Southeast Asian Journal of Health Professional 2021;4(1):1–4

Content available at: https://www.ipinnovative.com/open-access-journals

Southeast Asian Journal of Health Professional

Journal homepage: https://www.sajhp.com/

Review Article
Ayurvedic treatment of polycystic ovary syndrome (PCOS)

Deepak Kumar1 , Ravi Kumar2, *, Vipin Garg1 , Sayed Salman ali1

1 Dept. of Pharmaceutical Technology, MIET College, Meerut, Uttar Pradesh, India
2 Dept. of Pharmaceutical Technology, Shri Ram Group of Colleges, Muzaffarnagar, Uttar Pradesh, India

ARTICLE INFO ABSTRACT

Article history: PCOS is a complex endocrine disorder with a wide range of symptoms that affects around one in every
Received 05-02-2021 15 women throughout the world. Metoligoovulation or anovulation, clinical or biochemical evidence of
Accepted 15-02-2021 hyperandrogenism, and polycystic ovary shape are all diagnostic criteria for polycystic ovarian syndrome.
Available online xx xx xxxx Women with PCOS are more likely to develop metabolic abnormalities, hypertension, and cardiovascular
disease. Using the databases Pubmed and Scielo, the goal of this work was to provide a review of papers
Keywords: pertinent to polycystic ovaries, including causation, symptoms, diagnostic, and treatment aspects, as well
Hypothyroidism as its association with Cardiovascular and arterial hypertension illnesses.
PCOS
Menstrual cycle This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons
Hyperandrogenism Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon
the work non-commercially, as long as appropriate credit is given and the new creations are licensed under
Ovulation
the identical terms.
For reprints contact: [email protected]

1. Introduction variation A8 is associated to PCOS and shows a unique

metabolic profile, including insulin resistance. 6 PCOS
The Polycystic ovary syndrome (PCOS) is commonly
in the vitro studies of theca cells showing intrinsically
disorders in females that associated with hyperandrogenism
increased androgen biosynthesis and expression of several
and disturb in ovulation process in women’s. 1 Due the
steroidogenic enzymes, Ovarian hyperandrogenism is the
high level of androgen in women, the acne, alopecia,
cardinal feature of PCOS. 7
hirsutism, obesityand other related disorders are mostly
seen. 2 Typically, the PCOS is indirectly related to the
hyper-secretion of luteinizing hormone and androgens. 1.1. Types
After recently research, observe the various physiological The PCOS are categorized into 4 main types-
changes in women ovaries according to researchers. 3 The PCOS is hormone related disorder and this affect the
According to American research, the afflicts 15% women irregular periods.
that suffered with type 2 diabetes mellitus (type 2
DM) and cardiovascular disease but after some time it’s
1. Insulin Resistant of PCOS: In this case prevent of the
shown symptoms of PCOS in their reproductive years. 4
insulin level decreased ability to manage sugar level in
PCOS, particularly hyperandrogenism, is highly heritable,
body. Due to high level of sugar, directly decreased the
according to twin and genomic studies. A member of
level insulin. It’s a main cause of insulin resistant of
the TGF-ß superfamily that codes for the extracellular
PCOS.
matrix protein fibrillin 3 is the most reliable PCOS gene
2. Inflammatory of PCOS: In this types of PCOS,
candidate. 5 Even in close male relatives, the allelic fibrillin
the inflammatory effect are shown in the body, like
* Corresponding author. inflammation in digestive organ, e.g. irritable bowel
E-mail address: [email protected] (R. Kumar). syndrome (IBS), joint pain, skin problem. The hsCRP

https://doi.org/
2348-4055/© 2021 Innovative Publication, All rights reserved. 1
2 Kumar et al. / Southeast Asian Journal of Health Professional 2021;4(1):1–4

test are useful for detecting the Inflammationlevel in 1.6. Excess androgen
body.
The androgen are produced from ovaries high level, and
3. Post pills of PCOS: You may have the post-pill
result of androgen realese high level hirstuism and acne. 10
variety of PCOS, if your periods were normal before
using hormonal birth control and you now fulfill
the diagnostic criteria for PCOS. If you had PCOS 1.7. Ayurvedic treatment of PCOS
symptoms prior to starting the pill but never received 1.7.1. Aloe-vera
a formal diagnosis, it’s possible you had the condition (Botanical Name-Aloe barbadensis, Family-Liliacea)
before starting the pill. Aloe Vera is a medicinal plant, Aloe Vera plant various
4. Hidden cause of PCOS: The various other use in medicinal use such as, skin glow, improves digestive
pathological cause of PCOS are hidden which health, moisturizing and cooling properties and PCOS etc.
includes thyroid disease because hypothyroidism
affects ovulation and due deficiency of Vit. D, zinc,
or iodinebecause your ovaries need these nutrients, or
elevated prolactin because it can increase DHEA.

