ANS DRUGS

SYMPATHOMIMETIC/ ADRENERGIC DRUGS

SYMPATHOMIMETIC DRUGS

DIRECT INDIRECT MIXED

NON-SELECTIVE SELECTIVE

NOREPINEPHRINE
EPINEPHRINE α β
DOPAMINE

α-1 α-2 β -NS β-1 β-2

PHENYLEPHRINE ISOPROTERENOL DOBUTAMINE
Anti-Glaucoma Anti-HTN
METHOXAMINE
APRACLONIDINE METHYLDOPA
SABA LABA Tocolytics
PROPYHEXEDRINE BRIMODINE CLONIDINE SALBUTAMOL/ SALMETEROL RITODRINE
TETRAHYDRAZOLINE GUANFACINE ALBUTEROL
(Ventolin) FORMOTEROL ISOXUPRINE
OXYMETAZOLINE GUANABENZ (Duvadilan,
TERBUTALINE BAMBUTEROL
(Bricanyl) (PO)
Isoxilan)
NAFAZOLINE
METAPROTERENOL INDACATEROL

PIRBUTEROL

RCB, RPh 2022

ANS DRUGS
SYMPATHOMIMETIC/ ADRENERGIC DRUGS
SYMPATHOMIMETIC DRUGS

DIRECT INDIRECT MIXED

EPHEDRINE
Releasers Reuptake Inhibitors
PHENYLPROPANOLAMINE
TYRAMINE COCAINE
MEPHENTERMINE AND
EPHEDRINE ATOMOXETINE METARAMINOL

AMPHETAMINE SIBUTRAMINE

METHAMPHETAMINE

MODAFINIL

METHYLPHENIDATE

PHENMETRAZINE

RCB, RPh 2022

ANS DRUGS
SYMPATHOLYTIC/ ANTI-ADRENERGIC DRUGS

SYMPATHOLYTIC DRUGS

CENTRAL PERIPHERAL DIRECT

α-2 AGONIST
Storage Exocytosis α Blockers Β Blockers
RESERPINE GUANETHIDINE
α- NS α-1 α-2
GUANEDREL
PHENOXYBENZAMINE YOHIMBINE
Anti-HTN For BPH
BRETYLIUM
PHENTOLAMINE PRAZOSIN ALFUZOSIN RAUWOLSCINE

TERAZOSIN TAMSULOSIN
DOXAZOSIN

RCB, RPh 2022

ANS DRUGS
SYMPATHOLYTIC/ ANTI-ADRENERGIC DRUGS

β Blockers

β- NS β-1 ADDT’L MOA

NADOLOL CELIPROLOL
Membrane-
ISA stabilizing Action
With Vasodilation
BISOPROLOL,
SOTALOL
BETAXALOL CARTEOLOL, PROPRANOLOL, Alpha-1 Blockade
CELIPROLOL PINDOLOL Carvedilol, Labetalol
TIMOLOL ESMOLOL
LABETALOL ACEBUTOLOL
Inc. NO2: Nebivolol
ACEBUTALOL,
PROPRANOLOL ATENOLOL
ACEBUTALOL LABETALOL

METOPROLOL
PINDOLOL METOPROLOL

PENBUTANOL

RCB, RPh 2022

ANS DRUGS
PARASYMPATHOMIMETIC/ CHOLINERGIC DRUGS

CHOLINOMIMETIC DRUGS

DIRECT INDIRECT

Choline
Alkaloids Reversible Irreversible CNS-acting
Esters

Non-sel: TACRLINE
METHACHOLINE NS M-sel. N-sel. Aminoalcohol Carbamates Organophosphate
DONEZEPIL
M-sel.: ARECHOLINE MUSCARINE NICOTINE
EDROPHONIUM -STIGMINES Pesticide:
BETHACHOLINE MALATHION,
PILOCARPINE LOBELINE GALANTAMINE
AMBENOMIUM, PARATHION
DEMECARIUM
VARENICILINE Nerve Gases: RIVASTIGMINE
SOMAN,
TABBUN,
SARIN

