I RECOVER Post Vaccine Protocol

Updates:
- Section on anti-coagulation
- Reordering of preferred interventions
- Caution on Methylene Blue contraindications
Table of Contents
Summary of Suggested Therapies .......................................................................................... 3
Disclaimer ............................................................................................................................. 4
Contributors .......................................................................................................................... 4
Definition .............................................................................................................................. 4
Epidemiology......................................................................................................................... 4
Pathogenesis ......................................................................................................................... 5
Complications/ injuries caused by COVID injections ............................................................... 8
Treatment Approach ........................................................................................................... 10
Baseline Testing................................................................................................................... 11
Anticoagulation post-vaccination and the three clinical phenotypes of the vaccine injured ... 12
Antiplatelet drugs: ....................................................................................................................... 13
Direct oral anticoagulants (DOAC):................................................................................................ 14
Oral Fibrinolytic agents:................................................................................................................ 14
Provisional approach to anticoagulation in the post-vaccine phenotypes ....................................... 15
First-Line Therapies ............................................................................................................. 16
Adjunctive/Second-Line Therapies ....................................................................................... 24
Third Line Therapies ............................................................................................................ 26
Patients with elevated homocysteine levels ......................................................................... 27
Other Potential Treatments ................................................................................................. 28
Disease-Specific Therapeutic Adjuncts ................................................................................. 31
Small fiber neuropathy (SFN)/autonomic neuropathy ...................................................................31
Generalized neurologic symptoms/“brain fog”/fatigue/visual symptoms ......................................31
Depression ...................................................................................................................................32
Patients with elevated DIC and those with evidence of thrombosis ............................................... 33
Vaccine-induced myocarditis/pericarditis ..................................................................................... 33
Herpes virus reactivation syndrome .............................................................................................. 33
Tinnitus........................................................................................................................................ 34
Ageusia and anosmia (Loss of taste and smell) .............................................................................. 34
Bell’s palsy/facial paresthesia/visual issues ................................................................................... 35
Patients with new onset allergic diathesis/features of Mast Cell Activation Syndrome (MCAS)....... 35
Alopecia (hair loss) ....................................................................................................................... 35
References .......................................................................................................................... 37
I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 2

Summary of Suggested Therapies
First-Line Therapies Adjunctive/Second-Line Third Line Therapies
(Not symptom specific; listed Therapies
in order of importance) (Listed in order of importance)
Intermittent daily fasting or Magnesium; 100-400 mg daily Hyperbaric oxygen therapy

periodic daily fasts
Ivermectin; 0.2-0.3 mg/kg N-acetyl cysteine (NAC); 600-1500 Low Magnitude Mechanical
daily mg/day Stimulation (LMMS or
Whole-Body Vibration)
Moderating physical activity Cardio Miracle™ and L-arginine/L- “Mitochondrial energy
citrulline supplements optimizer”
Low-dose naltrexone (LDN); 1- Omega-3 fatty acids; we suggest a Hydroxychloroquine (HCQ);
4.5 mg daily combination of EPA/DHA with an 200 mg twice daily for 1-2
initial dose of 1 g/day (combined EPA weeks, then reduce as
and DHA) and increasing up to 4 tolerated to 200 mg/day
g/day (of the active omega-3 fatty
acids)
Resveratrol; 400-500 mg daily Sildenafil with or without L-arginine- Low dose corticosteroid; 10-
L-Citrulline 15 mg/day prednisone for 3
weeks. Taper to 10 mg/day
and then 5 mg/day, as
tolerated
Melatonin; 2-6 mg slow Nigella sativa; 200-500 mg
release/extended release prior encapsulated oil twice daily
to bedtime
Aspirin; 81 mg daily Vitamin C; 1000 mg orally two to
three times a day
Methylene blue; 10-30 mg Vitamin D (4000-5000 units/day) and
daily Vitamin K2 (100 mcg/day)
Sunlight and Fluvoxamine; 50 mg twice daily
Photobiomodulation (PBM)
Probiotics/prebiotics Non-invasive brain stimulation (NIBS)
Spermidine; 1000-2000 mg Intravenous Vitamin C; 25 g weekly,
(wheat germ extract) daily together with oral Vitamin C 1000
mg (1 gram) 2-3 times per day
Behavioral modification, relaxation
therapy, mindfulness therapy, and
psychological support

Disclaimer
This document is primarily intended to assist healthcare professionals in providing appropriate medical
care for vaccine-injured patients. Patients should always consult a trusted healthcare provider before
embarking on any new treatment.
Contributors
This protocol was a collaborative effort drawing on the expertise of a dozen world-renowned physicians.
Dr. Pierre Kory and Dr. Paul Marik are thankful for the contributions of: Dr. Keith Berkowitz; Dr. Flavio
Cadegiani; Dr. Suzanne Gazda; Dr. Meryl Nass; Dr. Tina Peers; Dr. Robin Rose; Dr. Yusuf (JP) Saleeby; Dr.
Eugene Shippen; Dr. Mobeen Syed; and Dr. Fred Wagshul.
We are also extremely grateful for the feedback of the many vaccine-injured people who shared their
experiences with us.
Definition
Although no official definition exists for ‘post-COVID-vaccine syndrome,’ a temporal correlation between
receiving a COVID-19 vaccine and the beginning or worsening of a patient’s clinical manifestations is
sufficient to diagnose as a COVID-19 vaccine-induced injury when the symptoms are unexplained by
other concurrent causes.
Since Phase 3 and Phase 4 clinical trials are still ongoing, the full safety and toxicity profile for COVID-19
vaccines cannot be fully determined. From a bioethical perspective, cases of any new-onset or worsened
signs, symptoms, or abnormalities following any dose of COVID-19 vaccine must be considered as an
injury caused by the vaccine, until proven otherwise.
Note that there are significant overlaps between the symptoms and features of long COVID/long-hauler
syndrome and post-vaccine syndrome. However, a number of clinical features appear to be
characteristic of post-vaccine syndrome; most notably, severe neurological symptoms appear to be
more common following vaccination. To complicate matters further, patients with long COVID are often
also vaccinated, making the issue of definition more difficult.
Epidemiology
The Centers for Disease Control (CDC), National Institutes for Health (NIH), Food and Drug
Administration (FDA), and World Health Organization (WHO) do not recognize post-COVID-19 vaccine
injuries as a specific medical condition, [1] even though there is a specific ICD-10 code. Curiously, the
code U12.9 is recognized in Europe but not in the United States. There have been no prospective studies
that have accurately classified and logged the incidence of this complication; therefore, the true
magnitude of post-vaccine syndrome is unknown.
However, as of December 2nd, 2022, 1 476 227 adverse events have been reported. This includes
32 621 deaths, 185 412 hospitalizations, 15 721 heart attacks, 35 718 cases of myocarditis and 60 758
cases of permanent disability according to OPEN VAERS, which tracks data recorded in the U.S. Vaccine
Adverse Event Reporting System (VAERS). Note that VAERS data is limited by underreporting, by a factor
of at least 30-fold. [2]

The true incidence of adverse events following COVID-19 injections, including deaths and serious vaccine
injuries, is unknown; this is complicated by the deliberate and willful manipulation of data
(underreporting) by governmental agencies in the United States, United Kingdom, Israel, and many
other countries. [2;3].
However, available data consistently and reproducibly demonstrates a rate of serious adverse events
(SAE) of about 8%. [2;3] Most importantly, the V-SAFE database administered by the CDC demonstrates
an 8% rate of SAE (https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/vsafe.htm,
https://icandecide.org/v-safe-data/. Translated to the U.S. vaccinated population, this would mean
approximately 18 million vaccine injuries. A Pollfish survey released on July 4, 2022 reported that 8.64%
of adult respondents who had received a COVID-19 vaccine in the U.S. developed a vaccine injury. A
Rasmussen report published in December 2022 reported a 7% rate of SAE those jabbed. In a nationwide
cohort of U.S. veterans, an adverse reaction was reported in 8.5% of recipients of the Pfizer vaccine and
7.9% of those receiving the Moderna vaccine. [4]
As the mainstream medical community does not recognize this serious humanitarian disaster, these
patients have been shunned and denied access to the care they need and deserve. Furthermore, there is
limited clinical, molecular, and pathological data on these patients to inform an approach to treating the
condition. Consequently, our approach to the management of vaccine-injured patients is based on the
presumed pathogenetic mechanism, pharmacologic principles, as well as the clinical observations of
physicians and patients themselves.
Pathogenesis
The spike protein, notably the S1 segment, is likely the major pathogenetic factor leading to post-
vaccine syndrome (see Figure 1). [4-6] The S1 protein is profoundly toxic. Multiple intersecting and
overlapping pathophysiologic processes likely contribute to the vast spectrum of vaccine injuries: [1;7]
• The acute, immediate reaction (within minutes to hours) is likely the result of an acute type I
IgE-mediated hypersensitivity reaction. The type I response may be due to preformed antibodies
against mRNA, polyethylene glycol (PEG) [8;9], or other components of the nano-lipid particle. In
addition, PEG activates multiple ‘complement components,’ the activation of which may be
responsible for both anaphylaxis and cardiovascular collapse. [9-11] A prospective study on
64,900 medical employees, in which reactions to their first mRNA vaccination were carefully
monitored, found that 2.1% of subjects reported acute allergic reactions. [12]
• The acute myocarditis/sudden cardiac death syndrome that occurs post-vaccination (within
hours to 48 hours), noted particularly in young athletes, may be caused by a “stress
cardiomyopathy” due to excessive catecholamines produced by the adrenal medulla in response
to spike protein-induced metabolic aberrations. [13]
• The subacute and chronic myocarditis is likely the result of a spike protein-induced
inflammatory response mediated by pericytes and macrophages. [14;15]
• The subacute (days) and chronic (weeks to years) vaccine-related injuries likely result from the
overlapping effects of an S1-induced inflammatory response, the production of autoantibodies,
activation of the clotting cascade, and secondary viral reactivation.
• The inflammatory response is mediated by spike protein-induced mononuclear cell activation in
almost every organ in the body but most notably involving the brain, heart, and endocrine
organs.

• Patients with long COVID and those post-vaccination may have spike protein circulating in the
blood for as long as 15 months. [16-18] Spike protein inhibits natural killer (NK) cell activity, [19-
22] cytotoxic T-cells, and inhibits autophagy [23]; this may account for the persistence of the
spike protein.
• The lipid nanoparticles (LNP) themselves are highly pro-inflammatory, as evidenced by excessive
neutrophil infiltration, activation of diverse inflammatory pathways, and production of various
inflammatory cytokines and chemokines. [24-26]
• Neuro-COVID, the neurological manifestations related to the spike protein, are related to the
complex interplay of neuroinflammation, [27] production of amyloid and prion protein, [28-34]
autoantibodies, microvascular thrombosis, and mitochondrial dysfunction. [35]
The spike protein of SARS-CoV-2 has extensive sequence homology with multiple endogenous human
proteins and could prime the immune system toward development of both auto-inflammatory and
autoimmune disease. [11] As a consequence of molecular mimicry with the spike protein, a diverse
spectrum of autoantibodies has been reported. [36-46] These autoantibodies are the likely cause of
Guillain-Barré Syndrome (GBS), transverse myelitis, immune thrombocytopenia, and Small Fiber
Neuropathy (SFN)/Autonomic neuropathy. [47-54]
Many of these antibodies are directed against G-protein-coupled cell membrane receptors. [43;45] Anti-
neuronal antibodies likely contribute to the myriad of neurological findings. SFN/autonomic neuropathy
appears to be a characteristic disorder following vaccination and is strongly associated with a vast array
of autoantibodies. Further, autoantibodies may result in a number of specific syndromes, including anti-
phospholipid syndrome, systemic lupus erythematosus (SLE), rheumatoid arthritis, etc.
The spike protein is highly thrombogenic, directly activating the clotting cascade; in addition, the clotting
pathway is initiated via inflammatory mediators produced by mononuclear cells and platelets. [6]
Activation of the clotting cascade leads to both large clots (causing strokes and pulmonary emboli) as
well as micro clots (causing microinfarcts in many organs, but most notably the brain). Emerging data
suggest that the vaccines can induce an allergic diathesis (eczema, skin rashes, asthma, skin and eye
itching, food allergies, etc.) This appears to be due to a unique immune dysregulation with antibody
class switching (by B cells) and the production of IgE antibodies. There is an overlap with Mast Cell
Activation Syndrome (MCAS) and the distinction between the two disorders is not clear. [55;56]
However, by definition MCAS has no identifiable causes, is not caused by allergen-specific IgE, and has
no detectable clonal expansion of mast cells. [55]
And finally, due to altered immune function, the activation of dormant viruses and bacterial pathogens
may occur, resulting in reactivated Herpes Simplex, Herpes Zoster, Epstein Barr Virus (EBV), and
cytomegalovirus (CMV) infection, as well as reactivation of Lyme disease and mycoplasma. [57-60]
The common factor underlying the pathogenic mechanism in the vaccine-injured patient is “immune
dysregulation.” The development of immune dysfunction and the severity of dysfunction likely result
from several intersecting factors, including:
• Genetics: First-degree relatives of patients who have suffered a vaccine injury appear to be at a
very high risk of vaccine injury. Those patients with a methylenetetrahydrofolate reductase
(MTHFR) gene mutation [61] and those with Ehlers-Danlos type syndromes may be at an
increased risk of injury. MTHFR C677T polymorphism is the most common MTHFR single
nucleotide polymorphism (SNP) and the most common genetic cause of hyper-

