Aspects of Biochemical Engineering - - Unit 9 -... https://onlinecourses.nptel.ac.in/noc18_bt02/uni...

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Unit 9 - Week 8

Course
outline
Week 8 Assignment 1
The due date for submitting this assignment has passed. Due on 2018-03-21, 23:59 IST.
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Week 1 1) The characteristic feature of a fed batch process are I. The volume of the medium increases with 1 point
time II. It eliminates the need for oxygen supply III. It helps in controlling repressive effects of the nutrient
Week 2 being fed

Week 3 Both I and II

Both II and III

Week 4
Both I and III
Week 5 I, II and III

Week 6 No, the answer is incorrect.

Score: 0
Week 7 Accepted Answers:
Both I and III
Week 8
2) In a fed batch culture, substrate inhibition can be overcome by 1 point
Lecture 36:
Kinetics of
Removal of waste material
substrate
utilization, Addition of substrate at regular interval of time
product
formation and Addition of substrate only in the beginning
biomass
production of Removal of culture fluid
microbial
No, the answer is incorrect.
cells-VI
Score: 0
Lecture 37:
Accepted Answers:
Kinetics of
substrate Addition of substrate at regular interval of time
utilization,
3) In a fed batch reactor, the rate of change in the bioreactor volume is assumed to be equal to 1 point
product
formation and
biomass Flow rate
production of
microbial
Production rate
cells-VII Cell mass formation rate
Lecture 38: © 2014 NPTEL - Privacy & Terms - Honor Code - FAQs -
None of these
Kinetics
A project of of In association with
substrate No, the answer is incorrect.
utilization, Score: 0
product
formation and Accepted Answers:
Funded by
biomass Flow rate

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Aspects of Biochemical Engineering - - Unit 9 -... https://onlinecourses.nptel.ac.in/noc18_bt02/uni...

production of 4) Saccharomyces cerevisiae

Powered by produces maximum biomass at low glucose concentration and high 1 point
microbial dissolved oxygen concentration. The ideal condition for maximizing biomass productivity should be
cells-VIII

Lecture 39: Batch fermenter with a high initial glucose concentration

Kinetics of
substrate Continuous fermenter with a low initial glucose concentration
utilization,
Fed batch fermenter
product
formation and All of the above
biomass
production of No, the answer is incorrect.
microbial Score: 0
cells-IX
Accepted Answers:
Lecture 40: Fed batch fermenter
Kinetics of
substrate 5) The yield coefficient (YX/S) is 1 point
utilization,
product g of biomass produced per g of substrate added
formation and
biomass g of biomass produced per g of substrate consumed
production of
microbial Rate of biomass production per g of substrate consumed
cells-X
All of the above
Quiz : Week 8
Assignment 1
No, the answer is incorrect.
Score: 0
Week 8 Lecture
Material
Accepted Answers:
g of biomass produced per g of substrate consumed
Week 8
Assignment 1 6) The growth of an organism on glucose is described by the following Monod model (μmax = 0.5 1 point
Solution h-1 and Ks =0.1 g.L-1). If the initial biomass concentration in the batch fermenter is 0.1 g L-1, the minimum
time required to double the biomass concentration would be
Week 9

1.4 h
Week 10
2.4 h
Week 11
3.4 h

Week 12 4.4 h

No, the answer is incorrect.

DOWNLOAD
VIDEOS Score: 0
Accepted Answers:
1.4 h

7) Initial volume repeated fed batch reactor is 2 L. If the feeding rate is 1 L/h, then after 10 h, the 1 point
volume of the reactor will be

2L

6L

10 L

12 L

No, the answer is incorrect.

Score: 0
Accepted Answers:
12 L

8) A fed-batch reactor containing 2 L of medium with 0.1 g L-l of biomass. At a flow rate of 1 L/h 1 point
containing 1 g L-l of substrate, after 10 h, the concentration of biomass in the reactor was 0.2 g L-l. Amount
of biomass produced during the 10 h period is

1.5 g

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Aspects of Biochemical Engineering - - Unit 9 -... https://onlinecourses.nptel.ac.in/noc18_bt02/uni...

2.2 g

3.0 g

6.0 g

No, the answer is incorrect.

Score: 0
Accepted Answers:
2.2 g

9) In the problem 8, if after 10 h, the concentration of substrate in the reactor was 0.5 g L-1, the 1 point
total substrate consumed by the culture in the reactor would be (assuming no substrate initially present in
the 2 L medium)

2g

6g

8g

4g

No, the answer is incorrect.

