Alcohol and your health

Research-based information from the

National Institutes of Health
U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
“Sometimes we do things out of habit and we don’t really stop to think
about it. This made me think about my choices.”

“It emphasized that drinking is not bad in and of itself—it’s how much
you’re doing it and how it’s affecting your life.”

“I thought the strategies for cutting down were really good.

It gives you tools to help yourself.”

These are comments from social drinkers who reviewed Rethinking

Drinking in focus testing. We welcome your comments as well. Send an
email to [email protected] or call 301–443–3860.

For an online version of this booklet with interactive

features and additional resources, visit
RethinkingDrinking.niaaa.nih.gov
Rethinking DRinking
Do you enjoy a drink now and then? Many of us do, often when socializing with
friends and family. Drinking can be beneficial or harmful, depending on your age and
health status, the situation, and, of course, how much you drink.

How much is too much?

Do you think you may drink too much at times? Do you think “everyone” drinks a lot?
See below for results from a nationwide survey of 43,000 adults by the National
Institutes of Health on alcohol use and its consequences.

Alcohol use by adults in the United States*

37%
7 in 10 adults 3 in 10 adults
always drink
always drink at drink at levels
at low-risk
low-risk levels 28% that put them
levels
drink at at risk for
or heavy or alcoholism,
do not drink 35% at-risk
liver disease, and
at all don’t drink levels
other problems
at all

Thinking about a change?

*Although the minimum legal drinking age in the U.S. is 21, this survey included people aged 18 or older.

For anyone who drinks, Rethinking Drinking offers valuable, research-based information.
The first part, How much is too much?, answers these questions and more:

• What’s “low-risk” drinking versus “at-risk” or “heavy” drinking?

• Why is being able to “hold your liquor” a concern?
• What are signs that drinking is causing harm?

Many heavy drinkers do not have alcohol-related problems yet and can reduce their
risk of harm by cutting back. For the nearly 18 million Americans who have alcoholism
or related problems, however, it’s safest to quit.

The second part of this booklet, Thinking about a change?, offers tips, tools, and
resources for people who choose to cut down or quit. Success is likely for those who
persist in their efforts. Even for those with alcoholism, studies show that most do
recover, often without professional treatment.

What do you think about taking a look at your drinking habits and how they may affect
your health? Rethinking Drinking can help you get started.

1
 hOW MUCh iS tOO MUCh?

What counts as a drink?

Many people are surprised to learn what counts as a drink. In the United States,
a “standard” drink is any drink that contains about 0.6 fluid ounces or 14 grams of
“pure” alcohol. Although the drinks pictured below are different sizes, each contains
approximately the same amount of alcohol and counts as a single drink.

12 fl oz of 8–9 fl oz of 5 fl oz of 1.5 fl oz shot of

regular beer = malt liquor = table wine = 80-proof spirits
(shown in a (“hard liquor”—
12 oz glass) whiskey, gin, rum,
vodka, tequila, etc.)

about 5% about 7% about 12% about 40%

alcohol alcohol alcohol alcohol

The percent of “pure” alcohol, expressed here as alcohol by volume (alc/vol), varies by beverage.

How many drinks are in common containers?

Below is the approximate number of standard drinks in different sized containers of

regular beer malt liquor table wine 80-proof spirits or “hard liquor”
12 fl oz = 1 12 fl oz = 1½ 750 ml (a regular a shot (1.5 oz glass/50 ml bottle) = 1
16 fl oz = 1 16 fl oz = 2 wine bottle) = 5 a mixed drink or cocktail = 1 or more
22 fl oz = 2 22 fl oz = 2½ 200 ml (a “half pint”) = 4½
40 fl oz = 3 40 fl oz = 4½ 375 ml (a “pint” or “half bottle”) = 8½
750 ml (a “fifth”) = 17

The examples shown on this page serve as a starting point for comparison. For
different types of beer, wine, or malt liquor, the alcohol content can vary greatly.
Some differences are smaller than you might expect, however. Many light beers,
for example, have almost as much alcohol as regular beer—about 85% as much,
or 4.2% versus 5.0% alcohol by volume (alc/vol), on average.
Although the standard drink sizes are helpful for following health guidelines, they
may not reflect customary serving sizes. A mixed drink, for example, can contain one,
two, or more standard drinks, depending on the type of spirits and the recipe.

