Pediatric Skin Disorders: Prepared by Dr. Darin Mathkor
Pediatric Skin Disorders: Prepared by Dr. Darin Mathkor
Pediatric Skin Disorders: Prepared by Dr. Darin Mathkor
Skin Disorders
Prepared by Dr. Darin Mathkor
General Objectives Specific Objectives
Objectives
skin disorders due to:
Bacterial infections •
Viral infections •
Fungal infections •
Parasitic infections/infestations •
Chemicals •
Bacterial infections
Staphylococci Streptococci
High risk children for developing bacterial infection
Debilitated condition
• Receiving immunosuppressive therapy, and those with a
• Generalized malignancy (such as, leukemia or lymphoma)
.اﻟﻔﯾروﺳﺎت ھﻲ طﻔﯾﻠﯾﺎت داﺧل اﻟﺧﻼﯾﺎ ﺗﻧﺗﺞ ﺗﺄﺛﯾرھﺎ ﺑﺎﺳﺗﺧدام اﻟﻣواد داﺧل اﻟﺧﻼﯾﺎ ﻓﻲ اﻟﺧﻼﯾﺎ اﻟﻣﺿﯾﻔﺔ
.اﻟﻔﯾروﺳﺎت ﻏﯾر ﻗﺎدرة ﻋﻠﻰ ﺗوﻓﯾر اﺣﺗﯾﺎﺟﺎﺗﮭﺎ اﻷﯾﺿﯾﺔ أو إﻋﺎدة إﻧﺗﺎج ﻧﻔﺳﮭﺎ
Viral infections
• Verruca (warts)
• Human papillomavirus (various types)
• Well-circumscribed, gray or brown, elevated, firm
(• اﻟﺛﺂﻟﯾل )اﻟﺛﺂﻟﯾل papules with a roughened, finely papillomatous
texture
(ﻓﯾروس اﻟورم اﻟﺣﻠﯾﻣﻲ اﻟﺑﺷري )أﻧواع ﻣﺧﺗﻠﻔﺔ •
• Usually appear on exposed areas, such as fingers,
، ﻣرﺗﻔﻌﺔ، رﻣﺎدﯾﺔ أو ﺑﻧﯾﺔ، • ﺣطﺎطﺎت ﻣﻘﯾدة ﺟﯾدًا hands, face, and soles
ﺻﻠﺑﺔ ذات ﻣﻠﻣس ﺣﻠﯾﻣﻲ ﺧﺷن
• May be single or multiple
ﻣﺛل اﻷﺻﺎﺑﻊ، • ﺗظﮭر ﻋﺎدة ﻋﻠﻰ اﻟﻣﻧﺎطق اﻟﻣﻛﺷوﻓﺔ
واﻟﯾدﯾن واﻟوﺟﮫ وﺑﺎطن اﻟﻘدم • Asymptomatic
ﻗد ﺗﻛون ﻣﻔردة أو ﻣﺗﻌددة • • Management
• ﺑدون أﻋراض ظﺎھرة • Local destructive therapy, individualized according
to location, type, and number—surgical removal,
• إدارة electrocautery, curettage, cryotherapy (liquid
ﻓردي ﺣﺳب اﻟﻣوﻗﻊ واﻟﻧوع، • اﻟﻌﻼج اﻟﻣدﻣر اﻟﻣوﺿﻌﻲ nitrogen)
، اﻟﻛﺣت، اﻟﻛﻲ اﻟﻛﮭرﺑﺎﺋﻲ، اﻹزاﻟﺔ اﻟﺟراﺣﯾﺔ- واﻟﻌدد
(اﻟﻌﻼج ﺑﺎﻟﺗﺑرﯾد )اﻟﻧﯾﺗروﺟﯾن اﻟﺳﺎﺋل
Viral infections
• Cold sore, fever blister:
• Herpes simplex virus (HSV) type 1
• Genital herpes: HSV type 2
