A Review On EEG Based Epileptic Seizures Detection Using Deep Learning Techniques
A Review On EEG Based Epileptic Seizures Detection Using Deep Learning Techniques
Abstract—Magnetic Resonance Imaging (MRI) and [20], [21]. Figure 1 represents the different DL tools used
Electroencephalography (EEG) modalities have been used in for detecting seizures in epilepsy.
several screening procedures to diagnose epileptic seizures with
a high-level accuracy. O ver the last two decades; significant TensorFlow
contributions have been made to automate the procedure of 11
2022 4th International Conference on Smart Systems and Inventive Technology (ICSSIT) | 978-1-6654-0118-0/22/$31.00 ©2022 IEEE | DOI: 10.1109/ICSSIT53264.2022.9716374
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EEG tests to diagnose epilepsy and seizures detection. Because 15 Keras
manual seizure detection will take more time for a doctor as 7
well as for technician to put their efforts into recognizing the Matlab
type of seizure within less time. Deep Learning (DL) helps in 7 Py Torch
automatic feature extraction and classification techniques. In
the Medical field, adopting these approaches has resulted in 14 Theano
the introduction of these approaches has led to a significant 14
breakthrough in substantial advancements including the
Octave
identification of epileptic seizures. This paper presents a
comprehensive summary of each section in depth and methods Fig. 1. Diagnosis of seizures in epilepsy using DL tools repeatedly in the
used to diagnose epilepsy from a variety of methods. In following reviewed papers.
addition, they are highlighted because they are best suited for
Since 2016, Convolutional Neural Network with
applied medicine, hardware execution, and cloud-based tasks.
This paper provides a review of novel seizure detection
Autoencoder (CNN-A E), Convolutional Neural Network-
applications and pre vious studies. The research concludes with
Recurrent Neural Network (CNN-RNN), Recurrent Neural
some fresh concepts for seizure detection utilizing DL Network (RNN), Convolutional Neural Network (CNN),
techniques which are becoming increasingly popular. Autoencoders (AE), and Deep belief network (DBN) are
Keywords—Classification, Deep Learning, Epileptic seizures, used for epilepsy detection [22], [23], [24], [25]. Figure 2
Electroencephalography, Feature Extraction, Magnetic shows the number of research done in identifying epileptic
Resonance Imaging. seizures applying several models of DL fro m 2014 to 2021.
Various DL models have been used to diagnose epileptic
I. INT RODUCT ION episodes, as shown in Figure 2.
Sudden attacks of seizures seem to be the most common
symptom of epilepsy, which would be a long-term Non- 5 22 2D-CNN
Co mmunicab le Disease (NCD) in hu mans [1]. Seizu res are 9
34
a type of epilepsy that affects the entire body and is caused 1D-CNN
by a quick and early disruption in the brain’s electrical 15 AE
activities [2]. Around 60 million people worldwide suffer
RNN
fro m various types of epileptic seizures [3]. Magnetic
resonance imag ing (MRI) [4], Magnetoencephalography 17
24 CNN-RNN
(MEG) [5], EEG [6], and functional imaging techniques
such as Positron emission tomography (PET) [7], Single - Fig. 2. Reviewed works carried out using several DL models from 2014 to
Photon Emission Computerized To mography (SPECT) [8], till2021.
Electrocorticography (ECo G) [9], are some of the screening
techniques used to diagnose epileptic seizu res. EEG signals 3
9 IEEE
are extensively used because they are inexpensive, portable,
Elsevier
and exhib it distinct frequency domain patterns [10]. EEG 13 38
signals provide the variation in supply voltage passes Springer
through neurons using cell memb rane in the brain, Others
representing that bio signaling takes place over here [11]. 14 Preprint
There’s also the chance of hu man mistakes, thus
establishing a computer-based diagnostic might help solve 16 Frontiers
these issues. To overcome the challenges, many researchers
have used Artificial Intelligence (AI) techniques with MRI Fig. 3. Various research strategies are applied to epileptic seizure detection.
