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Module 01 Introduction To Biomaterials

This document outlines the syllabus for the course "Introduction to Biomaterials" taught by Instructor Vivek Verma. The course meets twice a week and has a midterm and final exam weighting grades at 30% and 45% respectively. Reading assignments and quizzes make up the remaining 25% of the grade. The course covers definitions of biomaterials and biocompatibility, the evolution of biomaterials from bioinert to bioactive and regenerative applications, and characteristics of biomaterials science including its multidisciplinary nature and use of diverse materials driven by clinical needs.

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27 views

Module 01 Introduction To Biomaterials

This document outlines the syllabus for the course "Introduction to Biomaterials" taught by Instructor Vivek Verma. The course meets twice a week and has a midterm and final exam weighting grades at 30% and 45% respectively. Reading assignments and quizzes make up the remaining 25% of the grade. The course covers definitions of biomaterials and biocompatibility, the evolution of biomaterials from bioinert to bioactive and regenerative applications, and characteristics of biomaterials science including its multidisciplinary nature and use of diverse materials driven by clinical needs.

Uploaded by

The BS Channel
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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MSE 204A

Introduction to Biomaterials

Module 1:
Introduction to Biomaterials

Instructor: Vivek Verma


Course Policy
Classes: TF 12:00 – 1:00 PM, L3

Grading Policy: Grading will be relative. There is no upper/lower limit


how many will get A, B, C, D, or F. Granular grading will be followed.
Weightage of examinations is as follows:
• 30% for Mid semester examination
• 45% for End Semester
• 25% Reading assignments, quizzes (surprise) and assignments

Cut-off for ‘F’ grade is 40%


No makeup examinations for mid semester examination

Office Hours: 3:00 PM to 4:00 PM Wednesday

Attendance: Mandatory. Student with poor attendance will be


deregistered by the instructor. Attendance is necessary but not
sufficient to clear the course.

Instructor: Vivek Verma


Course Policy (continued)
Misconduct/ cheating/ plagiarism:
Misconduct: Will be dealt swiftly and strictly
Copying or helping in copying will have following
consequences:
• Will lead to ‘F’ grade and reporting to SSAC
• Quizzes: lead to zero in that quiz. Depending
on the seriousness, further action (see above)
may be taken.
• Assignments: same as for quizzes. Copy-
pasting (plagiarism) in assignments will also
be treated as copying in quizzes and will be
dealt as above.
Instructor: Vivek Verma
What is Biomaterial?
• Synthetic and natural materials used in
applications where they contact biological
systems
– Implants
– Devices
• Why biomaterials?
– Prosthesis
• Cardiovascular, orthopedic, dental, opthalmological
– Sutures
– Advanced drug delivery
• Highly Interdisciplinary!
– Science
– Engineering
– Medicine
Instructor: Vivek Verma
Instructor: Vivek Verma
Biomaterials
• So, what is common:
– The common thread in biomaterials is the physical
and chemical interactions between complex
biological systems and synthetic or modified
natural materials

Instructor: Vivek Verma


Biomaterials
• Rarely used as isolated material
– Commonly integrated into devices or implants
• Ex: Titanium
– Chemically pure titanium can be called biomaterial
– Ti machined and conjunction with UHMWPE*
becomes device (hip prosthesis)
• We must also consider how this device impacts
patient (subject) and vice versa
– Success or failure of device
• Biomaterial always considered in context of its
final fabricated and sterilized form

*Ultra High Molecular Weight PolyEthylene


Instructor: Vivek Verma
Definitions
• Biomaterial
– A biomaterial is a nonviable material used in a medical
device, intended to interact with biological systems
• Biocompatibility
– Biocompatibility is the ability of a material to perform
with an appropriate host response in a specific
application
• Biomaterials science is the study of materials
with special reference to their interaction with
the biological environment
• Biointerface: Interaction of materials with
physiological environment
Instructor: Vivek Verma
Instructor: Vivek Verma
Evolution of Biomaterials Field
1. Bioinert
– Suitable combination of functional properties to match those
of replaced tissue without deleterious response by the host
– Elicit minimal response from the host tissue
2. Bioactive
– Intended to elicit a controlled reaction with the tissues into
which they were implanted in order to induce desired
therapeutic effect
• Controlled localized drug release (drug eluting stents, active
protein-based drugs)
• Bioresorbable with tailored degradation rates (PGA sutures)
3. Tissue engineering, regenerative medicine
– Use living cells to aid tissue formation or regeneration
• Scaffold
– Supporting and stimulating regeneration of functional
tissue
• Beyond palliative – ease of symptom without curing
Instructor: Vivek Verma
Evolution of Biomaterials Field
• Tissue engineering is a broad term describing
a set of tools at the interface of biomaterials
and engineering sciences that use living cells
to aid tissue formation or regeneration, and
therefore produce therapeutic or diagnostic
benefit

Instructor: Vivek Verma


Characteristic of Biomaterials Science
• Multidisciplinary

Instructor: Vivek Verma


Instructor: Vivek Verma
Characteristic of Biomaterials Science
• Multidisciplinary
• Diverse materials are used

Instructor: Vivek Verma


Instructor: Vivek Verma
Characteristic of Biomaterials Science
• Multidisciplinary
• Diverse materials are used
• Clinical need driven
• Substantial world market
• Risk benefit issues

Instructor: Vivek Verma

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