss is present, specific language
activity in the right hemisphere—which is impairment has a strong genetic link and often runs in families.
why many dyslexics are highly creative.
CAN CHANGES
Attention deficit hyperactivity disorder IN DIET HELP PEOPLE
Inattentiveness, hyperactivity, and impulsiveness are the main symptoms WITH ADHD?
of the mental-health disorder known as attention deficit hyperactivity
disorder, or ADHD. It usually appears in early childhood, but symptoms
Some parents report behavior
may increase from the ages of six to 12 and persist into adulthood. spikes after certain foods are
eaten, but there is no
clear evidence that ADHD
The main symptoms of ADHD Additionally, people with ADHD
include impetuosity, difficulty may also experience additional is caused by diet or
concentrating, a “short fuse,” problems, such as sleep and nutritional issues.
disorganization, prioritization anxiety disorders.
issues, trouble multitasking, and
being extremely active or restless. What causes ADHD? linked to intelligence or ability
While attention deficit disorder Because ADHD is a developmental levels. Research has revealed
(ADD) shares similar symptoms, problem that appears to run in biological and structural
ADD sufferers are less hyperactive, families, researchers suspect that differences, including a smaller size
and their main problem is an there is some genetic basis for the and lower blood flow, in the brains
inability to concentrate. disorder. If genetic faults are to of people with ADHD compared to
ADHD symptoms can improve blame, they are likely to be those of people without it. Some
with age, but many adults who complex and involve more than one studies show that brain chemicals
have been diagnosed with the gene. The condition has been such as dopamine may be lower
condition as a child may continue linked to fetal impairment caused than normal in those with ADHD.
to experience problems throughout when a mother smoked or drank
their lives. Such difficulties often alcohol while pregnant. Being born MEN ARE THREE
become evident in the workplace, prematurely or coming into contact
where an employee has to comply with toxins such as lead in early TIMES MORE LIKELY
with routines and rules; in this childhood can also trigger ADHD. THAN WOMEN
scenario, a person with ADHD may People with ADHD often have
perform less well than would learning difficulties (see p.215),
TO BE DIAGNOSED
normally be expected. although these are not necessarily WITH ADHD
SYMPTOMS OF ATTENTION DEFICIT HYPERACTIVITY DISORDER
HYPERACTIVITY INATTENTIVENESS IMPULSIVITY

Hyperactivity is the term used for someone who Inattentiveness is associated with ADHD. It is Impulsivity is characterized by actions carried
is abnormally or extremely active. A hyperactive defined by behaviors such as a lack of focus, out without any forward planning or awareness
person is very restless, easily distracted at school failure to notice the needs of others, or being of immediate or future consequences. Impulses
or work, and often cannot sit still for more than a preoccupied and not capable of giving sustained can be related to emotional situations and
few seconds or minutes at a time. attention to the matter at hand. physical activity and can seem to be involuntary.
Difficulties sitting still Concentration difficulties Frequently interrupting
Constant fidgeting Clumsiness Inability to take turns
Talks more loudly than others Easily distracted Talking excessively
Little or no sense of danger Poor organizational skills Acting without thinking
Forgetfulness
DISORDERS 216 217
Autism spectrum disorders
Autism spectrum disorders (ASD) is a term used to describe a group of
developmental problems, all of which are characterized by communication
and behavioral difficulties. The word “spectrum” refers to the wide variety of
types and severity levels of symptoms experienced by people with ASD.
People who have ASD find it hard

SYMPTOMS OF AUTISM SPECTRUM DISORDERS
to interact and communicate with
others. They also tend to have SYMPTOM DESCRIPTION
restricted interests and repetitive Social ASD affects social communication because the development of
behaviors and are often more or communication language is impaired. Verbal and nonverbal social communication
less sensitive than others to light, problems include difficulties interpreting social situations, identifying
social cues, and blunt or inappropriate conversational interactions.
sound, or temperature. This causes
them to retreat into themselves. Repetitive behavior People with ASD often engage in repeated activities, such as hand
flapping or body rocking, or may harm themselves by continuous biting or
ASD occurs in people at all levels skin picking. They may also exhibit body twirling or other complex body
of intellectual ability and is most movements, along with rituals such as counting or arranging objects.
often diagnosed in the first two
Focused interests Those with autism often think in very black-and-white terms, with an
years of life. It is a lifelong condition. intense focus on specific interests or obsessions. These can range from
Physical symptoms may include spinning objects to collecting birthdates or identifying flight paths.
repetitive body movements, such
as pacing, rocking, or hand flapping. Sensory sensitivity Some type of sensory processing problem is usually (although not
always) related to a diagnosis of ASD. Those affected may be over-
or undersensitive and experience difficulties with smell, taste, sight,
Communication problems hearing, touch, balance, eye movement, and body awareness.
Children with ASD may have
language difficulties, and some
start talking relatively late in life. High-functioning adults with ASD Social awkwardness is usually
Their tone of voice might be very may be successful in academic accompanied by social anxiety.
flat, very fast, or singsong. About fields yet have difficulty with Other symptoms of ASD include
40 percent of children with ASD practical and social skills, such as a highly acute awareness of noise,
don’t talk at all, and between 25 understanding social cues. Most smell, touch, or light, and extreme
and 30 percent develop some seem blunt, cannot lie, and may food preferences.
language skills during infancy focus obsessively on one aspect ASD sufferers who have
but then lose them later in life. of life, such as cleanliness. intellectual disabilities may show
a high aptitude in other areas such
as having a photographic memory
or numerical ability; however,
sometimes the disability is so
profound that those affected cannot
speak meaningfully, engage in
self-harm, and need daily care.
ASD and normal brain comparisons

