Pathophysiology The Biologic Basis For Disease in Adults and Children Mccance 6th Edition Test Bank
Pathophysiology The Biologic Basis For Disease in Adults and Children Mccance 6th Edition Test Bank
Pathophysiology The Biologic Basis For Disease in Adults and Children Mccance 6th Edition Test Bank
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TRUE/FALSE
ANS: F
Eukaryotic cells have a characteristic set of membrane-bound intracellular
compartments called organelles that includes a well-defined nucleus. Prokaryotes
contain no organelles, and their nuclear material is not encased by a nuclear
membrane. Prokaryotic cells are characterized by lack of a distinct nucleus.
REF: p. 2
2. The primary functions of the cell nucleus are cell division and control of
genetic information.
ANS: T
The primary functions of the nucleus are cell division and control of genetic
information.
REF: p. 2
ANS: F
Their chief function is to provide sites for cellular protein synthesis.
REF: p. 5
ANS: T
Lysosomes remain fully active by maintaining a low internal pH. They do this by
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pumping hydrogen ions into their interiors.
REF: p. 5
5. Lipids and proteins are the major components of the plasma membrane.
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REF: p. 11
ANS: T
If deprived of appropriate signals, most cells undergo a form of cell suicide known
as programmed cell death, or apoptosis.
REF: p. 19
ANS: F
The function of ATP is not only to store energy but also to transfer it from one
molecule to another.
REF: p. 23
ANS: F
This process, called passive transport, occurs naturally through any
semipermeable barrier. It is driven by osmosis, hydrostatic pressure, and diffusion,
all of which depend on the laws of physics and do not require life.
REF: p. 25
ANS: F
Two types of endocytosis are designated based on the size of the vesicle formed.
Pinocytosis (cell drinking) involves the ingestion of fluids and solute molecules
through formation of small vesicles, and phagocytosis (cell eating) involves the
ingestion of large particles, such as bacteria, through formation of large vesicles
(also called vacuoles).
REF: p. 31
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ANS: T
All body cells are electrically polarized, with the inside of the cell more negatively
charged than the outside.
REF: p. 32
MULTIPLE CHOICE
ANS: C
In metabolic absorption all cells take in and use nutrients and other substances
from their surroundings.
REF: p. 2
ANS: C
The nucleus contains the nucleolus, a small dense structure composed largely of
RNA; most of the cellular DNA; and the DNA-binding proteins, the histones, that
regulate its activity.
REF: p. 2
REF: p. 7
ANS: D
The lysosomal membrane acts as a protective shield between the powerful
digestive enzymes within the lysosome and the cytoplasm, preventing their leakage
into the cytoplasmic matrix. Disruption of the membrane by various treatments or
cellular injury leads to a release of the lysosomal enzymes, which can then react
with their specific substrates, causing cellular self-digestion.
REF: p. 5
ANS: A
The enzyme is transcribed from DNA by RNA in the nucleus, proceeds to the
ribosome for synthesis, and is transported in a secretory vesicle to the cell
membrane.
ANS: A
The major chemical components of all cell membranes are lipids and proteins, but
the percentage of each varies among different membranes.
REF: p. 11
ANS: C
Proteins act as (1) recognition and binding units (receptors) for substances moving
in and out of the cell; (2) pores or transport channels for various electrically
charged particles called ions or electrolytes and specific carriers for amino acids
and monosaccharides; (3) specific enzymes that drive active pumps that promote
concentration of certain ions, particularly potassium (K+ ), within the cell while
keeping concentrations of other ions, for example, sodium (Na+ ), below
concentrations found in the extracellular environment;
REF: p. 12
ANS: B
Understanding the various steps involved is crucial for designing drug
interventions. Dysregulation of proteases features prominently in many human
diseases, including cancer, autoimmunity, and neurodegenerative disorders.