for epileptic seizure detection [12], [13]. Many machine One Dimensional-Convolutional Neural Network (1D-CNN)
learning methods have been created to identify epileptic and two Dimensional-Convolutional Neural Network (2D-
seizures utilizing statistical, nonlinear parameters, and CNN) are widely used deep learning techniques. 2D-CNN is
frequency domain [14], [15], [16], [17], [18], [19]. For little widely used by researchers to detect epilepsy. First EEG data
algorith ms may not perform as effectively as they formerly is converted into Two Dimensional (2D) images in the pre-
did as data availability has increased. As a result, DL processing stage by using Fourier-related transform which is
techniques, which are contemporary procedures, were used a Fourier spectrum on each shorter segment such as Short
Time Fourier Transform (STFT). By utilizing the converted episodes to detect aberrant patterns. The centrotemporal
images into a 2D-CNNN network is created. The second spikes and their properties were defined by Juozapaviciuset
group includes various 1D-CNN models, which are also used al. [39] to detect abnormalities in EEG signals. For autis m
for detecting epileptic seizures. Figure 3 depicts the various spectrum disease; Cociu et al. [40] outlined a mu ltimodal
ways of detecting epileptic seizures. The IEEE citation functional and structural brain connection strategy. Qian et
database appears to have the most widely recognized articles. al. [41] created a drowsiness monitoring system to reduce a
The major objectives of this research comprise of the large number of traffic accidents by analyzing EEG signal
following: records to predict tiredness levels. Yang et al. [42]
developed a hierarchical network structure containing
Available datasets related to EEG are provided. subnetwork nodes that might be used to distinguish between
Based on EEG, various DL models are d iscussed for three human emotions: positive, neutral, and negative. Costa
studying the epileptic seizures detection with the help et al. [43] investigated a trustworthy lead field mat rix to
of various modality signals;
overcome the Magnetoencephalography (MEG) source
Advancing forthcoming challenges on EEG in localization problem. Giri et al. [44] used an 1D-CNN to
epilepsy to detect seizures.
identify ischemic stroke based on EEG and
Investigation of the best-performing model in DL for
Electrooculogram (EOG).
several modality signals of data.
In section II, a Literature survey is performed on various DL III. SEIZURE DET ECT ION UT ILIZING DL TECHNIQUES BASED
techniques used in detecting epileptic seizures. Section III, ON CAD SYST EM
exp lains how a Co mputer-Aided Design (CAD) system is The DL model may emp loy EEG, Functional Near-
used in detecting epileptic seizures. In section IV, explains Infrared Spectroscopy-scan (fNIRS-scan), M EG-test, PET-
the design of the hardware approach applied to seizures scan, SPECT-scan, Electrocorticography, and MRI-scan as
detection using epilepsy. Section V shows that various inputs. Figure 4 describes the diagnosis of seizures using the
challenges that occurred during the specific process of CAD method using DL techniques. summarizing all the
epileptic seizure detection. Finally, Section VI represents the works accomplished carried out the epileptic seizure
conclusion. detection using DL methods are discussed in table 6.
II. LIT ERAT URE REVIEW A. Epileptic Datasets
Le et al. [26] According to the author, the most efficient The creation of an accurate and trustworthy CADS relies
model is the DBN, which builds the framework for deep heavily on datasets. Bern-Barcelona, Zenodo, CHB-MIT,
learning to detect seizures in the brain using EEG data. Yao Flint-Hills, Hauz Khas, Kaggle, Freiburg, and Bonn are only
et al. [27] EEG are evaluated and analyzed by pro fessional a few of the EEG datasets which recognize and distinguish
neurologists in contemporary clinical procedures to provide the seizures automatically. Several datasets that were utilized
support for medicinal reco mmendations. Iesmantas et al. to detect epileptic episodes using DL methods are
[28] provide a method for detecting and classifying seizures represented in Figure 5.
based on medical data fro m EEG tests and a trained B. EEG Signal Preprocessing
convolutional neural network through its brain
In the DL-based CAD approach, Electroencephalogram
synchronization in addition to the power spectrum of t ime -
signal pre-treatment for deep learning network applications
series properties. Liang et al. [29] constructed a model
termed an 18-layer Long-Term Recurrent Convolutional generally consists of three steps: Reduction of Noisy data,
normalizing the signals, and preparing the signal for giving
Network (LRCN) to recognize and localize seizure zones
input to the system. During this step reduction of
automatically. Tho mas et al. [30] presented an epileptic
EEG classificat ion method based on Interictal Ep ileptiform unnecessary noise in brain signals such as EEG. Finally,
various time-frequency approaches such as tempora l
Discharges (IED) detection. Wang et al. [31] emp loyed
frequency methods are utilized to imp rove signals in each
mu lticlass Support Vector Machines (SVM) to detect
epileptic and epilepsy seizures using EEG recordings. Jiang rapid classification of Deep Neural Networks (DNN).
et al. [32] exp lore ep ileptic seizure classification using C. Different Deep Learning Techniques
learning algorith ms and a fuzzy system. Abualsaudet al. [33]
discusses how the decomposition levels imp lement the CNN’s: In DL, Convolutional neural networks are one of the
development of mult iple wavelets. Tsiouris et al. [34] most prominent network models, accounting for the bulk of
describes how to reduce the effect and time which are machine learning research [22]. They were originally
required to process a huge volume of EEG info rmation. O designed for image processing but are now being utilized in
Solaija et al. [35] show how Dynamic mode deco mposition one and two-dimensional structures to identify and forecast
(DM D) is mostly utilized for fluid flow analysis. Saidi et al. disease using biological signals [51]. The identification of
[36] show how wavelet analysis in EEG signals has epileptic seizures using EEG data is a common application
specified sub-bands frequency for wavelet filters using for this type of deep learning network.
