International Journal of

Environmental Research
and Public Health

Review
Does Lactate-Guided Threshold Interval Training within a
High-Volume Low-Intensity Approach Represent the “Next
Step” in the Evolution of Distance Running Training?
Arturo Casado 1, * , Carl Foster 2 , Marius Bakken 3 and Leif Inge Tjelta 4

1 Center for Sport Studies, Rey Juan Carlos University, 28933 Madrid, Spain
2 Department of Exercise and Sport Science, University of Wisconsin-LaCrosse, La Crosse, WI 54601, USA
3 Søm Medical Center, 4637 Kristiansand, Norway
4 Departament of Education and Sports Science, University of Stavanger, 4021 Stavanger, Norway
* Correspondence: [email protected]; Tel.: +34-914888401

Abstract: The aim of the present study was to describe a novel training model based on lactate-
guided threshold interval training (LGTIT) within a high-volume, low-intensity approach, which
characterizes the training pattern in some world-class middle- and long-distance runners and to
review the potential physiological mechanisms explaining its effectiveness. This training model
consists of performing three to four LGTIT sessions and one VO2max intensity session weekly. In
addition, low intensity running is performed up to an overall volume of 150–180 km/week. During
LGTIT sessions, the training pace is dictated by a blood lactate concentration target (i.e., internal
rather than external training load), typically ranging from 2 to 4.5 mmol·L−1 , measured every one to
three repetitions. That intensity may allow for a more rapid recovery through a lower central and
peripheral fatigue between high-intensity sessions compared with that of greater intensities and,
therefore, a greater weekly volume of these specific workouts. The interval character of LGTIT allows
Citation: Casado, A.; Foster, C.; for the achievement of high absolute training speeds and, thus, maximizing the number of motor
Bakken, M.; Tjelta, L.I. Does units recruited, despite a relatively low metabolic intensity (i.e., threshold zone). This model may
Lactate-Guided Threshold Interval
increase the mitochondrial proliferation through the optimization of both calcium and adenosine
Training within a High-Volume
monophosphate activated protein kinase (AMPK) signaling pathways.
Low-Intensity Approach Represent
the “Next Step” in the Evolution of
Keywords: running; performance; physiological adaptations; endurance sports; lactate; training monitoring
Distance Running Training? Int. J.
Environ. Res. Public Health 2023, 20,
3782. https://doi.org/10.3390/
ijerph20053782
1. Introduction
Academic Editors: António
On 7 August 2021, 20-year-old Norwegian middle-distance runner Jakob Ingebrigtsen
Carlos Souse and Paul B.
Tchounwou
won the 1500 m Olympic title in Tokyo while breaking the Olympic and European records
with a time of 3:28.32 (min:s). He also has won the World 5000 m and European 1500 m,
Received: 27 December 2022 3000 m, 5000 m, and cross-country titles and owns the current indoor 1500 m world record
Revised: 16 February 2023 (3:30.60 (min:s)). Further, his brothers Henrik and Filip, also Olympians, won the European
Accepted: 17 February 2023 1500 m championships in 2012 and 2016, respectively. Their training pattern was described
Published: 21 February 2023 in a recent article [1] and is considered critical for their development as athletes. While
it does not differ greatly from usual training modes in world-class runners [2,3], there
is one specific characteristic which makes it unique and innovative: they were typically
measuring their blood lactate concentration ([BLa]) during most of their high-intensity
Copyright: © 2023 by the authors.
training sessions with the intent of matching a specific physiological intensity [1].
Licensee MDPI, Basel, Switzerland.
This article is an open access article
The main physiological performance determinants which account for success in dis-
distributed under the terms and
tance running events are: maximal oxygen uptake (VO2max ) [4–6]; running economy
conditions of the Creative Commons (RE), defined as steady-state VO2 at a given submaximal speed or as the VO2 per unit of
Attribution (CC BY) license (https:// distance [5,7–9]; the ability to sustain a high percentage of VO2max during competition
creativecommons.org/licenses/by/ (% VO2max ) [10–12]; the lactate threshold (LT), defined either as the velocity at which
4.0/). a non-linear increase in blood lactate occurs, the maximal lactate steady-state (MLSS),

Int. J. Environ. Res. Public Health 2023, 20, 3782. https://doi.org/10.3390/ijerph20053782 https://www.mdpi.com/journal/ijerph
Int. J. Environ. Res. Public Health 2023, 20, 3782 2 of 15

or the velocity corresponding to a blood lactate concentration of 4 mmol·L−1 [13]; ve-

locity at LT (vLT)/MLSS [14,15]; and the minimum velocity needed to achieve VO2max
(vVO2max ) [6,16,17]. To improve distance running performance, the training stimulus must
enhance one or more of these factors [18].
The training stimulus represents the interaction among training volume (km per
week), training frequency, and training intensity designed to enhance the aforementioned
performance physiological determinants and performance in distance runners (19). The
ideal relationship among these three training variables has, through several decades, been
a topic of discussion in both the scientific [19–25] and coaching [26–30] literature.
However, it remains unclear whether selecting the absolute training intensity com-
posing the training stimulus through the control of an internal training load marker (i.e.,
blood lactate concentration) to match specific metabolic (relative) intensities may represent
a training pattern optimizing the improvement of performance and its physiological deter-
minants in distance runners. Accordingly, the present article aims to describe this training
model and its similarities with those considered optimal according to the current scientific
literature and examine the potential physiological mechanisms which may support its
effectiveness. It would encourage the conduction of further intervention studies testing its
influence on performance and its physiological determinants. If this model represents a
more efficient training approach than those currently accepted, it may be useful for coaches
and athletes, thereby optimizing performance in the latter.