homocysteinemia. [62] Increased homocysteine levels have been linked to worse outcomes in
patients with COVID-19. [63;64] Increased homocysteine levels may potentiate the
microvascular injury and thrombotic complications associated with the “spikopathy”. [62;65]
• mRNA load and quantity of spike protein produced: This may be linked to specific vaccine lots
that contain a higher concentration of mRNA. [1] The Moderna vaccine is reported to contain
100 ug of mRNA as compared to 30 ug mRNA for the Pfizer vaccine (10 ug in children 5-11 years
of age), however, it is likely that the true concentration varies widely.
• Sex: It appears that about 80% of vaccine-injured patients are female. Furthermore, treatment
with estrogens has been reported to worsen or precipitate an event/relapse. Women are known
to be at a much higher risk of autoimmune diseases (especially SLE) and this likely explains this
finding. Estrogens interfere with glucocorticoid receptor signaling. [66] In addition, estrogens
modulate B and T cell function.
• Underlying nutritional status and comorbidities: Certain preexisting conditions may likely have
primed the immune system to be more reactive after vaccination. This includes those with
preexisting autoimmune disorders and chronic inflammatory diseases such as Lyme disease.
Those patients with a poor nutritional status including those with deficiencies of nutrients such
as Vitamin D, Vitamin B12, folate, and magnesium may be at an increased risk of injury.
Figure 1. Complex pathophysiology of spike-related vaccine-induced disease

Complications/ injuries caused by COVID injections
Over 2,400 peer-reviewed articles have been published on COVID vaccine injuries. Find links to these
studies at COVID Vaccine Injuries, REACT19, and on Substack. A selection of symptoms is listed below:
• Myocarditis, pericarditis, stress • Allergic reactions

cardiomyopathy (contraction band • Intracerebral hemorrhage
necrosis) • Strokes (thrombotic strokes)
• Takotsubo cardiomyopathy • Generalized neurological symptoms
• Acute coronary syndrome including “brain fog”, cognitive decline,
• Hypertension memory loss
• MIS-V, Multisystem Inflammatory • Alzheimer’s Disease like syndrome
Syndrome • Acute hyperactive encephalopathy
• Thrombosis, including pulmonary • Acute disseminated encephalomyelitis
emboli and stroke (prothrombotic • Neuromyelitis Optica
state) • Ageusia and anosmia
• Cerebral venous thrombosis • Aphasia
• Thrombocytopenia • Depression
• Thrombotic thrombocytopenic purpura • New onset panic disorders
• Idiopathic thrombocytopenic purpura • New onset psychosis and delirium
• Henoch Schönlein Purpura • Small fiber neuropathy
• Immune-mediated hemolysis • Autonomic neuropathy
• Reactivation and exacerbation of • POTS syndrome (postural Orthostatic
chronic underlying diseases/disorders Tachycardia syndrome)
• Immune dysregulation • Mononeuritis multiplex,
• Metabolic dysregulation (diabetes) polyneuropathy
• Menstrual irregularities • Acute inflammatory neuropathies
• Menorrhagia • Tinnitus (severe and persistent)
• Amenorrhea • Sensorineural hearing loss
• Spontaneous abortion • Vestibulitis
• Vulval and vaginal ulcers • Severe headaches and migraines
• Vasculitis, including Leukocytoclastic • Seizures and status epilepticus
vasculitis, Granulomatous vasculitis, • Prion disease i.e., Mad Cow Disease
microscopic polyangiitis • Acute macular retinopathy
• Guillain-Barre Syndrome • Uveitis
• Acute Myelitis • Acute Optic Neuropathy
• Systemic lupus erythematosus • Rhabdomyolysis
• Bell’s Palsy • Keratolysis
• Stills disease • Herpes Keratitis
• Sweets syndrome • Inflammatory myositis
• Facial nerve palsy • Immune mediate hepatitis
• Multiple sclerosis • Pancreatitis
• Polyarthralgia/polyarthritis • Acute kidney injury
• Cryoglobulinemia • Nephrotic syndrome
• Lymphadenopathy, local and • ANCA glomerulonephritis
generalized
• Anaphylaxis

• Skin reactions including rashes, • Epstein-Barr viral reactivation
urticaria, Pityriasis rosea • CMV reactivation
• Pemphigus vulgaris • Herpes Simplex reactivation
• Hemorrhagic bullous pyoderma • Zoster meningitis
gangrenosum • Ramsay Hunt syndrome
• Eosinophilic dermatosis • Thyroiditis
• Alopecia, including alopecia areata • Tolosa-Hunt syndrome
• Psoriasis • Acute eosinophilic pneumonia
• Toxic epidermal necrolysis • Cancer recurrences
• Erythema multiforme • New and unusual malignancies,
• Hemophagocytic histiocytosis including Angioimmunoblastic T Cell
• Varicella Zoster infection Lymphoma
The most common symptoms recorded in post-vaccine syndrome are presented in Figure 2. On average,
patients reported 23 distinct symptoms. (Results from PVS Survey Germany; Reproduced with
permission from React19.)
Figure 2. Post-Vaccine syndrome is a multi-symptomatic disease

Treatment Approach
A number of principles are essential for the optimal management of post-vaccine syndrome:
• It is important to emphasize that there are no published reports detailing the management of
vaccine-injured patients. Our treatment approach is, therefore, based on the postulated
pathogenetic mechanism, pharmacologic principles, clinical observation, and feedback from
vaccine-injured patients.
• The core problem in post-vaccine syndrome is chronic “immune dysregulation.” The primary
treatment goal is to help the body to restore and normalize the immune system—in other
words, to let the body heal itself. We recommend the use of immune-modulating agents and
interventions to dampen and normalize the immune system rather than the use of
immunosuppressant drugs, which may make the condition worse. However, the concomitant
use of a controlled course of an immunosuppressant drug may be appropriate in patients with
specific autoimmune conditions.
• The treatment strategy involves two major approaches i) promote autophagy to help rid the cell
of the spike protein and ii) interventions that limit the toxicity/pathogenicity of the spike
protein.
• Treatment must be individualized according to each patient’s presenting symptoms and disease
syndromes. Not all patients respond equally to the same intervention; this suggests that the
treatment must be individualized according to each patient’s specific response. A peculiar
finding is that a particular intervention (e.g., Hyperbaric oxygen therapy) may be lifesaving for
one patient and totally ineffective for another.
• Patients should serve as their own controls and the response to treatment should dictate the
modification of the treatment plan. One (or at most two) new interventions should be added at
a time in order to evaluate what helps the patient and those interventions that are not helpful.
• Early treatment is essential; the response to treatment will likely be attenuated when treatment
is delayed.
• Patients should be started on the primary treatment protocol; this should, however, be
individualized according to the patient’s particular clinical features. The response to the primary
treatment protocol should dictate the addition or subtraction of additional therapeutic
interventions. Second-line therapies should be started in those who have responded poorly to
the core therapies and in patients with severe incapacitating disease.
• Patients with post-vaccine syndrome must not receive further COVID-19 vaccines of any type.
Likewise, patients with long COVID should avoid all COVID vaccinations.
• Patients with post-vaccine syndrome should do whatever they can to prevent themselves from
getting COVID-19. This may include a preventative protocol (see FLCCC protocols). In the event
they do contract the virus or suspect infection, early treatment is essential (see FLCCC
protocols). COVID-19 will likely exacerbate the symptoms of vaccine injury.
• Vaccine-injured patients are frequently desperate to try any medication or intervention they
believe may help them. Unfortunately, unscrupulous providers will take advantage of these very
vulnerable patients and sell them expensive and unproven remedies.
• Patients should avoid unscientific and poorly validated “Spike Protein Detox” programs.
• Hyperbaric oxygen therapy (HBOT) should be considered in cases of severe neurological injury
and in patients showing a rapid downhill course (see below).
• Once a patient has shown a clinical improvement the various interventions should be reduced or
stopped one at a time. A less intensive maintenance approach is then suggested.

Baseline Testing
Post-vaccine patients are often subjected to an extensive battery of diagnostic tests. These tests are
rarely helpful, usually confusing the situation and leading to inappropriate therapeutic interventions.
Patients frequently undergo diagnostic tests that are “experimental,” unvalidated, and clinically
meaningless; patients should avoid getting such tests. Remember the dictum: Only do a test if the
result will change your treatment plan. We recommend a number of simple, basic screening tests that
should be repeated, as clinically indicated, every 4 to 6 months.
• CBC with differential and platelet count

• Standard blood chemistries, including liver function tests
• D-Dimer—as a marker of clotting activation. Those with a markedly elevated D-dimer should
probably undergo screening for an inherited thrombophilia.
• CRP—as a marker of ongoing inflammation (A comprehensive extensive cytokine/chemokine
panel is unnecessary and very costly, and the results will not change the treatment approach.)
• Early morning cortisol—some patients develop autoimmune adrenal failure)
• TSH—to exclude thyroid disease
• Homocysteine level (normal 5-15 μmol/l)
• HbA1C—Vaccine-injured patients are at an increased risk of developing diabetes
• Troponin and pro-BNP to exclude cardiac disease.
• CMV, EBV (early antigen-D IgG or nuclear antigen IgG), Herpes simplex, HHV6 and mycoplasma
serology/PCR—to exclude viral/bacterial reactivation (In patients who respond poorly to
therapy, it may be helpful to check for Lyme (Bb), Bartonella and Babesia tick-borne diseases—
e.g., https://igenex.com/ and https://www.mdlab.com/). [60]
• Vitamin D level (25OH Vitamin D)
• In patients with allergic features and those who experienced an acute reaction to the vaccine,
the following tests may be helpful: eosinophil count; IgE levels, RAST testing, and/or skin testing.
Serum tryptase, serum histamine, and/or 24-h urine N-methylhistamine should be considered
in MCAS. [55]
• In patients who present with deep venous thrombosis (DVT) and/or pulmonary embolism soon
after vaccination screening for an inherited thrombophilia is suggested. [67]
• Limited screening autoantibodies. Lupus anticoagulant (if positive B2 microglobulin etc.) and
ANA. Vaccine-injured patients, particularly those with autonomic dysfunction/SFN frequently
have an extensive array of autoantibodies directed against G-protein coupled cell surface
receptors, [43;45] ACE-2, [68] neurons, myelin, and other self-epitopes. The presence or
absence of these antibodies has little impact on the management of these patients.