1 ﻣن اﻟﻧوعHSV) ) ﻓﯾروس اﻟﮭرﺑس اﻟﺑﺳﯾط • Grouped burning and itching vesicles on
2 ﻣن اﻟﻧوعHSV :اﻟﮭرﺑس اﻟﺗﻧﺎﺳﻠﻲ
inflammatory base
• Usually on or near mucocutaneous
ﺣوﯾﺻﻼت ﺣرﻗﺔ وﺣﻛﺔ ﻣﺗﺟﻣﻌﺔ ﻋﻠﻰ ﻗﺎﻋدة اﻟﺗﮭﺎﺑﯾﺔ junctions (lips, nose, genitalia, buttocks)
ﻋﺎدة ﻋﻧد اﻟﺗﻘﺎطﻌﺎت اﻟﺟﻠدﯾﺔ اﻟﻣﺧﺎطﯾﺔ أو ﺑﺎﻟﻘرب ﻣﻧﮭﺎ • Vesicles dry, forming a crust, followed by
()اﻟﺷﻔﺎه واﻷﻧف واﻷﻋﺿﺎء اﻟﺗﻧﺎﺳﻠﯾﺔ واﻷرداف exfoliation
ﺗﺟف اﻟﺣوﯾﺻﻼت وﺗﺷﻛل ﻗﺷرة ﯾﺗﺑﻌﮭﺎ ﺗﻘﺷﯾر • Spontaneous healing in 8 to 10 days
أﯾﺎم10 إﻟﻰ8 اﻟﺷﻔﺎء اﻟﺗﻠﻘﺎﺋﻲ ﻓﻲ ﻏﺿون • May be accompanied by regional
ﻗد ﯾﻛون ﻣﺻﺣوﺑًﺎ ﺑﺗﺿﺧم اﻟﻌﻘد اﻟﻠﻣﻔﯾﺔ اﻟﻣوﺿﻌﻲ lymphadenopathy
إدارة • Management
ﻣﺿﺎد ﻟﻠﻔﯾروﺳﺎت ﻋن طرﯾق اﻟﻔم • Oral antiviral
Fungal infections
• Ringworm are infections caused by a group of closely
related filamentous fungi that invade primarily the stratum
corneum, hair, and nails.
• Manifestation
• ﻣظﺎھر • Round or oval, erythematous scaling
patch that spreads peripherally and
• رﻗﻌﺔ ﻣﺗﻘﺷرة ﺣﻣﺎﻣﯾﺔ داﺋرﯾﺔ أو ﺑﯾﺿﺎوﯾﺔ ﺗﻧﺗﺷر ﺑﺷﻛل
ﻣﺣﯾطﻲ وﺗﻧﺗﮭﻲ ﻣرﻛزﯾًﺎ ؛ ﻗد ﺗﺷﻣل اﻷظﺎﻓر clears centrally; may involve nails
Fungal infections
(Ringworm)
ﺷﺎﺋﻊ ﻋﻧد اﻟرﺿﻊ وواﺣد ﻣن اﻟﻌدﯾد ﻣن اﻻﺿطراﺑﺎت اﻟﺟﻠدﯾﺔ اﻻﻟﺗﮭﺎﺑﯾﺔ اﻟﺣﺎدة اﻟﺗﻲ ﺗﻧﺗﺞ ﺑﺷﻛل ﻣﺑﺎﺷر أو
.ﻏﯾر ﻣﺑﺎﺷر ﻋن طرﯾق ارﺗداء اﻟﺣﻔﺎﺿﺎت
. ﺷﮭًرا12 إﻟﻰ9 ﯾﺑﻠﻎ ﻋﻣر اﻟذروة ﻣن
ﯾﻛون اﻟﺣدوث أﻛﺑر ﻋﻧد اﻟرﺿﻊ اﻟذﯾن ﯾرﺿﻌون ﻣن اﻟزﺟﺎﺟﺔ ﻣﻘﺎرﻧﺔ ﺑﺎﻟرﺿﻊ اﻟذﯾن ﯾرﺿﻌون ﻣن
اﻟﺛدي
• Causes
• Prolonged and repetitive contact with an irritant (such s
• اﻷﺳﺑﺎب
urine, feces, soaps, detergents, ointments, friction).
• اﻻﺗﺻﺎل اﻟﻣطول واﻟﻣﺗﻛرر ﻣﻊ ﻣﺎدة ﻣﮭﯾﺟﺔ )ﻣﺛل اﻟﺑول • Diaper wetness
.(واﻟﺑراز واﻟﺻﺎﺑون واﻟﻣﻧظﻔﺎت واﻟﻣراھم واﻻﺣﺗﻛﺎك
• Chemical irritation from
ﺑﻠل اﻟﺣﻔﺎﺿﺎت •
• Urine, feces, especially diarrheal stools
ﺗﮭﯾﺞ ﻛﯾﻣﯾﺎﺋﻲ ﻣن • • Detergents or soaps from inadequately rinsed cloth
اﻟﺑول واﻟﺑراز وﺧﺎﺻﺔ اﻟﺑراز اﻹﺳﮭﺎل • diapers or the chemicals in disposable wipes.
