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B Echioseb

The document describes a skin care ingredient called EchiosebTM which is obtained from Echinacea purpurea and Rhodiola rosea. It has the ability to adapt and help normalize sebum content, pore size, elasticity and moisturization in combination and oily skin by regulating the sebum biosynthetic pathway. In vitro and in vivo efficacy studies show it is effective at controlling sebum production and release and reducing pores, sebum content, and oily spots on the skin.

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Priscilla Rosalyna Maranatha
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310 views2 pages

B Echioseb

The document describes a skin care ingredient called EchiosebTM which is obtained from Echinacea purpurea and Rhodiola rosea. It has the ability to adapt and help normalize sebum content, pore size, elasticity and moisturization in combination and oily skin by regulating the sebum biosynthetic pathway. In vitro and in vivo efficacy studies show it is effective at controlling sebum production and release and reducing pores, sebum content, and oily spots on the skin.

Uploaded by

Priscilla Rosalyna Maranatha
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Adaptogenicity

Sebum controller Pore eraser


IH-822/2.1/B94
for combination & oily skin

DESCRIPTION & MECHANISM


LIPOTRUE Adaptability is a critical quality for the survival of plants in hostile conditions.
GREENBEAT™ Echinacea purpurea, a drought tolerant plant, has developed mechanisms to
reduce water loss (e.g. partially opening stomata) and increase its
absorption, allowing it to survive during fluctuations in precipitations in
the North American prairies

INCI name of the active There are plants that not only adapt to hostile conditions, but also help other
ingredient: Echinacea Purpurea organisms cope with stressors to normalize metabolic functions. Rhodiola
rosea is an adaptogen known by the Vikings for enhancing physical
Extract, Rhodiola Rosea Extract
endurance and mental alertness
Recommended dose: 1-2%
Echioseb™ is an ingredient obtained from Echinacea purpurea and the stem cells
Solubility: Water soluble from Rhodiola rosea coming from the Greenology technology. Their ability to
adapt allows the skin to normalize sebum content and release, pore size, elasticity
and moisturization by regulating the sebum biosynthetic pathway following the
retinoids steps

Echioseb™ is the adaptogen sebum controller that customizes its efficacy by adapting
to the different needs of combination and oily skin
Raw material approved by ECOCERT GREENLIFE, conform to the COSMOS Standard
IN VITRO & HUMAN EXPLANTS EFFICACY IN VIVO EFFICACY

Controlling sebum pathway Adaptogen sebum controller


30 women (19-64 years old) with combination or oily skin applied a cream
Up-regulation of genes involved in the retinoid’s pathway with 2% Echioseb™ on half face and a placebo on the other, twice daily
for 28 days

-6% pores on average in 1 hour

Up to 20% and 43% less pores in 7 days in combination


& oily skin
+26% FOXO1 vs non-treated sebaceous glands (human skin explants)
T0 days T28 days

Non-treated 1% Echioseb™
sebaceous gland (FOXO1 in green)

-21% area occupied


-49% lipin-1 vs basal by pores

Slowing down sebocytes differentiation & growth Up to 20% and 34% less sebum content in 1 h in combination
& oily skin

+73% K7 (marker of early differentiation) vs basal


-13% and -21% sebum content in 7 days in combination
& oily skin

-22% pancytokeratin (cell size) vs basal


Up to 26% and 22% less oily drops on the forehead after
28 days in combination & oily skin

+5% and +11% elasticity and hydration on average in 1 h

T0 days T1 hour

Basal 2% Echioseb™
(pancytokeratin in green) (pancytokeratin in green)

Reduction of sebum production & release

Similar sebum reduction with 2% Echioseb™ as 50μM


retinoic acid when inducing sebum production with linoleic acid -8% area occupied
by oily spots

-60% TSLP release vs basal, modulating sebum hypersecretion

B2203
www.lipotrue.com | [email protected] science & biotechnologies

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