E Book Bio English 04
E Book Bio English 04
E Book Bio English 04
Neuritis
The processes associated with neurons are called neuritis.
These are mainly of two types
(i) Dendrites These are usually shorter, tapering and much branched structures, which contains neurofibrils, neurotubules and
Nissl’s granules. They conduct nerve impulse towards the cell body and this process is called afferent process (i.e., the receiving
process).
(ii) Axon It is a very long structure of uniform thickness. The part of cyton from where the axon arises is known as axon hillock. It is
mainly dependent on cell body for the supply of protein.
Each branch of axon fiber terminates as a bulb like structure called synaptic knob that possess special chemicals called
neurotransmitters.
Axons are mainly of two types
• Myelinated Axons are nerve fibers enveloped with Schwann cells that form a myelin sheath around the axon. It mainly
found in spinal and cranial nerves.
• Unmyelinated Axons are nerve fiber enveloped by a Schwann cell that does not form a myelin sheath around the axon and
is commonly found in autonomous and motor neurons somatic neural system.
Types of Neurons
Sensory Neurons (Afferent neurons) They conduct impulses from receptors to central nervous system. The terminal ends of
dendrites become modified to form receptor and acts as sensory.
Inter Neurons They act as connectors and functions in connecting the sensory and motor neuron. It mainly carries stimuli in brain
and spinal cord.
Motor Neurons They conduct impulses from central nervous system to the effectors i.e., they mainly transmit impulse from brain
and spinal cord to the muscle or gland, which will respond to the stimulus.
(Director & Author) •CAT •GMAT •GRE •SSC •BANK
On the basis of number of dendrites and axons neurons can be of other three types
i.e., Multipolar (with one axon and two or more dendrites), Bipolar (with one axon and one or more dendrites), Unipolar i.e., with
one axon only.
Cerebrospinal Fluid
The space between arachnoid membrane and piameter is known as subarachnoid space in which a fluid known as cerebrospinal
fluid, serves as a pad to cushion the central nervous system from shocks. It also provides a medium for exchange of food materials,
wastes, respiratory gases and other materials.
Cerebrum Structure
The outer portion of cerebrum is called the cerebral cortex. The surface of the cortex is greatly folded. The upward folds are known
as gyri. There is a cavity present inside the cerebrum whose outer part is known as grey matter and the inner part (i.e., beneath the
grey matter) is the white matter.
Functions of Cerebrum It has sensory areas that receives impulse from receptor and motor area that transmits impulse to the
effectors.
Diencephalon The main parts involved it diencephalon are epithalamus, thalamus and hypothalamus.
• Thalamus represents the lateral walls of diencephalon and mainly formed of grey matter. It is the relay station of sensory
inputs and does not produce hormones. It takes part in reproduction.
• Epithalamus thin membrane tissue that acts as a posterior segment of the diencephalon.
• Hypothalamus contains a number of centres that control urge for eating and drinking. It also called as thermostat of the
body, because it acts as thermoregulatory centre. It also integrates and controls the visceral activities. It is also called
“Master of master gland”.
Functions of Diencephalon It controls and coordinates various functions like body temperature, feeling of satisfaction, appetite,
thirst etc.
Mid Brain
It is mainly the portion located in between the thalamus/hypothalamus of the forebrain and pons of the hind brain. There is a canal
known as cerebral aqueduct that passes through the mid brain.
Mid brain and hind brain together forms the brain stem.
Functions of Midbrains
(i) It relays impulse back and forth between cerebrum, cerebellum, pons and medulla.
(ii) It is also concerned with sense of sight.
Hind Brains It involves some parts like cerebellum and pons, medulla.
Cerebellum It is the second largest part of the human brain. It has convoluted surface in order to provide more space for many
more neurons Alcohol effects our brain firstly in cerebellum.
Functions of Cerebellum It controls rapid muscular activities such as running, typing and even talking. Nearly all activities are
involuntary in nature but sometimes may involve learning in early stages.
Pons It is located below mid brain and above the medulla oblongata.
Functions of Pons It relays impulses between medulla to regulate breathing.
Medulla (Oblongata) It extends from the pons varolli in above direction and is continuous with the spinal cord in below direction.
(Director & Author) •CAT •GMAT •GRE •SSC •BANK
Functions of Medulla It functions as receiver, integrates signals from spiral cord and sends resulting signal to the cerebellum and
thalamus.
It mainly have centres that regulate heart rate, blood pressure, breathing swallowing salivation, sneezing, coughing, vomiting and
involuntary movements etc.
Reflex Arc
A reflex action is an automatic response to a stimulus. The pathway taken by nerve impulses in a reflex action is called the reflex
arc. The simplest unit of nervous activity involves the detection of stimulus in the environment by sensory nerve endings, followed
by impulses that travel via the sensory neurons to the spinal cord.