• اﻟﻣﻧظﻔﺎت أو اﻟﺻﺎﺑون ﻣن ﺣﻔﺎﺿﺎت اﻟﻘﻣﺎش اﻟﻣﻐﺳوﻟﺔ • Candida albicans infection -It is seen in up to 90% of
ف أو اﻟﻣواد اﻟﻛﯾﻣﯾﺎﺋﯾﺔ اﻟﻣوﺟودة ﻓﻲ
ٍ ﺑﺷﻛل ﻏﯾر ﻛﺎ infants with chronic diaper dermatitis
.اﻟﻣﻧﺎدﯾل اﻟﻣﺑﻠﻠﺔ اﻟﺗﻲ ﺗﺳﺗﺧدم ﻟﻣرة واﺣدة • Ammonia ---- association between the strong odor on
ﺗظﮭر ﻓﻲ ﻣﺎ ﯾﺻل إﻟﻰ- • ﻋدوى اﻟﻣﺑﯾﺿﺎت اﻟﺑﯾض diapers and dermatitis.
ﻣن اﻷطﻔﺎل اﻟﻣﺻﺎﺑﯾن ﺑﺎﻟﺗﮭﺎب اﻟﺟﻠد اﻟﺣﻔﺎﺿﻲ٪90
اﻟﻣزﻣن • The lesions represent a variety of types and configurations.
اﻻرﺗﺑﺎط ﺑﯾن اﻟراﺋﺣﺔ اﻟﻘوﯾﺔ ﻋﻠﻰ---- • اﻷﻣوﻧﯾﺎ • Manifested primarily on convex surfaces or in folds.
.اﻟﺣﻔﺎﺿﺎت واﻟﺗﮭﺎب اﻟﺟﻠد
.ﺗﻣﺛل اﻵﻓﺎت ﻣﺟﻣوﻋﺔ ﻣﺗﻧوﻋﺔ ﻣن اﻷﺷﻛﺎل واﻟﺗﻛوﯾﻧﺎت •
• ﺗﺗﺟﻠﻰ ﺑﺷﻛل أﺳﺎﺳﻲ ﻋﻠﻰ اﻷﺳطﺢ اﻟﻣﺣدﺑﺔ أو ﻓﻲ
.اﻟطﯾﺎت
Nursing interventions are aimed at altering the three factors
that produce dermatitis: wetness, pH, and fecal irritants.
Nursing Care
Changing the diaper as soon as it becomes wet.
Management
• ﺗﮭدف اﻟﺗدﺧﻼت اﻟﺗﻣرﯾﺿﯾﺔ إﻟﻰ ﺗﻐﯾﯾر اﻟﻌواﻣل
اﻟﺑﻠل ودرﺟﺔ:اﻟﺛﻼﺛﺔ اﻟﺗﻲ ﺗؤدي إﻟﻰ اﻟﺗﮭﺎب اﻟﺟﻠد
.اﻟﺣﻣوﺿﺔ واﻟﻣﮭﯾﺟﺎت اﻟﺑرازﯾﺔ Removing the diaper to expose healthy skin to air facilitates
.• ﺗﻐﯾﯾر اﻟﺣﻔﺎض ﺑﻣﺟرد أن ﯾﺑﺗل drying.
• إزاﻟﺔ اﻟﺣﻔﺎض ﻟﺗﻌرﯾض اﻟﺟﻠد اﻟﺳﻠﯾم ﻟﻠﮭواء ﯾﺳﮭل
.اﻟﺗﺟﻔﯾف Diaper construction has a significant impact on the
• ﺑﻧﺎء اﻟﺣﻔﺎﺿﺎت ﻟﮫ ﺗﺄﺛﯾر ﻛﺑﯾر ﻋﻠﻰ ﺣدوث وﺷدة incidence and severity of diaper dermatitis.