2. Historical Trends in Distance Runners’ Training Principles

During the last 100 years, the training principles used by middle- and long-distance
runners have been inspired by training theories that provided success for contemporary
outstanding runners. To a lesser extent, principles derived from physiological research
have contributed to our understanding of how to train runners.
In the 1920s and 1930s, international distance running was dominated by Finnish
runners. The Finnish sports professor Lauri Pikhala inspired Pavo Nurmi (nine-time
Olympic champion from 1920–1928 in events ranging from 1500 m to 10,000 m and cross
country) and other Finnish runners with training principles he brought home from the
United States. Their training system during the spring and summer seasons was a precursor
to interval training [27]. Nurmi could, for instance, incorporate 6 × 400 m in 60 s into a
slow run of 10 to 20 km in the forest [31]. The term “interval training” was introduced in
the 1930s by the German coach Woldmar Gerschler and physician Herbert Reindel [27].
Their interval training represented a way to quantify the training load on the basis of
repetitive runs to a heart rate of 180 beats/min, with a recovery interval to a heart rate of
120 beats/min. An interval training session consisted of repetitions of shorter (100 m to
400 m) runs. Gerschler was the coach of elite German middle-distance runners, such as
Rudolf Harbig, who broke the 800 m world record in 1939 with a time of 1:46.6 (min:s).
Importantly, in the 1930s, many years before the advent of portable heart rate monitors,
accurately measuring a heart rate of 180 was nearly impossible, and the rationale for
choosing “run to 180, recover to 120” is lost to history. Gösta Holmér was the coach of the
Swedish runners Gunder Hägg and Arne Anderson who set numerous world records (WR)
over distances from 1500 m to 5000 m in the 1940s. Holmér developed “fartlek”, which
consisted of intensive efforts of varying distance and duration, interspersed with slower
running [32]. It was very similar to Gerschler’s interval training but less formally organized
and often conducted “by feel” in the forests rather than on a track. Czech runner Emil
Zatopek, multiple-time Olympic champion in events from 5000 m to marathon from 1948
to 1952, typically performed an interval training regime consisting of a very high number
of repetitions over 400 m (i.e., 60 × 400 m or 40 × 400 m with a recovery period between
repetitions typically of a 200 m jog). The pace used and effort made during these repetitions
were submaximal [27].
Int. J. Environ. Res. Public Health 2023, 20, 3782 3 of 15

An interval training regime was also used by Mihály Igloi, who coached Hungarian
Sandor Iharos. Iharos broke WRs in the events ranging from 1500 m to 10,000 m during the
1950s. Training intensity during their intervals was higher than that used by Gerschler [27].
In the 1960s, the New Zealand coach Arthur Lydiard criticized the hard interval
training regimes, primarily on the grounds that predicting when peak performance would
occur was difficult. Lydiard proposed that effective distance running training should be
founded on the basis of high volume of continuous low- to moderate-intensity running.
He coached his countrymen Peter Snell (three-time Olympic gold medallist in 800 m and
1500 m between 1960 and 1964) and Murray Halberg (5000 m gold in 1960). His training
philosophy involved a periodized training pattern. Three main training periods were
completed: a 10–12 week preparation period which consisted mainly of high mileage of
easy continuous running targeted at reaching 100 miles (160 km) per week, a 6–8 week
period characterized by a high volume of hill running, and a 10–12 week competitive period
consisting mainly of track interval training at or near race pace leading up to the main
competition of the year [26]. In particular, the net effort during the competition period was
fairly low, based on Lydiard’s saying, “you can’t train hard and race hard at the same time”.
In the same general timeframe, German coach and physician Ernst Van Aaken proposed
the Pure Endurance Training Method, which was based on very similar principles as those
proposed by Lydiard, but without fixing a specific training volume (i.e., 100 miles per
week), using hill repetitions and developing a periodized pattern. Van Aaken coached
German runner Harald Norpoth, who achieved a silver medal at the 1964 Olympic Games
in the 5000 m event [29].
In the 1970s and 1980s, many athletes who competed at an international level in
distance running used a training regime based on Lydiard’s high volume of continuous
training principle, but in contrast to Lydiard, they also incorporated sessions of interval
training during the preparation period [33–35]. The “hard day–easy day” approach to
training system is usually attributed to University of Oregon coaches Bill Bowerman and
Bill Dellinger (bronze medallist in 5000 m in the 1964 Olympic Games), in which two to
three high intensity interval sessions per week were separated by easier days (some with a
training volume of <5 km/day) with continuous running [30,36].
From the 1970s and 1980s to the present day, most athletes have used a training regime
consisting of two to five weekly sessions of interval training and/or longer tempo runs
combined with a relatively high volume of easy and moderate intensity continuous run-
ning [33,34,37,38]. A variety of sources have reported that successful distance runners have
typically run between 120 and 250 km per week distributed across 11 to 18 sessions [37–41].
Most of these training characteristics have been determined through a ‘trial and error’
approach rather than by the outcomes of intervention studies. Furthermore, apart from
Gerschler, internal physiological intensity control during high intensity interval sessions
has rarely been proposed as a training strategy to improve performance.

3. External and Internal Training Load in Distance Running

The training load, which refers to the interaction between training intensity and
training volume, can be understood as either external (i.e., measurable aspects of training
occurring externally to the athlete such as volume or intensity (i.e., running speed)) or
internal (actual psychophysiological response that the body initiates to cope with the
requirements elicited by the external load) [42]. Therefore, external load refers to the actual
distance covered and speed achieved during a given training session. In turn, internal load
can be measured through the monitoring of heart rate or [BLa]. While external training
load represents an important reference to understand the performance evolution during
the training process [3], it is generally believed that internal load may be the most accurate
indicator of the effort for distance runners [22] as well as for other sports [42]. Accordingly,
measuring internal training load (i.e., [BLa]) during training and using that information
to control the absolute training intensity (i.e., speed or duration of repetitions) in order to
Int. J. Environ. Res. Public Health 2023, 20, 3782 4 of 15

achieve the most optimal stimulus represents a conceptually attractive training protocol
which agrees with current recommendations [42].

