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    Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME), is a disorder characterized by extreme fatigue that lasts for at least six months. It is estimated to affect 1-2.5% of the global population. CFS disproportionately affects women, and its prevalence is highest in developed countries and low-income populations. The hallmark symptom is debilitating fatigue not explained by other conditions. Other common symptoms include muscle and joint pain, cognitive difficulties, and sleep disturbances. Diagnosis involves ruling out other potential causes and is based on the presence of fatigue and at least four other symptoms for six months. While the cause is unknown, potential contributing factors include infections, immune dysfunction,

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    CFS Main File

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    Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME), is a disorder characterized by extreme fatigue that lasts for at least six months. It is estimated to affect 1-2.5% of the global population. CFS disproportionately affects women, and its prevalence is highest in developed countries and low-income populations. The hallmark symptom is debilitating fatigue not explained by other conditions. Other common symptoms include muscle and joint pain, cognitive difficulties, and sleep disturbances. Diagnosis involves ruling out other potential causes and is based on the presence of fatigue and at least four other symptoms for six months. While the cause is unknown, potential contributing factors include infections, immune dysfunction,

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    Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME), is a disorder characterized by extreme fatigue that lasts for at least six months. It is estimated to affect 1-2.5% of the global population. CFS disproportionately affects women, and its prevalence is highest in developed countries and low-income populations. The hallmark symptom is debilitating fatigue not explained by other conditions. Other common symptoms include muscle and joint pain, cognitive difficulties, and sleep disturbances. Diagnosis involves ruling out other potential causes and is based on the presence of fatigue and at least four other symptoms for six months. While the cause is unknown, potential contributing factors include infections, immune dysfunction,

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    © All Rights Reserved
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    11 views40 pages

    CFS Main File

    Uploaded by

    aryano
    Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME), is a disorder characterized by extreme fatigue that lasts for at least six months. It is estimated to affect 1-2.5% of the global population. CFS disproportionately affects women, and its prevalence is highest in developed countries and low-income populations. The hallmark symptom is debilitating fatigue not explained by other conditions. Other common symptoms include muscle and joint pain, cognitive difficulties, and sleep disturbances. Diagnosis involves ruling out other potential causes and is based on the presence of fatigue and at least four other symptoms for six months. While the cause is unknown, potential contributing factors include infections, immune dysfunction,

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    of 40

    CFS

    Chronic fatigue syndrome


    ALI BAVIYEH 2100476
    HESSAN MOLLAZADEH 2018116
    SONA CHAHARDAHCHERIK 2101394
    MEHRAN MAHINI 2104783
    Table of contents
    Below topics will cover in this presentation.

    Introduction 3-5
    History 6-8
    Epidemiology 9-12
    Etiology 13-16
    Clinic 16-20
    Diagnosis 20-25
    Treatment and Exercise 26-30
    conclusion 31-38
    References 40
    Introduction!

    How many people all over the world suffer from Chronic
    Fatigue Syndrome?

    ● 1% to 2.5% of people in

    ● 0.76% average prevalence

    ● 80% of patients with CFS are female


    What is CFS ?!
    Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis
    (ME), is a disorder characterized by extreme fatigue with no underlying
    medical condition.
    symptom
    The hallmark symptom of CFS is persistent and debilitating fatigue that
    lasts for at least six months and is not explained by other medical or
    psychiatric conditions.
    CFS & ME
    History
    1930s
    CFS was first identified as a condition called "myalgic encephalomyelitis" (ME)
    1980s
    The term "chronic fatigue syndrome" began to be used to describe a
    related number of symptoms, and the two terms are now often used
    interchangeably
    Epidemiology
    CFS affects people of all ages, races, and
    socioeconomic backgrounds, but it is more
    common in women than in men.
    Key points

    *120,000,000 m
    It is estimated to affect of this the population worldwide

    *highest prevalence
    found in developed countries and low-income
    populations
    How CFS affect minority and
    low-income populations?