2 RethinkingDrinking.niaaa.nih.gov
What’s your drinking pattern?
Using the drink sizes on page 2, answer the questions below:

How much is too much?

1. On any day in the past year, have you ever had
• For MEN: more than 4 drinks? yes no

• For WoMEN: more than 3 drinks? yes no

2. Think about your typical week:

• on average, how many days a week do you drink alcohol? (a)

• on a typical drinking day, how many drinks do you have? X (b)

(multiply a x b)
weekly average =

Sometimes even a little is too much

Even moderate levels of drinking (up to 2 drinks per day for men or 1 for women) can
be too much in some circumstances. It’s safest to avoid alcohol if you are
• planning to drive a vehicle or operate machinery
• taking medications that interact with alcohol
• managing a medical condition that can be made worse by drinking
• pregnant or trying to become pregnant

Can you “hold your liquor”?

if so, you may be at greater risk. For some people, it takes quite a few
drinks to get a buzz or feel relaxed. often they are unaware that being able to
“hold your liquor” isn’t protection from alcohol problems, but instead a reason
for caution. They tend to drink more, socialize with people who drink a lot,
and develop a tolerance to alcohol. As a result, they have an increased risk for
developing alcoholism. The higher alcohol levels can also cause liver, heart, and
brain damage that can go unnoticed until it’s too late. And all drinkers need to
be aware that even moderate amounts of alcohol can significantly impair driving
performance, even when they don’t feel a buzz from drinking.

3
 What’s “low-risk” drinking?
A major nationwide survey of 43,000 U.S. adults by the National Institutes of Health
shows that only about 2 in 100 people who drink within both the “single-day” and
weekly limits below have alcoholism or alcohol abuse. How do these “low-risk”
levels compare with your drinking pattern from page 3?

Low-risk drinking limits Men WOMen

no more than no more than

4 3
On any
single
3 DAY drinks on any day drinks on any day
1 2
9 10
4 5
6 7
8
5 16 17 ** AND ** ** AND **
1
13 14 24 no more than no more than
11 12 22 23
18 19
25 26
20 21 9 30 31
27 28
2 Per
Week 14 7
drinks per week drinks per week
To stay low risk, keep within BOTH the single-day AND weekly limits.

“Low risk” is not “no risk.” Even within these limits, drinkers can have problems if they
drink too quickly, have health problems, or are older (both men and women over 65 are
generally advised to have no more than 3 drinks on any day and 7 per week). Based on
your health and how alcohol affects you, you may need to drink less or not at all.

What’s “heavy” or “at-risk” drinking?

For healthy adults in general, drinking more than the single-day or weekly amounts
shown above is considered “at-risk” or “heavy” drinking. About 1 in 4 people who drink
this much already has alcoholism or alcohol abuse, and the rest are at greater risk for
developing these and other problems.

It makes a difference both how much you drink on any day and how often you have
a “heavy drinking day”—that is, more than 4 drinks in a day for men or more than 3
drinks for women. The more drinks in a day and the more heavy drinking days over
time, the greater the chances for problems (see “What’s the harm?” on the next page).

Why are women’s low-risk limits different from men’s?

Research shows that women start to have alcohol-related problems at lower

drinking levels than men do. one reason is that, on average, women weigh less
than men. In addition, alcohol disperses in body water, and pound for pound,
women have less water in their bodies than men do. So after a man and woman
of the same weight drink the same amount of alcohol, the woman’s blood alcohol
concentration will tend to be higher, putting her at greater risk for harm.

4 RethinkingDrinking.niaaa.nih.gov
How much do U.S. adults drink?
The majority—7 out of 10—either abstain or always drink within low-risk limits.
Which group are you in?

How much is too much?

Drinking patterns in U.S. adults

drink more than both the single-day

9% highest risk
limits and the weekly limits
drink more than either the single-day
19 % increased risk
limits or the weekly limits

37 % always drink within low-risk limits Low risk

35 % never drink alcohol —

What’s the harm?