4. Training Volume and Intensity Distribution Analysis in Runners Based on Their

Internal Response to Exercise
The aerobic–anaerobic transition as a framework for predicting performance in en-
durance events was introduced in 1979 by Kindermann et al. [43]. During the last five
decades, this framework has been espoused and updated by several scientists using either
gas exchange or [BLa] markers [14,40,44,45]. During the last 50–60 years, several definitions
related to the LT parameter have been presented [14]. Today it is common to refer to two
breakpoints from a plot of the [BLa] during an incremental exercise test in a laboratory. The
first threshold (LT1) was named aerobic threshold by Skinner and McLellan [44] and refers
to the upper limit of aerobic metabolism. Intensities up to this point could last for hours.
The second threshold or second lactate threshold (LT2) that has also been associated with the
MLSS is known as the highest constant workload during continuous dynamic work, where
there is an equilibrium between lactate production and lactate elimination [14,41,46,47]. At
a slightly higher intensity than MLSS, the critical power (CP) concept, which is related to
the hyperbolic relationship between speed or power output and the duration for which
that speed or power output can be sustained, is an alternative approach to defining the
maximal metabolic steady state [48].
According to these concepts, three training intensity zones (see Table 1) for endurance
athletes are commonly used [22,49]. Zone 1 represents speeds below first ventilatory
threshold or 2 mmol·L−1 [BLa]. Zone 2 is represented by speeds between the two ventilatory
thresholds or 2 and 4.5 mmol·L−1 [BLa] (vLT1 and vLT2, respectively). Zone 3 represents
speeds above vLT2 [50]. However, this classification does not differentiate between low-
and high-intensity Zone 2 training, nor does it demarcate the different intensity zones
that are in Zone 3, such as lactate tolerance and sprint training, being both above the
VO2max intensity.
Table 1. Intensity scale for distance runners.

Scale [BLa] HR VO2max RPE Training Methods

6-Zone 3-Zone mmol·L−1 % Max % 6–20
SST (6) 3 n/a n/a n/a n/a Sprint
VHIT (5) 3 8–18 >97 94–140 18–20 Lactate tolerance (i.e., 800 m and 1500 m pace)
HIT (4) 3 4.5–8 92–97 88–94 16–18 Intensive aerobic interval (i.e., 5000 m pace)
MIT (3) 2 3.5–4.5 87–92 84–88 14–16 Threshold training: interval running (10,000 m pace)
Threshold training: continuous/interval running
MIT (2) 2 2–3.5 82–87 80–84 12–14
(marathon pace)
LIT (1) 1 0.7–2 62–82 55–80 9–12 Easy and moderate continuous running
[BLa]: Blood lactate concentration; HR: heart rate; VO2max : maximal oxygen uptake; RPE: rate of perceived
exertion according to original Borg scale; SST: short sprint training; VHIT; very-high-intensity training, HIT:
high-intensity training; MIT: moderate-intensity training; LIT: low-intensity training; n/a: not applicable; numbers
in parentheses in the first column refer to each zone of the 6-zone scale and numbers in the second column refer to
each zone of the 3-zone scale.

Furthermore, the transition between the different intensity zones does not follow
clearly defined limits and are not anchored on exactly defined physiological markers [22].
The relationship between HR and [BLa] will also vary among different runners and in the
same athlete across different training periods or seasons [51]. Table 1 describes the type of
training performed, typical [BLa], typical % of HRmax, and % VO2max in the various zones
for well-trained distance runners. Table 1 uses the intensity scales (i.e., three- and six-zone
models) that will be referred to in this article and is elaborated upon according to previous
suggestions [1,52,53]. Further mentions of training zones in the present article are referred
to by the six-zone scale as z1, z2, . . . , and z6.
Int. J. Environ. Res. Public Health 2023, 20, 3782 5 of 15

In order to analyze the effect of particular combinations of training volume and

intensity in each of these zones, different training intensity distribution models (TID) have
been described.
1. The pyramidal model is characterized by a decreasing training volume from z1 to z2
and z3, respectively. Approximately 70–80% of volume is covered in z1, with the
remaining 20–30% in z2 and z3 [50].
2. The polarized model is characterized by the completion of approximately 80% of the
volume at z1, with most of the remaining 20% covered at z3 and as little training as
possible in z2 [50].
3. The threshold model features a greater proportion of overall volume conducted in z2
(i.e., >35%) than other models.
According to recent reviews [3,54], either polarized or pyramidal approaches improved
performance in distance runners to a greater extent than other models, which was also
the main conclusion of a recent debate regarding which of the two models was more
effective [24,25]. However, a more recent review reported that a pyramidal approach was
typically adopted more often in highly trained and elite distance runners, despite the fact
that polarized TID also appears to be effective [55]. Most importantly, a high-volume
low-intensity approach is carried out in both the pyramidal and polarized TID models.