.اﻟﺗﮭﺎب اﻟﺟﻠد اﻟﺣﻔﺎظﻲ
• اﻟﺣﻔﺎﺿﺎت اﻟورﻗﯾﺔ ﻓﺎﺋﻘﺔ اﻻﻣﺗﺻﺎص ﺗﻘﻠل ﻣن Superabsorbent disposable paper diapers reduce diaper
ﻧﺷﺎ اﻟذرة ﻓﻌﺎﻟﺔ ﻓﻲ ﺗﻘﻠﯾل.اﻟﺗﮭﺎب اﻟﺟﻠد اﻟﺣﻔﺎﺿﻲ dermatitis.
.اﻻﺣﺗﻛﺎك
Cornstarch is effective in reducing friction.
Guidelines for controlling diaper rash
• Keep skin dry
• Use superabsorbent disposable diapers to reduce skin wetness.
• Change diapers as soon as soiled especially with stool.
• Expose healthy or only slightly irritated skin to air, not heat, to dry completely.
• Apply ointment, such as zinc oxide or petrolatum, to protect skin, especially if skin is very red or has
moist, open areas.
.ﺗﺟﻧب إزاﻟﺔ ﻛرﯾم ﺣﺎﺟز اﻟﺟﻠد ﻣﻊ ﻛل ﺗﻐﯾﯾر ﻟﻠﺣﻔﺎﺿﺎت ؛ إزاﻟﺔ اﻟﻧﻔﺎﯾﺎت وإﻋﺎدة ﺗطﺑﯾق ﻛرﯾم ﺣﺎﺟز اﻟﺑﺷرة
.اﺳﺗﺧدام اﻟزﯾوت اﻟﻣﻌدﻧﯾﺔ ﻹزاﻟﺔ اﻟﻣرھم ﻧﮭﺎﺋﯾﺎ ً وﺧﺎﺻﺔ أﻛﺳﯾد اﻟزﻧك
. ﺧﺎﺻﺔً ﺑﺎﻟﺻﺎﺑون اﻟﻣﻌطر أو اﻟﻣﻧﺎدﯾل اﻟﻣﺑﻠﻠﺔ اﻟﺗﺟﺎرﯾﺔ، ﺗﺟﻧب اﻹﻓراط ﻓﻲ ﻏﺳل اﻟﺟﻠد
. ﻟﻣﺳﺢ اﻟﺑول ﻣن اﻟﺟﻠد، ﻣﺛل اﻟﻛرﯾم اﻟﺑﺎرد أو ﺳﯾﺗﺎﻓﯾل، ﯾﻣﻛن اﺳﺗﺧدام ﻣرطب أو ﻣﻧظف ﻏﯾر ﺻﺎﺑون
اﺳﺗﺧدم ﻣﻧﺎدﯾل ﺣﻔﺎﺿﺎت ﯾﻣﻛن اﻟﺗﺧﻠص ﻣﻧﮭﺎ وﺧﺎﻟﯾﺔ ﻣن اﻟﻣﻧظﻔﺎت واﻟﻛﺣول.اﻣﺳﺢ اﻟﺑراز ﻣن اﻟﺟﻠد ﺑرﻓق ﺑﺎﺳﺗﺧدام ﻗطﻌﺔ ﻗﻣﺎش ﻧﺎﻋﻣﺔ وﻣﺎء داﻓﺊ
Atopic Dermatitis (AD)
(Eczema)
• A type of pruritic eczema that usually begins during infancy and
is associated with an allergic contact dermatitis with a
hereditary tendency (atopy)
• AD’s manifestation based on child's age and the distribution of
lesions
• ﻧوع ﻣن اﻹﻛزﯾﻣﺎ اﻟﺣﺎﻛﺔ ﯾﺑدأ ﻋﺎدة ً ﻓﻲ أﺛﻧﺎء اﻟطﻔوﻟﺔ وﯾﺗراﻓق ﻣﻊ اﻟﺗﮭﺎب اﻟﺟﻠد
(اﻟﺗﻣﺎﺳﻲ اﻟﺗﺣﺳﺳﻲ ﻣﻊ ﻣﯾل وراﺛﻲ )اﻟﺗﺄﺗب
• ظﮭور ﻣرض اﻟزھﺎﯾﻣر ﺑﻧﺎًء ﻋﻠﻰ ﻋﻣر اﻟطﻔل وﺗوزﯾﻊ اﻵﻓﺎت
Child’s Age Distribution of Lesions Appearance of Lesions
Infantile (infantile eczema) begins at 2 to 6 months of age, generally Generalized, especially cheeks, Erythema, vesicles papules, weeping oozing,
undergoes spontaneous remission by 3 scalp, trunk, and extensor surfaces crusting scaling, often symmetric
years of age of extremities
Childhood occurs at 2 to 3 years of age; 90% of Flexural areas (antecubital and Symmetric involvement, Clusters of small
children have manifestations by 5 years popliteal fossae, neck), wrists, erythematous or minimally scaling patches,
of age ankles, and feet Dry and may be hyperpigmented,
Lichenification (thickened skin with
accentuation of creases, Keratosis pilaris
(follicular hyperkeratosis) common
Preadolescent and Begins at about 12 years of age; may Face, sides of neck, hands, feet, same as childhood manifestations, Dry, thick
adolescent continue into the early adult years or face, and antecubital and popliteal lesions (lichenified plaques) common
indefinitely fossae (to a lesser extent) Confluent papules
clinical Manifestations of AD
Therapeutic Management
• The major goals of management are to hydrate the skin, relieve pruritus, prevent and
minimize flare-ups or inflammation, and prevent and control secondary infection.