Those with ASD find it hard to process faces.
In a nonautistic person, activity shows in the
Activity in fusiform gyrus No activity in fusiform gyrus temporal lobe’s fusiform gyrus, where
recognition occurs. In the autistic brain,
NORMAL BRAIN AUTISTIC BRAIN there is no such corresponding activity.
Index
amusia 215 axons 20, 21, 22–23, 26–27, 86, brain waves 42, 103, 151, 163, 168,
amygdala 32, 33, 38, 39, 48, 59, 108, 98–99, 136 172
213 brain/Cloud interface (B/CI) 192–193
B
and emotions 107, 110, 111, brain stem 28, 29, 32, 33, 36–37, 44,
Page numbers in bold refer 134 45, 200
to main entries and senses 77, 78 babies and emotion 186
analytical thinking 152 brain development 44–45 and movement 97, 98
A
anatomy 28–29 language learning 124–125, 130 and senses 74, 75, 81, 82, 84
aneurysms 199 sense of self 178, 179 brain stem death 162
abscesses, brain 197, 198 anger 39, 106, 108–109, 111, 116 sight 70 breathing 13, 90, 92, 108, 109, 162
abstraction 151 angiotensin 93, 95 taste 81 breathing exercises 88
acetylcholine 24, 99 angular gyrus 127 bacteria 198 breathing rate 121
action potential 22–23, 136, 137 animals balance 50, 84, 98, 199 Broca’s area 31, 102, 119, 126, 127,
action selection 33 brains 14–15 basal ganglia 32–33, 50, 51, 97, 174, 128, 131
actions hearing 77 209 Brodmann areas 31
conscious control over 168–169 mirror neurons 102, 103 basilar membrane 76 Brodmann, Korbinian 31
mirror neurons 102–103 with no brain 15 belief 158–159 Bucy, Paul 39
active efflux 19 sense of self 179 Bell’s Palsy 203 bulimia nervosa 214
actual self 179 vision 69 beta brain waves 42, 151, 163
C
adaptive behaviors 111 anodal tDCS 191 Big Five test 177
adaptive forgetting 188 anorexia nervosa 214 bilingualism 125
ADD (attention deficit disorder) 216 anoxia 206 binge-eating disorder (BED) 214 caffeine 24, 174
addiction 24, 25, 112, 113, 212 antagonists 24 binocular visual field 69 calcium/calcium ions 23, 26, 27
adenine 56 anterograde amnesia 146, 147 bionic limbs 184, 185 cancer
ADH (antidiuretic hormone) 95 antidepressants 111, 210 bipolar disorder 207 brain tumors 200
ADHD (attention deficit antioxidants 55, 61 bipolar neurons 20, 67 MRI scans 40
hyperactivity disorder) 47, anxiety 108, 109, 147, 185, 186 bladder 13, 109 capillaries 17, 18, 35
164, 186, 216 disorders 47, 206, 208, 213, 214 blind spot 67 carbohydrates 54
adipose tissue 94 apathy 200, 206 blind zone 69 carotid arteries 18, 19
adoption 61 aphasia 127 blood clots 199 CAT (computerized axial
adrenal gland 93 appetite 38 blood pressure 24, 36, 121, 199 tomography) scans 41
adrenaline 93, 137, 208 arachnoid mater 16, 198 blood sugar levels 94, 109 cataplexy 205
adrenocorticotropic hormone arcuate fasciculus 151 blood supply 18–19, 109, 198, 199, catatonia 211
(ACTH) 208 arteries 18, 19, 199 200 cathodal tDCS 190
adults articulation 126, 128, 131 blood vessels 17, 28, 61, 108 caudate nucleus 32, 33, 121, 134
brain 48–49 artificial intelligence 37, 163, blood-brain barrier 17 cells
IQ 152 188–189 crossing 18–19 brain 20–21
male and female brains 58–59 associations 65, 127, 142 BMI 214 cell membranes 22–23
perception of time 175 associative visual cortex 31 body, brain in the 11, 12–13 cortex 31
personality 177 astrocytes 17, 21, 173 body clock 207 cellular wall 18
aging attachment 114, 115 body language 118–119, 121, 176, central executive network 154, 155
aging brain 40–41, 61 attention 24, 37, 51, 59, 100, 177 central nervous system (CNS) 12
how to slow the effects of 52–53 164–165 body shape 214 cerebellum 28, 36–37, 44, 84, 97,
and time 175 ADHD 47, 164, 186, 216 bones 134, 200
aggression 38 focusing 166–167 cranium 16 cerebral arteries 19
agnosia 39 span 164, 207 ear 74–75 cerebral cortex see cortex
agonists 24 attraction 114, 115 skeleton 98 cerebral palsy 203, 204, 215
alcohol 24, 25, 52 auditory area 119, 183 borderline personality disorder cerebral sinuses 18
and language 125 auditory canal 74 (BPD) 213 cerebrospinal fluid (CSF) 16–17,
and memory 146 auditory cortex 65, 74, 76, 127, 136 brain cells see neurons 173, 198, 205
aldosterone 93 auditory nerve 77 brain damage cerebrum 29, 44, 200
alertness 28, 35 augmented reality 162 before or during birth 204 chemical weapons 23
alpha brain waves 42 aura, and migraine 196 head injuries 197 chemicals, brain 24–25
alphabetic principle 131 autism spectrum disorders (ASD) and language 126, 127 chemoreceptors 82
altered states 170–171 148, 215, 217 and learning 215 childbirth 34, 35, 206
alternating attention 165 automatic functions 162 and memory 139 children
altruism 123 autonomic nervous system 12, 13, and morality 123 brain development in older 46–47
Alzheimer’s disease 39, 50, 51, 57, 92, 107 and personality 177 brain development in young
185, 200 autosomes 56, 57 brain disorders 170, 174, 185, 190, 44–45
amino acids 55 awareness 90, 96, 107, 162, 171, 196–217 core beliefs 159
amnesia 39, 146, 197 173, 178 brain scans 40–41 IQ 152
218 219
children continued coordination 201, 204, 215 digital “maps” 182, 183 emotions continued
perception of time 175 coordinated actions 100 disease see brain disorders conscious 110–111
personality 176 core beliefs 159 disgust 39, 111, 116 control of 200, 211
reading and writing 130–131 cornea 66 dissociative amnesia 146 emotional awareness 171
sense of self 178–179 corpus callosum 29, 48, 58, 77 distractions 146, 165, 167, 169 emotional reactions 111
sleep 172 cortex 28, 29, 30–31, 38, 39, 49 divided attention 165 emotional response 32, 167