Only Clinically Useful:

ECHOTHIOPHATE

RCB, RPh 2022

ANS DRUGS
PARASYMPATHOLYTIC/ ANTICHOLINERGIC DRUGS
CHOLINOLYTIC DRUGS

Antimuscarinics Antinicotinics

ATROPINE MISCELLANEOUS

GIT and Urinary

CNS Eyes Bronchi Gastric Gland
Bladder

TRIHEXYPHENIDYL HOMATOTROPINE PIRENZEPINE METHSCOPOLAMINE

SAMA LAMA
BENZTROPINE ANISTROPINE TELENZEPINE GLYCOPYRROLATE
IPRATROPIUM TIOTROPIUM
BIPERIDEN CYCLOPENTOLATE
OXYTROPIUM GLYCOPYRRONIUM HYOSCINE-N-BUTYL
SCOPOLAMINE BROMIDE (BUSCOPAN)
UMECLINIDIUM

DICYCLOVERINE

OXYBUTININ

SCOPOLAMINE

RCB, RPh 2022

ANS DRUGS
PARASYMPATHOLYTIC/ ANTICHOLINERGIC DRUGS
CHOLINOLYTIC DRUGS

Antimuscarinics Antinicotinics

Nn Nm

HEXAMETHONIUM
Depolarizing Non-Depolarizing
MECAMYLAMINE
SUCCINYLCHOLINE
TRIMETHAPHAN Isoquinoline Steroidal

ATRACURIUM PANCURONIUM

TUBUCURARINE ROCURONIUM

RCB, RPh 2022

 H1 ANTIHISTAMINES

First Generation Second Generation

Ethanolamines Ethylenediamines Piperazine Alkylamines Phenothiazine Piperidine Piperazine Piperidine Newer Agents

DIPHENHYDRAMINE PROMETHAZINE
PYRILAMINE HYDROXYZINE CHLORPHENAMINE CYPROHPETADINE CETIRIZINE LORATADINE BILASTIN (Bilaxten)
(Phenergan)

DIMENHYDRINATE TRIPENNAMINE MECLIZINE BROMPHENIRAMINE LEVOCETIRIZINE DESLORATADINE EBASTINE with

Betamethasone (Co-
CARBINOXAMINE alleva)
FEXOFENADINE

DOXYLAMINE (Unison)

RCB, RPh 2022

DRUGS FOR COAGULATION DISORDERS

ANTITHROMBOTICS

Anticoagulants Antiplatelets

Direct Indirect Destroys clotting factors which

Inhibits IIa
activate prothrombin (II)

HIRUDIN Forms an active

Parenteral complex with AT-III Oral
LIPIRUDIN APIXABAN
(DOC: Heparin Induced
Thrombocytopenia)
Inhibits Xa
UNFRACTIONATED RIVAROXABAN
BEVALURIDIN HEPARIN/ REGULAR/ LMW HEPARIN
HIGH MW HEPARIN WARFARIN Inhibits hepatic synthesis of
Vit K.-dep factors (10, 9, 7, 2)
ARGATROBAN
ENOXAPARIN

DABIGATRAN
(Pradaxa) –PO DALTEPARIN

TINZAPARIN

FONDAPARINUX

DANAPROID

RCB, RPh 2022

DRUGS FOR COAGULATION DISORDERS

ANTITHROMBOTICS

Anticoagulant Antiplatelets

Phosphodiesterase
TXA2 Synthesis Inhibitor ADP Inhibitors GPIIa/GPIIb Inhibitors
Inhibitors

DIPYRIMADOLE
ASPIRIN EPTIFIBATIDE
Irreversible (PERSANTIN)
Reversible
(Thienopyridines)
CILOSTAZOL (PLETAAL) ABCIXIMAB
TICLOPIDINE TICAGRELOR
TIROFIBAN
CLOPIDOGREL

RCB, RPh 2022