Income Tax Inspector •CAT •GMAT •UPSC •SSC •BANK
Here, the impulses synapse with interneurons, which intern generate impulses to respond to the stimulus. The impulses thus, travel
along the motor neutrons to muscles or glands that respond appropriately.
In some cases, a reflex arc involves an interpretation, for this activity, interneurons transmit impulses up to the spinal cord to the
conscious area of the brain, where an analysis occurs.
Some examples of reflex action are moving our foot away when we step on something sharp, moving our hand away on touching a
hot place a knee jerk, movement of diaphragm during respiration, coughing, yawning etc.
Glands
A gland is an organ which synthesizes some substances and secretes them at various locations, e.g., sweat gland secretes sweat,
endocrine gland secretes hormones like growth hormone.
Type of Glands
In vertebrates, glands may be classified on the basis of pressure or absence of ducts. These are called exocrine and endocrine
glands.
Differences Between Exocrine and Endocrine Glands
Exocrine Glands Endocrine Glands
These are glands with ducts. These are ductless glands or glands or internal secretions.
The secretions of these glands are carried by ducts to a These glands have no ducts and their secretions
particular organ for some metabolic activities, e.g., salivary (hormones) get absorbed into the immediate surrounding
glands, liver, etc. blood circulation to reach the target (specific) organs to
initiate a particular metabolic change, e.g., thyroid,
parathyroid, adrenals
Hormones
These are the non-nutrient chemicals made up of amino acid derivatives, peptides and steroids etc., that are secreted by endocrine
glands in response to change in external or internal environment. They act as intercellular messengers that regulate the biological
processes in organisms, and are produced in trace amounts. Ernest H Starling coined the term hormone.
The first hormone was discovered by the English physiologist William M Bayliss and Ernest H Starling in 1903.
Characteristics of Hormones
(i) Hormone release directly into the blood and circulate in the body for performing regulatory functions.
(ii) It is always released out in very small amount.
(iii) It regulates various functions in the body like growth and development, behavioral characters, sexual characters,
reproductive activities, metabolic activities act.
(iv) It also helps in maintaining body balance.
It includes the following organs for the purpose of secretion
Endocrine Glands Thyroid, parathyroid, adrenal, pituitary, thymus and pineal.
Mixed Glands Pancreas
Other Structures include hypothalamus, skin, gastrointestinal mucosa, heart, kidneys, gonads (ovaries in women and testes in
men), placenta and liver.
Income Tax Inspector •CAT •GMAT •UPSC •SSC •BANK
Pituitary Gland
Gland Hormone Type Action
Posterior Oxytocin Peptide Initiates labor and milk ejection
Antidiuretic hormone Peptide Stimulates water resorption by kidneys
Anterior Growth hormone Protein Stimulates body growth
Prolactin Protein Promotes lactation
Follicle-stimulating Glycoprotein Stimulates follicle maturation and production of estrogen.
hormone
Luteinising hormone Glycoprotein Triggers ovulation and production of estrogen and progesterone
by ovary.
Thyroid gland T3 (Triiodothyronine) Amine Increases metabolism, blood pressure and regulates tissue
growth
T4 (Thyroxine) Amine Increase metabolism, blood pressure and regulates tissue
growth
Calcitonin Peptide Childhood regulation of blood calcium levels through uptake by
bone
Parathyroid Parathyroid hormone Peptide Increase blood calcium levels through action on bone, kidneys
and intestine
Pancreas Insulin Protein Reduces blood sugar level by regulating cell uptake
Glucagon Protein Increase blood sugar levels
Adrenal Gland
Gland Hormone Type Action
Adrenal medulla Epinephrine Amine Short-term stress response: increased blood sugar levels,
vasoconstriction, increased heart rate and blood diveration
Norepinephrine Amine Short-term stress response; Increased blood glucose levels,
blood volume maintenance and immune suppression
Adrenal cortex Glucocorticoids Steroid Long-term stress response; Increased blood glucose levels,
blood volume maintenance. Immune suppression
Mineralocorticoids Steroid Long term stress response; blood volume and pressure
maintenance, sodium and water retention by kidneys
Pineal gland Melatonin Amine Circadian timing
Thymus Thymosin Peptide Development of T-lymphocytes
Gonads
Gland Hormone Type Action
Testes Androgens Steroid Reproductive maturation and sperm production
Ovaries Estrogens Steroid Reproductive maturation and regulation of menstrual cycle
Progesterone Steroid Regulation of menstrual cycle
(Director & Author) •CAT •GMAT •GRE •SSC •BANK
• The study of endocrine glands and hormones secreted by them is called endocrinology.
• The first hormone to be discovered was secretin but the first hormone to be isolated was insulin, by Banting and Mceod.
• Hypothalamus is considered as supreme commander of endocrine system.