cholesterol 205 and danger 108 dizziness 197, 199, 202, 208, 214 facial expressions 110, 116–117
chorea 201 folds and grooves 30, 45 DNA 56, 57, 60, 61, 176 and memory 38, 107, 137, 140, 147
choroid 66 and memory 138, 139, 140, 144, docility 39 mimicking 123
chromosomes 56, 58, 60, 204 145, 191, 200 dogs 179 and morality 122, 123
cilia 78 monitoring 42–43 DOI (diffuse optical imaging) scans sex and love 114–115
cingulate cortex 121, 134, 178, 209 neural implants 193 41 and sleep 173
cingulate gyrus 30, 39 and pain 196 dopamine 24, 112, 113, 114, 174, teenagers 46, 47
circadian rhythm 46, 92, 93, 187 sensory areas 64–65 175, 201, 211, 212 versus mood 111
Circle of Willis 19 cortical intraweb 193 dorsal raphe 186 empathy 123, 200
circulatory system 17 cortical layers 31 dorsal (upper) route, in visual encephalins 87
CJD 200 cortisol 93, 208 processing 70–71, 100 encephalitis 198
the Cloud 192–193 cranial nerves 12, 13, 36, 81 dorsolateral prefrontal cortex 122 endocannabinoids 113
clumsiness 47, 201, 215, 216 cranial ultrasound 41 Down syndrome 204, 215 endocrine glands 93
cocaine 24, 25, 212 craniotomy 200 dreams 172–3 endocrine system 34, 92–93
cochlea 64, 75, 76 cranium 16 dropout, in neural networks 188 endorestiform nucelus 187
cochlear implants 182, 183 cravings 113 drugs 24, 25 endorphins 87, 107, 212
cochlear nerve 75 creativity 154–155 addiction 113, 212 energy consumption 18–19
cognitive ability 153 boosting 156–157 and altered states 170, 211 enhancement, technological
cognitive behavioral therapy (CBT) Creutzfeldt-Jakob Disease and memory 146 190–191
88, 207, 209, 210 (CJD) 200 painkillers 88 environment
cognitive decline 51, 146 crying 106 DTI (diffusion tensor imaging) 40, and altered states 170
cognitive disorders 185 CT (computer tomography) scans 43 and belief 158
cognitive distortions 171 41, 198 dualism 162, 163 and brain development 44, 52,
cognitive function 52, 58–59, cytosine 56 dura mater 16, 198 60–61
61, 215 dyscalcula 215 and brain disorders 202, 211
D
cognitive illusions 73 dysgraphia 130 and personality 176
cognitive inflexibility 159 dyslexia 130, 131, 215 scanning 165
cognitive tasks 26, 211 danger 101, 108, 109 dyspraxia 215 enzymes 137
color associations 65 daydreaming 154, 170 ependymal cells 21
color vision 70 death 162 epidermis 82
E
coma 170, 197, 206 decision-making 122, 123, 168, epigenetic changes 60, 61
communication see language; 169 epilepsy 147, 170, 185, 197, 215
speech declarative (explicit) memories eardrum 74 episodic memories 135
computers 188–189, 190, 192–193 135, 147 ears epithalamus 34
concentration 54, 55, 167, 186, 216 deep sleep 172 hearing 74–77 ESP (extrasensory perception) 182
concussion 197 deep brain stimulation (DBS) 185, and position 84 estrogen 93, 115
conditioning 38, 134 187, 201 eating disorders 214 Eustachian tube 74
cones, in retina 67 default mode network 154 EEG (electroencephalograph) 42, events, and belief 158
congenital heart defects 198 defecation 13 43, 168, 189 evolution 80, 123, 126, 150, 165
congruence 179 dehydration 54, 94, 95, 196 efflux transporters 19 excitatory neurotransmitters 24
connectome 59 deictic gestures 119 eidetic memory 149 exercise 52, 111
conscientiousness 177 déjà vu 141 Einstein, Albert 153 expressions, facial 116–117, 118, 119
conscious action 101 delta brain waves 42 electrical signals 20, 22–23, 24, 74, extroversion 177
conscious vision 70, 71 delusions 171, 211 75, 136–137, 197 eye contact 121
consciousness 10, 29, 30, 35, dementia 50, 52, 127, 146, 200 electrode implants 190 eyes
162–163, 164 dendrites 20, 21, 22, 23, 26–27, 136 electromagnetic fields 42 and attention 164
altered states of 170–171 dentate nucleus 97 electromagnets 49 body language 118
conscious emotion 110–111 depolarization 22, 23, 24 electromyograph (EMG) 168 facial expressions 116, 117, 119
levels of 169 depression 147, 185, 206, 207 electrosniffers 182 movement 36
locating 162–163 diabetes 206 embryos 44–45, 58 and position 84
requirements of 163 diet see food emotions 11, 48, 77, 106–107 seeing 64, 66–73
consolidation, of memories 138–139 diffusion tensor imaging 40, 43 and belief 158
control 10, 11 diffusion, and blood-brain barrier body language 118–119
conversation 128–129 18 and brain stem 186
conversion disorder 210 digestion 13, 92, 108 and cataplexy 205
F G
heart 18, 95, 198 illusions 73, 153, 174
heart defects 215 imagination 10
face recognition area 44, 68 gamma brain waves 42, 151 heart disease 205 imaging technology 40–41
facial expressions 116–117, 118, 119 gamma-aminobutyric acid (GABA) heart rate 13, 24, 36, 90, 92, 107, immune system 109, 202
and conversation 128, 129 24, 25 108, 109, 110 implants
reflex and conscious 110 ganglia 13 hemiplegia 203 brain/Cloud interfaces 193
facial recognition 71, 72, 149, 217 ganglion cells 67 hemispheres 10, 29, 58, 59, 125 nano neurobots 190
facial symmetry 115 garden path statements 128 hemorrhages 41, 197, 199, 206 neurograins 191
factitious disorders 210 gastrin 93 high-functioning ASD 217 and senses 182
factual beliefs 159 gender 148 hindbrain 28, 37 improvisation, in music 155
false memory 141 general anesthesia 90, 163 hippocampal fold 31 impulses 39, 46, 48, 184, 190, 191
fasting 170, 171 general intelligence factor (g) 153 hippocampus 38, 39, 48, 49, 58, 60, impulsiveness 213, 216
fat genetics 61, 102 inattentiveness 216
in brain 10, 55 and addiction 113, 212 and brain disorders 200, 203, 211, infantile amnesia 146
in diet 52, 54 and brain development/function 212, 213 infections 17, 18, 198, 206