5. Physiological and Performance Development Using Lactate-Guided Threshold

Interval Training (LTIT) within a High-Volume Low-Intensity Approach
5.1. Physiological Mechanisms Underpinning the Effectiveness of the Use of High Training Volume
at Low Intensity
Different hypotheses have been proposed to explain the underpinning mechanisms
regarding the reason why a great proportion (70–80%) of overall training volume conducted
at low intensity yields optimal performance development in endurance athletes who will
race at comparatively high intensities (e.g., low specificity of training). The improvement
of endurance performance through high volume of low/moderate continuous training
is generated by sustaining increased cardiac output over a prolonged time (therefore
augmenting oxygen delivery to working skeletal muscle) and by increased capacity for
the oxidative metabolism through mitochondrial biogenesis and capillarization in Type I
skeletal muscle fibers [56,57]. Importantly, the mozaic architecture of human skeletal
muscle dictates that increased capillarization in Type I skeletal muscle fibers also serves
to augment O2 delivery in Type II muscle fibers. Two primary signaling pathways for
mitochondrial proliferation (both convergent on PGC1-α expression) exist. One is based
on calcium signaling, which is more likely used with high-volume training [57,58], and
the other is based on signaling derived from adenosine monophosphate (AMP)-activated
protein kinase (AMPK) pathway, which is more likely used with high-intensity training, as
[ATP] and AMP levels are reduced and increased, respectively [59,60]. As recruiting certain
motor units elicited during competitive intensity exercise is needed in order to generate
adaptative responses leading to increase mitochondrial density and aerobic metabolism, it
can be achieved through the completion of at least a modicum of high-intensity training.
The fact that most studies conclude that most of the training volume in distance runners
should be covered at easy intensity to optimize performance development implies that
adaptive potential of calcium signaling pathway is much larger than that of the AMPK
signaling pathway. Accordingly, only relatively small training volume of the latter is
needed to reach saturation in the adaptive response using this pathway [58,61].
Alternatively, evidence suggests that some homeostatic disturbances leading to failure
to adapt to training (i.e., overtraining or non-functional overreaching) may be related
to either inflammatory responses [62] or that slow autonomic recovery following high
intensity training [63] may be caused by monotonic loads of high intensity training. These
disturbances could lead to a reduction of the capacity for aerobic ATP generation through
deficiencies in the mitochondrial electron transport chain or selective delivery of blood
flow and/or reductions in maximal cardiac output [24]. Despite the mechanisms involved,
Int. J. Environ. Res. Public Health 2023, 20, 3782 6 of 15

quasi-experimental observations [64,65] have suggested the negative effects of an excessive

amount of high intensity training. The optimal combination of low- and high-intensity
training is typically achieved with a hard day–easy day pattern which avoids monotony
during the training process and may act to ensure a sufficient recovery period and to
prevent non-functional overreaching. This may augment adaptive responses, such as gene
expression for mitochondrial proliferation [50,66]. This specific training pattern is adopted
by well-trained and elite long- and middle-distance runners [52,55,64,67–70]. However,
evidence of the exact balance of different types of training on mitochondrial adaptive
responses is limited. Particularly in already well-trained athletes, the range of options for
achieving additional adaptive responses seems likely to be relatively small. Given the large
volume of low-intensity training already performed by high-level athletes, further adaptive
responses may largely lie in optimizing adaptive responses in Type II muscle fibers.