Figure 3. Time course of sudden cardiac deaths following COVID-19 vaccination
Anticoagulation post-vaccination and the three

clinical phenotypes of the vaccine injured
The need for anticoagulation in post-vaccination patients is a very complex and controversial issue.
Three distinct clinical phenotypes with differing pathophysiological and clinical presentations exist (see
Figure 3).
The first is the “typical” post-vaccine, muti-symptomatic syndrome characterized typically by fatigue,
brain fog, and other multiple complex symptoms (see figure 2). This syndrome is characterized by
microvascular inflammation and microvascular thrombosis as part of the complex pathophysiology of
post-vaccine spike related disease (see Figure 1).
The second is that of sudden cardiac death within the first 2 weeks (usually first 7 days) following the
last dose of vaccination. The early sudden deaths are likely arrhythmogenic deaths related to
catecholamine-induced contraction band necrosis and spike-induced inflammatory myocarditis (often
focal myocarditis).
The third phenotype includes those otherwise healthy patients who “die suddenly” 4 to 6 months after
the last dose of the COVID vaccine. Patients with this phenotype typically lack the typical symptoms
characteristic of post-vaccine syndrome. While the pathology of this syndrome has not been studied (as

it has been dismissed by governmental agencies), it is likely the result of a progressive spike-induced
endothelialitis complicated by thrombosis.
Dr. Steven R. Gundry, a cardiac surgeon, performed a biomarker-based cardiac risk assessment score
(the PULS Cardiac Test now available as the SMARTVascular Dx provided by SmartHealth Dx
https://www.smarthealthdx.com) in 566 patients 2 to 10 weeks following the 2nd mRNA COVID shot
and compared this score to the PULS score drawn 3 to 5 months prior to the jab. [69] The PULS score is a
marker of endothelial inflammation. In this study, the 5-year Acute Coronary Risk Score (ACS) increased
from a baseline of 11% to 25% after the jab. This study clearly demonstrates that the mRNA ‘jabs” lead
to progressive endothelial inflammation.
To complicate matters further, the clots (micro-clots and macro-clots) that develop in patients with
spike-related disease are distinctly different from “usual clots” and have a number of unique
characteristics. These clots are rich in fibrin with amyloid-like fibrils and are more resistant to
fibrinolysis. Immunohistochemical staining demonstrates a high concentration of spike protein within
the clots; this is important as spike protein via multiple mechanisms activates clotting as well as altering
the structure of fibrin resulting in amyloid-like fibrils.
Based on this information, it would seem intuitive that the use of anti-coagulants and the approach to
treatment would be different for these three phenotypes; however, the ideal approach has yet to be
determined. A provisional approach to anticoagulation is provided below. A review of the
pharmacological properties of the various anticoagulants available to the healthcare provider is
provided. The general approach to the management of the multi-symptom vaccine syndrome is then
reviewed.
The greatest risk with the use of anticoagulant drugs is clinically significant bleeding. A number of
factors increase the risk of bleeding; [70-72] these include age > 65 years (advanced age is a major risk
factor for bleeding), hypertension, renal impairment, diabetes, previous stroke, a previous bleed, and
male sex. Furthermore, the risk of bleeding increases exponentially as the number of anticoagulant/anti-
platelet drugs is increased. [71;73]
Antiplatelet drugs:
• Aspirin (ASA): ASA produces a clinically relevant antiplatelet effect by irreversibly acetylating
the active site of cyclooxygenase-1 (COX-1), which is required for the production of
thromboxane A2, a powerful promoter of platelet aggregation. These effects are achieved by
daily doses of 75 mg (and higher). The major adverse effect is bleeding. Bleeding most
commonly occurs in the gastrointestinal tract and is rarely fatal. Bleeding also occurs at other
sites, with intracranial bleeding being the rarest (approximately 4 per 10,000) but the most
serious (with a 50% case fatality rate).
• Clopidogrel (Plavix): Clopidogrel requires in vivo biotransformation to an active thiol metabolite.
The active metabolite irreversibly blocks the ADP receptors on the platelet surface, which
prevents activation of the GPIIb/IIIa receptor complex, thereby reducing platelet aggregation.
Similar to ASA, platelets blocked by clopidogrel are affected for the remainder of their lifespan
(~7 to 10 days). The usual dose is 75mg daily.

Direct oral anticoagulants (DOAC):
• Apixaban (Eliquis): Inhibits platelet activation and fibrin clot formation via direct, selective, and
reversible inhibition of free and clot-bound factor Xa (FXa). FXa, as part of the prothrombinase
complex consisting also of factor Va, calcium ions, and phospholipid, catalyzes the conversion of
prothrombin to thrombin. Thrombin both activates platelets and catalyzes the conversion of
fibrinogen to fibrin. Typical dose is 2.5 to 5mg twice daily.
• Rivaroxaban (Xarelto): Mechanism of action similar to apixaban. Typical dosage is 10–20 mg
once daily with the evening meal.
Oral Fibrinolytic agents:

• Nattokinase: Nattokinase (NK) is a serine protease purified and extracted from natto, a
traditional Japanese (cheese like) food produced from the fermentation of soybeans with the
bacterium, Bacillus subtilis. [74-76] Recent studies demonstrated that a high natto intake was
associated with decreased risk of total cardiovascular disease mortality and, in particular, a
decreased risk of mortality from ischemic heart diseases. [77] Nattokinase has potent
fibrinolytic, antithrombotic, and antiplatelet activity. [74;75;78-81] NK degrades fibrin directly
and also increases the release of tPA with a subsequent increase in the formation of plasmin.
[82] Furthermore, NK enhances fibrinolysis through cleavage and inactivation of PAI-1. [76;81]
In a study comparing the antiplatelet effects of NK and aspirin, NK was shown to display
excellent antiplatelet aggregation and antithrombotic activities in vitro and in vivo, inhibiting
thromboxane B2 formation from collagen-activated platelets. [83] In addition, in both animal
and human studies, NK also has antihypertensive, anti-atherosclerotic, lipid-lowering, and
neuroprotective actions. [75;81;84] Of particular relevance to patients with spike-related
clotting, nattokinase causes the proteolytic cleavage of both spike protein and amyloid proteins.
[85] In a randomized study, NK proved to be more effect than statins (simvastatin) in reducing
carotid artery atherosclerosis. [86] Chen et al demonstrated that high dose NK (10 800 Fibrolytic
Units [FU]/day; ~ 500 mg/day) reduced the thickness of the carotid artery intima-media and the
size of the carotid plaque. [87] The authors reported a synergistic effect between NK and ASA.
Studies indicate that an oral administration of NK can be absorbed by the intestinal tract.
[84;88] NK, unlike most proteins, is more resistant to the highly acidic gastric fluids in the
stomach and can be absorbed in the later sections of the digestive tract. The optimal dose of
nattokinase is unclear, however, a dose of 100-200 mg (4000- 8000 FU/day) twice daily has been
suggested. While NK appears to have an excellent safety profile, [87;89] bleeding has rarely
been reported in patients with risk factors for bleeding (advanced age, renal failure,
hypertension, concomitant ASA, etc). [90;91] High concentrations of vitamin K2 in natto can
reduce the INR when coadministered with warfarin; this may also occur with nattokinase
supplements if vitamin K2 is not removed during the production process. Information regarding
safety and efficacy in pregnancy and lactation is lacking.
• Lumbrokinase: Lumbrokinase derives from a group of enzymes extracted from earthworms.
The enzymes are sourced mostly from the earthworm Lumbricus rubellus. Lumbrokinase has
very similar pharmacodynamic properties to Nattokinase, i.e., it directly breaks down fibrin
clots, inhibits PAI-1 activity, enhances t-PA activity, has antiplatelet activity, and proteolytically
cleaves amyloid. [92-94] The recommended dose is 300,000 to 600,000 IU/day (20-40 mg).
Lumbrokinase has been widely used for patients with acute ischemic stroke in China; however,
because rigorously designed studies are lacking, the safety and efficacy of lumbrokinase remains
largely unknown. [95] As the pharmacology, clinical effectiveness, and safety of nattokinase has

been assessed in a number of experimental and clinical studies, this agent is preferred over
lumbrokinase.
Provisional approach to anticoagulation in the post-vaccine phenotypes
• “Typical” post-vaccine syndrome. The default treatment is low-dose aspirin (ASA) (81mg daily).
In patients at low risk of bleeding (see risk factors) nattokinase can be added. Pretorius et al
reported on the use of “triple therapy” in 24 patients with long COVID and the presence of fibrin
amyloid microclots on live blood analysis. [96] Patients were treated with one month of dual
antiplatelet therapy (Clopidogrel 75mg/Aspirin 75mg) once a day, as well as Apixaban 5 mg
twice a day. This was followed by ASA and nattokinase alone. These authors reported that “each
of the 24 treated cases reported that their main symptoms were resolved, and this was also
reflected in a decrease of both the fibrin amyloid microclots and platelet pathology scores.”
Triple therapy can be considered in patients at low risk of bleeding (see risk factors) who have
responded poorly to the combination of ASA and nattokinase alone; however, triple therapy
should only be instituted under the direct supervision and monitoring of a clinician with
expertise in the management of anti-coagulation.
• Early sudden death. Early post-vaccination sudden cardiac death is a condition of young
patients, especially men. This is the most problematic phenotype with no clear guidance on the
prevention of this fatal condition (except to stop vaccination in this high-risk group). Many of
the deaths occur during physical activity (sudden death in soccer players); consequently,
vigorous physical activity should be avoided for at least 3 weeks following vaccination.
Magnesium supplementation (see section on magnesium) may reduce the risk of arrhythmic
deaths. The role of anti-inflammatory agents (e.g., curcumin, resveratrol, Nigella sativa, Omega-
3 fatty acids) is unclear.
• Late cardiac deaths (4-6 months after “jab”). Ideally, these asymptomatic patients should be
risk stratified with the initiation of prophylactic measures in the moderate to high-risk groups.
Unfortunately, as this catastrophic disorder is not generally recognized and has therefore not
been studied, there is no data to allow for risk stratification. Serial cardiac risk biomarker
analysis may be helpful; [69] however, this test is expensive and not widely available. In the
absence of a risk stratified approach, the following interventions may reduce the risk of acute
myocardial infarction and sudden death: [97]
• ASA 81 mg daily
• Nattokinase 100-200 mg twice daily (in those with low risk of bleeding)
• Omega-3 fatty acids 2-4 g daily
• Resveratrol or flavonoid combination supplement
• “Green based diet”- Low carbohydrate, high fat diet (low in omega-6 vegetable oils)

First-Line Therapies
(Not symptom specific; listed in order of importance)
• Intermittent daily fasting or periodic daily fasts. Fasting

has a profound effect on promoting immune system “A little starvation can really do
homeostasis, partly by stimulating the clearing of more for the average sick man
damaged cells (autophagy), damaged mitochondria than can the best medicines
(mitophagy), and misfolded and foreign proteins. Fasting and the best doctors.”
also improves mitochondrial health and increases stem —Mark Twain
cell production. [98-104] Autophagy plays an important (1835-1910)
role in preventing Alzheimer’s disease by removing
amyloid protein. Autophagy likely removes spike protein and misfolded proteins induced by the
spike protein. Autophagy may therefore play a critical role in reversing the “spikopathy” induced
by COVID injections. Indeed, activation of autophagy may be the only mechanism to remove
intracellular spike protein.
Note that fasting is contraindicated in patients younger than 18 (impairs growth), malnourished
patients (BMI < 20 kg/m2), and during pregnancy and breastfeeding. Patients with diabetes,
gout, and serious underlying medical conditions should consult their primary care physician
before undertaking fasting, as changes in their medications may be required and these patients
require close monitoring.
Proton pump inhibitors (PPI) should be avoided as they prevent the acidification of lysosomes
and block autophagy. [105] Patients may develop rebound esophagitis if a PPI is suddenly
discontinued. H2-blockers (famotidine, ranitidine, etc.) may be an alternative. Aloe Vera
Stomach Formula (Aloe Vera contains over 200 biologically active components) and diluted
Apple Cider vinegar (tastes awful) have been suggested as an alternative to a PPI; however,
there is limited data to support these interventions. [106;107]
Chloroquine and hydroxychloroquine (HCQ) act by alkalinizing lysosomes and therefore interfere
with the autophagy process. [108;109] Based on this data, HCQ may limit the benefit of
intermittent fasting.
Paradoxically, while autophagy may prevent cancers, autophagy may promote the growth of
cells that have already undergone malignant transformation. Cancer cells, which have an
increased metabolic demand for energy and macromolecular building blocks to proliferate,
show elevated levels of autophagy to recycle nutrients. [110] High-dose HCQ (more than 800
mg/day) has been demonstrated to improve the outcome of patients with certain cancers by
inhibiting autophagy. [111-115] This data suggests caution in activating autophagy (fasting) in
patients with cancer. However, “fasting mimicking diets” as an adjunct to chemotherapy have
been reported to improve quality-of-life indicators. [116-118] Patients should discuss fasting and
fasting protocols with their treating oncologist.
A number of intermittent fasting plans can be adapted and modified to best suit the patient’s
lifestyle. [98] For timed fasting, begin slowly: start with a 12-hour eating window 5 days a week
and reduce weekly to an 8-hour eating window 7 days a week. This eating window can be
shortened to 4 hours or less over time. Timed fasting can be interspersed with 36- to 48-hour