• Pituitary gland was considered as master gland of the body but today it is considered as orchestra of endocrine system. Size
– 3-4 cm, Weight – 0.5gm.
• Pituitary gland is the smallest endocrine gland in the human body.
• Thyroid gland is the largest endocrine gland in the human body.
Thyroid Gland
• Located on both side of trachea
• Shape like Butterfly
• Balance Iodine
• Secrete Hormone – Thyroxine Hormone – Activate growth Hormone
• Iodine deficiency – Gland swelling - Goitre
in this
Pineal Gland
• Connects with thalamus
• Found in fibrous form –
• Responsible for daily routine
• Secretes:
(i) Melatonin Hormone:
• Works as anti-melanine
(ii) Serotonin Hormone:
• Provide contraction in Blood Vessels.
• Blood Pressure
Thymus Gland
• Located under/behind sternum
• Secrets Thymosin Hormone
• maintain our immune system
• In old age – Thymosin Hormone become weak and Immunity decreases.
9. Gynecomastia It is the development of enlarged mammary glands (breasts) in males due to excessive secretion of female
sex hormones (estrogen) in males.
10. Precocious Puberty It is early maturation of ovaries and testes with production of ova before the age of 9 years in girls or
sperms before 10 years in boys, called sexual pseudoprecocity.
11. Eunuchoidism It is a disorder which affects males due to failure of testosterone secretion. A eunuch has under developed
and non-functional secondary sex organs, lacks external or accessory sex characters and does not produce sperms.
Income Tax Inspector •CAT •GMAT •UPSC •SSC •BANK
GENETICS
Genetics is a branch of biology that deals with inheritance as well as variation of characters from parents to offspring's. The term
genetics was firstly used by W Bateson in 1905. Inheritance is the process by which characters are passed on from parents to progeny
and is the basis of heredity.
It is due to heredity that, the born offspring's resemble their parents. All organisms such as human beings, plants or animals, exhibit
various characteristics. Each character is carried forward to offspring's by the genes (core component of chromosomes). Variation is the
degree by which progeny differ from their parents.
(Director & Author) •CAT •GMAT •GRE •SSC •BANK
Mendel’s Experiment
Gregor Johann Mendel of Austria, was the first who started research on heredity, thus known as father of genetics. He conducted
experiments on garden pea (Pisum sativum) and proposed the laws of inheritance in living organisms.
Mendel’s Experimental Material
Mendel grew pea plant (Pisum sativum) in his garden and selected seven pairs of species varieties, i.e., those plants which had shown
same characters for atleast three successive generations.
Mendel’s Observation
He selected two varieties of pure plants (one tall and one dwarf) and crossed them. The resulting plants of next generation were all tall
like one of their parents. The offspring's obtained by crossing two plants with contrasting characters were called hybrids and their
generations were F1 and F2.
Mendel also coined two words for designating result of his experiment, i.e., dominant and recessive. Out of which, the dominant factor
was denoted by the capital letter like ‘T’ (for tallness). He also deduced from his experiments that there are two factors which express
the same inherited characteristic in every reproductive cell. If these two factors are same then it is called homozygous (i.e., TT) while if
these two factors are opposite, it is called heterozygous (i.e., Tt).
Genetic Disorders
These diseases or disorders are caused due to the absence or excess or abnormal arrangement of one or more chromosomes.
Central Dogma
This was given by Francis Crick. According to this phenomenon, the genetic information flows in a forward direction i.e., form DNA
→ RNA → Protein.
Transcription TranslationProtein
Replication of DNA mRNA
Evolution
Evolution is defined as the sequence of gradual changes from simple life forms to complex life forms, i.e., from primitive organisms
that existed over millions of years to new organisms that exists today. It is all about changes, improvement and modification from
simple life forms.
(Director & Author) •CAT •GMAT •GRE •SSC •BANK
Origin of Life
Mainly, it was known that life originated approximately 3,600 million years ago.
The most widely accepted theory of ‘origin of life’ was given AI Oparin, JBS Haldane, SL Miller and SW Fox that states that life
originated on earth through physiochemical processes of atom that combined to form molecules, to produce inorganic and organic
compounds.
Agents of Evolution
The agents or factors affecting evolution are
Agents of Evolution
Fossils
Remains of ancient lives, as bone, teeth, shale etc. are called fossils. These are generally found in sedimentary rocks. Age of fossil is
determined by lead-uranium method, carbon dating method, Fission track and electron spin resonance methods.
Note:
• Lobefins evolved into first amphibians that lived on both land and water. These were considered as the ancestors of modern
frog and salamanders.
(Director & Author) •CAT •GMAT •GRE •SSC •BANK
• It is believed that in future, human could change due to various factors like gene mutation, gene recombination, natural
selection. HL sapiro named the future man Homo sapiens futuris.