This document provides an introduction to a journal issue focusing on hepatobiliary manifestations (effects on the liver and bile ducts) of diseases involving other organ systems. It summarizes several articles in the issue that review liver involvement from cardiovascular, pulmonary, renal, endocrine, hematologic/oncologic, gastrointestinal/nutritional, infectious, rheumatologic, dermatologic, and pregnancy-related conditions. The goal is to provide physicians with knowledge of these clinical relationships to improve patient care.
This document provides an introduction to a journal issue focusing on hepatobiliary manifestations (effects on the liver and bile ducts) of diseases involving other organ systems. It summarizes several articles in the issue that review liver involvement from cardiovascular, pulmonary, renal, endocrine, hematologic/oncologic, gastrointestinal/nutritional, infectious, rheumatologic, dermatologic, and pregnancy-related conditions. The goal is to provide physicians with knowledge of these clinical relationships to improve patient care.
This document provides an introduction to a journal issue focusing on hepatobiliary manifestations (effects on the liver and bile ducts) of diseases involving other organ systems. It summarizes several articles in the issue that review liver involvement from cardiovascular, pulmonary, renal, endocrine, hematologic/oncologic, gastrointestinal/nutritional, infectious, rheumatologic, dermatologic, and pregnancy-related conditions. The goal is to provide physicians with knowledge of these clinical relationships to improve patient care.
This document provides an introduction to a journal issue focusing on hepatobiliary manifestations (effects on the liver and bile ducts) of diseases involving other organ systems. It summarizes several articles in the issue that review liver involvement from cardiovascular, pulmonary, renal, endocrine, hematologic/oncologic, gastrointestinal/nutritional, infectious, rheumatologic, dermatologic, and pregnancy-related conditions. The goal is to provide physicians with knowledge of these clinical relationships to improve patient care.
Hepatobiliary Manifestations of Diseases Involving Other Organ Systems
Preface Hepatobiliary Manifestati ons of Systemic Diseases
Ke-Qin Hu, MD Guest Editor
Hepatobiliary manifestations can be the clinical presentation of other systemic disor-
ders that are commonly seen in our daily practice and usually require gastroenterology or hepatology consultation. Understanding these clinical issues would enrich our knowledge and improve outcomes of the patient care. Some of these conditions have been well reviewed in a 2002 issue of Clinics in Liver Disease edited by Dr Herbert L. Bonkovsky. This issue of Clinics in Liver Disease denotes to an updated and system- atic review on hepatobiliary manifestations of other systemic disorders. It has been my privilege and pleasure to assemble a group of expert clinicians to present their views and share their vast experiences in these complicated clinical issues. The first review by Drs Weisberg and Jacobson provides an excellent summary on common hepatobiliary manifestations of cardiovascular diseases. The article begins by introducing a physiologic base of macro- and microcirculation of the liver, followed by most common clinical issues, such as ischemic hepatitis and congestive hepatopathy. Both hepatopulmonary syndrome and portopulmonary hypertension are well- known pulmonary complications of liver diseases. The article by Drs Kochar and Fallon reviews hepatobiliary manifestations of some common pulmonary disorders, including respiratory failure and hepatic dysfunction, genetic and granulomatous disorders, and the liver. Many liver diseases coexist with chronic renal disease. Dr Wong’s article provides an up-to-date summary on this complicated topic. Besides covering nephrogenic ascites, a common clinical presentation, this article covers some other common but sometimes overlooked issues, such as nephrogenic hepatic dysfunction, renal tubular disorders, and cholestasis, dialysis, and the liver. Liver diseases and endocrine disorders may have a bidirectional and complex rela- tionship. Drs Maheshwari and Thuluvath’s article systematically reviews these issues.
Clin Liver Dis 15 (2011) xiiiexiv
doi:10.1016/j.cld.2010.09.009 liver.theclinics.com 1089-3261/11/$ e see front matter Ó 2011 Elsevier Inc. All rights reserved. xiv Preface
The article concisely summarized the complicated relationship between metabolic
syndrome and non-alcoholic fatty liver disease. It also reviews the hepatobiliary mani- festation of other common endocrine disorders, such as thyroid dysfunction, adrenal insufficiency, and sex hormone-related disorders. Drs Singh and Pockros provide a very detailed review on hepatobiliary manifesta- tions of hematologic and oncologic diseases by dividing their article into two sections: nonmalignant hematologic disorders and malignant hematologic disorders. Hepatobiliary manifestations of gastrointestinal and nutritional disorders can occur as part of the clinical spectrum of the underlying disease or as a consequence of the treatment of the disease. The article by Dr Samarasena and me provides a thorough review on a selection of gastrointestinal and nutritional disorders including inflamma- tory bowel disease, celiac disease, Whipple’s disease, and parenteral nutrition asso- ciated disorders. Infectious disease can present with a wide variety of hepatobiliary manifestations from asymptomatic elevations in aminotransaminases to acute liver failure, hepatic fibrosis, and cirrhosis. Drs Talwani, Gilliam, and Howell contribute an excellent review on this complicated topic. HIV infection can be associated with various hepatobiliary manifestations. Dr Merwat and Vierling’s article well addresses two major and common issues: HIV and HCV coinfection and hepatotoxicity of HIV medications. Rheumatologic diseases typically have multisystem involvement, including common hepatobiliary manifestations. Drs Schlenker, Halterman, and Kowdley’s article provide an in-depth review on this complicated topic. Few publications have covered the topic “Dermatologic disorders and the liver” in the past. Drs Satapathy and Bernstein have done an excellent job. Their article provides a great review on primary dermatologic disorders affecting the liver. Liver dysfunction is common in both critically ill and postoperative patients. Drs Aronsohn and Jensen’s article addresses this important and complicated topic from hypoxic liver injury, liver dysfunction in sepsis, postoperative liver dysfunction, to parenteral nutrition-associated hepatobiliary manifestations. Pregnancy may cause complex physiologic changes that may result in hepatobili- ary manifestations and related liver disorders. Thus, we include this topic in this issue of Clinics in Liver Disease. We appreciate that Drs Pan and Perumalswami have contributed a thorough review on this topic. I hope that you will enjoy this issue of Clinics in Liver Disease. I am indebted to all the authors for their outstanding contributions of this issue, and Dr Norman Gitlin, the Consulting Editor, for his invitation and support to my participation as Guest Editor for this issue. Also, I would like to thank Kerry Holland for her outstanding editorial support. Finally, I would like to thank my wife Chang Hong Yu and my daughter Shirley X. Hu for their love, support, and inspiration.
Ke-Qin Hu, MD Division of Gastroenterology and Hepatology University of California, Irvine School of Medicine 101 The City Drive Orange, CA 92868, USA E-mail address: [email protected]
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