fasts. For caloric fasting, eat normally for 5 days and fast for 2 days by restricting caloric intake
on those days to 500-1000 calories per day. Intermittent fasting/timed restricted eating needs
to be coupled with a diet that consists of “real food,” minimizing the intake of processed foods,
sugar, fructose, and omega-6 polyunsaturated fatty acids. [119]
It is important to stay well-hydrated during fasting periods; drink lots of water and/or an
electrolyte solution. In his book the “Complete Guide to Fasting,” Jason Fung, MD recommends
drinking coffee with added coconut oil (medium chain triglycerides)/heavy cream (no CHO or
protein) during fasting. [98] Remarkably, caffeine stimulates autophagy, [120-122] while
coconut oil has numerous health benefits. [123-125]
Several studies have suggested that intermittent fasting may not be as beneficial for pre-
menopausal women as it is for men. This is likely because calorie restriction in females is
associated with changes in the release of hypothalamic hormones, which may impact the
menstrual cycle.
Although there are no comparable human studies, experiments in rats have shown that 3–6
months of alternate-day fasting caused a reduction in ovary size and irregular reproductive
cycles in female rats. [126] Similarly, in a murine model, Kumar and Kaur demonstrated that
intermittent fasting negatively influences reproduction in young animals due to its adverse
effects on the complete hypothalamus-hypophysial-gonadal axis. [127] However, it should be
noted that, in this study, the female rats were very young (3 months old), which corresponds to
a human aged 9 years old. [128] Heilbronn et al reported that alternate-day fasting adversely
affected glucose tolerance in nonobese women but not in nonobese men. [129]
Changes in gonadotropins during fasting have only been assessed in one clinical trial to date. In
this trial by Li et al., young women with obesity and polycystic ovarian syndrome (PCOS)
followed an early 8-hour time-restricted eating regimen for 5 weeks. [130] At the conclusion of
the study, LH and FSH remained unchanged. It is possible that alternate-day fasting results in
greater disruption of the hypothalamus-hypophysial-gonadal axis than does 8-hour time-
restricted eating. In addition, the timing of time-restricted eating may be important. Jakubowicz
et al demonstrated that a large meal later in the day (at dinner) augmented estrogen levels in
women with PCOS as compared to eating earlier in the day. [131]
There are many anecdotal stories of women who have experienced changes to their menstrual
cycles after starting intermittent fasting (likely alternate-day or fasting > 24 hours). For this
reason, pre-menopausal women may need to follow a modified approach. To reduce any
adverse effects, women should take a mild approach to fasting: shorter fasts and fewer fasting
days. We would suggest beginning a program of time-restricted eating consisting of fasting for
12 hours for two to three days a week and increasing from there (see Figure 4). Furthermore,
the fasting window should begin at least 4 hours before going to sleep.
It is important to emphasize that patients should eat real food (as opposed to processed food)
and a low-carbohydrate, high-fat (LCHF) diet is preferred (e.g., Keto diet,). Fasting days should
be nonconsecutive and spaced evenly across the week (for example, Monday, Wednesday, and
Friday). With time, the fasting window can slowly be increased to 16 hours and the number of
fasting days per week increased. It has been suggested (with no published data) that the cycle of
intermittent fasting be linked to the menstrual cycle; namely, with a 16-hour fasting window

from day 1 to day 10 (including Keto), a 12-hour fasting window on days 11-16 (with Keto), and a
“normal” dietary pattern on days 17-28 (including more carbohydrates with a less strict Keto
diet). In women who follow a more conservative intermittent fasting regimen, the addition of
resveratrol and spermidine may augment autophagy (see below).
Figure 4. An Intermittent Fasting Plan for Pre-Menopausal Women
Feedback on “productive approach” from a pre-menopausal patient:
“I started 14:10 daily for a couple of weeks (14 hours fasting, eating for 10 hours); Then 16:8
daily for another two weeks (16 hours fasting; eating for 8 hours); Finally,18:6 for 3-4 days
out of a week with the rest of the week 16:8.
I try to stop any oral intake other than water three hours before bedtime — I found this is the
most critical factor in how I feel the next day. I have not noticed any side effects from
intermittent fasting other than a few pounds of unintentional weight loss. However, I have
experienced an improvement in my health.”
____________________________

• Ivermectin; 0.2-0.3 mg/kg daily. Ivermectin has potent anti-inflammatory properties. [110-112]
Ivermectin binds to the spike protein, aiding in the elimination by the host. [113-115] It is likely
that ivermectin and intermittent fasting act synergistically to rid the body of the spike protein.
Ivermectin is best taken with or just following a meal for greater absorption. A trial of ivermectin
should be included in the first-line treatment approach. The duration of treatment is
determined by the clinical response. If no improvement is noted after 4-6 weeks, the drug
should be stopped. In patients who have a suboptimal response a trial of a higher dose can be
considered (0.6mg/kg day). It appears that vaccine-injured patients can be grouped into two
categories: i) ivermectin responders and ii) ivermectin non-responders. This distinction is
important, as the latter are more difficult to treat and require more aggressive therapy. Due to
the possible drug interaction between quercetin and ivermectin, these drugs should not be
taken simultaneously (i.e., should be staggered morning and night). The safety of ivermectin in
pregnancy is uncertain and this drug should therefore be avoided in the first trimester of
pregnancy. [132]
Table 1. How to Calculate Ivermectin Dose
Note that ivermectin is available in different strengths (e.g., 3, 6 or 12 mg) and administration forms (tablets,
capsules, drops, etc.). Note that tablets can be halved for more accurate dosing, while capsules cannot.
How much do I weigh? What dose does the protocol say?

In pounds In kilos 0.2 mg/kg 0.3 mg/kg 0.4 mg/kg 0.6 mg/kg
70–90 32–41 6-8 mg 10-12 mg 13-16 mg 19-25 mg
91–110 41–50 8-10 mg 12-15 mg 17-20 mg 25-30 mg
111–130 50–59 10-12 mg 15-18 mg 20-24 mg 30-35 mg
131–150 60–68 12-14 mg 18-20 mg 24-27 mg 36-41 mg
151–170 69–77 14-15 mg 21-23 mg 27-31 mg 41-46 mg
171–190 78–86 16-17 mg 23-26 mg 31-35 mg 47-52 mg
191–210 87–95 17-19 mg 26-29 mg 35-38 mg 52-57 mg
211–230 96–105 19-21 mg 29-31 mg 38-42 mg 58-63 mg
231–250 105–114 21-23 mg 32-34 mg 42-45 mg 63-68 mg
251–270 114–123 23-25 mg 34-37 mg 46-49 mg 68-74 mg
271–290 123–132 25-26 mg 37-40 mg 49-53 mg 74-79 mg
291–310 132–141 26-28 mg 40-42 mg 53-56 mg 79-85 mg
• Moderating physical activity. Patients with long COVID and post-vaccine symptoms frequently
suffer from severe post-exertional fatigue and/or worsening of symptoms with exercise.
[133;134] Aerobic exercise is reported to be one of the worst therapeutic interventions for these
patients. Similar to patients with chronic fatigue syndrome, post-exertional fatigue may be
related to mitochondrial dysfunction and the inability to augment production of ATP.
[133;135;136] Magnetic resonance–augmented cardiopulmonary exercise testing suggests
failure to augment stroke volume as a potential mechanism of exercise intolerance in patients
with long COVID. [137] We recommend moderating activity to tolerable levels that do not
worsen symptoms, keeping the patient’s heart rate under 110 BPM. Furthermore, patients need
to identify the activity level beyond which their symptoms worsen, and then aim to stay below
that level of activity. Stretching and low-level resistance exercises are preferred over aerobic
exercises.

• Low-dose naltrexone (LDN); 1-4.5 mg daily. LDN has been demonstrated to have anti-
inflammatory, analgesic, and neuromodulating properties. [138;139] Begin with 1 mg/day and
increase to 4.5 mg/day, as required. May take 2 to 3 months to see the full effect.
• Resveratrol; 400-500 mg daily. Resveratrol is a plant phytochemical (flavonoid) that has

remarkable biological properties. [140-142] Most importantly it activates autophagy. [143;144]
In addition, resveratrol has anti-inflammatory, antiviral (SARS-CoV-2), antioxidant and
anticoagulant properties and has beneficial effects on the microbiome. Resveratrol also binds to
spike protein helping to promote autophagy. Generally, the oral bioavailability of resveratrol is
poor. [145] However, a bio-enhanced formulation containing trans-resveratrol from Japanese
Knotweed Root appears to have improved bioavailability. Quercetin, a plant flavonoid with
many of the biological properties of resveratrol, acts synergistically with resveratrol and
remarkably increases the bioavailability of resveratrol. [146-148] Pterostilbene, is another plant
flavonoid similar to resveratrol in structure with similar biological properties. [149-151]
However, pterostilbene's unique structure makes it more oil-soluble than resveratrol, which
increases its absorption and cellular uptake while reducing the rate of elimination from the
body. Research has shown that pterostilbene has seven times the half-life of resveratrol and has
greater bioactivity in reducing the effects of oxidative stress. We, therefore, suggest a “high
quality” combination supplement with resveratrol and quercetin and ideally also containing
pterostilbene. For acutely symptomatic patients, resveratrol in a dose of 500 mg twice daily is
suggested. In recovered patients and those on preventative/maintenance therapy, a dose of
400-500 mg/day should suffice. The safety of these phytochemicals has not been determined in
pregnancy and they should therefore be avoided. Due to the possible drug interaction between
quercetin and ivermectin, these drugs should not be taken simultaneously (i.e., should be
staggered morning and night). The use of quercetin has rarely been associated with
hypothyroidism. [152] The clinical impact of this association may be limited to those individuals
with pre-existent thyroid disease or those with subclinical thyroidism. Quercetin should be used
with caution in patients with hypothyroidism and TSH levels should be monitored.
• Melatonin; 2-6 mg slow release/extended release before bedtime. Melatonin has anti-
inflammatory and antioxidant properties and is a powerful regulator of mitochondrial function.
[153-157] The dose should be started at 750 mcg (μg) to 1 mg at night and increased as
tolerated. Patients who are slow metabolizers may have very unpleasant and vivid dreams with
higher doses.
• Aspirin; 81 mg daily (see previous anticoagulation section).
• Methylene blue; 10-30 mg daily. Methylene blue (MB) has several biological properties that
may be potentially beneficial in vaccine-injured patients. MB induces mitophagy (mitochondrial
autophagy) and has anti-inflammatory, antioxidant, neuroprotective, and antiviral properties.
[158;159] A study in 2013 found that methylene blue-induced neuroprotection is mediated, at
least in part, by macroautophagy through the activation of AMPK signaling. [160] MB easily
crosses the BBB and preferentially enters neuronal mitochondria. MB has high bioavailability in
the brain with brain tissue levels tenfold higher than serum levels. [161;162] Low-dose
methylene blue (LDMB) stimulates mitochondrial respiration by donating electrons to the
electron transport chain. MB can reroute electrons directly from complex I to complex III,
avoiding electron leakage and subsequent ROS production.

MB and photobiomodulation (PBM) have similar beneficial effects on mitochondrial function,
oxidative damage, and inflammation. Treatment with MB is therefore often combined with PBM
therapy. [163;164]. However, because PBM and MB exert beneficial effects through distinct
mechanisms, combining the use of these two therapies is expected to improve therapeutic
outcomes synergistically. Numerous studies indicate an improvement in brain mitochondrial
function and neurological function following treatment with MB and PBM for a spectrum of
neurological diseases. [162;163;165]
Low Dose Methylene Blue (LDMB) is a therapeutic option in patients with brain fog and other
neurological symptoms; this can be combined with transcranial photobiomodulation. Patients
and/or their healthcare providers must purchase high-quality, impurity-free, pharmaceutical-
grade methylene blue. Patients may purchase a 1% methylene blue solution (e.g.
https://www.bphchem.com/product/methylene-blue-1-usp-grade-50-ml-1-drop-contains-0-5-
mg-of-methylene-blue/), MB Buccal Trouches (https://troscriptions.com/products/), or MB in a
powder form requiring reconstitution into a 1% solution (e.g. from CZTL at
https://cztl.bz/?ref=Lwr85 ). Trouches will cause blue staining of the mouth and teeth; they can
be swallowed to avoid this effect.
A 1% methylene blue solution contains 10 mg MB in 1 ml solution (and 0.5 mg/drop). A 1% MB

solution is formulated by mixing 1 gram of methylene blue with 100 ml of water. Use a dropper
bottle to administer — 1 drop of 1% solution is approximately 0.5 mg of methylene blue).
Dosing of LDMB:
• Start with 5 mg (.5 ml or 10 drops) twice daily for the first week.
• Then gradually increase the dosage every 2-3 days (guided by symptoms - i.e.,
improvement in fatigue and/or cognitive improvement) until you reach a maximum of
30 mg (3 ml) per day (30 drops twice daily).
• Take the 7th day off every week to allow the body to “reset”.
The optimal dose is highly individualized and each patient needs to find the right dose for them.
LDMB will cause your urine to be blue or blue-green. Some patients may experience a Herx
reaction. A Herx reaction may cause fatigue, nausea, headache, or muscle pain. If you
experience a Herx reaction, stop the protocol for 48 hours and then resume again slowly.
CAUTIONS:
• DO NOT take MB if you are pregnant or breastfeeding.