• Management strategies for reducing pruritus include:
• Avoiding exposure to skin irritants or allergens (e.g. soaps, detergents, fabric
softeners, perfumes, and powders)
• Avoiding overheating (proper dress for climatic conditions is essential)
• Administrating medications such as antihistamines, topical immunomodulators,
topical steroids, and (sometimes) mild sedatives, as indicated.
• Enhancing skin hydration and preventing dry skin
.• ﺗﺗﻣﺛل اﻷھداف اﻟرﺋﯾﺳﯾﺔ ﻟﻺدارة ﻓﻲ ﺗرطﯾب اﻟﺟﻠد وﺗﺧﻔﯾف اﻟﺣﻛﺔ وﻣﻧﻊ وﺗﻘﻠﯾل اﻟﻧوﺑﺎت أو اﻻﻟﺗﮭﺎﺑﺎت وﻣﻧﻊ اﻟﻌدوى اﻟﺛﺎﻧوﯾﺔ واﻟﺳﯾطرة ﻋﻠﯾﮭﺎ
:• ﺗﺷﻣل اﺳﺗراﺗﯾﺟﯾﺎت اﻹدارة ﻟﺗﻘﻠﯾل اﻟﺣﻛﺔ ﻣﺎ ﯾﻠﻲ
(ﺗﺟﻧب اﻟﺗﻌرض ﻟﻣﮭﯾﺟﺎت اﻟﺟﻠد أو ﻣﺳﺑﺑﺎت اﻟﺣﺳﺎﺳﯾﺔ )ﻣﺛل اﻟﺻﺎﺑون واﻟﻣﻧظﻔﺎت وﻣﻧﻌﻣﺎت اﻷﻗﻣﺷﺔ واﻟﻌطور واﻟﻣﺳﺎﺣﯾق •
(• ﺗﺟﻧب ارﺗﻔﺎع درﺟﺔ اﻟﺣرارة )ارﺗداء اﻟﻣﻼﺑس اﻟﻣﻧﺎﺳﺑﺔ ﻟﻠظروف اﻟﻣﻧﺎﺧﯾﺔ أﻣر ﺿروري
. ﻛﻣﺎ ھو ﻣﺣدد، و )أﺣﯾﺎﻧًﺎ( اﻟﻣﮭدﺋﺎت اﻟﺧﻔﯾﻔﺔ، واﻟﻣﻧﺷطﺎت اﻟﻣوﺿﻌﯾﺔ، وﻣﻌدﻻت اﻟﻣﻧﺎﻋﺔ اﻟﻣوﺿﻌﯾﺔ، • إدارة اﻷدوﯾﺔ ﻣﺛل ﻣﺿﺎدات اﻟﮭﯾﺳﺗﺎﻣﯾن
• ﯾﻌزز ﺗرطﯾب اﻟﺑﺷرة وﯾﻣﻧﻊ ﺟﻔﺎﻓﮭﺎ
Nursing Care Management
• Assessment of the child with AD includes:
:• ﯾﺷﻣل ﺗﻘﯾﯾم اﻟطﻔل اﻟﻣﺻﺎب ﺑﻣرض اﻟزھﺎﯾﻣر • A family history for evidence of atopy
• ﺗﺎرﯾﺦ ﻋﺎﺋﻠﻲ ﻟﻠﺣﺻول ﻋﻠﻰ دﻟﯾل ﻋﻠﻰ اﻟﺗﺄﺗب • A history of previous involvement
• ﺗﺎرﯾﺦ ﻣن اﻟﺗدﺧل اﻟﺳﺎﺑق • Any environmental or dietary factors associated with the present and
previous exacerbations.