REF: p. 13
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ANS: D
The bilayer’s structure accounts for one of the essential functions of the plasma
membrane—it is impermeable to most water-soluble molecules (molecules that
dissolve in water) because they are insoluble in the oily core region. The bilayer
serves as a barrier to the diffusion of water and hydrophilic substances while
allowing lipid-soluble molecules, such as O2 and CO2, to diffuse through it readily.
ANS: A
The fluid mosaic model accounts for the flexibility of cellular membranes, their
self-sealing properties, and their impermeability to many substances.
REF: p. 13
11. Using the fluid mosaic model, a cell is actively capable of protecting itself
against injurious agents by:
a. closing down the membrane transport channels to hormones and chemicals.
b. altering the number and patterns of receptors to bacteria, antibodies, and
chemicals.
c. increasing the number and sensitivity of lysosomes to destroy bacteria.
d. shifting the bilayer from hydrophobic to hydrophilic in response to antibodies.
ANS: B
Hormones, bacteria, viruses, drugs, antibodies, chemicals that transmit nerve
impulses (neurotransmitters), and other substances attach to the plasma membrane
by means of receptor molecules on its outer layer. The number of receptors present
may vary at different times, and the cell is capable of modulating the effects of
injurious agents by altering receptor number and pattern. This aspect of the fluid
mosaic model has drastically modified previously held concepts concerning the
onset of disease.
REF: p. 13
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ANS: A
The concentration of cholesterol in the plasma membrane affects membrane
fluidity.
In cirrhosis of the liver, for example, the cholesterol content of the red blood cell’s
plasma membrane increases. This causes an overall decrease in membrane fluidity
that seriously affects the cell’s ability to transport oxygen.
REF: p. 13
13. Which form of cell communication is used to communicate within the cell
itself and with other cells in direct physical contact?
a. Protein channel (gap junction)
b. Plasma membrane-bound signaling molecules (involving receptors)
c. Hormone secretion such as neurotransmitters
d. Extracellular chemical messengers such as ligands
ANS: B
Cells communicate in three ways: (1) they form protein channels (gap junctions)
that directly coordinate the activities of adjacent cells; (2) they display plasma
membrane–bound signaling molecules (receptors) that affect the cell itself and
other cells in direct physical contact; and (3) (the most common means) they
secrete chemicals that signal to cells some distance away (Figure 1-16).
REF: p. 18
ANS: D
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REF: p. 18
15. Which mode of chemical signaling uses local chemical mediators that are
quickly taken up, destroyed or immobilized?
a. Paracrine signaling
b. Autocrine signaling
c. Neurotransmitter signaling
d. Hormone signaling
ANS: A
In paracrine signaling, cells secrete local chemical mediators that are quickly
taken up, destroyed, or immobilized.
REF: p. 18
ANS: D
In each type of chemical signaling, the target cell receives the signal by first
attaching to its receptors.
REF: p. 18
17. How do cells receive communication from the extracellular fluid surrounding
them?
a. Protein channel (gap junction)
b. Plasma membrane–bound signaling molecules (involving receptors)
c. Hormone secretion such as neurotransmitters
d. Chemical messengers such as ligands
ANS: D
Channel opening and closing can be initiated in one of three ways:
(1) by binding a ligand to a specific membrane receptor that is closely associated
with the channel (for example, G proteins); (2) by changes in electric current in the
plasma membrane, altering flow of Na+ and K+; and (3) by stretching or other
chemical deformation of the channel. Figure 1-19 summarizes ways by which
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ANS: B
The two major second messenger pathways are cyclic adenosine monophosphate
(cyclic AMP, cAMP) and Ca++.
REF: p. 20
ANS: B
Glycolysis produces a net of two molecules of ATP per glucose molecule through
the process of oxidation, or the removal and transfer of a pair of electrons.
REF: p. 23
20. What is the mechanism by which the energy produced from carbohydrates,
proteins and lipids is transferred to adenosine triphosphate (ATP)?
a. Anaerobic glycolysis
b. Oxidative cellular metabolism
c. Oxidative phosphorylation
d. Tricarboxylic acid phosphorylation
ANS: C
Oxidative phosphorylation occurs in the mitochondria and is the mechanism by
which the energy produced from carbohydrates, fats, and proteins is transferred to
ATP.