• MB is a potent monoamine oxidase inhibitor (MAOI) that, in conjunction with an SSRI,
can potentiate serotonin syndrome, a life-threatening medical emergency. This
combination of medications is to be strongly avoided. [162] Do not take fluvoxamine,
fluoxetine or bupropion, or any other SSRI/NDRI (Norepinepine-Dopamine Reuptake
Inhibitor) with MB.
• MB increases the toxicity of hydrocodone bitartrate by increasing serotonin levels in the
blood. This combination should be avoided.

• Individuals with glucose-6-phosphate dehydrogense deficiency (G6PD) should not be
treated with MB as it can cause hemolytic anemia.
• Sunlight and Photobiomodulation (PBM). PBM is referred to in the literature as low-level light
therapy, red light therapy, and near-infrared light therapy. Our forefathers roamed the earth
and were exposed to sunlight daily, likely with profoundly important health benefits. [166] The
spectral radiance of solar radiation extends from 10 nm to about 3000 nm i.e., the spectrum
from ultraviolet (10-400 nm), visible (400-700 nm with red light 600-700 nm), near-infrared
radiation (750-1500 nm (NIR-A)) and mid-infrared radiation (1500- 3000 nm (NIR-B)).
Of all the wavelengths of sunlight, NIR-A radiation has the deepest penetration into tissues,
being up to 23cm. NIR-A in the range of 1000 to 1500 nm is optimal for heating tissues. Sunlight
has great therapeutic powers. Indeed, during the 1918 influenza pandemic, “open-air treatment
of influenzae” appeared to be the most effective treatment for seriously ill patients. [167] The
Surgeon-General of Massachusetts reported that “plenty of air and sunshine” was highly
effective for the treatment of influenza pneumonia. He reported that “very little medicine was
given after the value of plenty of air and sunshine had been demonstrated.” Further, he
comments “from being discouraged, the medical staff became enthusiastic, and the patients
were treated with the confidence that at last something had been found which would give good
results.”
A more recent large prospective study demonstrated that avoiding sun exposure is a risk factor
for all-cause mortality. [168] In this study, the mortality rate amongst avoiders of sun exposure
was approximately twofold higher compared with the highest sun exposure group. Apart from
UV radiation stimulating vitamin D synthesis, red and near-infrared (NIR) radiation have a
profound effect on human physiology, notably acting as a mitochondrial stimulant and
increasing ATP production. [169]
The most well-studied mechanism of action of PBM centers around enhancing the activity of
cytochrome c oxidase, which is unit four of the mitochondrial respiratory chain, responsible for
the final reduction of oxygen to water. In addition, one of the most reproducible effects of PBM
is an overall reduction in inflammation. PBM has been shown to reduce markers of M1
phenotype in activated macrophages. [169] Many reports have shown reductions in reactive
nitrogen species and prostaglandins in various animal models. In addition, PBM activates a wide
range of transcription factors leading to improved cell survival. It has also been suggested that
NIR light increases the production of melatonin in mitochondria. [170]
In an outstanding in vitro study, Aguida et al demonstrated that infrared light caused a marked
reduction in the TLR-4-dependent inflammatory response pathway in a human cell culture line.
[171] In this study, infrared light exposure resulted in a significant decline in NFkB and AP1
activity as well as a marked decrease in the expression of proinflammatory genes. The increased
body temperature induced by NIR-A and NIR-B activates the production of heat shock proteins
(which increase autophagy) as well as essential cell stress survival pathways.
Emerging data suggest that transcranial PBM has beneficial effects in a range of neuro-
psychiatric diseases including stroke, traumatic brain injury, Alzheimer's disease, Parkinson’s
disease, and depression. [172-175] PBM has been suggested to have a role in the prevention
and treatment of COVID-19. [176] A recent double-blind, sham-controlled study using an LED

device demonstrated a marked improvement in the condition of hospitalized patients with
acute COVID-19 infection. [177] Based on this data we suggest that patients expose themselves
to about 30 mins of midday sunshine whenever possible (at least 3 times a week). A brisk
midday walk is a viable alternative. When neither of these interventions is feasible or practical,
and in those who wish to avoid ultraviolet radiation exposure, patients can expose themselves
to red and NIR radiation emitted from LED panels. Those interested in this therapy are
recommended to read the book by Ari Whitten entitled “The Ultimate Guide to Red Light
Therapy.” [178] A number of LED panels with multiple red and IR lights are commercially
available (e.g. https://mitoredlight.com/, https://hoogahealth.com/,
https://platinumtherapylights.com/.
The disadvantage of LED panels is they do not mimic that of solar radiation as they deliver 1-10
nm wide spiked emissions of red light at 660 nm and NIR-A at 830 nm. In contrast, ThermaLight®
bulbs (SaunaSpace® Saunas™) have a radiation spectrum closely resembling that of solar
radiation, but without UV radiation. About 39% of the emitted spectrum of the ThermaLight®
bulb is NIR-A (the solar spectrum has 41% IR-A) and about 41% of the radiation is in the IR-B
range; part of IR-A and IR-B (1000-3000 nm) contributes to the thermal effects of emitted
radiation, which promotes induced hyperthermia (sauna therapy) and is discussed below under
“Other Potential Therapies”.
• Probiotics/prebiotics; Patients with post-vaccine syndrome classically have a severe dysbiosis

with loss of Bifidobacterium. [179-181] A no-sugar-added, Greek yogurt with both pre- and
probiotics is recommended. Suggested probiotics include Megasporebiotic (Microbiome labs),
TrueBifidoPro (US Enzymes), and yourgutplus+. [182] In addition, the use of Glucomannan
(from Konjac root) and/or Chia seeds provide soluble and insoluble fiber (prebiotic) required for
the normalization of the microbiome. [297-299] If patients have moderate to severe dysbiosis
and/or small bowel bacterial overgrowth (SBIO) then prebiotics may have the unwanted effect
of ''feeding the bad bacteria" and contributing to worsening of the dysbiosis. Probiotics alone
and/or fermented foods are less likely to harbor and nourish commensal and abnormal gut
microbes. Depending on the brand, some pro/prebiotic products can be very high in sugar,
which promotes inflammation. Look for brands without added sugar and try to choose products
that are also gluten-free, casein-free, and soy free.
• Spermidine; 1000-2000 mg (wheat germ extract) daily. Spermidine is a naturally occurring

polyamine that, like resveratrol, has anti-inflammatory and antioxidant properties. It preserves
mitochondrial function and has been shown to reduce cardiovascular disease and all-cause
mortality, and prolong lifespan. [183;184] Furthermore, like resveratrol, spermidine promotes
autophagy. However, resveratrol and spermidine activate autophagy via different metabolic
pathways and are therefore likely to have additive or synergistic effects. [185] Wheatgerm,
mushrooms, grapefruit, apples, and mango are high natural sources of spermidine. [186]
Wheatgerm supplements contain high amounts of spermidine with good bioavailability. A dose
of 1000-2000 mg wheat germ extract daily is suggested. Cancer cells are reported to have
dysregulated polyamine metabolism and spermidine is therefore best avoided in patients with a
known malignancy. [187] In addition, spermidine should be avoided in men over the age of 60
who are at high risk of an ischemic stroke. [188]

Adjunctive/Second-Line Therapies
(Listed in order of importance)
• Magnesium; 100-400 mg daily. There are at least 11 different types of magnesium that can be
taken in supplement form with varying bioavailability. Generally, organic salts of Mg have a
higher solubility than inorganic salts and have greater bioavailability. [189] Magnesium citrate is
a widely used type of magnesium in salt form and is often recommended to treat constipation;
high doses may cause diarrhea and prolonged use should be avoided. Magnesium oxide and
magnesium citrate compounds, commonly prescribed by physicians, have poor bioavailability.
[190] Magnesium Malate, Taurate, Glycinate, and L-threonate have good bioavailability and will
readily increase RBC magnesium levels. Magnesium taurate and magnesium L-
threonate significantly increase magnesium levels in brain cells; hence they are used in the
treatment of depression and Alzheimer’s disease. [190;191] A starting dose of 100 to 200 mg
daily is suggested, increasing the dose as tolerated up to 300 mg (females) to 400 mg daily.
Endpoints of treatment include an RBC-Mag at the higher end of the normal range (between 4.2
and 6.8 mg/dL to be about 6.0 ng/dL). High intakes of magnesium from dietary supplements and
medications can cause diarrhea, nausea, and abdominal cramping.
• N-acetyl cysteine (NAC); 600-1500 mg/day [192-194] NAC is the precursor of reduced
glutathione. NAC penetrates cells where it is deacetylated to yield L-cysteine thereby promoting
GSH synthesis. [194] Based on a broad range of antioxidant, anti-inflammatory, and immune-
modulating mechanisms, the oral administration of NAC likely plays an adjuvant role in the
treatment of the vaccine injured. Several studies showed that NAC is well absorbed by the
intestine and that supplementation with NAC is effective for increasing GSH levels.
Oral glutathione is poorly absorbed and is generally not recommended. [195;196] However,
acetyl glutathione is more lipophilic than glutathione, sufficiently so to be taken up intact by
cells, and has been shown to rapidly raise intracellular GSH levels. A combination supplement
that contains acetyl glutathione, NAC, and Vitamin C may enhance the bioavailability of
glutathione. In addition, liposomal glutathione has been demonstrated to increase tissue levels,
antioxidant capacity, and immune function. [197]
• Cardio Miracle™ and L-arginine/L-citrulline supplements. Cardio Miracle is a supplement with

over 50 ingredients formulated to increase nitric oxide (NO) production. The supplement
contains L-arginine, L-citrulline, Beetroot (high in dietary nitrates), L-Ornithine, CoQ10, as well as
a blend of fruit and vegetable phytonutrients. L-Arginine is the substrate used for NO production
by nitric oxide synthetase (NOS). [257] Patients with acute COVID-19 infection have been
demonstrated to have low plasma L-arginine levels. [258] In addition, COVID-19 syndromes are
characterized by suppressed endothelial nitric oxide synthase (eNOS) activity compounding the
deficiency of NO. [259;260] The spike protein itself may play a major role in inhibiting eNOS
activity. The NO deficiency is a major factor causing endothelial dysfunction and thrombotic
events. Furthermore, activation of the NO-cyclic GMP pathway has anti-inflammatory effects
modulating activated T cells, reducing cytokine release, and stimulating vascular repair. [261] In
addition, L-arginine itself is important for normal T cell function and macrophage M1-to-M2
switch. [257] It is likely that an L-arginine/L-citrulline supplement will have additive or
synergistic effects when combined with a phosphodiesterase-5 inhibitor. (see below). L-arginine
should likely be avoided in patients with active malignancies. [198;199]