Not all drinking is harmful. You may have heard that regular light to moderate drinking
(from ½ drink a day up to 1 drink a day for women and 2 for men) can even be good
for the heart. With at-risk or heavy drinking, however, any potential benefits are
outweighed by greater risks.

injuries. Drinking too much increases your chances of being injured or even killed.
Alcohol is a factor, for example, in about 60% of fatal burn injuries, drownings, and
homicides; 50% of severe trauma injuries and sexual assaults; and 40% of fatal
motor vehicle crashes, suicides, and fatal falls.

health problems. Heavy drinkers have a greater risk of liver disease, heart disease,
sleep disorders, depression, stroke, bleeding from the stomach, sexually transmitted
infections from unsafe sex, and several types of cancer. They may also have problems
managing diabetes, high blood pressure, and other conditions.

Birth defects. Drinking during pregnancy can cause brain damage and other serious
problems in the baby. Because it is not yet known whether any amount of alcohol is
safe for a developing baby, women who are pregnant or may become pregnant should
not drink.

Alcohol use disorders. Generally known as alcoholism and alcohol abuse, alcohol
use disorders are medical conditions that doctors can diagnose when a patient’s
drinking causes distress or harm. In the United States, about 18 million people have
an alcohol use disorder. See the next page for symptoms.

5
 What are symptoms of an alcohol use disorder?
See if you recognize any of these symptoms in yourself. In the past year, have you

had times when you ended up drinking more, or longer, than you intended?
more than once wanted to cut down or stop drinking, or tried to, but couldn’t?
more than once gotten into situations while or after drinking that increased
your chances of getting hurt (such as driving, swimming, using machinery,
walking in a dangerous area, or having unsafe sex)?
had to drink much more than you once did to get the effect you want? or found
that your usual number of drinks had much less effect than before?
continued to drink even though it was making you feel depressed or anxious or
adding to another health problem? or after having had a memory blackout?
spent a lot of time drinking? or being sick or getting over other aftereffects?
continued to drink even though it was causing trouble with your family or
friends?
found that drinking—or being sick from drinking—often interfered with taking
care of your home or family? or caused job troubles? or school problems?
given up or cut back on activities that were important or interesting to you, or
gave you pleasure, in order to drink?
more than once gotten arrested, been held at a police station, or had other
legal problems because of your drinking?
found that when the effects of alcohol were wearing off, you had withdrawal
symptoms, such as trouble sleeping, shakiness, restlessness, nausea, sweating,
a racing heart, or a seizure? or sensed things that were not there?

If you don’t have symptoms, then staying within the low-risk drinking limits on
page 4 will reduce your chances of having problems in the future.

If you do have any symptoms, then alcohol may already be a cause for concern. The
more symptoms you have, the more urgent the need for change. A health professional
can look at the number, pattern, and severity of symptoms to see whether an alcohol
use disorder is present and help you decide the best course of action.

Thinking about a change? The next section may help.

Note: These questions are based on symptoms for alcohol use disorders in the American Psychiatric
Association’s Diagnostic and Statistical Manual (DSM) of Mental Disorders, Fourth Edition. The DSM is
the most commonly used system in the United States for diagnosing mental health disorders.

6 RethinkingDrinking.niaaa.nih.gov
thinking ABOUt A ChAnge?

 thinking ABOUt A ChAnge?

It’s up to you
It’s up to you as to whether and when to change your drinking. other people may be
able to help, but in the end it’s your decision. Weighing your pros and cons can help.

Pros: What are some reasons why you might want to make a change?
to improve my health to lose weight or get fit
to improve my relationships to save money
to avoid hangovers to avoid more serious problems
to do better at work or school to meet my own personal standards

Cons: What are some possible reasons why you might not want to change?

Compare your pros and cons. Put extra check marks by the most important one(s).
Is there a difference between where you are and where you want to be?

Ready . . . or not?
Are you ready to change your drinking? If so, see the next sections for support. But
don’t be surprised if you continue to have mixed feelings. You may need to re-make
your decision several times before becoming comfortable with it.

If you’re not ready to change yet, consider these suggestions in the meantime:

• Keep track of how often and how much you’re drinking.

• Notice how drinking affects you.
• Make or re-make a list of pros and cons about changing.
• Deal with other priorities that may be in the way of changing.
• Ask for support from your doctor, a friend, or someone else you trust.

Don’t wait for a crisis or to “hit bottom.”

When someone is drinking too much, making a change earlier is likely to be

more successful and less destructive to individuals and their families.