fear 38, 39, 106, 108–109, 111, 44, 52, 56–57, 60–61 and emotions 107 inferior frontal gyrus 103
116, 117 and brain disorders 201, 202, 209, and memory 32, 134, 135, 136, inferior temporal gyrus 30
feedback loops 35, 91 211, 212, 216 137, 138, 139, 146, 147, 148, inflammation 198
feelings see emotions and creativity 154 149, 191 information processing 215
female brain 58–59 and intelligence 151 histamine 24 inherited diseases 57, 60, 201
fetus, sex of 58 and learning disabilities/ histone modification 61 inhibition 48
fields of vision 69 difficulties 215 homeostasis 34, 82, 90–91, 92 inhibitory neurotransmitters 24
fight-or-flight 13, 107, 108, 109, and memory 148 homosexuality 59 injuries, and pain signals 86
154 and migraines 196 hormones 19, 34, 35, 187, 196 innate responses 110
filaments 20 mutations 57, 201 and emotions 106, 107 inner ear 75, 84
fine motor skills 215 and personality 176 fear and anger 108, 109 insula 81, 158
flaccid paralysis 203 gestures 118, 119, 129 hunger and thirst 94 insulin 93, 94
flashbulb memories 148 ghrelin 93, 94 motherhood 49 intelligence 150–151
Flynn effect 153 glands 93 neuroendocrine system 92–93 artificial intelligence 188–189
fMRI (functional MRI) scans 40, 43, glia 10, 21, 28 sex and love 114–115 ASD 217
102, 103, 121, 154 globus pallidus 32, 33, 97 see also endocrine system measuring 152–153
focusing 155, 166–167, 186 glucagon 93 hunger 94, 95, 112 types of 150–151
food 52, 54–55, 61, 94, 95, 113, glucose 18, 19, 91, 93, 94 Huntington’s disease 57, 201 intensity, sound 76
216 glutamate 24, 25, 26, 27, 211 hydration 54 intention 103
eating disorders 214 glymphatic system 173 hydrocephalus 16, 205 interfering memories 145
taste 80–81 golgi tendon organs 85 hyperactivity 164, 190, 216 interior cortex 69
foramina 16 Google effect 145 hyperorality 39 internal clocks 174–175
forebrain 28, 29, 32 grand mal 197 hypersexuality 39 internet 145, 192
foreign accent syndrome 126 graphene 183 hypnagogic state 170 intracerebral hemorrhage 199
forgetfulness 146, 200, 216 gravity 84 hypnosis 170 introspection 169
forgetting 49, 144–145, 188 gray matter 10, 20, 28, 32, 51, 60, hypocretin 205 intrusive thoughts 209
amnesia 146–147 99, 211, 212 hypomania 207 invertebrates 14
free radicals 55 growth 35 hypothalamus 32, 34–35, 38, 39, 59, involuntary functions 12, 13
free will 168 spurts 85 187 ion balances 90
frequencies 76, 77 guarine 56 and brain disorders 196, 205, 207 IQ (intelligence quotient) 61,
Freud, Sigmund 169 Guillain-Barré syndrome 203 and emotions 107 152–153, 215
frontal cortex 46, 117, 171, 212 gyri 30, 118, 127 hunger and thirst 94, 95 irises 66
and emotion 110, 111 neuroendocrine system 92–93 ironic process theory 169
H
and movement 96, 97, 209 regulatory system 90, 91
J
reward centers 112 sex and love 114, 115
and senses 81, 87 habituation 134 hypothesis testing, and intelligence
frontal lobe 29, 30, 48, 111, 211 hallucinations 171, 200, 211 150 joint receptors 84, 85
and attention 100, 164 happiness 39, 106, 107, 116, 117 judgment 48
I
and consciousness 163 and aging 50 jugular veins 18
and intelligence 150 and ideal self 179 junk food 113
and memory 134 head injuries 197, 198, 206 ideal self 179
K
and senses 68, 77 headaches 196 ideas, flow of 154–155, 156
frontotemporal dementia 200 health identical twins 61, 176
fungal infections 198 anxiety about 210 identity, self and 179 Kennedy disease 202
fusiform gyrus 217 brain 52 ideological beliefs 159 kidneys 93, 95
hearing 36, 64, 74–77, 182 illness anxiety disorder 210 Klüver, Heinrich 39
220 221
Klüver-Bucy syndrome 39 long-term potentiation (LTP) 136, memory circuits, electronic 189 movement receptors 84
Knowledge, the (London taxi 137, 138, 139, 189 memory palace technique 142 MRI (magnetic resonance imaging)
drivers) 148–149 longitudinal fissure 29 memristors 189 scans 40–41, 43, 155, 198, 202
knowledge love 48, 114–115 meninges 16, 196, 198, 200 mucus 78
and belief 158 lust 114, 115 meningitis 198 multiple sclerosis (MS) 202, 203
and creativity 154 lying 120–121 menstrual cycle 35, 196 multipolar neurons 20
Lyme disease 203 mental health multitasking 165
L
lymphatic ducts 173 brain disorders 196–217 Munchausen syndrome 210
teenagers 47 Munchausen syndrome by proxy
M
labor 91 mental self 178 210
lamina terminals 95 Merkel’s disks 82 muscle receptors 85, 99
language 29, 61, 151 machine learning 36, 188 metabolism 175 muscles
and brain damage 126 macrophage cells 202 methamphetamine 175, 212 movement 98–99, 168
conversation 128–129 magnesium ions 26, 27 methylation 61 movement memory 96
and dementia/aging 52, 200 magnetism 40–41, 42–43, 186, 190, micro expressions 116 reflex actions 101
learning 124–125 191 microglia 21 spasms 203
learning disabilities/difficulties 215 male brain 58–59 microphones 182, 183 stiffness 201
processing 37 mammals 15 microprocessors 184 tensing 108
reading and writing 130–131 mammillary bodies 38, 134 microvilli 80 weakness 198, 199, 202, 203
language areas 126–127, 130 mandible (jawbone) 16 midbrain 28, 36, 98 music 60, 77, 103, 150, 155
language centers 77, 136 mania 207 middle ear 74 mutation, genetic 57, 201
lateral corticospinal tract 98, 99 mechanoreceptors 82 migraines 196 myasthenia gravis 203
lateral geniculate nucleus 68 medial frontal gyrus 123 mind, brain and 162–163 myelin sheaths 21, 46, 48, 50, 202
laughter 107, 205 medically induced coma 206 mind-body therapies 88
N
learning 32, 49 meditation 170 mindfulness 88
and aging 51, 52 medulla 32, 36, 196 mirror neurons 102–103, 118