• Omega-3 fatty acids; we suggest a combination of EPA/DHA with an initial dose of 1 g/day
(combined EPA and DHA) and increasing up to 4 g/day (of the active omega-3 fatty acids). The
omega-3 fatty acids have anti-inflammatory and cardioprotective effects and play an important
role in the resolution of inflammation by inducing resolvin production. [200;201] Furthermore,
omega-3 fatty acids are believed to afford potent vasculoprotective effects, by improving
endothelial function, limiting vascular inflammation, reducing thrombosis, and limiting reactive
oxygen species production. [202] Fish, particularly wild Atlantic (or Alaskan) salmon, are a good
source of omega-3 fatty acids. Omega-3 supplements include Vascepa™ (icosapent ethyl; an
ethyl ester of eicosapentaenoic acid [EPA]), Lovaza ™ (a combination of ethyl esters of EPA and
docosahexaenoic acid [DHA]) as well as “regular fish oil supplements” containing a combination
of EPA/DHA. It is unclear if the reported cardiovascular and anti-inflammatory benefits of
omega-3 fatty acids are predominantly due to EPA (i.e., Pharma marketing) or the combination
of EPA and DHA. [203-210] However, it is now widely appreciated that ”EPA and DHA are
metabolized to different mediators and are equally important with respect to cardiovascular
protection (and inflammation).” [207] Based on this data we suggest a combination of EPA/DHA
with an initial dose of 1 g/day (combined EPA and DHA) and increasing up to 4 g/day (of the
active omega-3 fatty acids).
• Sildenafil with or without L-arginine-L-Citrulline [211-216]; Sildenafil doses titrated up from 25

to 100 mg 2-3 times daily with L-arginine/L-citrulline powder twice daily. May be helpful for
brain fog as well as microvascular disease with clotting and poor perfusion. It is noteworthy that
curcumin, resveratrol, EGGG, and valproic acid all potentiate phosphodiesterase 5 (PDE5)
inhibitors.
• Nigella sativa; 200-500 mg encapsulated oil twice daily. Nigella sativa is a small shrub native to
Southern Europe, North Africa, and Southeast Asia. The seeds and oil of Nigella sativa have been
used as a medical agent for thousands of years. The most important active component is
thymohydroquinone. Nigella sativa has antibacterial, antifungal, antiviral (SARS-CoV-2), anti-
inflammatory, antioxidant, and immunomodulatory properties. [217;218] A dose of 200-500 mg
twice daily of the encapsulated oil is suggested. [217-220] It should be noted that
thymohydroquinone decreases the absorption of cyclosporine and phenytoin. Patients taking
these drugs should, therefore, avoid taking Nigella sativa. [221] Furthermore, two cases of
serotonin syndrome have been reported in patients taking Nigella sativa who underwent
general anesthesia (probable interaction with opiates). [222]
• Vitamin C; 1000 mg orally two to three times a day. Vitamin C has important anti-inflammatory,
antioxidant, and immune-enhancing properties, including increased synthesis of type I
interferons. [223-227] Avoid in patients with a history of kidney stones. Oral Vitamin C helps
promote the growth of protective bacterial populations in the microbiome.
• Vitamin D (4000-5000 units/day) and Vitamin K2 (100 mcg/day); The dose of Vitamin D should
be adjusted according to the baseline Vitamin D level. However, a dose of 4000-5000 units/day
of Vitamin D, together with Vitamin K2 100 mcg/day is a reasonable starting dose.
• Fluvoxamine; 50 mg twice daily: Start on a low dose of 12.5 mg/day and increase slowly as
tolerated. NOTE: Some individuals who are prescribed fluvoxamine experience acute anxiety,

which needs to be carefully monitored for and treated by the prescribing clinician to prevent
rare escalation to suicidal or violent behavior.
• Non-invasive brain stimulation (NIBS), using transcranial direct current stimulation or

transcranial magnetic stimulation, has been demonstrated to improve cognitive function in
patients with long COVID as well as other neurological diseases. [228-235] NIBS is painless,
extremely safe, and easy to administer. NIBS is a recognized therapy offered by many Physical
Medicine and Rehabilitation Centers (e.g., see
https://www.hopkinsmedicine.org/physical_medicine_rehabilitation/services/programs/brain-
stimulation/treatment.html). Patients may also purchase an FDA-approved device for home use
(e.g., https://www.fisherwallace.com)
• Intravenous Vitamin C; 25 g weekly, together with oral Vitamin C 1000 mg (1 gram) 2-3 times
per day. High-dose IV vitamin C is “caustic” to the veins and should be given slowly over 2-4
hours. Furthermore, to assess patient tolerability the initial dose should be between 7.5-15 g.
Total daily doses of 8-12 g have been well-tolerated, however, chronic high doses have been
associated with the development of kidney stones, so the duration of therapy should be limited.
[103-108] Wean IV Vitamin C as tolerated.
• Behavioral modification, relaxation therapy, mindfulness therapy [236], and psychological

support may help improve patients’ overall well-being and mental health. [237] Suicide is a real
problem in the vaccine-injured patient. Support groups and consultation with mental health
professionals are important. Tai Chi, a health-promoting form of traditional Chinese martial art,
has been shown to be beneficial for preventing and treating diseases including long COVID.
[238;239] Yoga has immunomodulating properties that may be beneficial in vaccine-injured
patients. [240]
Third-Line Therapies
• Hyperbaric oxygen therapy (HBOT) [241-249]; HBOT has potent anti-inflammatory properties,
decreasing pro-inflammatory cytokines while increasing IL-10. Furthermore, HBOT polarizes
macrophages toward the M2 phenotype and improves mitochondrial function. Surprisingly, it is
the increased pressure, rather than the increase in the concentration of dissolved oxygen, that
appears to mediate these effects. HBOT is delivered at varying pressures, both with and without
oxygen. The addition of oxygen increases the clinical response. Maximal clinical response is
achieved via the use of high-pressure chambers (typically reaching 2.4 ATM) with 100% oxygen
for 60-90 minutes. If HBOT is delivered using lower pressure chambers (less than 1.5 ATM)
without supplemental oxygen, the clinical response, although present, is significantly less such
that a higher number of sessions will be needed to reach a clinical plateau.
Zilberman-Itskovich et al performed a randomized, sham-controlled, double-blind trial that

evaluated the effect of HBOT in 73 patients with long COVID. [250] Both HBOT and sham
patients received 40 daily sessions (five times a week) in a multi-place chamber. The HBOT
protocol included breathing 100% oxygen by mask at 2 ATM for 90 minutes. In the HBOT group,
there was a significant improvement in global cognitive function, attention, and executive
function as well as an improvement in the energy domain, psychiatric symptoms, and pain level.
Clinical outcomes were associated with significant improvement in brain MRI perfusion and

microstructural changes. In general, the duration of treatment of HBOT should be based on
clinical response and continued for at least 40 sessions and until the benefit has plateaued. If no
benefit is evident clinically after 10 sessions, then HBOT should be considered a therapeutic
failure. This therapy is limited by logistical issues and cost. Several companies offer to rent
portable, low-pressure chambers with the option to purchase
(https://www.oxyhealth.com/vitaeris-320.html, https://summit-to-sea.com/, https://www.aha-
hyperbarics.com/)
• Low Magnitude Mechanical Stimulation (LMMS or Whole-Body Vibration). Low-magnitude (0.3-

0.4G), high-frequency (32-40 Hz) mechanical stimulation has been demonstrated to increase
bone density as well as indices of general well-being in patients with a variety of medical
disorders. [251] It is postulated that this intervention recruits bone marrow stem cells in
addition to having metabolic and immunologic effects. In humans, low-magnitude acceleration
is applied through the feet by standing on a platform oscillating at relatively high resonant
frequency. These parameters are very safe, painless, and easy to administer. This therapy is
offered by Physical Medicine and Rehabilitation Centers, or a device may be purchased for
home use https://www.juvent.com/health/) similarly with noninvasive brain stimulation (NIBS).
• “Mitochondrial energy optimizer” with pyrroloquinoline quinone, glycophospholipids, CoQ10,

NADH, and other nutrients (e.g., Life Extension Energy Optimizer, Restorative Solutions
Mitochondrial Nutrition PQQ, Researched Nutritionals ATP 360® and ATP Fuel® and Pure
Encapsulations Mitochondria-ATP) [252-258]
• Hydroxychloroquine (HCQ); 200 mg twice daily for 1-2 weeks, then reduce as tolerated to 200
mg/day. HCQ is a potent immunomodulating agent and is considered the drug of choice for
systemic lupus erythematosus (SLE), where it has been demonstrated to reduce mortality from
this disease. Thus, in patients with positive autoantibodies or where autoimmunity is suspected
to be a prominent underlying mechanism, HCQ should be considered earlier. Further, it should
be noted that SLE and post-vaccine syndrome have many features in common. HCQ is safe in
pregnancy; indeed, this drug has been used to treat preeclampsia. [259-263] With long-term
usage, the dose should be reduced (100 or 150mg/day) in patients weighing less than 61 kg (135
lbs.). It should be noted that HCQ will limit the effectiveness of intermittent fasting.
• Low dose corticosteroid; 10-15 mg/day prednisone for 3 weeks. Taper to 10 mg/day and then 5
mg/day, as tolerated.
Patients with elevated homocysteine levels

Patients with elevated homocysteine levels may benefit from treatment with 800 ug of 5-methyl
tetrahydrofolate (5-MTHF), the most biologically active form of folic acid. [264] Supplementation with
folic acid alone will paradoxically increase homocysteine levels, particularly in patients with MTHFR
polymorphism. [264] In addition, B complex vitamins containing B2 (riboflavin) and Vitamin B6,
magnesium, and Vitamin D should be added. [62]

Other Potential Treatments
(Further evaluation required)
• Plasmapheresis. Plasmapheresis improves systemic cytokine levels, coagulopathy, and immune

responsiveness in patients with severe COVID with a potential mortality benefit. [265-272]
Kiprov, et. al. have published a case report of a dramatic clinical improvement in a patient with
long COVID. [273] In this report, the patient’s markers of inflammatory macrophages
diminished, and markers of lymphocytes, including natural killer cells and cytotoxic CD8 T-cells,
increased; in addition, circulating inflammatory proteins diminished. Furthermore, it is likely
that plasmapheresis removes autoantibodies and improves the coagulopathy of these patients.
We are aware of anecdotal reports of marked improvement in neurological symptoms,
especially SFN and brain fog in vaccine-injured patients treated with this therapeutic modality.
However, this is a limited and expensive resource that, in itself, is not without complications.
Furthermore, the durability of the clinical response needs to be determined. While
plasmapheresis/plasma exchange is a therapeutic option for the severely neurologically
impaired patient following vaccination, additional data is required before this modality can be
widely recommended.
• Valproic acid [274;275]; Depakote, 250mg 2-3 times daily. Valproic acid has anti-inflammatory
effects and polarizes macrophages towards an M2 phenotype. [276] Histone deacetylase (HDAC)
inhibitors are being studied for neural regeneration. In addition, valproic acid has important
anticoagulant and anti-platelet effects [277] and is an inducer of heat shock proteins. [278]
Valproic acid may be helpful for neurological symptoms. Treatment should be limited to less
than 6 to 9 months due to the concern for the loss of brain volume particularly in those patients
with cognitive dysfunction. [279] In a cerebral ischemia/hypoxia model resveratrol markedly
enhanced the neuroprotective effects of valproic acid. [280] Furthermore, resveratrol has been
reported to reverse the toxicity of valproic acid, [281;282]. These data suggest that resveratrol
(in a dose of 500 mg – 1000 mg twice daily) should be recommended in patients prescribed
valproic acid.
• Induced hyperthermia and Cold Hydrotherapy. The role of sauna bathing and cold therapy
(cold showers, cold baths) in patients with long COVID and vaccine injury is unknown. [283;284]
Regular sauna bathing has been proven to reduce all-cause and cardiovascular mortality,
prolong lifespan, improve exercise performance, and improve the outcome of patients with
neuropsychiatric disease. [285-289] Induced hyperthermia increases the expression of heat
shock proteins, which activates autophagy. In addition, heat therapy increases the expression of
cell stress pathways, has antioxidant and anti-inflammatory effects, and improves mitochondrial
function. [283] Sauna bathing has very similar physiologic effects to that of aerobic exercise
(increase heart rate, stroke volume, and cardiac output). [290;291] As patients with long COVID
and the vaccine-injured are exercise intolerant (they cannot increase cardiac output) [137]
sauna bathing may be poorly tolerated. However, sauna bathing and induced hyperthermia
have been shown to improve endothelial and cardiac function in patients with chronic heart
failure. [292] Furthermore a recent meta-analysis reported that sauna bathing improved cardiac
function in patients with chronic heart failure. [293] Waon therapy (infrared dry sauna) has
shown promising results in patients with chronic fatigue syndrome. [294;295] Patients
interested in sauna bathing should determine their tolerance to short sessions (5-10 mins) and
increase the duration as tolerated (up to 20 minutes) three to four times a week. Similarly, the