8 RethinkingDrinking.niaaa.nih.gov
To cut down or to quit . . .
If you’re considering changing your drinking, you’ll need to decide whether to cut
down or to quit. It’s a good idea to discuss different options with a doctor, a friend,
or someone else you trust. Quitting is strongly advised if you
• try cutting down but cannot stay within the limits you set
• have had an alcohol use disorder or now have symptoms (see page 6)
• have a physical or mental condition that is caused or worsened by drinking
• are taking a medication that interacts with alcohol
• are or may become pregnant
If you do not have any of these conditions, talk with your doctor to determine whether
you should cut down or quit based on factors such as
• family history of alcohol problems
• your age
• whether you’ve had drinking-related injuries
• symptoms such as sleep disorders and sexual dysfunction
If you choose to cut down, see the low-risk drinking limits on page 4.

Thinking about a change?

Planning for change
Even when you have committed to change, you still may have mixed feelings at times.
Making a written “change plan” will help you to solidify your goals, why you want to
reach them, and how you plan to do it. A sample form is provided on page 14, or you
can fill out one online at the Rethinking Drinking Web site.

Reinforce your decision with reminders.

enlist technology to help. Change can be hard, so it helps to have concrete

reminders of why and how you’ve decided to do it. Some standard options include
carrying a change plan in your wallet or posting sticky notes at home. If you have
a computer or mobile phone, consider these high-tech ideas:
• Fill out a “change plan” online at the Rethinking Drinking Web site, email it
to your personal (non-work) account, and review it weekly.
• Store your goals, reasons, or strategies in your mobile phone in short text
messages or notepad entries that you can retrieve easily when an urge hits.
• Set up automated mobile phone or email calendar alerts that deliver
reminders when you choose, such as a few hours before you usually go out.
• Create passwords that are motivating phrases in code, which you’ll type each
time you log in, such as 1Day@aTime, 1stThings1st!, or 0Pain=0Gain.

9
 Strategies for cutting down
Small changes can make a big difference in reducing your chances of having alcohol-
related problems. Here are some strategies to try. Check off perhaps two or three
to try in the next week or two, then add some others as needed. If you haven’t
made progress after 2 to 3 months, consider quitting drinking altogether, seeking
professional help, or both.

keep track.
Keep track of how much you drink. Find a way that works for you, such as a 3x5”
card in your wallet (see page 15 for samples), check marks on a kitchen calendar,
or notes in a mobile phone notepad or personal digital assistant. Making note of
each drink before you drink it may help you slow down when needed.

Count and measure.

Know the “standard” drink sizes so you can count your drinks accurately (see
page 2). Measure drinks at home. Away from home, it can be hard to keep track,
especially with mixed drinks. At times you may be getting more alcohol than
you think. With wine, you may need to ask the host or server not to “top off” a
partially filled glass.

Set goals.
Decide how many days a week you want to drink and how many drinks you’ll
have on those days. It’s a good idea to have some days when you don’t drink.
Drinkers with the lowest rates of alcohol use disorders stay within these limits
(also shown on page 4): For men, no more than 4 drinks on any day and 14 per
week; and for women, no more than 3 drinks on any day and 7 per week. Both
men and women over age 65 generally are advised to have no more than 3 drinks
on any day and 7 per week. Depending on your health status, your doctor may
advise you to drink less or not at all.

Pace and space.

When you do drink, pace yourself. Sip slowly. Have no more than one standard
drink with alcohol per hour. Have “drink spacers”—make every other drink a
nonalcoholic one, such as water, soda, or juice.

include food.
Don’t drink on an empty stomach. Have some food so the alcohol will be
absorbed into your system more slowly.

10 RethinkingDrinking.niaaa.nih.gov
 Find alternatives.
If drinking has occupied a lot of your time, then fill free time by developing new,
healthy activities, hobbies, and relationships or renewing ones you’ve missed.
If you have counted on alcohol to be more comfortable in social situations,
manage moods, or cope with problems, then seek other, healthy ways to deal
with those areas of your life.

Avoid “triggers.”
What triggers your urge to drink? If certain people or places make you drink
even when you don’t want to, try to avoid them. If certain activities, times of
day, or feelings trigger the urge, plan something else to do instead of drinking.
If drinking at home is a problem, keep little or no alcohol there.

Plan to handle urges.