Discrete Wavelet Transform (DWT). Yuan et al. [37] 2D –CNN: Nowadays, deep 2D networks such as X- ray
discuss the use of encodes for feature extraction to learn [52], [53], tests of CT and M RI modalities [27] are utilized
channel-specific and global viewpoints. Fan et al. [38] in different therapeutic applications. Image
discuss the synchronization of EEG signals for epileptic
T ABLE I. LIST OF P OP ULAR DATASETS UTILIZED FOR DETECTION OF EP ILEP TIC EP ISODES USING EEG RECORDINGS.
Se iz ure Subject Duration Frequency Types of
Datase ts Description
Count count (hours) (Hz) Recordings
Intracranial The database contains 21 patients’ invasive long-term EEG
Freiburg
87 21 708 256 Electroencephal recordings and has a sampling rate of 256 Hz during invasive
[45]
ography (IEEG) process.
Continues
Flint-Hills The dataset consists of continues electrocardiography signals
59 10 1419 249 intracranially
[17] with whole period of 1419 h and sampling rate of 249 Hz.
term ECoG
In Kaggle dataset, considering the intracranial EEG signals
Kaggle
48 2 627 400 IEEG from two subjects with count 48 as seizures and 627 h whole
[46]
period.
The CHB-MIT corpus contains duration of 844 hours related
CHB-MIT
163 22 844 256 Seeg to continuous scalp EEG signal recording, and also collected
[47]
seizure data of 163 from 23 paediatric subjects.
Bonn dataset contains five files, A, B, C, D, and E, each
Surface and
Bonn [48] NA 10 39 173.61 consists of 100 single channel EEG recordings with duration
IEEG
of 23.6 sec, sampling rate of 173.61 Hz.
Barcelona Each dataset includes 3750 pairs of recorded signals with
3750 5 83 512 IEEG
[49] duration of 20-sec, and sampling rate of 512-Hz.
The database describes about scalp EEG recordings from ten
Hauz Khas Scalp EEG
NA 10 NA 200 subjects, recorded from AS40 system with sampling
[17] (sEEG)
frequency at 200 Hz.
This dataset contains EEG data which are interpreted by three
Zenodo
460 79 74 256 Seeg clinicians, and each clinician is dealt with 460 seizures and
[50]
seizure free are 22, 39 neonates.
b) Visual Geometry Group(VGGNet): In 2014, a
group of Oxford researchers presented the VGG CNN
model [62]. VGC-16 was the name given to the model since
it had 16 layers.
c) GOOGLENET: GoogLeNet in 2014 won the
challenge with the top five of ImageNet benchmark with
93.3 percent accuracy, [64]. The variant of the inception
Network is a 22-layer network represented as GoogLeNet
d) ResNet (RESNET): Microsoft’s ResNet achieved
the competition using the ImageNet model with 96.4 percent
precision by employing a deep network consisting of 152-
layer with a ResNet model [65]. Two ResNet and DenseNet
designs were effectively employed by [66] to diagnose
epileptic episodes.
1D-CNN’S: 1D-CNNs are well-suited to processing
biological data like EEG for seizure detection.
T ABLE VI. OUTLINE OF DL TECHNIQUES UTILISIZED FOR AUTOMATED DETECTION OF EP ILEP TIC EP ISODES.
Ref erence
Year Dataset Preprocessing Model Limitations
s
As future work, the use o f deep auto-encoder with various signal processing methods
[82] 2018 Bonn DWT SAE
may produce new results.
Down Sampling,
[30] 2018 Clinical 1D-CNN In future, planning to combine the rejection of artifacts, to overcome the false detections.
Filtering
In this overfitting of deep neural network takes place and also in future, intends to
[73] 2018 TUH EEG Distinct methods 1D-CNN-GRU
produce customized RNNs to undertake this problem.
IndRNN approach is more difficult and extensive. Finally requires more training samples
[27] 2019 CHB-MIT Windowing IndRNN
and is limited to processing imbalanced data.
CHB-MIT, This work focuses on what way it utilizes the dense IndRNN model with attention on
[83] 2019 Windowing ADIndRNN
Bonn seizure detection in real time.
Extraction, Working more hours on trained data regarding patient may not be always fe asible to use
[74] 2014 Clinical DBN
Standardization this as a model.