role of cold therapy in the vaccine-injured is unknown; patients should similarly determine their
tolerance to this treatment approach. [296;297]
• Pentoxifylline (PTX); PTX ER, 400 mg three times daily, should be considered in those patients
with severe microcirculatory disturbances. PTX is a non-selective phosphodiesterase drug that
has anti-inflammatory and antioxidant effects. [224] In addition, PTX improves red blood cell
deformability and reduces blood viscosity, so can mitigate the hyper-viscosity and RBCs hyper-
aggregation, which is linked with the development of coagulopathy in the vaccine injured.
• Maraviroc; 300 mg orally twice daily. If 6 to 8 weeks have elapsed and significant symptoms
persist despite the above therapies, this drug can be considered. Note Maraviroc can
be expensive and has a risk of significant side effects and drug interactions. Maraviroc is a C-C
chemokine receptor type 5 (CCR5) antagonist. While many long COVID and post-vaccine patients
have been treated with Maraviroc, the role of this drug requires further evaluation. [298]
• Sulforaphane (broccoli sprout powder) 500 mcg – 1g twice a day. While sulforaphane has many
potential benefits in patients with COVID, [299-301] long COVID and post-vaccine syndrome,
there is limited clinical data to support this intervention. Sulforaphane has immunomodulatory
effects by targeting monocytes/macrophages, suggesting a benefit in chronic inflammatory
conditions. [299-301] Sulforaphane is a beneficial supplement that may be useful for reducing
microglial-mediated neuroinflammation and oxidative stress. In addition, as has been well-
popularized, sulforaphane has an important role in cancer prophylaxis. The pharmacology and
optimal dosing of sulforaphane are complex. Sulforaphane itself is unstable. The supplement
should contain the two precursors, glucoraphanin and myrosinase, which react when the
supplement is consumed. Broccoli “extracts” are produced in a way that completely destroys
the activity of the myrosinase enzyme. As such, these extracts are incapable of producing
sulforaphane when consumed in a supplement or food. [302;303] We recommend a 100%
whole broccoli sprout powder, which maximally retains both glucoraphanin and
myrosinase whilst, at the same time, deactivating the inhibitors.
• Dandelion (Taraxacum officinale). The root, flower, and leaves of dandelion contain an array of
phytochemicals that have anti-inflammatory, antioxidant, hypolipidemic, antimicrobial, and
anticoagulant properties. [304;305] It is widely reported that dandelion is effective for
‘detoxifying’ spike protein. An in vitro study demonstrated that a dandelion leaf extract altered
the binding of SARS-CoV-2 spike protein to the ACE receptor. [306] It would appear that this
effect was due to alterations (binding) of the ACE-2 receptor rather than binding to the spike
protein. It, therefore, remains unclear whether dandelion extract actually binds to the spike
protein and would potentiate clearance of this protein. The European Scientific Cooperative on
Phytotherapy recommends a dose of 4-10 g TID (20-30mg/ml in hot water). [307] It should be
noted that Dandelion extract is considered contraindicated in those with liver and biliary
disease, bile duct obstruction, gallstones, cholangitis, and active peptic ulcer. [307] Furthermore
dandelion is rich in potassium and should be used cautiously in patients with kidney failure.
• VEDICINALS® 9; a unique phytopharmaceutical-based therapeutic suspension that consists of

nine bioactive compounds with antiviral, anti-inflammatory, immune-modulatory, antipyretic,
and analgesic properties. The compounds include Baicalin, Quercetin, Luteolin, Rutin,
Hesperidin, Curcumin, Epigallocatechin Gallate, Piperine, and Glycyrrhizin.
(https://www.vedicinals.com/vedicinals-9/). A number of these compounds are included in our

protocol and the additional benefit of this 9 phytopharmaceutical combination over more
widely available flavonoid combinations is unknown. [308]
• C60 or C60 fullerenes [309;310]; C60, short for Carbon 60, is composed of 60 carbon atoms
forming something that looks like a hollow soccer ball and is considered as a “free radical
sponge.” C60 is considered the single most powerful antioxidant ever discovered. Robert Curl,
Harold Kroto, and Richard Smalley were awarded the Nobel Prize for chemistry in 1996 for its
discovery.
• Intravenous immunoglobulin (IVIG) treatment; The role of IVIG in the treatment of the vaccine
injured is unclear. The response to IVIG in the general population of vaccine-injured patients is
mixed, with very few showing long-term improvement. Many patients who report an initial
improvement will relapse in 2 to 3 weeks. Other patients report no benefit, while some appear
worsened. Due to the presence of non-neutralizing anti-SARS-CoV-2 antibodies and anti-ACE-2
antibodies, etc., the real possibility exists that IVIG will cause antibody-dependent immune
enhancement (ADE) with a severe exacerbation of symptoms.
IVIG is, however, recommended in specific autoimmune syndromes, which include Guillain Barré
Syndrome, transverse myelitis, and immune thrombocytopenia. These patients should
concomitantly be treated with the core immune-modulating therapies. IVIG proved to be
ineffective in an RCT that enrolled patients with small fiber neuropathy. [311]
The fact that many patients report an initial response to IVIG supports the notion that many
aspects of this disease are due to autoantibodies. IVIG will remove preformed antibodies, but
they do not prevent the B cells from ongoing antibody production; hence the response is likely
to be short-lived, and interventions that limit the production of autoantibodies are therefore
required (core immune-modulating therapies).
• Immunosuppressive therapies; As a rule, immunosuppressive therapy should be avoided, as

these drugs may exacerbate the immune dysfunction in vaccine-injured patients and prevent
the restoration of immune homeostasis. A trial of immunosuppressive therapy may be indicated
in patients with an established autoimmune syndrome who have failed other therapeutic
interventions.

Disease-Specific Therapeutic Adjuncts
Small fiber neuropathy (SFN)/autonomic neuropathy

• Low-dose naltrexone (LDN) appears to play a pivotal role in the treatment of SFN.
• Tricyclic antidepressants (start at a low dose and increase as tolerated)
• Gabapentin: 300 mg twice daily and increase as tolerated
• Alpha lipoic acid; 600 mg/day (alpha-lipoic acid is an inducer of heat shock proteins). [312]
• POTS – ensure sufficient hydration and consider the use of compression stockings or abdominal
binders
• POTS – Clonidine; 0.1 mg twice daily as tolerated
• POTS – Fludrocortisone; 0.1 to 0.2 mg/day or licorice root (has glycyrrhizinic acid, an
aldosterone-like compound).
• POTS – midodrine; 5-10 mg three times daily
• Whole-body vibration therapy has been shown to improve symptoms of small fiber neuropathy.
[313;314]
• A trial of hyperbaric oxygen therapy (HBOT).
• Zinc; 25 mg daily (elemental zinc) together with the zinc ionophore quercetin. SFN is an
autoimmune disease; zinc deficiency has been associated with the development of autoimmune
diseases. [315]
• It should be noted that the diagnosis of small fiber neuropathy/autonomic neuropathy is a
clinical diagnosis. [47-54] Complex and expensive tests are NOT required to make this diagnosis.
It should be noted that SFN is closely associated with multiple autoantibodies. Testing for these
autoantibodies serves no useful clinical purpose as it does not change the treatment plan.
Generalized neurologic symptoms/“brain fog”/fatigue/visual symptoms

• LDN appears to play a pivotal role in the treatment of many neurological symptoms
• Methylene blue (as indicated above) and photobiomodulation
• Nigella Sativa; 200-500 mg twice daily.
• Non-invasive brain stimulation (NIBS) should be considered in patients with “brain fog,” memory
disturbances, and as well as other cognitive issues.
• Bupropion, a norepinephrine-dopamine reuptake inhibitor has been demonstrated to improve
fatigue and “brain fog” in patients with both cancer and non-cancer-related fatigue.[316;317]
The suggested dose is 150 mg extended-release tablet daily. After a month the dose can be
cautiously increased to 300 mg daily. Bupropion is contraindicated in combination with
methylene blue.
• Intranasal oxytocin. Oxytocin is a nonapeptide produced in the hypothalamus, acting as a
neuropeptide in different brain areas (most notably the amygdala and hippocampus) and as a
hormone and paracrine substance in peripheral organs. [316-318] Oxytocin has colloquially been
referred to as the “love hormone’’, given its role in social interaction and bonding. [319]
Oxytocin has powerful anti-inflammatory and immunomodulating properties and may play an
important role in minimizing neuro-inflammation. [184-186] In addition, oxytocin has been
demonstrated to stimulate neuronal growth [317] Oxytocin plays an important role in
modulating the stress response. [320] Oxytocin has also been reported to have a role in the
prevention and treatment of migraine. [321;322] The nasal route appears to be the preferred
mode of administration. Martins et al performed a dose-finding study in healthy human
volunteers. [187] These authors measured changes in amygdala blood flow and demonstrated

an inverse dose-response curve, with lower doses resulting in a greater increase in blood flow.
They report the optimal dose as being between 9-18 IU. This suggests that one to two puffs to
each nostril (4 IU per puff) two times a day may be optimal (total dosage of 16-32 IU per day).
Oxytocin must be avoided in pregnancy. Oxytocin nasal spray should be compounded at 12 to
15 units/0.1ml (spray) and administered at onset aggressively to upregulate receptors at 2
sprays each nostril BID (8-sprays per day) for the first week and then maintenance at 2 sprays
ea. nostril (4/d) once daily. [323] Oxytocin can also be delivered via SL liquid or via lozenge.
• Spermidine and Resveratrol. Experimental studies have demonstrated that spermidine reduces
neuroinflammation, reduces accumulation of amyloid protein, and improves cognitive function.
[324;325] Similarly, resveratrol has been shown to be useful in the prevention and treatment of
Alzheimer’s disease. [144]
• Valproic acid and pentoxifylline may be of value in these patients.
• Fluvoxamine: Start on a low dose of 12.5 mg/day and increase slowly as tolerated. Some
patients report a significant improvement with fluvoxamine while other patients appear to
tolerate this drug poorly. Fluoxetine 20 mg/day is an alternative, as are tricyclic anti-depressants
(see section on Depression below).
• These symptoms may be mediated by Mast Cell Activation Syndrome (MCAS); see specific
treatment below.
Depression
• Depression is a serious problem in long COVID and post-vaccine patients and, unfortunately, suicide
is not uncommon. [326-328] Patients with a history of depression and/or those taking SSRI
medications appear to be at particular risk of severe depression.
• Patients with depression are best managed by mental health providers with expertise in this area.
Long-term SSRI medications are generally not recommended due to the long-term effects of these
drugs on serotonin receptors, and intracellular messenger pathways as well genetic and epigenetic
effects. [329;330] Short-term fluvoxamine may have a role in these patients. It should be noted that
most SSRI/SNRI agents, but notably sertraline, paroxetine, venlafaxine, and duloxetine are
associated with self-inflicted harm, suicide, anger outbursts, physical violence, homicidal thoughts,
and homicide. [331-333] Patients who are treated with antidepressant agents, therefore, require
close monitoring for the development of these serious adverse reactions.
• There appears to be an interaction between vaccination, COVID-19, zinc levels, and depression.
[334-337] COVID-19 infection and COVID vaccines may lead to low zinc levels. Zinc deficiency is
associated with an increased risk of depression. Treatment with zinc has been shown to have
antidepressant effects and to act synergistically with SSRI medication. [338] 25 mg zinc daily
(elemental), together with the zinc ionophore quercetin is therefore suggested. [337]
• Non-invasive brain stimulation (NIBS) using transcranial direct current stimulation or transcranial
magnetic stimulation has been demonstrated to be highly effective in the treatment of depression.
[339-343] Indeed, The Fisher Wallace Stimulator® is FDA-approved for the treatment of depression,
anxiety, and insomnia. NIBS is painless, extremely safe, and easy to administer. NIBS is a recognized
therapy offered by many Physical Medicine and Rehabilitation Centers. Patients may also purchase
an FDA-approved device for home use (https://www.fisherwallace.com/).
• Methylene blue (dose as indicated above) has been proven to be beneficial in patients with
depression. [344;345] Do NOT TAKE FLUVOXAMINE, FLUOXETINE, BUPROPION, or any other SSRI-
NDRI with MB.
• Photobiomodulation and sauna bathing have been shown to be highly effective for the treatment of
depression. [288;346-348]