When you cannot avoid a trigger and an urge hits, consider these options:
Remind yourself of your reasons for changing (it can help to carry them in
writing or store them in an electronic message you can access easily). or

Thinking about a change?

talk things through with someone you trust. or get involved with a healthy,
distracting activity, such as physical exercise or a hobby that doesn’t involve
drinking. or, instead of fighting the feeling, accept it and ride it out without
giving in, knowing that it will soon crest like a wave and pass.

know your “no.”

You’re likely to be offered a drink at times when you don’t want one. Have a
polite, convincing “no, thanks” ready. The faster you can say no to these offers,
the less likely you are to give in. If you hesitate, it allows you time to think of
excuses to go along.

Tools to help you manage urges to drink and build drink refusal skills are available on
the Rethinking Drinking Web site.

if you want to quit drinking—

The four strategies on this page are especially helpful. But if you think you

may be dependent on alcohol and decide to stop drinking completely, don’t go

it alone. Sudden withdrawal from heavy drinking can be life threatening. Seek

medical help to plan a safe recovery.

11
 Support for quitting
The suggestions in this section will be most useful for people who have become
dependent on alcohol, and thus may find it difficult to quit without some help. Several
proven treatment approaches are available. one size doesn’t fit all, however. It’s a
good idea to do some homework on the Internet or at the library to find social and
professional support options that appeal to you, as you are more likely to stick with
them (see also Resources on the inside back cover). Chances are excellent that you’ll
pull together an approach that works for you.

Social support
one potential challenge when people stop drinking is rebuilding a life without
alcohol. It may be important to
• educate family and friends
• develop new interests and social groups
• find rewarding ways to spend your time that don’t involve alcohol
• ask for help from others

When asking for support from friends or significant others, be specific. This could
include
• not offering you alcohol
• not using alcohol around you
• giving words of support and withholding criticism
• not asking you to take on new demands right now
• going to a group like Al-Anon

Consider joining Alcoholics Anonymous or another mutual support group (see

Resources). Recovering people who attend groups regularly do better than those who
do not. Groups can vary widely, so shop around for one that’s comfortable. You’ll get
more out of it if you become actively involved by having a sponsor and reaching out to
other members for assistance.

Feeling depressed or anxious?

It’s common for people with alcohol problems to feel depressed or anxious. Mild
symptoms may go away if you cut down or stop drinking. See a doctor or mental
health professional if symptoms persist or get worse. If you’re having suicidal
thoughts, call your health care provider or go to the nearest emergency room
right away. Effective treatment is available to help you through this difficult time.

12 RethinkingDrinking.niaaa.nih.gov
Professional support
Advances in the treatment of alcoholism mean that patients now have more choices
and health professionals have more tools to help.

Medications to treat alcoholism. Newer medications can make it easier to quit

drinking by offsetting changes in the brain caused by alcoholism. These options
(naltrexone, topiramate, and acamprosate) don’t make you sick if you drink, as does
an older medication (disulfiram). None of these medications are addictive, so it’s fine
to combine them with support groups or alcohol counseling.

A major clinical trial recently showed that patients can now receive effective alcohol
treatment from their primary care doctors or mental health practitioners by combining
the newer medications with a series of brief office visits for support. See Resources
for more information.

Alcohol counseling. “Talk therapy” also works well. There are several counseling
approaches that are about equally effective—12 step, cognitive-behavioral,
motivational enhancement, or a combination. Getting help in itself appears to be
more important than the particular approach used, as long as it offers empathy,

Thinking about a change?

avoids heavy confrontation, strengthens motivation, and provides concrete ways
to change drinking behavior.

Specialized, intensive treatment programs. Some people will need more

intensive programs. See Resources for a treatment locator. If you need a referral
to a program, ask your doctor.

Don’t give up.

Changing habits such as smoking, overeating, or drinking too much can take
a lot of effort, and you may not succeed with the first try. Setbacks are common,
but you learn more each time. Each try brings you closer to your goal.
Whatever course you choose, give it a fair trial. If one approach doesn’t work,
try something else. And if a setback happens, get back on track as quickly
as possible.
In the long run, your chances for success are good. Research shows that most
heavy drinkers, even those with alcoholism, either cut back significantly or quit.
For tools to help you make and maintain a change, visit the Rethinking Drinking
Web site.

