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    This document provides a summary of Barbara Pogorelčnik's professional experience and qualifications. She currently works as an AS&T Manager at Novartis with over 20 years of experience in quality control and analytical chemistry. Previously, she was a Quality Control Analyst at MARIFARM and worked at the National Institute of Chemistry, focusing on structure-based drug design of human DNA topoisomerase IIα inhibitors.

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    This document provides a summary of Barbara Pogorelčnik's professional experience and qualifications. She currently works as an AS&T Manager at Novartis with over 20 years of experience in quality control and analytical chemistry. Previously, she was a Quality Control Analyst at MARIFARM and worked at the National Institute of Chemistry, focusing on structure-based drug design of human DNA topoisomerase IIα inhibitors.

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    This document provides a summary of Barbara Pogorelčnik's professional experience and qualifications. She currently works as an AS&T Manager at Novartis with over 20 years of experience in quality control and analytical chemistry. Previously, she was a Quality Control Analyst at MARIFARM and worked at the National Institute of Chemistry, focusing on structure-based drug design of human DNA topoisomerase IIα inhibitors.

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    17 views2 pages

    Profile

    Uploaded by

    Cristian Atik
    This document provides a summary of Barbara Pogorelčnik's professional experience and qualifications. She currently works as an AS&T Manager at Novartis with over 20 years of experience in quality control and analytical chemistry. Previously, she was a Quality Control Analyst at MARIFARM and worked at the National Institute of Chemistry, focusing on structure-based drug design of human DNA topoisomerase IIα inhibitors.

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    Contact
    +386 40 16 44 77 (Home)
    Barbara Pogorelčnik
    [email protected] AS&T Manager
    om Ljubljana, Ljubljana, Slovenia
    www.linkedin.com/in/barbara-
    pogorelčnik-0b912a8a (LinkedIn) Experience
    www.researchgate.net/profile/
    Barbara_Pogorelcnik (Other)
    Novartis
    izumbib.izum.si/bibliografije/
    Y20150617204724-33211.html AS&T Manager
    (Portfolio) July 2020 - Present (2 years 5 months)

    Top Skills MARIFARM, proizvodnja in storitve d.o.o.


    Good Manufacturing Practice (GMP) Quality Control Analyst
    Standard Operating Procedure September 2018 - July 2020 (1 year 11 months)
    (SOP) •Working in department for quality control
    Quality Control •Responsible for validation and qualifications of different analytical equipment
    (UV VIS spectrofotometer, FTIR, refractometer, titrator, densitometer,
    Languages aplicator, aparature for disintegration of tablets, moisture analyser, ...)
    English (Professional Working) •Reviewing and approving analytical results
    German (Elementary) •Writing SOPs
    Slovene (Native or Bilingual)
    •Writing instructions for safe work with analytical equipment
    Russian (Elementary)
    writing analytical procedures
    •Resolving OOS/OOT/OOE situations.
    Honors-Awards
    •Extensive experience with Audit Trail
    Krka Award
    extensive knowledge about GMP and ICH

    Publications
    Kemijski Inštitut - National Institute of Chemistry
    Recent advances in the development
    Working in the Department for Computational Biochemistry and Drug
    of catalytic inhibitors of human DNA
    topoisomerase II[alpha] as novel Design
    anticancer agents October 2010 - July 2015 (4 years 10 months)
    Hajdrihova 19, 1001 Ljubljana
    Recent developments of
    DNA poisons - human DNA • Production and purification of recombinant protein (human topoisomerase IIα
    topoisomerase II[alpha] inhibitors -
    as anticancer agents from S. cerevisiae).

    Discovery of Mono- • Extensive experience with expression method (growing of a starter culture),
    and Disubstituted 1H- preparation of cell lysates from S. cerevisiae (homogenisation, enzymatic
    Pyrazolo[3,4]pyrimidines and 9H-
    lysis), purification using Ni-NTA and measuring concentration (measuring the
    Purines as Catalytic Inhibitors of
    Human DNA Topoisomerase IIα absorption at 280 nm).
    Monocyclic 4-amino-6- • Training for a doctor in the field of pharmacy, medicinal chemistry in the area
    (phenylamino)-1,3,5-triazines
    of structure-based drug design.
    as inhibitors of human DNA
    topoisomerase IIα

      Page 1 of 2
       

    4,6-Substituted-1,3,5-triazin-2(1H)- • My work involved the Structure-based design of novel human DNA


    ones as monocyclic catalytic
    inhibitors of human DNA topoisomerase IIα inhibitors with the aim of developing novel inhibitors for
    topoisomerase IIα targeting the ATP cancer.
    binding site
    • Software application for in silico design.
    • Evaluation of biological activity of compounds utilizing enzyme assay kits.
    • Evaluation of compounds using MTT assay (a colorimetric assay for
    assessing cell viability), handling with cancer and non cancer cell lines
    (HepG2, HUVEC and MCF-7 cell lines).
    • Determination of constant dissociation using surface Plasmon resonance
    (SPR), and Microscale thermophoresis (MST).
    • Experimental data processing and results publishing in international journals.

    Lek Pharmaceuticals d.d.


    Working in the laboratory for quality control
    October 2008 - December 2009 (1 year 3 months)
    Perzonali 47, 2391 Prevalje

    • Diploma work and student practise.


    • Identification pharmaceutical compound using near infrared spectroscopy
    (NIR).
    • Working in laboratory for quality control
    • Samples analysing and quality control of products in accordance with GMP
    and ICH guidelines.
    • Extensive experience using different analytical methods: KF titration, UV
    spectroscopy, disintegration of tablets, spectrophotometrics identification
    test,...

    Education
    University of Ljubljana, Faculty of Pharmacy
    PhD, Medicinal and Pharmaceutical Chemistry · (2010 - 2015)

    Faculty of Chemisty and Chemical Engineering, University of Maribor


    Bachelor's degree, Chemical Engineering · (2004 - 2010)

      Page 2 of 2

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