and brain disorders 201, 216 MEG (magnetoenchepalography) mirror test 178 nano neurobots 190
disabilities/difficulties 204, 215 43, 186 mnemonics 142 nanobots, cerebral 193
environmental factors 61 Meissner corpuscles 83 monism 162 narcolepsy 205
improving memory 142–143 melanocortin 94 monitoring systems 42–43 nature and nurture 60–61
language 124–125 melatonin 46, 93 mood navigation 102
and limbic system 38, 39 memory 10, 11, 26, 49, 77, 102, and brain stem 186 near-death experiences 170, 174
and memory 136–137, 138, 148 134–135 disorders 47, 207 negative feedback 91
mirror neurons 102–103 and aging 52, 146 emotion versus 111 nerve agents 23
new skills 52, 100, 101, 102, 156, and artificial intelligence 189 and nutrition 55 nerve bundles 86, 87
215 distortions 171 morality 122–123 nerve signals 22–23
nonassociative 134 emotional 38, 107, 137, 140, 147 motor control 32, 33, 201, 211 nervous system 12–13, 98
perceptual 134 environmental factors 61 motor cortex 47, 77, 178, 184 networks of neurons 26–27, 61,
reading and writing 130–131 false 141 brain disorders 203, 204 138, 139, 140, 144, 150, 151
and reward centers 112, 186 forgetting 144–145 and emotions 110, 111, 117, 119 neural dust 193
and sleep 142 formation 136–137 and language 126, 128 neural implants 193
left hemisphere 10, 29, 126 improving 142–143 and movement 96, 98, 101, 103 neural lace 193
lenses 66 and limbic system 38 proprioception 65, 85 neural networks 36, 188
leptin 94 long-term 135, 136, 139, 167, 173 motor gestures 119 neural pathways 26, 33, 37, 59,
Lewy body dementia 200 and nutrition 55 motor homunculus 98 100–101, 136, 175, 176, 189
lexical gestures 119 problems 50, 51, 146–147, motor loop 33 neural tube 44
Libet, Benjamin 168 185, 200 motor neuron disease (MND) neurobots 190, 193
light 66, 67 recalling 38, 139, 140–141, 142, 202 neuroendocrine system 92–93
light sleep 172 144–145, 149, 167, 178 motor neurons 12, 98, 99, 101 neurofeedback 43
light therapy 207 and sense of self 178 mouth neurogenesis 49
limbic loop 33 short-term 29, 52, 134 facial expressions 117, 119 neurograins 191
limbic system 38–39, 47, 78, 79, 87, and skills 100 language 126 neurohormones 92
110, 171 and smell 79 movement 10, 11, 29, 98–99 neuromodulators 244
limbs, loss of 284 special types of 148–149 brain disorders 185, 201, 203, 204 neuromuscular junction 99
listening 128–129 storing 138–139, 140, 142, 145 and cerebellum 37 neurons 10, 20–21, 28
lobes, cortex 29, 30 technological enhancement 190 involuntary 201, 209 artificial 188
locked-in syndrome 206 and tiredness 100 mirroring 102–103 brain development 44–45, 49
locus coeruleus 137, 186 types of 134–135 planning 86–87, 168 and consciousness 163
loneliness 61 visual 71 repetitive 217 in cortex 30, 31
long-term memory 135, 136, 139, for words and faces 59 unconscious 100–101 death of 199
167, 173 memory chips 191 voluntary 84 degeneration 50
neurons continued organizational skills 200 personality 176–177 primary motor area 97, 98
and memory 136 organum vasculosum 95 assessing 177 primary taste area 65
mirror 102–103 ossicles 74 disorders 200, 201, 210, 213 priming 134
networks of 26–27, 61, 138, 139, outer ear 74 PET (positron emission procedural memories 135
140, 144–145, 150, 151 ovaries 93 tomography) scans 41 progesterone 93
production of 60 overclocking 190 petit mal 197 proportional theory 175
synchronicity of 163 oxygen 52, 199, 204, 206 pH regulation 90 proprioception 64, 65, 84–85
neuroplasticity 26, 45 oxytocin 48, 91, 107, 114, 115 phobias 109, 208 proprioceptors 82, 84, 85
neuropsychiatric disorders 190 phonological recoding 131 prosopagnosia 71
PQ
neuroscience 10, 11 phosphates 137 prostaglandins 86
neuroticism 177 photographic memory 149 prostheses 182, 184, 190
neurotransmitters 20, 22–25, Pacinian corpuscles 83 photoreceptors 67 protein transporters 19
26–27, 55, 57 packets of time 174 phrenology 30 proteins 57, 200
and attention 154, 164 pain physical brain 10 in diet 54
and brain disorders 185, 212 brain tissue 10 male and female 58–59 protons 40–41
and emotions 111, 112, 114 feeling 86–87 physical illusions 73 psychometric testing 153
and memory 136, 137 headaches and migraines 196 physical self 178 psychopathy 123
and movement 99 managing 88–89, 186 physiological illusions 73 psychotic disorders 170, 211
and personality 176 pain fibers 86 pia mater 16, 198 PTSD (post-traumatic stress
and time 175 pain receptors 86 pica 39 disorder) 147, 208
nicotine 24, 52 pain relief, natural 87 pictures 153 pulse 121
NIRS (near infrared spectroscopy) pancreas 93, 94 pineal gland 93, 200 pulvinar nucleus 187
186 panic attacks 109, 208 Pinocchio illusion 85 punishment 39
nociceptors 82 papillae 80 pituitary gland 34, 35, 92, 93, 95, pupils 66, 108, 118
noise, filtering out 75 paracellular transport 18 114, 200, 208 purging 214
nonassociative learning 134 parahippocampal gyrus 38 placebo effect 158 putamen 33, 96, 100, 134
nonbinary brains 59 paralysis 199, 203 planning 101 quadriplegia 203
nondeclarative (implicit) memories paraplegia 203 plaques 50, 202
R
135 parasympathetic nervous plasma 17
nonverbal communication system 13 plasticity 151
118–119, 129 parathyroid gland 93 pleasure 39, 113, 212 radial glia 21
noradrenaline 24, 114, 137, 154, pareidolia 72 polarization 22–23 radio waves 41, 190
186 parenthood 48, 114 polygraphs 121 rationality 122
nose 78, 81 parietal cortex 121, 173, 178 pons 32, 36 reaction pathways 100
nuclei 32–33, 36, 92, 186, 187 and intelligence 150 position, sense of 84, 85 readiness potential 96