5.2. Physiological Mechanisms Explaining the Effectiveness of LT2 Intensity Training

It is widely accepted that lactate metabolism serves as a useful index [40,71], although
not likely as a cause [72], of muscular fatigue and that a strong correlation exists between
lactate accumulation and level of performance in endurance events [15,73–76]. The rela-
tionship between running intensity/speed and [BLa] is widely used to predict and identify
performance in distance runners [14,40,74]. A strong correlation between the speed at
vLT2/vMLSS and performance in long-distance running has been consistently observed,
regardless of the method used to determine these physiological variables [73,77–79]. In
this sense, Tjeta et al. [51] demonstrated that VO2max , RE, and %VO2max explained 89% of
the variation in vLT2 among distance runners of national to international level. According
to Billat et al. [41], vLT2/vMLSS is a running speed that a well-trained distance runner
can sustain for approximately one hour (half-marathon pace for elite runners). Similarly,
Roecker et al. [74] found that vLT2/vMLSS was slightly faster than half-marathon pace in
427 competitive runners. This was especially the case for the best runners. As vLT2 during
continuous running is close to half-marathon pace, continuous tempo runs from 8–20 km
are classified as threshold training in z2 and z3. Tempo runs have been included in the train-
ing regime of distance runners from the 1970s up to now [39,70,80,81]. Casado et al. [82]
found that elite Kenyan distance runners performed more of their total training volume as
tempo runs compared with that in the best Spanish distance runners.
The combination of high training volumes in z1 with moderate volumes in z2 and z3
is a very common pattern in contemporary distance runners. It generated improvements in
performance [64,83] or has been associated with very high performance in highly trained
and elite middle- and long-distance runners [41,67–69]. Furthermore, the use of this ap-
proach was reported to be related to either high levels [67,69,70] or an improvement in
RE [64,83]. Some research also found either improvements in [64,83–85] or were related to
high levels of vVO2max [41,69,70]. A few studies, using high volumes in z1 and moderate
volumes in z2 and z3, were associated with high levels of VO2max [67,70,86]. Studies us-
ing this training pattern also found either improvements in [83,85] or were related with
high levels of vLT2 [41,67,69,70]. In any case, there are comparatively few contempo-
rary elite runners who have a total training volume <100 km/week, and most perform
>160 km/week [53,55]. This approach has, in most cases, one primary characteristic in
common, a high proportion of z2 and z3 training was covered at intensities at or near vLT2
(i.e., high intensity within z2–z3) [41,64,67–69,83,87].
The underpinning mechanisms explaining the relationship between training near/at
vLT2 and the development of performance and its physiological determinants are not clear.
However, it has been hypothesized that the use of this specific exercise intensity improves
muscle specific adaptations, including clearing of lactate as opposed to reducing lactate
production [88]. Since only recruited motor units are likely to experience increases in
mitochondrial number and capillary density, with the exception that increases in capillary
density in Type I muscle fibers may benefit O2 delivery to Type II muscle fibers, it may
be speculated that training near vLT2 optimizes the number of motor units recruited
 vLT2 and the development of performance and its physiological determinants are not
clear. However, it has been hypothesized that the use of this specific exercise intensity
improves muscle specific adaptations, including clearing of lactate as opposed to reducing
lactate production [88]. Since only recruited motor units are likely to experience increases
in mitochondrial number and capillary density, with the exception that increases in capil-
Int. J. Environ. Res. Public Health 2023, 20, density
lary 3782 in Type I muscle fibers may benefit O2 delivery to Type II muscle fibers, 7 ofit15
may be speculated that training near vLT2 optimizes the number of motor units recruited
without having to accept the consequences of elevated levels of catecholamines likely to
bewithout
experienced
havingwith z4 training.
to accept It is also important
the consequences of elevatedto consider that the speed associated
levels of catecholamines likely to be
with a [BLa] of
experienced 4 mmol·L
with −1
z4 training.is somewhat specific totothe
It is also important pace of
consider competitions
that in the 10–20
the speed associated with
km range,ofwhich
a [BLa] 4 mmol ·L−1 is somewhat
represents a large percentage
specific to oftheavailable competitions.inAdditionally,
pace of competitions the 10–20 km
this velocity
range, which can be thought
represents of as percentage
a large «speed work» for marathon
of available runners. Sjodin
competitions. et al. [76]
Additionally, this
tried to elucidate
velocity the effects
can be thought of training
of as «speed work»at the speed associated
for marathon with onset
runners. Sjodinofet[BLa] (vOBLA
al. [76] tried to
orelucidate
speed associated
the effectswith a [BLa]atofthe
of training 4 mmol·L −1) and the
speed associated mechanisms
with involved
onset of [BLa] (vOBLA explaining
or speed
those effectswith
associated in eight well-trained
a [BLa] − 1
·L ) and the mechanisms
of 4 mmolmiddle-distance runners. After the addition
involved explaining of those
one
effects training
weekly in eight session
well-trained middle-distance
consisting of 20 min of runners.
continuousAfterrunning
the addition
at vOBLAof onetoweekly
their
training
usual session
training consisting
regime for 8 of 20 minthe
weeks, of continuous running at vOBLA
rate of glycogenolysis duringtoexercise
their usual training
decreased
regime
(i.e., for 8 weeks,
reduction the rate of glycogenolysissynthase
of phosphofructokinase/citrate during exercise decreased
ratio), while (i.e., reduction
the potential to oxi-of
phosphofructokinase/citrate
dize pyruvate and/or lactate increased synthase(i.e.,
ratio), while the
increased potential
relative to oxidize
activity pyruvate and/or
of heart-specific lac-
lactate increased (i.e., increased relative activity of heart-specific
tate dehydrogenase). These enzymatic changes were accompanied by an increase in vO- lactate dehydrogenase).
These
BLA enzymatic
and/or changes
a decrease were accompanied
of [BLa] by an increase
at a same absolute in vOBLA
speed. This and/or
specific traininga decrease
effect isof
[BLa] at ainsame
displayed absolute
Figure 1, whichspeed. This specific
illustrates training effect is displayed
the evolution/displacement to theinright
Figure 1, which
of the lac-
illustratescurve
tate/speed the evolution/displacement
yielded from an incremental to the right of the
intensity lactate/speed
test (see Figure 1). curve yielded from
an incremental intensity test (see Figure 1).

Figure 1. Blood lactate concentration changes between two different incremental intensity tests
Figure 1. Blood lactate concentration changes between two different incremental intensity tests char-
characterized
acterized by a displacement
by a displacement of the lactate/speed
of the lactate/speed curve to curve to the
the right afterright after including
including a certain
a certain amount
amount of training at the velocity associated with the second lactate threshold during
of training at the velocity associated with the second lactate threshold during a training period a training
in a
period in a hypothetical
hypothetical distance runner.
distance runner.

InInaddition,
addition,these
these authors
authors [76]
[76] found
foundthat
thatthe
therunners who
runners whowere ableable
were to maintain [BLa]
to maintain
−1 during the 20 min runs experienced greater performance improvement after
at 4 mmol · L
[BLa] at 4 mmol·l during the 20 min runs experienced greater performance improvement
−1
the training
after period
the training thanthan
period runners who who
runners allowed [BLa][BLa]
allowed to “drift”. TheseThese
to “drift”. data are
datathe first
are theto
suggest that relatively tight control of [BLa] during training might be advantageous.
first to suggest that relatively tight control of [BLa] during training might be advanta-
geous.
5.3. Potential Benefits of Lactate-Guided Threshold Interval Training
In any case, the association between this physiological intensity (i.e., vLT2 or vOBLA)
and speed is usually assumed when the run is continuous. However, manipulating the
variables composing an interval training session (i.e., repetition velocity, duration, and
inter-repetition recovery time) to match vLT2/vMLSS through [BLa] monitoring during
the session may allow for the adoption of faster speeds (i.e., faster than those derived
from continuous runs) and, thus, optimize the adaptive potential of muscle-fiber-type-
specific adaptations required for race pace achievement (i.e., in middle-distance runners).
In this sense, Kristensen et al. [89] demonstrated that an interval training program using a
higher intensity than that derived from continuous exercise yielded a greater activation of
AMP-activated protein kinase in Type II muscle fibers. In this way, conducting training
Int. J. Environ. Res. Public Health 2023, 20, 3782 8 of 15