13
 Ready to begin?
If so, start by filling out the change plan below or online at the Rethinking Drinking
Web site, where you can print it out or email it to yourself. If you are cutting down
as opposed to quitting, you can use the drinking tracker cards on the next two pages.
Change plan
goal:
I want to drink no more than ___ drink(s) on any day and
no more than ___ drink(s) per week (see page 4 for low-risk limits) or
I want to stop drinking

timing: I will start on this date:

Reasons: My most important reasons to make these changes are:

Strategies: I will use these strategies (see pages 10–11):

People: The people who can help me are (names and how they can help):

Signs of success: I will know my plan is working if:

Possible roadblocks: Some things that might interfere and how i’ll handle them:

14 RethinkingDrinking.niaaa.nih.gov
Drinking tracker cards
If you want to cut back on your drinking, start by keeping track of every drink. Below
are two sample forms you can cut out or photocopy and keep with you. Either one can
help make you aware of patterns, a key step in planning for a change. The “4-week
tracker” is a simple calendar form. If you mark down each drink before you have it,
this can help you slow down if needed. The “drinking analyzer” can help you examine
the causes and consequences of your drinking pattern. Try one form, or try both to see
which is more helpful. These are also available on the Rethinking Drinking Web site.

4-week tracker

gOAL: no more than ____ drinks on any day and ____ per week.

Week
starting Su M t W th F Sa total

___/___

Thinking about a change?

___/___

___/___

___/___

Drinking analyzer

Situation (people, place) or type of Consequence

Date trigger (incident, feelings) drink(s) Amount (what happened?)

15
 Drinking tracker cards (continued)
These are the same cards as on the previous page. If you cut one out, you will have
the drinking analyzer on one side and the 4-week tracker on the other side.

Drinking analyzer

Situation (people, place) or type of Consequence

Date trigger (incident, feelings) drink(s) Amount (what happened?)

4-week tracker

gOAL: no more than ____ drinks on any day and ____ per week.

Week
starting Su M t W th F Sa total

___/___

___/___

___/___

___/___

16 RethinkingDrinking.niaaa.nih.gov
Resources
Professional help Mutual-help groups
Your regular doctor. Primary care and Alcoholics Anonymous (AA)
mental health practitioners can provide www.aa.org
effective alcoholism treatment by combining 212–870–3400 or check your local
new medications with brief counseling phone directory under “Alcoholism”
visits. See “Helping Patients Who Drink Too Moderation Management
Much” at www.niaaa.nih.gov/guide or call www.moderation.org

301–443–3860. 212–871–0974

Specialists in alcoholism. For specialty Secular Organizations for Sobriety

addiction treatment options, contact your www.secularsobriety.org

doctor, health insurance plan, local health 323–666–4295

department, or employee assistance program.

SMART Recovery
Other resources include
www.smartrecovery.org

Medical and non-medical 440–951–5357

addiction specialists
Women for Sobriety
American Academy of Addiction
www.womenforsobriety.org

Psychiatry
215–536–8026

www.aaap.org

401–524–3076
Groups for family and friends
American Psychological
Al-Anon/Alateen
Association
www.al-anon.alateen.org

1–800–964–2000 (ask for your state’s 1–888–425–2666 for meetings

referral number to find psychologists

with addiction specialties) Adult Children of Alcoholics
www.adultchildren.org

American Society of Addiction

310–534–1815

Medicine

301–656–3920 (ask for the phone

Information resources
number of your state’s chapter)

National Institute on Alcohol Abuse

NAADAC Substance Abuse

and Alcoholism
Professionals

www.niaaa.nih.gov

www.naadac.org

301–443–3860

1–800–548–0497

National Institute on Drug Abuse

National Association of Social

www.nida.nih.gov

Workers

301–443–1124

www.helpstartshere.org

(search for social workers with

National Institute of Mental Health
addiction specialties)
www.nimh.nih.gov

1–866–615–6464

Treatment facilities
National Clearinghouse for Alcohol
Substance Abuse Treatment

and Drug Information

Facility Locator

www.ncadi.samhsa.gov

www.findtreatment.samhsa.gov
1–800–729–6686

1–800–662–HELP

For additional resources, visit RethinkingDrinking.niaaa.nih.gov

NATIONAL INSTITUTE ON ALCOHOL AbUSE AND ALCOHOLISM

NIH Publication No. 10-3770

Revised April 2010