nucleus accumbens 112, 113 and movement 96, 97, 98, 100, positive feedback 91 reading 127, 130–131, 215
numerical ability 51 103, 111 post-traumatic stress disorder reasoning 171
nutrition 52, 54–55 parietal lobe 29, 30, 171 (PTSD) 147, 208 receptors
and attention 164 postconcussive amnesia 197 bionic limbs 184
O
and intelligence 151 posterior cingulate cortex 123 crossing the blood-brain barrier
and memory 134 posterior superior temporal lobe 19
obsessive-compulsive disorder and morality 122 122 memory 136, 137
(OCD) 185, 209 and movement 100, 102 postsynaptic neurons 23, 113 nerve signals 22
occipital lobe 29, 30 and senses 70, 71, 84 posture 37, 118, 119 olfactory 78
occipital-temporal area 131 parietal-temporal cortex 131 potassium ions 22 senses 64, 65
odors 78–79, 81 Parkinson’s disease 33, 130, 174, practice, and memory 136, 139, 142 smell 65
olfactory bulb 38, 78, 81, 134 185, 200, 201 preconscious 169 stretch 91
olfactory cortex 65, 78 parsing, in speech decoding 129 preference beliefs 159 taste 65, 80, 81
olfactory epithelium 78 pattern sequences 153 prefrontal cortex 45, 47, 102, 173, thermoreceptors 91
oligodendrocytes 21 Pavlov, Ivan 134 174, 178 touch 82, 83
omega-3/-6 fatty acids 55, 61 pedunculopontine nucleus 186 and emotions 107, 114, 121, 167 recognition 38, 70, 71, 141, 200
openness 177 peers and memory 145, 167 red blood cells 93
opioids 113 peer pressure 47 prefrontal loop 33 reflex actions 86, 100, 101, 108
optic chasm 68 and sense of self 179 pregnancy 44, 147, 204 regulatory system 90–91
optic nerve 12, 66, 67, 68 perception 72–73, 162–163, 171 premotor area (PMA) 96, 97, 102, rehabilitation 212
optical illusions 73 of time 175 103 rehearsing actions, and mirror
orbitofrontal cortex 30, 78, 81, 118, perceptual learning 134 premotor cortex 31 neurons 103
209 perceptual theory 175 prenatal screening 204 relationships 52
orbitofrontal prefrontal cortex 123 perfectionism 214 pressure sensors 84 relaxation techniques 88
organ of Corti 75 periaqueductal gray 186 presynaptic neurons 23, 113, 136 REM (rapid eye movement) sleep
organelles 21 peripheral nervous system 12, 36 primary auditory cortex 75, 76 172, 173
222 223
renin 93, 95 senses continued spatial awareness 59, 70, 71, 148, survival 112
repetition 136, 137 smell 78–79 171, 215 sustained attention 165
repetitive behaviors 217 superhuman 182–183 spatial information 68, 164 swallowing 36, 202
repolarization 22 taste 80–81 spatial recognition 152 sweating 107, 108, 109, 110, 121
“rest-and-digest” state 13 touch 82–83 specific language impairment 215 symbolic gestures 119
resting potential 22, 23 sensory cortex 107 speech 29, 119, 126–127, 217 symbols, and reading 130
resting state 156, 189 sensory data 184 conversation 128–129 sympathetic nervous system 13,
reticular formation 36, 87, 90 sensory deprivation 170 loss of 202 108
reticulospinal tract 98 sensory nerves 12, 101 and lying 121 synesthesia 64
retinal implants 182–183 sensory perception 26, 28, 111, slurred 198, 199, 201, 203 synapses 20, 22, 23, 24, 25, 26
retina 66, 67, 68 211 spina bifida 203, 205 aging 51
retrograde amnesia 146 septicemia 198 spinal cord 12, 13, 17, 28, 29, 36, 87 in babies 45
retronasal olfaction 81 serotonin 24, 107, 111, 114, 186 disorders 202, 203 and memory 136, 138, 139, 145,
reuptake inhibitors 24, 25 sex 112, 113, 114–115 movement 97, 98–99, 101 189
reward centers 39, 112–113, 123, determination of 58 spinal nerves 12, 28 synaptic cleft 23, 26, 27, 99
186, 209, 212 sexual abuse 214 spindle fibers 85 synaptic pruning 46
rhythm 76 sexual arousal 13 spinocerebellum 37 synaptic weight 26
right hemisphere 10, 29 shapes 14–15 sports 100–101 syntax 128, 129
risk-taking 46, 212 shell shock 147 SQUIDS (superconducting
T
rituals 209 short-term memory 29, 52, 134 quantum interference
robotics 184, 188, 190 sight 64, 66–73, 182 devices) 43
rods, in retina 67 sign language 119 stapes 75 talking 37, 124–125
root hair plexus 82 sinuses 16 stem cells 49 talking therapies 213
rubrospinal tract 98 sinusitis 198 stereoscopic vision 69 taste 65, 79, 80–81
Ruffini endings 83 size, brain 14–15 stimuli taste buds 80, 81
skeleton 98 and aging 52 Tay-Sachs disease 57
S
skills, new 52, 100–101, 102, 147, and consciousness 162, 163 tDCS 190–191
156, 215 hypothalamus 34 technology addiction 24
sadness 106, 107, 111, 116, 206 skin 64, 82–83 innate responses 110 teenagers 46–47, 172
salience network 154, 155 artificial 183 and reward centers 112, 212 telepathy, electronic 189
saliva 108 skull 16–17, 197 senses 64–65 temperature, body 90, 91, 175, 187
salt levels 95 fractures 41 skin sensors 82 temporal lobe 29, 30, 39, 171, 211
savant syndrome 148 sleep 28, 35, 156, 172–173 stomach 93 and memory 134, 147
scanning technology 40–41 deprivation 173, 205 stress 52, 61, 88, 147, 156, 196, 208, and movement 100
schizophrenia 47, 170, 211 disorders 173, 206 209, 211 and senses 70, 71, 76, 127
Schwann cells 21 and memory 138, 142 stretch receptors 84, 85 temporal pole 122
sciatic nerve 12 narcolepsy 205 striatum 32 tendon receptors 84, 85
sclera 66 in teenagers 46, 172 strokes 41, 127, 197, 199, 203, 205 tension sensors 84
seasonal affective disorder (SAD) sleep-wake cycle 36, 187 study technique 138 tertiary auditory cortex 76
207 sleepwalking 173 subarachnoid hemorrhage 199 testes 93
Seattle Longitudinal Study 51 small-world networks 27 subarachnoid space 50, 51 testosterone 93, 115
secondary auditory cortex 76 smell 38, 39, 65, 78–79, 182 subdural hematoma 199 thalamus 29, 32, 33, 34, 35, 36, 37,