in z2 and z3 while recruiting Type II muscle fibers may provide the mechanical and
metabolic advantages both of running close to race pace and at LT2 intensity, respectively.
Furthermore, there is an additional advantage of covering interval training at LT2 intensity
rather than in z4, which is related to fatigue generation. Burnley et al. [90] found that
isometric quadriceps contractions conducted at 10% above the critical torque (i.e., just
above LT2 intensity in z4) generated a rate of global and peripheral fatigue four to five
times greater than that yielded by the same contractions at 10% below of critical torque
(i.e., just below LT2 intensity in z3). These findings agree with the existence of a threshold
in fatigue development dependent on whether exercise is carried out at, just below, or
just above LT2 intensity. Accordingly, distance runners may benefit from covering some
of their interval training sessions at z3 but at faster absolute speeds than vLT2 (assessed
through a continuous incremental test) rather than in z4. Nonetheless, this should be
done through short duration repetitions so that [BLa] does not progressively rise, as by
doing so runners would be able to recover faster from ‘high-intensity’ training sessions.
However, the use of intensities within z4–z5 has also been found to be useful in performance
development in distance runners (2, 82). A recent systematic review by Rosenblat et al. [91]
determined that high-intensity interval training at or below intensities of VO2max allows the
improvement in central factors influencing VO2max , such as plasma volume, left ventricular
mass, maximal stroke volume, and maximal cardiac output. However, peripheral factors
influencing VO2max , such as skeletal muscle capillary density, maximal citrate synthase
activity, and mitochondrial respiratory capacity in Type II fibers can be developed through
sprint interval training (i.e., 30 s repetitions) [91]. Therefore, given that these physiological
adaptations may not all be achieved through lower intensity training (especially those
derived from sprint interval training), a certain but tolerable [65] amount of high intensity
training within z4–z6 is also needed to improve performance optimally in distance runners.

6. Putting This Training Model into Practice

These theoretical physiological advantages derived from LGTIT within a high-volume
low-intensity model are attributed as beneficial by current Norwegian middle- and long-
distance runners specialized in events ranging from 1500 m to 10,000 m. In the late 1990s,
Marius Bakken (co-author of the present article), a Norwegian elite 5000 m runner, started
to test a new training model on himself, which consisted of accumulating a high volume
of training at an easy pace, a moderate volume of interval training at threshold intensity
while controlling the pace through [BLa] testing during the session and including a low
volume of interval training in z5 [92]. He typically covered 180 km overall, conducted four
interval training sessions (i.e., two double sessions through a hard day–easy day pattern) at
threshold intensity (i.e., at [BLa] ranging from 2 to 4.5 mmol·L−1 depending on the specific
goal of the session) and one session at z5 per week [92]. Bakken experienced that when
following LGTIT, he could perform a much higher training volume compared with that
when he carried out interval training in z4. On the assumption that a higher total volume
of training is associated with larger adaptive responses, this pattern might be thought of as
beneficial. This assumption also agrees with findings of Burnley et al. [90] on the reduced
fatigue generation at LT2 intensity when compared with that yielded by z4 training. Bakken
developed this training model through a ‘trial and error’ approach and achieved a personal
best time in 5000 m of 13:06.39 (min:s), which remains as the second all-time best Nordic
best. He transmitted his training knowledge and experience to Gjert Ingebrigtsen, father
and former coach of the three Ingebrigtsen brothers, who developed it for the achievement
of their well-known athletic performances [92]. Bakken’s approach became a model for
contemporary Norwegian runners, and much of the success of Norwegian huge runners
at present is based on Bakken’s training principles. For example, Tokyo 2021 triathlon
Olympic champion, Norwegian Kristian Blummenfelt, also used LGTIT [92]. This model
has been developed within a successful system of endurance training. Norway, with a
population of only 5.5 million, has similar men’s national records in distance running events
to those of the USA: 1:42.58, 3:28.32, 7:27.05, and 12:48.45 (min:s) and 2:05:48 (h:min:s) for
Int. J. Environ. Res. Public Health 2023, 20, 3782 9 of 15

the 800, 1500, 3000, and 5000m and marathon, respectively. For women, Norwegians
have held some of the previous 3000, 5000, and 10,000 m and marathon world records.
They also achieved the top national medal count for the cross-country and biathlon skiing
events at the 2022 Winter Olympic Games, and both the triathlon 2019 and 2021 World
Champion (Gustav Iden) and the aforementioned 2021 Olympic champion (Blummenfelt)
are Norwegians [BLa] measurement and scientific testing are/were part of their training
processes in most of these athletes.
Interval-training performed with lactate values in z2 and z3 is also classified as thresh-
old training even though the absolute speed at which they are performed can be faster
than half-marathon pace. This is especially the case for shorter intervals, and the authors
of this article have observed international level distance runners showing 20–25 × 400 m
in 64 s average recovering 30 s between repetitions (13:20 (min:s) pace for 5000 m and
26:40 (min:s) for 10,000 m) and 20 × 400 m in 62 s average recovering 60 s between repeti-
tions (12:55 (min:s) pace for 5000 m and, therefore, much faster than half-marathon pace),
with [BLa] remaining below 4 mmol·L−1 . The reason why this can be achieved is that
duration of the running time/distance is too short for [BLa] to rise above LT2, and the rest
period between repetitions is long enough for [BLa] to return to levels near LT1 but not
long enough to decrease under that threshold.
It has been reported that the Ingebrigtsen brothers conducted LGTIT over distances
from 2000 m to 3000 m at close to half-marathon pace as well as over distances from
400 m to 1000 m at paces between 5000 m and 10,000 m race paces. The volume of this
LGTIT sessions ranges between 8 and 12 km, and the recovery time between repetitions
ranges between 20 s and 1.5 min. They often covered two LGTIT sessions in the same day
and a fifth specific session at a much higher intensity in z4 or z5 (i.e., 20 × 200 m uphill
jogging back in 70 s) (1, 67, 92). Their training intensity has been tightly controlled via
measures of heart rate and [BLa] during all interval sessions (1). While the extensive use
of LGTIT (i.e., up to four sessions per week) represents a novelty in the training of elite
distance runners, several studies have reported the combined use of LT2 and z4/z5 training
during the training week. For example, runners may conduct two (or more) different
interval training sessions per week covered at LT2 and VO2max intensities, respectively
(41, 68–70, 85). On the one hand, the addition of a greater number (i.e., two or three) of
‘high-intensity’ sessions to those typically observed in highly trained and elite runners may
represent an advantage in training adaptation, as assimilating this higher training load
may provide greater performance improvements. On the other hand, it also may represent
an increased risk of injury/overtraining syndrome. Furthermore, the characteristics of
LGTIT are different from those accepted in the current literature in distance runners given
that traditionally LT2 training is conducted as continuous runs at much slower absolute
speeds (31). Furthermore, the use of one sprint training session as well as some strength
training sessions have been suggested as part of this training model [92]. In addition, it
has been reported that this model involved the completion of a high training volume (i.e.,
157–185 km/week) [67,92], which also agrees with the accepted efficacy of high training
volume in elite distance runners [2,55,82]. However, the longest run does not exceed
21 km [92]. Finally, while no mention of the periodization approach adopted by these
runners through this training model exists, the authors’ personal observations suggest that
this training pattern involves the use of a traditional periodization approach, as observed
in other elite distance runners [55]. Furthermore, during the competitive period, the z5
hill interval training session should be partly substituted for track workouts targeting
competition pace at high [BLa] (i.e., from 5 to 10 mmol·L−1 ), and two LGTIT sessions are
removed from the weekly plan. In this way, the goal during the competitive period is to
achieve the minimum dose of threshold work which can sustain the previously developed
aerobic base allowing for the completion of high volumes of competition pace above z3. This
would be consistent with the current literature regarding optimal training periodization in
highly trained and elite distance runners and shows a trend from a pyramidal TID during
the preparatory period towards a polarized TID during the competitive period [38,55,69,85].
Int. J. Environ. Res. Public Health 2023, 20, 3782 10 of 15