.أي ﻋواﻣل ﺑﯾﺋﯾﺔ أو ﻏذاﺋﯾﺔ ﻣرﺗﺑطﺔ ﺑﺎﻟﺗﻔﺎﻗم اﻟﺣﺎﻟﻲ واﻟﺳﺎﺑق •
• Examined the skin lesions for type, distribution, and evidence of secondary
• ﻓﺣﺻت اﻵﻓﺎت اﻟﺟﻠدﯾﺔ ﻟﻣﻌرﻓﺔ ﻧوﻋﮭﺎ وﺗوزﯾﻌﮭﺎ وإﺛﺑﺎت وﺟود infection.
.ﻋدوى ﺛﺎﻧوﯾﺔ
ﺧﺎﺻﺔ ﻓﯾﻣﺎ، • • أﺟرى ﻣﻘﺎﺑﻠﺔ ﻣﻊ اﻟواﻟدﯾن ﺑﺧﺻوص ﺳﻠوك اﻟطﻔلInterviewed the parents regarding the child's behavior, especially in relation
.ﯾﺗﻌﻠق ﺑﺎﻟﺧدش واﻟﺗﮭﯾﺞ وأﻧﻣﺎط اﻟﻧوم to scratching, irritability, and sleeping patterns.
اﺳﺗﻛﺷﺎف ﻣﺷﺎﻋر اﻷﺳرة وطرق اﻟﺗﻌﺎﯾش ﻣﻌﮭﺎ • • Exploration of the family's feelings and methods of coping
.اﻟﺳﯾطرة ﻋﻠﻰ اﻟﺣﻛﺔ اﻟﺷدﯾدة • • Controlling the intense pruritus.
ﻟﻣﻧﻊ أو ﺗﻘﻠﯾل اﻟﺧدش • • To prevent or minimize the scratching
.ﯾﺗم ﻗص أظﺎﻓر اﻟﯾدﯾن واﻟﻘدﻣﯾن واﻟﺣﻔﺎظ ﻋﻠﯾﮭﺎ ﻧظﯾﻔﺔ • • Fingernails and toenails are cut short, kept clean.
• Gloves or cotton stockings can be placed over the hands and
• ﯾﻣﻛن وﺿﻊ اﻟﻘﻔﺎزات أو اﻟﺟوارب اﻟﻘطﻧﯾﺔ ﻋﻠﻰ اﻟﯾدﯾن وﺗﺛﺑﯾﺗﮭﺎ
.ﻋﻠﻰ أﻛﻣﺎم اﻟﻘﻣﺻﺎن pinned to shirtsleeves.
• One-piece outfits with long sleeves and long pants also decrease
• ﻛﻣﺎ أن اﻟﻣﻼﺑس اﻟﻣﻛوﻧﺔ ﻣن ﻗطﻌﺔ واﺣدة ﺑﺄﻛﻣﺎم طوﯾﻠﺔ
.ﺿﺎ ﻣن اﻻﺗﺻﺎل اﻟﻣﺑﺎﺷر ﺑﺎﻟﺟﻠد
ً وﺳراوﯾل طوﯾﻠﺔ ﺗﻘﻠل أﯾ direct contact with the skin.
Cont.
• Proper dress for climatic conditions
• Pruritus is often precipitated by exposure to the irritant effects of certain components of common
products, such as soaps, detergents, fabric softeners, perfumes, and powders.
• Avoid the exposure to latex products, such as gloves and balloons
• Apply wet soaks and compresses and administer medications for pruritus or infection as directed.
• Educate the family about the preparation and use of soaks, special baths, and topical medications
• Emphasize that one thick application of topical medication is not equivalent to several thin
applications and that excessive use of an agent (steroids) can be hazardous.