REF: p. 24
ANS: A
Water and small electrically uncharged molecules move easily through pores in the
plasma membrane’s lipid bilayer. This process, called passive transport, occurs
naturally through any semipermeable barrier. It is driven by osmosis, hydrostatic
pressure, and diffusion, all of which depend on the laws of physics and do not
require life.
REF: p. 25
ANS: C
Other molecules cannot be driven across the plasma membrane solely by forces of
diffusion, hydrostatic pressure, or osmosis because they are too large or are ligands
that have bound with receptors on the cell’s plasma membrane.
REF: p. 25
23. What is the name of the method of transport that uses transmembrane proteins
with receptors that have a high degree of specificity for the substance being
transported?
a. Active transport
b. Mediated transport
c. Transmembranous transport
d. Passive transport
ANS: B
Mediated transport (passive and active) involves integral or transmembrane
proteins with receptors having a high degree of specificity for the substance being
transported. Inorganic anions and cations (e.g., Na+, K+, Ca++, Cl-, HCO3–) and
charged and uncharged organic compounds (e.g., amino acids, sugars) require
specific transport systems to facilitate movement through different cellular
membranes.
REF: p. 28
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ANS: A
Hydrostatic pressure is the mechanical force of water pushing against cellular
membranes. In the vascular system, hydrostatic pressure is the blood pressure
generated in vessels by the contraction of the heart. Blood reaching the capillary
bed has a hydrostatic pressure of 25 to 30 mmHg, which is sufficient force to push
water across the thin capillary membranes into the interstitial space.
ANS: C
In plasma, less of the plasma weight is water and the overall concentration of
particles is therefore greater. The osmolality will be greater than the osmolarity
because of the smaller proportion of water. Osmolality is thus the preferred
measure of osmotic activity in clinical assessment of individuals.
REF: p. 27
ANS: C
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REF: p. 28
27. How is the transport of glucose from the blood to the cell accomplished?
a. By active-mediated transport (active transport)
b. By active diffusion
c. By passive osmosis
d. By passive-mediated transport (facilitated diffusion)
ANS: D
Perhaps the most widely referred to passive transport system is that for glucose in
erythrocytes (red blood cells).
REF: p. 29
28. How are potassium and sodium transported across plasma membranes?
a. By passive electrolyte channels
b. By coupled channels
c. By adenosine triphosphate enzyme (ATPase)
d. By diffusion
ANS: C
The exact mechanism for transport of Na+ and K+ across the membrane is
uncertain. One proposal is that ATPase induces the transporter protein to undergo
several conformational changes, causing Na+ and K+ to move short distances
(Figure 1-29).
REF: p. 30
ANS: A
In eukaryotic cells, secretion of macromolecules almost always occurs by
exocytosis (Figure 1-30, B).
REF: p. 31
ANS: C
Because the resting plasma membrane is more permeable to K+ than to Na+, K+ can
diffuse easily from its area of higher concentration in the ICF to its area of lower
concentration in the ECF. Because Na+ and K+ are both cations, the net result is an
excess of anions inside the cell, resulting in the resting membrane potential.
REF: p. 32
ANS: C
The cellular uptake of cholesterol, for example, depends on receptor-mediated
endocytosis.
REF: p. 31
32. What causes the rapid change in the resting membrane potential that initiates
an action potential?
a. Potassium gates open and potassium rushes into the cell, changing the
membrane potential from negative to positive.
b. Sodium gates open and sodium rushes into the cell, changing the membrane
potential from negative to positive.
c. Sodium gates close allowing potassium into the cell to change the membrane
potential from positive to negative.
d. Potassium gates close allowing sodium into the cell to change the membrane
potential from positive to negative.