The main goal of the present approach is to improve the speed while keeping [BLa] (and
heart rate) stable during LGTIT sessions across the season. An example of speed and
Int. J. Environ. Res. Public Health physiological responses
2023, 20, x FOR PEER REVIEW(i.e., [BLa] and heart rate) responses during three similar LGTIT
11 of 17
sessions conducted by Bakken during the 2003–2004 season, leading to his former Nordic
5000 m record of 13:06.39 (min:s) is highlighted in Figure 2 and shows the dramatic fitness
improvement derived from the use of the present training model.

Figure 2. Average speed (A) and heart rate (C) per repetition, and post-repetition blood lactate con-
Figure(B)
centration 2. during
Average speed
three (A) and heart
lactate-guided rate (C) interval
threshold per repetition,
trainingand post-repetition
sessions conductedblood lactate con-
by Marius
centration (B) during three lactate-guided threshold interval training sessions conducted
Bakken across the 2003–2004 season, leading to his former 5000 m Nordic record of 13:06.39 (min:s).by Marius
Bakken across the 2003–2004 season, leading to his former 5000 m Nordic record of 13:06.39 (min:s).
Six × 2000, seven × 2000, and five × 2000 m with a recovery time between repetitions of one min
Six ×1000, seven × 1000, and five × 1000 m with a recovery time between repetitions of one min were
were completed in December 2003 (mid-preparation period), February 2004 (late-preparation period),
completed in December 2003 (mid-preparation period), February 2004 (late-preparation period),
and June 2004 (competitive period), respectively.
and June 2004 (competitive period), respectively.

Rather than a revolutionary training model, it seems much more the result of an evo-
lutionary pattern, as it is based on training practice which has been developed during the
last 100 years of history of training in distance runners. Gerschler trained his athletes
within a specific heart rate range; Zatopek covered interval training at submaximal paces
and effort; Lydiard and Van Aaken established the need for developing a big aerobic base
Int. J. Environ. Res. Public Health 2023, 20, 3782 11 of 15

Rather than a revolutionary training model, it seems much more the result of an
evolutionary pattern, as it is based on training practice which has been developed during
the last 100 years of history of training in distance runners. Gerschler trained his athletes
within a specific heart rate range; Zatopek covered interval training at submaximal paces
and effort; Lydiard and Van Aaken established the need for developing a big aerobic base
through high training volumes at an easy pace; and Bowerman demonstrated the usefulness
of a hard day–easy day basis. These characteristics were implemented during the training
process of the Ingebrigtsen brothers. Other coaches and researchers also assisted in the
development of an evidence-based and traditional training pattern, which helped these
Norwegian coaches and scientists to generate this new and effective training model for
distance runners. An example of one training week in which this training model is being
used is described in Table 2.
Table 2. Sample training week. Adapted from Bakken [92].

Morning Evening
Monday 15 km (z1) 12 km (z1). Sprints (z5) and technique.
5 km (z1). 5 × 6 min at 2.5 mmol·L−1 recovering (r.) 1 min 5 km (z1). 10 × 1000 m at 3.5 mmol·L−1 recovering 1 min
Tuesday
between repetitions (z2). 2 km (z1) between repetitions (z2). 2 km (z1).
Wednesday 16 km (z1). Strength training. 10 km (z1). Sprints (z5) and technique.
5 km (z1). 5 × 2 km at 2.5 mmol·L−1 recovering 1 min between 5 km (z1). 25 × 400 m at 3.5 mmol·L−1 recovering 30 s
Thursday
repetitions (z2). 2 km (z1). between repetitions (z2). 2 km (z1).
Friday 15 km (z1). Rest.
5 km (z1). 20 × 200 m uphill at 8 mmol·L−1 recovering 70 s
Saturday 10 km (z1).
jogging back (z4). 2 km (z1).
Sunday 21 km (z1). Rest.
Z1–5: Zone 1 to Zone 5 according to the 6-zone scale; mmol·L−1 is a measure of blood lactate concentration.