Score: 0
Accepted Answers:
6g

10)A continuous reactor has a dilution rate of 0.5 h-1. The hydraulic retention time would be 1 point

1h

1.5 h

2h

0.5 h

No, the answer is incorrect.

Score: 0
Accepted Answers:
2h

11)Escherichia coli has a maximum specific growth rate of 0.8 h-1 on glucose medium. If this 1 point
organism is being grown in a chemostat with a dilution rate of 1.2 h-1, then at steady state condition the
concentration of E. coli will be

increased

zero

changed randomly

decreased

No, the answer is incorrect.

Score: 0
Accepted Answers:
zero

12)A chemostat has a liquid volume of 2 L and is being fed at a rate of 4 L/h. Dilution rate for this 1 point
reactor will be

2L

2 L h-1

2 h-1

4 L h-1

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Aspects of Biochemical Engineering - - Unit 9 -... https://onlinecourses.nptel.ac.in/noc18_bt02/uni...

No, the answer is incorrect.

Score: 0
Accepted Answers:
2 h-1

13)In a chemostat, steady state biomass and substrate concentrations are 0.04 g/L and 0.02 g/L of 1 point
phenol, respectively. The feed(sterile) contained 0.1 g/L of phenol. The biomass yield would be

0.4 g/g

0.5 g/g

1.0 g/g

5.0 g/g

No, the answer is incorrect.

Score: 0
Accepted Answers:
0.5 g/g

14)The cell growth in glucose medium follows Monod model. Given parameters are: μm = 0.3 h-1, 1 point
Ks = 0.05 g/L and YX/S = 0.3 g/g. When this organism is grown in a 2 L chemostat on a medium containing
10 g/L of glucose added at a flow rate of 1 L/h, the steady state concentration of biomass in the reactor will
be

0 g/L

0.4 g/L

0.5 g/L

10 g/L

No, the answer is incorrect.

Score: 0
Accepted Answers:
0 g/L

15)In a glucose-yeast extract medium, Lactococcus lactis has a maximum specific growth rate 1 point
(μmax) of 1.23 h-1. What would be the specific growth rate of this organism at steady state in a 4 L reactor
being fed at 2 L h-1?

0.5 h-1

1.2 h-1

2.4 h-1

4 h-1

No, the answer is incorrect.

Score: 0
Accepted Answers:
0.5 h-1

16)The maximum dilution rate Dmax can be mathematically expressed as 1 point

Dmax = μmax (1 + √‾‾‾‾

kS +S‾
kS
0
)
S 0

Dmax = μmax (1 − √‾‾‾‾

kS +S‾
k
0
)
S

Dmax = μmax (1 − √‾k‾‾‾

kS ‾
+S
)
S 0

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Aspects of Biochemical Engineering - - Unit 9 -... https://onlinecourses.nptel.ac.in/noc18_bt02/uni...

Dmax = μmax (1 − √‾‾‾‾

kS +S‾
kS
0
)
S 0

No, the answer is incorrect.

Score: 0
Accepted Answers:

Dmax = μmax (1 − √‾k‾‾‾

kS ‾
+S
)
S 0

17)The maximum cell mass productivity of a chemostat can be expressed as (where X is biomass 1 point
concentration, S is the substrate concentration and Dmax is the maximum dilution rate)

XS

X/Dmax

X/S

XDmax

No, the answer is incorrect.

Score: 0
Accepted Answers:
XDmax

18)Diauxic growth appears when 1 point

medium contains one carbon sources

medium contains two carbon sources

medium contains no carbon sources

none of the above

No, the answer is incorrect.

Score: 0
Accepted Answers:
medium contains two carbon sources

19)In case of endogenous respiration of the cell, the plot of 1/Y vs. 1/D should be (where Y is yield 1 point
coefficient and D is dilution rate)

Linear

hyperbolic

sigmoidal

sinusoidal

No, the answer is incorrect.

Score: 0
Accepted Answers:
Linear

20)A microbial species is inhibited by its growth associated product P over a concentration of 5 mM. 1 point
At high concentrations of P, the growth rate of the species can be enhance by using

Chemostat

Multiple stirred tank reactors

Fed batch reactor

All of the above

No, the answer is incorrect.

Score: 0

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Aspects of Biochemical Engineering - - Unit 9 -... https://onlinecourses.nptel.ac.in/noc18_bt02/uni...

Accepted Answers:
Multiple stirred tank reactors

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