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1) The document contains pharmacokinetic data from an experiment measuring drug concentration in plasma over time. It includes concentration values at various timepoints, as well as parameters calculated from the data like half-life, volume of distribution, dose, and area under the curve. 2) Graphs are presented showing the distribution curve based on measured concentration values fit to an exponential decay model, as well as the terminal curve calculated from the same model. 3) A second set of pharmacokinetic data is presented from another experiment, again including measured concentration values over time and calculated parameters like half-life, volume of distribution, dose, and area under the curve. Graphs of the distribution and terminal curves based on

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I Kadek Diki Dwipayana
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36 views6 pages

Untitled

1) The document contains pharmacokinetic data from an experiment measuring drug concentration in plasma over time. It includes concentration values at various timepoints, as well as parameters calculated from the data like half-life, volume of distribution, dose, and area under the curve. 2) Graphs are presented showing the distribution curve based on measured concentration values fit to an exponential decay model, as well as the terminal curve calculated from the same model. 3) A second set of pharmacokinetic data is presented from another experiment, again including measured concentration values over time and calculated parameters like half-life, volume of distribution, dose, and area under the curve. Graphs of the distribution and terminal curves based on

Uploaded by

I Kadek Diki Dwipayana
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as XLSX, PDF, TXT or read online on Scribd
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Waktu Konsentrasi Plasma cp terminal cp residual AUC

0.5 19.3 19.4220926510619 0.12209265 9.2175


1 17.57 17.6707585584125 0.10075856 13.072
1.8 15.11 15.1911225516604 0.08112255 27.61
4 9.99 10.0232882910466 0.03328829 15.408
5.8 7.13 13.024
8 4.71 13.86
12 2.22 8.817
18 0.719 2.847
24 0.23
103.8555
Y=0,1494e-0,371+21,347e-0,189x

Obat/Parameter ke T1/2 Vd D
Antibiotik 0.189 3.66666666666667 70267.4849 1500000
Kurva Distribusi
0.15

0.1 f(x) = 0.149370493325797 exp( − 0.37082807709097 x )


R² = 0.995596759974024
0.05

0
0 0.5 1 1.5 2 2.5 3 3.5 4 4.5
0.5 0.122093
1 0.100759
1.8 0.081123
4 0.033288

Kurva Terminal
AUC Cl F Cp0
5
103.8555 14443.1445614 1 21.347 4.5 f(x) = 21.3470669757816 exp( − 0.188645680574564 x )
4 R² = 0.999992906015859
3.5
3
2.5
2
1.5
1
0.5
0
6 8 10 12 14 16 18 20 22 24 26
0574564 x )

22 24 26
t(jam) c (ug/mL) cp Terminal cp residual AUC
0 54.05 9.0009 45.0491 2.1265
0.05 31.01 8.700883500939 22.3091165 1.262
0.1 19.47 8.410867101835 11.0591329 0.827
0.15 13.61 8.130517481024 5.479482519 0.605
0.2 10.59 0.48875
0.25 8.96 0.42475
0.3 8.03 0.387
0.35 7.45 0.36225 0
0.4 7.04 0.34425 0.05
0.45 6.73 0.33 0.1
0.5 6.47 0.3175 0.15
0.55 6.23 0.306
0.6 6.01 0.2955
0.65 5.81 0.2855
0.7 5.61 0.27575
0.75 5.42 0.2665
0.8 5.24 0.2575
0.85 5.06 0.24875
0.9 4.89 0.2405
0.95 4.73 0.2325
1 4.57
AUC Total 9.8835

Y= 45,04e-14,04+9,0009e-0,678x

Obat/Parameter Ke T1/2 Vd D AUC


Anti Nyeri 0.678 1.022123894 7221.5000722 65000 9.8835
Kurva Distribusi
50
45
40 f(x) = 45.0399013270341 exp( − 14.0439316690225 x )
35 R² = 0.999999926230785
30
25
20
15
45.0491 10
22.309116499061 5
0
11.059132898165 0 0.02 0.04 0.06 0.08 0.1 0.12 0.14 0.16
5.479482518976

Kurva Teminal
5.1
5 f(x) = 9.00094102721739 exp( − 0.677653872325443 x )
R² = 0.999960861765406
4.9
4.8
4.7
4.6
4.5
4.4
4.3
0.84 0.86 0.88 0.9 0.92 0.94 0.96 0.98 1 1.02

CL F Cp0
6576.6175949815 1 9.0009
443 x )

0.98 1 1.02

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