Augmentation, In this work, patient’ s frequency domain fe atures can be mor e biased than the feature
[84] 2019 Clinical Downsampling, SeizNet extraction fro m ti me domain and this model triggers false alar ms for the respective
Z-normalization subjects.
In 2d-CNN evaluating the neonatal subject recordings is the limitation and not
[85] 2018 Clinical Normalization 2D-CNN
represented for general scenario of EMU monitoring.
Down Sampling 2D-CNN
In this DL approaches were discussed which result in a prima ry shift o f clinical analysis
[68] 2018 Clinical Down Sampling NA
based on EEG recordings.
NA NA
TUH EEG The basic e rror modalities mentioned were false alar ms generated through the shorter
[75] 2017 Filtering method CNN-RNN
(Clinical) duration of the delta range, which results in irregular, slow patterns.
CHB-MIT
[80], 2018 Channel Selection CNN-AE Lower the feature dimensions will effects the performance of a model
Bonn
AlexNet
Bern
[71] 2017 NA GoogleNet Complex model, high-level classification, dimensionality features.
Barcelona
LeNet
Marginal increase of AUC values based on inputs of sensitivity by applying techniques
[28] 2019 TUH EEG Feature Extraction 2D-CNN
of dimensionality reduction.
In this TGCN model, si milar datasets are used but not configured identically and to train
[58] 2019 Clinical STFT TGCN the model utilizing the pooled dataset fro m various hospitals with different scalp EEG
sessions.
In future, the real time alar m based wearable device are available to detect before seizure
[67] 2019 Bonn Filtering 2D-CNN onset using single channel EEG detection. This may save the one’s life, not to occur
seizure furtherly.
Down Sampling,
Over conventional methods, AE has some i mportant benefits such as detecting the
[89] 2019 Clinical Filtering, Auto Encoder
seizures of any subject universally without lacking.
Normalization
GRU is a light weight model contain order of trainable parameters such as 100,000. In
[90] 2017 Bonn Auto-Correlation GRU
future this model will focus on huge multivariate datasets of EEG.
Seizure detection can be detected automatically by using this fra mework inorder to
[91] 2019 TUH EEG Different Methods SDA
classify various tasks.
1D-CNN
Limited time might be available inorder to investigate huge amount of EEG recordings
[79] 2018 Bonn Signal windowing with Bi
without errors. Hence automation may require in future.
LSTM
ASAE-CNN,
[81] 2018 Clinical Mapping In future, the use of deep subdural electrodes as an alternative source of iEEG data.
AAE-CNN
analysis of seizu re ep isodes. Singh et al. presented the imaging modalities and DL methods. Firstly, availab le
schematic layout of survival system for seizure detection datasets contain only selected EEG record ings, so that it is
within Figure 6. Kiral-Ko rnek et al. [88] described the not suitable to apply these signals in real world applicat ions,
specific hardware used for wearable devices which supports because the clinical dataset may not be available to public
long term performance and patient specific. Table VI and it’s hard to detect real time signals. All authors can be
indicates the detailed outline about works reviewed in this utilized this model to diagnose the seizures of epileptic
survey. patient with the help of CAD system by using DL
approaches. Secondly, these huge volumes of datasets are
V. CHALLENGES cannot be joined simply due to non-identical frequencies,
Currently, several challenges are faced by the researchers to sampling rate and also to train a model with s mall usable
data. Researchers acting in the domain of ep ileptic seizures
diagnose the seizures of epileptic patient using brain
cannot have acquired always high-power hard ware is still members, with the help of wearable devices, such that the
challenging to perform novel DL approaches. This leads to patients can get proper treatment on time.
develop the computerized development of hardware which
is expensive and not effortlessly available to clinicians. So,
the researchers are required to work in this direction to
hinder with the epileptic episodes with effective prototypes,
to help the patients at any moment, any place.
VI. CONCLUSION
Over the last few years, several types of DL techniques like
AE, RNN, CNN are used for detecting epileptic seizures. In
this study, different screening techniques such as MRI and
EEG are used. Hardware and deep learn ing-based practical
methods are used in detecting epileptic seizures detection. In
the future, a detailed and carefu l study will be perfo rmed on
hardware and practical applications to get precise results.
Hence, various applications s uch as wearable devices and
mobiles have been used along with the models, cloud
servers for computational purposes. Diagnosis of seizures Fig. 6. Schematic layout of the proposed method utilizing DL approaches
through epilepsy using some alert notificat ions, where these for detecting seizures using EEG recordings.
alerts will send to doctors, relatives, hospitals, family
[11] Sharma, Rajeev, and Ram Bilas Pachori. "Classification of
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