1.2. Symptoms
The various symptoms of PCOS are 8

1. Irregular or absence of periods

2. Pain in Pelvic region
3. Elevated Luteinizing Hormone (LH) and decreased
Follicle stimulating hormone (FSH)
4. Hirsutism
5. Acne
6. Weight gain or difficulty losing weight
7. Infertility
Fig. 1: Aloe Vera
1.3. Causes
The efficiency of Aloe vera gel formulation in a PCOS
The some important causes of PCOS rat model was investigated in this study. To generate
1. Insulin level PCOS, five-month-old Charles Foster female rats were
2. Stress orally administered letrozole, a non-steroidal aromatase
3. Contraceptive pills inhibitor. The rats were subsequently given the Aloe vera
4. Genetic predisposition gel formulation orally (1 ml dose daily for 45 days).
5. Strong stimulation in adrenals in childhood Their estrus cyclicity, glucose sensitivity, and steroidogenic
activity were all restored as a result of this. The formation
of the PCO phenotype was inhibited by combining the
1.4. Genetic predisposition
inductive agent (letrozole) with the Aloe vera gel. By
Genes like CAPN10, Cytochrome family p450, Insulin restoring ovarian steroid status and modifying important
gene, AR, FTO, FSHR have been discussed. According steroidogenic function, aloe vera gel formulation protects
to very recent research involving almost 30,000 women, against the PCOS phenotype. 11
genetics may play a part in whether or not you develop
PCOS. 3.4% of women whose mothers had PCOS will also 1.8. Cinnamon
be diagnosed with PCOS later in life, while only 0.6% of
women whose mothers did not have the disorder will receive (Botanical Name-Cinnamomum zeylanicum, Family:
this diagnosis 9 Lauraceae)
Cinnamon is a medicinal plant. Cinnamon plant is many
medicinal uses, contain antioxidant, redues blood pressure
1.5. Insulin level
and pcos etc.
Insulin is a hormone generated by the pancreas that helps In vitro and in vivo studies have revealed that
cells to consume sugar, which is your body’s main source cinnamon extract reduces insulin resistance by boosting
of energy. Your blood sugar levels may rise and your body phosphatidylinositol 3-kinase activity in the insulin
may create more insulin if your cells grow resistant to the signalling pathway and thereby potentiating insulin action.
effects of insulin. For eight weeks, fifteen women with polycystic ovarian
 Kumar et al. / Southeast Asian Journal of Health Professional 2021;4(1):1–4 3

Fig. 3: Spearmint tea

weeks of voluntary exercise in the Estradiol Valerate (EV)-

Fig. 2: Cinnamon induced PCO rat model influenced ovarian shape and the
expression of sympathetic markers. The effect of exercise
on.
syndrome (PCOS) were given either daily oral cinnamon or
a placebo. 12 1. MRNA and protein expression of nerve growth factor
2. MRNA and number of ovarian-expressing cells for the
1.9. Spearmint tea NGF
(Botanical Name: Mentha spicata, Family: Labiates) 3. Ovarian morphology
Mentha spicata is medicinal plnt. Mentha plant is use 4. In adult rats cycle, PCO was produced by a single
many medicinal uses sach as gastrointestinal disorders, intramuscular injection of EV, while controls were
stomach ache and pcos etc. treated with oil alone. 19
Free and total testosterone levels and degree of hirsutism
were reduced over the 30-day period in the spearmint tea 1.12. Dietary intake treatment of PCOS
group. LH and FSH were increased. It was demonstrated
In women with PCOS, a low glycemic index diet may help
and confirmed that spearmint has anti androgen properties.
manage insulin resistance, cardiovascular risk, and irregular
The study was conducted in two centres in Turkey as a 30-
menstruation cycles. Consumption of saturated fats should
day randomised controlled experiment. For one month, 42
be avoided. In women with polycystic ovarian syndrome,
individuals were randomly assigned to drink spearmint tea
lifestyle change, including effective exercise regimes and
twice a day or a placebo herbal tea. 13
food guidance, should be the primary line of treatment. 20
1.10. Allopathic treatment for PCOS
2. Conclusion
1. Laproscopy 14
2. Spironolactone 15 Women with PCOS are more prone to develop hypertension
3. Triglitazone 16 and cardiovascular disease as a result of metabolic
4. Clomiphene 17 syndrome, in addition to anovulation and infertility. Clinical
5. Metformin 18 examination is the most common method of diagnosing
PCOS. Because the aetiology of PCOS is unknown, therapy
is limited to managing the signs and symptoms. To
1.11. Life style modification
better understand the pathophysiology of PCOS and the
A. Exercise treatment of PCOS — The exercise very help development of high blood pressure in women with the
to treatment of pcos. The goal of the study was to see if 5 illness, more study is needed.
4 Kumar et al. / Southeast Asian Journal of Health Professional 2021;4(1):1–4

