Test Bank For The Biology of Cancer Second Edition

Test Bank for The Biology of Cancer Second Edition
Full version at:

https://testbankbell.com/product/test-bank-for-the-biology-of-cancer-
second-edition/
The Biology of Cancer, 2nd Edition, Question Bank
© 2014 Garland Science
Chapter 2 The Nature of Cancer
Level 1: Comprehension of reading, knowledge of terminology
Level 2: Understanding and application of information to compare and contrast or

interpretation of data
Level 3: Analysis and application of information to a problem, an experiment, a

secondary concept, or previous knowledge
2.1 Which of the following is true of carcinomas? (Level 2)
A. They are responsible for >80% of Western world cancer deaths.
B. They involve cell types arising from all three embryonic germ layers. C.
They often involve epithelial cells.
D. Examples of tissue sites where they are found include the lung and pancreas. E. All
of the above.
2.2 Tumors that arise from mesenchymal cell types are called (Level 1) A.
Carcinomas
B. Lymphomas
C. Sarcomas
D. Adenocarcinomas
E. Leukemias
2.3 Which of the following types of cellular changes would be considered to be
malignant? (Level 2)
A. Dysplasia
B. Squamous cell carcinoma
C. Papilloma
D. Fibroma E.
Adenoma
2.4 Which of the following schematics MOST likely describes the correct order of cellular
changes that occur in the progression of malignancy? (Level 2)
A. Normal → hyperplastic → dysplastic → neoplastic → metastatic B.
Normal → dysplastic → hyperplastic → neoplastic → metastatic C. Normal
→ hyperplastic → dysplastic → metastatic → neoplastic D. Normal →
neoplastic → dysplastic → hyperplastic → metastatic E. None of the above
2.5 Analysis of a patient’s lung tumor reveals that all of the malignant cells in this tumor have
a specific chromosomal abnormality involving a fusion event between two sets of
chromosomes. This MOST likely suggests that (Level 3)
A. This mutation was inherited. B.
The tumor is polyclonal.
C. The tumor is monoclonal in origin.
D. A large number of normal cells simultaneously underwent this mutation.

E. None of the above.
2.6 In the revised Ames test, Bruce Ames mixed chemicals with homogenized rat liver prior
to adding them to bacteria to assess their mutagenicity. What was the purpose of this
step of the experiment? (Level 3)
A. To determine whether the chemicals killed mammalian cells
B. To determine whether the chemicals induced cancer in mammalian cells
C. To detoxify the chemicals prior to assessing their mutagenicity
D. To metabolically activate the chemicals prior to assessing their mutagenicity
E. None of the above
2.7 Which of the following is NOT a test for mutagenicity? (Level 2) A.
Proliferation assay
B. Ames test
C. Test for sister chromatid exchange (SCE) D.
Karyotype analysis
E. Analysis of micronuclei
2.8 A tumor promoter (Level 3)
A. Induces mutations in DNA.
B. Can cause cancer on its own.
C. Enhances tumorigenesis through nongenetic mechanisms.

D. Is always a naturally occurring compound. E.
B and C.
2.9 The level of mutagenicity of a particular chemical may depend upon (Level 2) A. Its
metabolic conversion within an organism.
B. The cell type with which it comes in contact.
C. Expression levels of genes coding for proteins that are able to inactivate
mutagens within the cell.
D. The presence of other tumor-promoting compounds. E.
All of the above.
2.10 Which of the following compounds was identified as being carcinogenic by the
Ames test? (Level 1) A.
Black pepper
B. Rhubarb
C. Celery
D. Coffee
E. All of the above
2.11 Malignant tumors (Level 2)
A. Always contain a single cell type.
B. Have acquired characteristics of invasiveness.

C. Are surrounded by an intact basement membrane. D.
Are often described as being in-situ.
E. C and D.
2.12 Which of the following is true of energy metabolism by cancer cells? (Level 2) A.
They usually generate ATP through the Krebs cycle.
B. They are more efficient at energy metabolism than normal cells and generate
36 molecules of ATP for every glucose molecule metabolized.
C. They generate energy through glycolysis only when cells are experiencing
hypoxia.
D. They import much higher levels of glucose in comparison with normal cells. E.
None of the above.
Answers
2.1 E
2.2 C
2.3 B
2.4 A
2.5 C
2.6 D
2.7 A
2.8 C
2.9 E
2.10 E
2.11 B
2.12 D

Test Bank For The Biology of Cancer Second Edition

Uploaded by

Copyright:

Available Formats

Test Bank For The Biology of Cancer Second Edition

Uploaded by

Document Information

Original Description:

Original Title

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

Test Bank For The Biology of Cancer Second Edition

Uploaded by

Copyright:

Available Formats

Test Bank for The Biology of Cancer Second Edition

Full version at:

The Biology of Cancer, 2nd Edition, Question Bank

© 2014 Garland Science

Chapter 2 The Nature of Cancer

Level 1: Comprehension of reading, knowledge of terminology

Level 2: Understanding and application of information to compare and contrast or

Level 3: Analysis and application of information to a problem, an experiment, a

2.1 Which of the following is true of carcinomas? (Level 2)

A. They are responsible for >80% of Western world cancer deaths.

They often involve epithelial cells.

B. Squamous cell carcinoma

A. Normal → hyperplastic → dysplastic → neoplastic → metastatic B.

Normal → dysplastic → hyperplastic → neoplastic → metastatic C. Normal

→ hyperplastic → dysplastic → metastatic → neoplastic D. Normal →

neoplastic → dysplastic → hyperplastic → metastatic E. None of the above

A. This mutation was inherited. B.

The tumor is polyclonal.

C. The tumor is monoclonal in origin.

D. A large number of normal cells simultaneously underwent this mutation.

A. To determine whether the chemicals killed mammalian cells

B. To determine whether the chemicals induced cancer in mammalian cells

C. To detoxify the chemicals prior to assessing their mutagenicity

D. To metabolically activate the chemicals prior to assessing their mutagenicity

E. None of the above

2.7 Which of the following is NOT a test for mutagenicity? (Level 2) A.

C. Test for sister chromatid exchange (SCE) D.

2.8 A tumor promoter (Level 3)

A. Induces mutations in DNA.

B. Can cause cancer on its own.

C. Enhances tumorigenesis through nongenetic mechanisms.

metabolic conversion within an organism.

B. The cell type with which it comes in contact.

D. The presence of other tumor-promoting compounds. E.

All of the above.

E. All of the above

2.11 Malignant tumors (Level 2)

A. Always contain a single cell type.

B. Have acquired characteristics of invasiveness.

Are often described as being in-situ.

They usually generate ATP through the Krebs cycle.

None of the above.

You might also like