    There are several reasons why CFS may disproportionately


    affect minority and low-income populations
    Three areas

    Access to healthcare and diagnostic testing

    Environmental factors that can trigger CFS

    cultural differences
    Etiology
    . Some studies have suggested that CFS may be triggered by:
    bacterial infections, genetic predisposition, immune
    dysfunction, andenvironmental factors such as stress.
    For example

    _Studies have shown that CFS patients have alterations


    in immune function and increased inflammation,
    suggesting that immune dysregulation may play a
    role in the development of the illness.
    _Additionally, CFS patients have been
    found to have alterations in brain
    function, including abnormalities in the
    hypothalamic-pituitary-adrenal (HPA)
    axis, which regulates the body's
    response to stress.
    Clinic
    muscle and joint pain
    Pain 01

    cognitive
    memory and concentration
    problems difficulties 02

    sleep
    It can significantly impact a
    person's quality of life disturbances 03
    muscle and joint pain

    alterations in central nervous system function may also contribute to the


    development of muscle and joint pain in CFS patients.
    memory and concentration problems

    CFS is associated with inflammation and immune dysregulation, which can impact the
    brain and nervous system
    sleep disturbances
    alterations in the immune system seen in CFS patients may disrupt the normal sleep-
    wake cycle.
    Diagnosis
    The presence of at least four of the following
    symptoms for at least six months:

    Impaired memory or Muscle pain and Joint


    concentration pain

    Sore throat Headaches

    Tender lymph nodes Post-exertional malaise


    How to diagnosis

    Medical history 01 02 Physical exam

    Laboratory tests 03 04 Additional tests


    Note A:

    It is important to note that CFS is a


    diagnosis of exclusion
    Note B:

    Chronic Fatigue Syndrome (CFS) is a complex and


    controversial condition characterized by persistent
    fatigue that does not improve with rest, and which is
    not caused by any underlying medical condition.
    Treatment and
    Exercise
    Medications
    Certain medications may
    be prescribed to manage
    specific of CFS, such as
    pain, sleep disturbances,
    or depression.
    Lifestyle changes
    Lifestyle changes such as
    pacing activities, improving
    sleep habits, and managing
    stress may be helpful in
    managing symptoms of
    CFS.
    Cognitive-behavioral therapy (CBT)

    CBT is a type of talk


    therapy that can be
    helpful in managing the
    psychological symptoms
    of CFS, such as anxiety
    or depression.
    Graded exercise therapy (GET)

    GET involves gradually


    increasing physical activity
    levels in a supervised and
    structured manner.
    conclusion
    Treatment and
    Epidemiology Clinic Exercise

    01 02 03 04 05 06

    History Etiology Diagnosis


    History

    1930s 1930s
    ME CFS
    Epidemiology

    ^0.76% average prevalence

    ^120,000,000 m
    Etiology
    ^bacterial infections
    ^genetic predisposition
    ^immune dysfunction
    ^andenvironmental factors
    Clinic
    ^muscle and joint pain
    ^cognitive difficulties
    ^sleep disturbances
    Diagnosis

    ^Medical history
    ^Physical exam
    ^Laboratory tests
    ^Additional tests
    Treatment and Exercise

    ^Medications
    ^Lifestyle changes
    ^Cognitive-behavioral therapy (CBT)
    ^Graded exercise therapy (GET)
    COLLABORATORS

    ALI BAVIYEH 2100476

    HESSAN MOLLAZADEH 2018116

    SONA CHAHARDAHCHERIK 2101394

    MEHRAN MAHINI 2104783


    References

    -- Institute of Medicine. Beyond Myalgic Encephalomyelitis/Chronic Fatigue


    Syndrome: Redefining an Illness. Washington, DC: The National Academies
    Press; 2015.

    Home - Solve ME/CFS Initiative (solvecfs.org)

    The ME Association – We Support, Inform, Campaign and Invest in Biomedical


    Research

    --Friedberg F, Jason LA. Understanding Chronic Fatigue Syndrome: An


    Empirical Guide to Assessment and Treatment. Washington, DC: American
    Psychological Association; 1998

    Home - Solve ME/CFS Initiative (solvecfs.org)

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