• In experimental models, Nigella sativa has been shown to have a role in the treatment of
depression. [349]
• Altered gut flora/dysbiosis has been linked to anxiety and depression and the use of probiotics has
been associated with an improvement in mood. [350-354] Since infection with SARS-CoV-2 and
those who have been vaccinated have dysbiosis the use of pre- and probiotics are suggested.
[180;181;355;356] Unsweetened Greek yogurt with pre and probiotics is recommended. Suggested
probiotics include Megasporebiotic (Microbiome labs) and TrueBifidoPro (US Enzymes) and
yourgutplus+. [182] In addition, the use of Glucomannan (from Konjac root) and/or Chia seeds
provide soluble and insoluble fiber required for the normalization of the microbiome. [357-359] If
patients have moderate to severe dysbiosis and/or small bowel bacterial overgrowth (SBIO) then
prebiotics may have the unwanted effect of ''feeding the bad bacteria" and contributing to
worsening of the dysbiosis. Probiotics alone and/or fermented foods are less likely to harbor and
nourish commensal and abnormal gut microbes.
Patients with elevated DIC and those with evidence of thrombosis

• See the section on anticoagulation. The patient’s risk of bleeding needs to be assessed as this
will determine the aggressiveness of anticoagulation.
• These patients should be treated with a DOAC or coumadin for at least three months and then
reevaluated for ongoing anticoagulation.
• Patients should continue ASA 81 mg/day unless at high risk of bleeding.
• Nattokinase 100-1220mg twice daily is suggested unless at high risk of bleeding.
• Triple anticoagulation should be considered in select patients. [96] Treat no longer than one
month. Triple anticoagulation increases the risk of serious bleeding; patients should be
counseled regarding this complication.
• In those patients with marked microvascular disease/thrombosis, the combination of
pentoxifylline and sildenafil should be given a therapeutic trial. [360;361]
Vaccine-induced myocarditis/pericarditis
• ACE inhibitor/ARB, together with carvedilol as tolerated to prevent/limit progressive decline in
cardiac function.
• Colchicine in patients with pericarditis – 0.6 mg/day orally; increase to 0.6 mg twice daily if
required. Reduce dose if patients develop diarrhea. Monitor white blood cell count. Decrease
dose with renal impairment.
• Magnesium to reduce the risk of serious arrhythmias (see dosing above).
• Coenzyme Q (CoQ) 200-400mg/day. [362-365]
• Omega-3 fatty acids – EPA/DHA 2-4 g/day [366-368] Increase dose slowly as tolerated.
• Resveratrol/flavanoid combination for its anti-inflammatory and antioxidant properties.
• Referral to a cardiologist or ER in case of persistent chest pain or other signs and symptoms of
cardiac events are observed.
Herpes virus reactivation syndrome

• Valtrex; 500-1000 mg twice daily for 7-10 days (acyclovir is an alternative). [369]
• Spironolactone 50-100 mg daily [370]. Spironolactone has antiviral properties against Epstein
Barr Virus by inhibiting viral capsid antigen synthesis and capsid formation. Spironolactone likely
has antiviral effects against other Herpes viruses.
• L-Lysine; 1000 mg twice daily [371;372]

• Valproic acid; Depakote, 250 mg 2-3 times daily. Valproic acid has activity against HSV-1, HSV-2,
HZV, CMV, and EBV. [373-375]
• Zinc 40 mg daily [376;377]
• Quercetin “Phytosome” 500 mg twice daily (antiviral properties and a Zinc ionophore) [378]
Tinnitus
• This a frequent and disabling complication reported in post-vaccine syndrome.
• Tinnitus refers to the sensation of sound in the absence of a corresponding external acoustic
stimulus and can, therefore, be classified as a phantom phenomenon. Tinnitus sensations are
usually of an unformed acoustic nature, such as buzzing, hissing, or ringing. Tinnitus can be
localized unilaterally or bilaterally, but it can also be described to emerge within the head. [379]
• Ideally, patients should be evaluated by an ENT specialist or audiologist to exclude underlying
disorders.
• Several treatment approaches exist to manage this disabling disease including [379-381]
o Cognitive behavioral therapy [382]
o Specialized therapy including tinnitus retraining therapy, hearing aids, sound therapy,
auditory perceptual training, and repetitive transcranial magnetic stimulation. [379]
o A number of pharmacologic agents have been used to treat tinnitus. Anticonvulsants
including carbamazepine have generally been disappointing. The following drugs have
shown some clinical benefit.
• Tricyclic antidepressant agents particularly nortriptyline and amitriptyline.
[383;384] In addition, the SSRI sertraline has shown some efficacy. [385]
• Clonazepam and or other benzodiazepines. These drugs may provide temporary
relief, however, due to issues of dependence, long-term use is not
recommended. [386]
• Melatonin slow release 2-6 mg at bedtime. [387]
• Oxytocin nasal spray. Oxytocin acts as a neurotransmitter affecting several neural circuits,
particularly in the hypothalamus and amygdala. [318] Oxytocin nasal spray has shown promising
results for the treatment of tinnitus (one puff to each puff nostril two times a day; a total dosage
of 16 IU per day). [388] Oxytocin must be avoided in pregnancy. Oxytocin nasal spray should be
compounded at 12 to 15 units/0.1ml (spray) and administered at onset aggressively to
upregulate receptors at 2 sprays each nostril BID (8-sprays per day) for the first week and then
maintenance at 2 sprays ea. nostril (4/d) once daily. [323] Oxytocin can also be delivered via SL
liquid or via lozenge.
• Non-invasive brain stimulation (NIBS) has proven to be effective in controlling treatment-
resistant tinnitus. [234;235]
Ageusia and anosmia (Loss of taste and smell)

• Loss of smell and taste is a troubling symptom in post-COVID patients and in the vaccine injured.
The loss of taste usually follows the loss of smell. Multiple mechanisms may explain the loss of
smell including direct injury to the olfactory bulb. [389] Anosmia is a particularly difficult
condition to treat. [390]
• Oxytocin nasal spray. Oxytocin receptors are highly expressed on olfactory neurons as well as
limbic structures. Oxytocin nasal spray has been demonstrated to improve the sense of smell in
patients with schizophrenia. A dose of one puff in each nostril two times a day for a total dosage
of 16 IU per day is suggested. [391] Oxytocin must be avoided in pregnancy.

• Olfactory training appears to be a promising therapy for patients with post-viral olfactory loss to
partly regain their sense of smell. [392]
• Nasal corticosteroids appear ineffective and are not recommended for the use of anosmia. [393]
Bell’s palsy/facial paresthesia/visual issues

• Low-dose naltrexone. Begin with 1 mg/day and increase to 4.5 mg/day as required. May take 2-
3 months for full effect.
• Low dose corticosteroid: 10-15 mg/day prednisone for 3 weeks. Taper to 10 mg/day and then 5
mg/day as tolerated.
• Reduced workload, stress, and light exercises for a couple of months.
Patients with new onset allergic diathesis/features of Mast Cell Activation Syndrome
(MCAS)
• The novel flavonoid luteolin is reported to be a potent mast cell inhibitor. [394-397] Luteolin 20-
100 mg/day is suggested.
• Turmeric (curcumin); 500 mg/day. Curcumin has been reported to block H1 and H2 receptors
and to limit mast cell degranulation. [398;399] Curcumin has low solubility in water and is poorly
absorbed by the body; [400] consequently, it is traditionally taken with full-fat milk and black
pepper, which enhance its absorption. Nano-curcumin preparations or formulations designed to
enhance absorption are encouraged. [401-404]
• H1 receptor blockers. Loratadine 10 mg/day, Cetirizine 5-10 mg/day, Fexofenadine 180 mg/day.
• H2 receptor blockers. Famotidine 20 mg twice daily as tolerated. [405]
• Montelukast 10 mg/day. Caution as may cause depression in some patients. The efficacy of
montelukast as a “mast cell stabilizer’ has been questioned. [55]
• Ketotifen. 1 mg in 5 ml. Start with 0.5 ml at night. Once they get used to it, as it has a strong
hypnotic effect, increase by 0.5ml increments up to 5ml. Some patients can increase up to 10 ml
daily (1 mg BID). Ketotifen has antihistamine effects and is a mast cell stabilizer. Ketotifen may
be particularly useful in patients with GI hypersensitivity. [406;407]
• Vitamin C; 1000 mg twice daily. Vitamin C is strongly recommended for allergic conditions and
MCAS. Vitamin C modulates immune cell function and is a potent histamine inhibitor.
• Low histamine diet.
Alopecia (hair loss)

Three types of alopecia have been described in connection with COVID-19 infection, long COVID, and
post-vaccine syndrome. [408]
• Androgenetic alopecia (worsening of male pattern baldness)
• Alopecia areata, an autoimmune disorder that usually results in unpredictable, patchy hair loss.
In most cases, hair falls out in small patches around the size of a quarter. There is currently no
cure for alopecia areata; referral to a dermatologist is suggested. Preliminary research in
animals has found that quercetin can protect against the progression of alopecia areata and may
promote hair regrowth. [409;410]
• Telogen effluvium, which results in temporary thinning of the hair, particularly on the scalp.
Telogen effluvium is a reversible condition in which hair falls out after a stressful experience.
The stress pushes large numbers of hair follicles into a resting phase. Within a few months,
those hairs can fall out. This condition occurs predominantly in females and may be related to

increased expression of pro-inflammatory mediators. No specific treatment is required, as the
hair will usually grow back.
• Photobiomodulation treatments appear to be very effective in inducing hair regrowth. [411;412]
• Nutritional supplements containing omega-3 fatty acids (Vascepa), vitamin D, vitamin C, and zinc
are useful adjuncts to promote hair regrowth. [413-415]
• Topical minoxidil may promote hair regrowth. [416] Finasteride 2.5 mg daily is an option in both
men and women; [417] consult with a dermatologist and treatment for less than 1 year is
generally recommended.
• Topical valproic acid has been shown to stimulate hair regrowth. [418;419]

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I RECOVER Post Vaccine Protocol

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I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 2

Intermittent daily fasting or Magnesium; 100-400 mg daily Hyperbaric oxygen therapy

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 3

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 4

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 5

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 6

Figure 1. Complex pathophysiology of spike-related vaccine-induced disease

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 7

• Myocarditis, pericarditis, stress • Allergic reactions

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 8

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 9

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 10

• CBC with differential and platelet count

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 11

Anticoagulation post-vaccination and the three

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 12

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 13

Oral Fibrinolytic agents:

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 14

Provisional approach to anticoagulation in the post-vaccine phenotypes

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 15

• Intermittent daily fasting or periodic daily fasts. Fasting

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 16

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 17

Figure 4. An Intermittent Fasting Plan for Pre-Menopausal Women

Feedback on “productive approach” from a pre-menopausal patient:

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 18

How much do I weigh? What dose does the protocol say?

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 19

• Resveratrol; 400-500 mg daily. Resveratrol is a plant phytochemical (flavonoid) that has

• Aspirin; 81 mg daily (see previous anticoagulation section).

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 20

A 1% methylene blue solution contains 10 mg MB in 1 ml solution (and 0.5 mg/drop). A 1% MB

• DO NOT take MB if you are pregnant or breastfeeding.

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 21

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 22

• Probiotics/prebiotics; Patients with post-vaccine syndrome classically have a severe dysbiosis

• Spermidine; 1000-2000 mg (wheat germ extract) daily. Spermidine is a naturally occurring

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 23

• Cardio Miracle™ and L-arginine/L-citrulline supplements. Cardio Miracle is a supplement with

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 24

• Sildenafil with or without L-arginine-L-Citrulline [211-216]; Sildenafil doses titrated up from 25

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 25

• Non-invasive brain stimulation (NIBS), using transcranial direct current stimulation or

• Behavioral modification, relaxation therapy, mindfulness therapy [236], and psychological

Zilberman-Itskovich et al performed a randomized, sham-controlled, double-blind trial that

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 26

• Low Magnitude Mechanical Stimulation (LMMS or Whole-Body Vibration). Low-magnitude (0.3-

• “Mitochondrial energy optimizer” with pyrroloquinoline quinone, glycophospholipids, CoQ10,

Patients with elevated homocysteine levels

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 27

• Plasmapheresis. Plasmapheresis improves systemic cytokine levels, coagulopathy, and immune

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 28

• VEDICINALS® 9; a unique phytopharmaceutical-based therapeutic suspension that consists of

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 29

• Immunosuppressive therapies; As a rule, immunosuppressive therapy should be avoided, as

I-RECOVER: An approach to managing post-vaccine syndrome (1/9/2023) 30

Small fiber neuropathy (SFN)/autonomic neuropathy