3. Acknowledgment ovarian syndrome rat model. J Ayurveda Integr Med. 2010;1(4):273–

9. doi:10.4103/0975-9476.74090.
Thankful to Mr Ravi Kum‘ar from Shri Ram Group of 12. Wang JG, Anderson RA, 3rd GMG, Chu MC, Sauer MV, Guarnaccia
Colleges, MZN U P India MM, et al. The effect of cinnamon extract on insulin resistance
parameters in polycystic ovary syndrome a pilot study. Fertil Steril.
2007;88(1):240–3. doi:10.1016/j.fertnstert.2006.11.082.
4. Source of Funding 13. Grant P. Spearmint herbal tea has significant anti-androgen effects
in polycystic ovarian syndrome: A randomized controlled trial.
None. Phytother Res. 2010;24(2):186–8. doi:10.1002/ptr.2900.
14. Felenbam A, Tan SL, Tulandi T. Laparoscopic treatment of polycystic
5. Conflict of Interest ovaries with insulated needle cautery: a reappraisal. Fertil Steril.
2000;73(2):266–9. doi:10.1016/s0015-0282(99)00534-8.
None. 15. Legro RS, Huiman X, Bruce R. Clomiphene Metformin, or Both
for Infertility in the Polycystic Ovary Syndrome New Engl. J Med.
2007;356(1):551–66. doi:10.1056/NEJMoa063971.
References 16. Dunaif A, Scott D, Finegood D, Quintana B, Whitcomb
1. Franks S. Polycystic ovary syndrome. N Engl J Med. R. The insulin-sensitizing agent troglitazone improves
metabolic and reproductive abnormalities in polycystic ovary
1995;28(333):853–61. doi:10.1056/NEJM199509283331307.
syndrome. J Clin Endocrinol Metab. 1996;81(9):3299–306.
2. Stein IF, Leventhal ML. Amenorrhea associated with bilateral
doi:10.1210/jcem.81.9.8784087.
polycystic ovaries. Am J Obstet Gynecol. 1935;29(2):181–91.
17. Legro RS. Clomiphene Metformin or Both for Infertility in the
doi:10.1016/S0002-9378(15)30642-6.
Polycystic Ovary Syndrome. New Engl J Med. 2007;356(6):551–66.
3. Yen SS, Vela P, Rankin J. Inappropriate secretion of follicle-
doi:10.1056/NEJMoa063971.
stimulating hormone and luteinizing hormone in polycystic
18. Lord JM. Review: Metformin used alone or combined with clomifene
ovarian disease. J Clin Endocrinol Metab. 1970;30(4):435–77.
may improve ovulation rates in the polycystic ovary syndrome. Br
doi:10.1210/jcem-30-4-435.
Med J. 2003;327:951–56.
4. Wild RA, Kandarakis CED, Dokras A, Morreale HFE, Lobo RFW,
19. Manni L. Effect of exercise on ovarian morphology and expression of
Norman RJ, et al. Assessment of cardiovascular risk and prevention of
nerve growth factor and alpha (1) - and beta (2)-adrenergic receptors
cardiovascular disease in women with the polycystic ovary syndrome:
in rats with steroid-induced polycystic ovaries. J Neuroendocrinol.
a consensus statement by the Androgen Excess and Polycystic
2005;17(12):846–58. doi:10.1111/j.1365-2826.2005.01378.x.
Ovary Syndrome (AE-PCOS) Society. J Clin Endocrinol Metab.
20. Colombo O, Pinelli G. Dietary intakes in infertile women a pilot study.
2010;95(5):2038–49. doi:10.1210/jc.2009-2724.
Nutr J. 2009;8:53. doi:10.1186/1475-2891-8-53.
5. Ewens KG, Stewart DR, Ankener W, Urbanek M, Baig KM, Parker
SCJ, et al. Family-based analysis of candidate genes for polycystic
ovary syndrome. J Cline Endocrinal Metab. 2010;95(5):2306–15.
doi:10.1210/jc.2009-2703. Author biography
6. Urbanek M, Sam S, Legro RS, Dunaif A. Identification of a
polycystic ovary syndrome susceptibility variant in fibrillin-3 and Deepak Kumar, Student
association with a metabolic phenotype. J Clin Endocrinol Metab.
2007;92(11):4191–8. doi:10.1210/jc.2007-0761.
Ravi Kumar, Assistant Professor
7. Nelson VL, Legro RS, Strauss JF, McAllister JM. Augmented
androgen production is a stable steroidogenic phenotype of propagated
theca cells from polycystic ovaries. Mol Endocrinol. 1999;13(6):946– Vipin Garg, Director
57. doi:10.1210/mend.13.6.0311.
8. Elsheikh M, Caroline M. Polycystic Ovary Syndrome; 2008. p. 220. Sayed Salman ali, Assistant Professor
9. AR androgen receptor [ Homo sapiens (human) ]; 2018. Available
from: https://www.ncbi.nlm.nih.gov/gene/367.
10. Polycystic ovary syndrome (PCOS); 2020. Available from:
https://www.mayoclinic.org/diseases-conditions/pcos/symptoms- Cite this article: Kumar D, Kumar R, Garg V, Salman ali S. Ayurvedic
causes/syc-20353439. treatment of polycystic ovary syndrome (PCOS). Southeast Asian J
11. Maharjan R, Nagar PS, Nampoothiri L. Effect of Aloe Health Prof 2021;4(1):1-4.
barbadensis Mill. Formulation on Letrozole induced polycystic