secondary taste area 65 and taste 79, 81 subfornical organ 95 58
seizures 147, 197, 198, 201 smiling 110, 117 substance abuse 24, 25, 47, 212, and brain disorders 196, 209
selective attention 165 smoking 24, 52 214 and emotions 107, 108, 121
self, sense of 10, 178–179 sneezing 66 substantia nigra 28, 32, 33, 97, 175, and memory 134
self-awareness, physical 84 social anxiety disorder 208 201 and movement 97, 100
self-consciousness 47, 125 social communication 217 subthalamic nucleus 33, 97 as relay station 187
self-control 46, 61, 171, 209, 212 social interactions 52, 117, 118, 217 suicide 206 and senses 68, 74, 75, 84, 87, 90
self-description 179 social media 179 sulcus 30 thermoreceptors 82
self-esteem 214 social networks 61 sunlight 207 thermoregulation 28
self-harm 217 social norms 122 superior autobiographical memory theta brain waves 42
self-image 208 sodium ions 22 149 thinking 11
selflessness 123 somatic nervous system 12, 13 superior colliculus 164 thinking speed 52
semantic memories 135 somatic symptom disorder 210 superior temporal gyrus 118 thirst 94, 95
semantics 128 somatosensory cortex 31, 65, 81, supernatural explanations 159 thymine 56
senses 10, 64–65 82, 83, 87, 178, 183, 184 supplementary motor area (SMA) thymus 93
and attention 164 somatostatin 93 96, 97 thyroid gland 93
hearing 74–77 sound, perceiving 76–77 suprachiasmatic nucleus (SCN) 187 TIA (transient ischemic attack) 199,
proprioception 84–85 sound waves 64, 74 supramarginal gyrus 127 203
sight 66–73 spastic paralysis 203 surprise 111, 116, 117 tics 209
U WY
time 171, 174–175 ventromedial prefrontal cortex
tiredness 100 122, 158
TMS 189, 191 ultrasound 41 verbal tics 209 waste, elimination of 173
tolerance, and addiction 113, 212 unconscious, the 168–169 vermis 37 water
tongue 80 unconscious emotions 107 vertebrae 99 in brain 10
touch 64, 82–83 unconscious movement 100–101 vertebral arteries 18, 19 hydration 54, 55
Tourette’s syndrome 209 unconscious vision 70, 71 vertebrates 14 thirst 95
toxins 52, 173 unconsciousness 169, 197, 206 vesicles 19, 113, 136 waves 42
trances 170 understanding 126 vestibular canal 75 weight
trancytosis 19 unipolar neurons 20 vestibulospinal tract 98 of brain 10
transcranial direct current unwanted thoughts 169 vibrations 74 eating disorders 214
stimulation (tDCS) 190 urges 112, 113, 212 video cameras 182 Wernicke’s area 31, 119, 126, 127,
transcranial magnetic stimulation urination 35, 95 video processing unit (VPU) 182, 129
(TMS) 189, 191 183 white blood cells 93
V
transgender people 59 virtual reality 162 white matter 10, 20, 21, 28, 29, 32,
transient global amnesia 146 viruses 198 43, 49, 50, 51, 99
transnasal surgery 200 vagus nerve stimulation (VNS) 185 vision see sight wireless signals 182
trauma 146, 206, 208, 209, 210, vascular dementia 200 visual cortex 64, 68–71, 77, 96, 100, working memory 52, 135
211 vascular system 18 101, 131, 136, 173, 183 World Wide Web 192–193
tremors 187, 201 vasopresin 115 visual processing 72–73, 100 writing 127, 130–131, 215
true memory 141 vegetative state 206 visual reflexes 28 yawning 103
tumors, brain 127, 197, 200, 203 ventral horn 99 visualization 88
Turing Test 188 ventral (lower) route, and visual vitamins and minerals 55, 61
twins 61, 176, 212 processing 70, 71, 100 vocabulary 51, 124–125, 131
twitching 201 ventral tegmental area (VTA) 112, volume, of brain 10
186 voluntary movements 12, 84, 98
ventricles 16, 17, 50, 51, 211
Acknowledgments
DK would like to thank the following people for help in preparing pnas.1003744107 (bl). 51 APA: (Excluding explanatory annotation): Based
this book: Janet Mohun and Claire Gell for helping plan the contents; on Fig. 2—Longitudinal estimates of age changes in factor scores on six
Helen Peters for compiling the index; Joy Evatt for proofreading; and primary mental abilities at the latent construct level. From “The Course
Katy Smith for design assistance. of Adult Intellectual Development” by K. W. Schaie 1994, American
Psychologist, 49, pp. 304–313 © 1994 by the American Psychological
Senior DTP Designer Harish Aggarwal Association (br). 59 PNAS: Based on Fig. 2A from “Sex differences in
structural connectome,” Madhura Ingalhalikar et al., Proceedings of the
Jackets Editorial Coordinator Priyanka Sharma National Academy of Sciences Jan 2014, 111 (2) 823–828; DOI: 10.1073/
pnas.1316909110 (crb). 103 PLoS Biology: Based on Fig. 4 from “Grasping
Managing Jackets Editor Saloni Singh the Intentions of Others with One’s Own Mirror Neuron System,” Iacoboni
M., Molnar-Szakacs I., Gallese V., Buccino G., Mazziotta J. C., Rizzolatti G.,
The publisher would like to thank the following for their kind permission Feb 2005 PLoS Biol 3(3):e79. doi:10.1371 / journal.pbio.0030079 (crb).
to reproduce or adapt graphs and brain images: 155 PLoS ONE: Based on Fig. 3A from “Neural Substrates of Interactive
Musical Improvisation: An fMRI Study of ‘Trading Fours’ in Jazz,” Gabriel F.
(Key: a-above; b-below/bottom; c-center; f-far; l-left; r-right; t-top) Donnay, Summer K. Rankin, Monica Lopez-Gonzalez, Patpong Jiradejvong,
Charles J. Limb, Feb 2014 PLoS ONE 9(2): e88665. https://doi.org/10.1371/
46 Data from the American Academy of Sleep Medicine: (bl). 50 PNAS: journal.pone.0088665 (bc).
Based on Fig. 1 from “A snapshot of the age distribution of psychological
well-being in the United States,” Arthur A. Stone et al., Proceedings of the For further information see:
National Academy of Sciences Jun 2010, 107 (22) 9985–9990; DOI: 10.1073/ www.dkimages.com