7. Limitations, Future Studies, and Practical Applications

The present article examined the current training regime of some of the best run-
ners in the world and its derived potential physiological benefits on the basis of only
observational studies and reports. Therefore, the assumptions stated previously should
be taken cautiously since no controlled studies have tested the efficacy of this training
model. Furthermore, whereas [BLa] ranges for training zones were suggested according to
current recommendations [1,52,53] allowing for interindividual variability, specific values
demarcating zones should be detected for each athlete through physiological tests [14].
Additionally, the training characteristics and its effects on performance and its develop-
ment have been described only in 1500 m and 5000 m runners. Its applicability in other
endurance events, such as the marathon, remains uncertain. However, our article presented
sufficient evidence showing that these training characteristics display agreement with those
reported in the current scientific literature in highly trained and elite distance runners.
In addition, their differences may, in fact, be considered advantages of this new training
approach from a physiological perspective:
1. The allowance of a greater number of ‘high-intensity’ sessions compared with adopt-
ing a usual z4 interval training-based approach.
2. Achieving pre-established goals of internal load during the training session.
3. The possibility of adjusting and individualizing the specific training sessions within
the model framework in a periodized approach (i.e., month by month, year by year,
etc.). In this way, it is possible to accurately monitor not only the training adaptations
being achieved without the need of specific tests but also the response to the different
sessions through [BLa] measurements and make individual adjustments to the training
program on the basis of this information.
4. Adaptation to altitude training while preventing excessive internal training loads
derived from low air’s O2 partial pressure, given that [BLa] monitoring ensures that
internal load remains at the pre-established levels.
Int. J. Environ. Res. Public Health 2023, 20, 3782 12 of 15
Int. J. Environ. Res. Public Health 2023, 20, x FOR PEER REVIEW 13 of 17

Forthese
For thesereasons,
reasons,new
newinterventions
interventions comparing
comparing thethe physiological
physiological andand performance
performance
effects of the previously described training characteristics with those of traditional
effects of the previously described training characteristics with those of traditional train- training
ing methods in highly trained distance runners are particularly encouraged. In this way,this
methods in highly trained distance runners are particularly encouraged. In this way,
newnew
this training model
training maymay
model represent an evolution
represent of the
an evolution of training characteristics
the training of highly
characteristics of
trained and elite distance runners, and if future studies demonstrate its efficacy
highly trained and elite distance runners, and if future studies demonstrate its efficacy and safety,
it may
and be implemented
safety, in other runners.
it may be implemented in otherTraining
runners.characteristics and intensity
Training characteristics distribution
and intensity
characterizing
distribution this training
characterizing model
this andmodel
training its derived
and itspotential
derived physiological benefits are
potential physiological
illustrated in Figure 3.
benefits are illustrated in Figure 3.

Figure
Figure3.3.Training
Trainingcharacteristics andand
characteristics intensity distribution
intensity characterizing
distribution the training
characterizing methodology
the training methodol-
described in the present article and its derived potential physiological mechanisms leading to per-
ogy described in the present article and its derived potential physiological mechanisms leading
formance improvement. LT1: first lactate threshold; LT2: second lactate threshold; vLT2: speed as-
to performance improvement. LT1: first lactate threshold; LT2: second lactate threshold; vLT2:
sociated to second lactate threshold; VO2max: maximum oxygen uptake; vVO2max: minimum speed
speed associated
needed to second lactate
to achieve maximum oxygen threshold; VOZone
uptake; z1–6: 2max : 1maximum oxygen uptake;
to Zone 6 according vVO2max
to the 6-zone : mini-
scale;
mum speed
AMPK: needed
Adenosine to achieve maximum
monophosphate activatedoxygen
proteinuptake; z1–6:
kinase; and Zone 1Peroxisome
PGC1-α: to Zone 6 according to the
proliferator-
activated receptor-γ
6-zone scale; AMPK:coactivator.
Adenosine monophosphate activated protein kinase; and PGC1-α: Peroxisome
proliferator-activated receptor-γ coactivator.
Author Contributions: A.C., L.I.T., M.B. and C.F. contributed to the design of the paper; A.C. and
L.I.T. prepared the first draft of the manuscript. All authors have read and agreed to the published
Author Contributions: A.C., L.I.T., M.B. and C.F. contributed to the design of the paper; A.C. and
version of the manuscript.
L.I.T. prepared the first draft of the manuscript. All authors have read and agreed to the published
Funding:
version ofNothefunding was provided for the completion of the present study.
manuscript.
Institutional
Funding: ThisReview Board
research Statement:
received Not applicable.
no external funding.
Informed Consent
Institutional Statement:
Review Not applicable.
Board Statement: Not applicable.
Data Availability
Informed Consent Statement:
Statement:Not applicable.
Not applicable.
Acknowledgments: The present article is dedicated to the memory of one of its coauthors, the re-
Data Availability Statement: Not applicable.
cently deceased Leif Inge Tjelta, who significantly contributed to the development of distance run-
ning training research The
Acknowledgments: presentand
in Norway article is dedicated to the memory of one of its coauthors, the
worldwide.
recently deceased Leif Inge Tjelta, who significantly contributed to the development of distance
Conflicts of Interest: Arturo Casado, Carl Foster, Marius Bakken, and Leif Inge Tjelta have no con-
running training research in Norway and worldwide.
ficts of interest relevant to the content of this article.
Conflicts of Interest: Arturo Casado, Carl Foster, Marius Bakken, and Leif Inge Tjelta have no conficts
References of interest relevant to the content of this article.
Int. J. Environ. Res. Public Health 2023, 20, 3782 13 of 15

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