Herpesvirus: Classification
Herpesvirus: Classification
Herpesvirus: Classification
Ali Sabri
i
Herpesvirus
· All of the Herpesviruses have
structure -
a core of double stranded DNAin the form of a teroid.
exhibit icosahedral symmetry.
and - Surrounded by a protein coat
eN- EBU.
~ HHV-8 CKSHV).
·
IV:Causes chickenpox (varicella) on the primary infection,
- VIV and establishes laten infection in neurons.
BU:replicates
I in epithelial cells of the oropharynxand
·EBV Parotid gland and establish laten infection in lympocytes.
⑤
z
18
·
Itcauses Infections mononucleosis and it can induce human
-
serisy, Lymphoproliferative disorders, especiallyin immunocomporomised
paiteints.
~
1 9 11?
8l
-
HAU D
-
/Vogeda infantum) as well as infections in immuno-
-compromise paiteints.
any specific
· has been
not linked with disease.
Tummer That
is common in AIDS patients.
other Herpesvirus
· with malignantdisease
diseases
· EBU with Burkitt lymphoma ofAfrican Children,
with nasopharyngeal carcinoma ·b- j'ya
-
KSAV (HHV-8)
· With Kaposi Sarcom.
Doxviruses:
· are the largest
and of
mostcomplex Viruses
Infections
· with poxvirus are Charchtrized By rash althouth
are markedly proliferative.
leshions induced by some members of the family
& The grout includes (variola Virus - The exiologic agentof smallpox.
lightmicroscope to be
a / the Virus are large enough seen
nm.
. one
The
to
sudden.
onsetusually
of fever
5 days and
S
malaise preceded the
appearance of
the exanthers which began as macules then a Papules then
Treatment of
a treatment smallpoxis primally supportive.
Live Vaccinia Virus)
* vaccinia immune globulin has shown
not a Survival benefit
for established disease, is prepaired from Vescular lesion (Lymph)
- contains, 40%
It glycerole to stabilize the Virus.
-0.4% phenol to destroy Bacteria.
Methisazone is chemotheraputic
* a
agenthistorically evaluated
againstDox viruses.
Adenoviruses · Ade uses can replicates and produce diseases in the respiratory
, gastrointestinal and urinary tracts and in the eye.
many infections
· are subclinical (j'si, s.).
·
third of 57 serotypes cause disease.
Clinical Respiratory
1) diseases.
findings -
symptoms:Cough, nasal congation, fever, love throat.
· mostcommonly in infants and Children.
B) Eye infections:
-
Mild Ocular
may be
involvement a of
part the respiratory
phageal Syndrome caused by Adenoviruses.
9) Gastrointestinal Diseases:-
caused By Type 40/41 a causes gastroenteritis.
ISI
PAPILLOMa_ ·
highly tropic for epithelial cells of the skin and mucous membrane.
- VirUS HBV
·
Cervical Cancer is the second most frequentcancer in women world Wide.
·
Types APV16 and II have high Cancer risk.
Hepatitis · HBV is classified as hepadnavirus (infects infants)
MyPCB ·
is
It a major factor in the eventual developementof Liver diseases
and hepatocellular Carcinoma.
(HBCASS
· Hepatitis e autigen
⑤The genome
- for patents
Treatment whith chronic active hepatitis.
·
firstLine Treatment:Pegylated interferon alpha-zaa