How The Brain Works

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First American Edition, 2020

Sensing the World 64

Fueling the Brain 18 Older Children 46 Touch 82

Fear and Anger 108 What Is Consciousness? 162

Reading and Writing 130 Why We Forget 144

Memory Problems 146

Special Types 148

How to Boost 156

Headache and Migraine 196 Seasonal Affective 207

Motor Neuron Disease 202 Eating Disorders 214

Depression 206 INDEX 218

Bipolar Disorder 207 ACKNOWLEDGMENTS 224

The physical brain Weight Fat

LEFT BRAIN VS. RIGHT BRAIN

SMOOTHING OUT ALL THE WRINKLES OF THE

THE TOTAL LENGTH

Nerves branch Esophagus

0.04 oz 1.76 oz 49.4 oz

0 0.03 oz (0.9g) 1 g 0 1.05 oz (30g) 50 g 0 47.6 oz (1,350g) 1,400 g

Olfactory bulbs Cerebral cortex

The cranium forms a bony case IP EM

The blood-brain barrier

surround the blood vessels.

Tight junction Some water-soluble

As well as the brain, CSF KEY Selectively permeable

surrounds the spinal Normal blood vessels allow fluid to pass

along the back of the fat-based hormones, and non-water-soluble

Crossing the blood-brain barrier Paracellular transport Diffusion

barrier. Other than that, nothing gets in or out.

The physical blood-brain barrier is created by the Molecule

Astrocytes collect material from

The Circle of Willis

Protein transporters Receptors Transcytosis Active efflux

Glucose Hormone reaches Protein molecule

Types of neurons Dendrites act like antennae to

An axon may be covered in a

Inside a neuron Cilia help move

Membrane channels Excess of ions inside

CELL’S AXON MEMBRANE

Resting potential Depolarization

Chemicals AS DRUG ADDICTION?

TYPES OF NEUROTRANSMITTERS TYPE OF DRUG EFFECTS

NEUROTRANSMITTER USUAL POSTSYNAPTIC A molecule that does the opposite

Dopamine Excitatory and inhibitory

SENDING NEURO SENDING NEURO

Normal dopamine levels With use of cocaine

The patterns of nerve-cell connections in the SYNAPTIC CLEFT

The dominant theory of how the brain remembers

Neuroplasticity Strong Weak

fixed but seem to change and adapt

Channel open More receptors

between the brain and sensory Hindbrain

rear of the brain and the brain stem, which

The cortex is the thin outer layer that forms the LS

Folds and grooves

surface area of the cortex, thereby RI Sulcus

providing more room for larger

cortical areas. The groove in a fold