ANS: B
When a resting cell is stimulated through voltage-regulated channels, the cell
membranes become more permeable to sodium. There is a net movement of
sodium into the cell, and the membrane potential decreases, or “moves forward,”
from a negative value (in millivolts) to zero. The sodium gates open, and sodium
rushes into the cell, causing the membrane potential to reduce to zero and then
become positive (depolarization).
ANS: C
Different types of cells require different factors; for example, platelet-derived
growth factor stimulates the production of connective tissue cells.
REF: p. 35
ANS: A
Growth factors, also called cytokines, are peptides that transmit signals within and
between cells. They have a major role in the regulation of tissue growth and
development (Table 1-6).
REF: p. 35
35. Which cells, if any, lose their ability to replicate and divide?
a. None; all cells have the ability to replicate and divide.
b. Cells of the lung and intestinal tract
c. Cells of the skin
d. Cells of the lens of the eye and skeletal muscle
ANS: D
All types of cells undergo mitosis during formation of the embryo, but many adult
cells, such as nerve cells, lens cells of the eye, and muscle cells, lose their ability to
replicate and divide.
REF: p. 35
36. Cellular reproduction is a process that:
a. often takes months or years to complete.
b. typically has a short interphase.
c. results in two diploid cells called daughter cells.
d. involves the interaction of male and female cells.
ANS: C
The M phase of the cell cycle, mitosis and cytokinesis, begins with prophase, the
first appearance of chromosomes. As the phase proceeds, each chromosome is seen
as two identical halves called chromatids, which lie together and are attached at
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REF: p. 34
ANS: B
The four designated phases of the cell cycle are: (1) the G1 phase (G = gap), which
is the period between the M phase and the start of DNA synthesis; (2) the S phase
(S = synthesis), in which DNA is synthesized in the cell nucleus; (3) the G2 phase,
in which RNA and protein synthesis occurs, the period between the completion of
DNA synthesis and the next phase (M); and (4) the M phase (M = mitosis), which
includes nuclear and cytoplasmic division (Figure 1-33).
REF: p. 34
MATCHING
Match the structure with its function. Answers may be used more than once.
a. Endoplasmic reticulum
b. Ribosome
c. Secretory vesicle
d. Lysosomes
1. ANS: A REF: p. 5
NOT: The endoplasmic reticulum (endo = "within"; plasma = "cytoplasm";
reticulum = "network") is a membrane factory that specializes in the synthesis and
transport of the protein and lipid components of most of the cell's organelles.
2. ANS: C REF: p. 5
NOT: Proteins from the endoplasmic reticulum are processed and packaged into
small membrane-bound sacs or vesicles called secretory vesicles that collect at the
end of the membranous folds of the Golgi bodies The secretory vesicles then break
off from the Golgi complex and migrate to a variety of intracellular and
extracellular destinations, including the plasma membrane. The vesicles fuse with
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3. ANS: A REF: p. 5
NOT: The endoplasmic reticulum (endo = "within"; plasma = "cytoplasm";
reticulum = "network") is a membrane factory that specializes in the synthesis and
transport of the protein and lipid components of most of the cell's organelles.
4. ANS: D REF: p. 5
NOT: Lysosomes function as the intracellular digestive system (Figure 1-6).
Lysosomal enzymes are capable of digesting most cellular constituents down to
their basic forms, such as amino acids, fatty acids, and sugars.
Match the structure with its function. Answers may be used more than once.
a. Passive-mediated transport
b. Active-mediated transport
c. Osmosis
5. Movement of water
6. Protein carrier
7. Facilitated diffusion
5. ANS: C REF: p. 27
NOT: Osmosis is the movement of water "down" a concentration gradient, that is,
across a semipermeable membrane from a region of higher water concentration to
a lower water concentration.
6. ANS: B REF: p. 29
NOT: In active mediated transport, also called active transport, the protein
transporter moves molecules against, or up, the concentration gradient. Unlike
passive mediated transport, active mediated transport requires the expenditure of
energy.
7. ANS: A REF: p. 29
NOT: In passive mediated transport, also called facilitated diffusion, the protein
transporter moves solute molecules through cellular membranes without expending
metabolic energy.