Bacteria Disease

1-Pyogenic :
i.Focal suppuration:abcesses,Boils,carbuncles
ii.invasive:spread To lymph & blood to cause :
(osteomyelites,pneumonia,Empyma,Endocarditis,memingitis,septicemia)
Staphylococcus aureus
“hospital aquired infections” 2-Toxigenic:
i.Food poisoning
ii.Toxic shock syndrome:fever,vomiting,Diarhea,muscle pain,Rash,HF,RF
iii.Scalded skin syndrome

Staphylococcus epidermidis 1-infection of prosthetic devices

“hospital aquired infections” 2-spesis in neonates

Staphylococcus 1-urinary tract infection in sexual intercourse young women

saprophyticus

1-Pyogenic :
i.sore throat\follicular tonsillitis:
pharyngitis,fever,enlarged cervical LN,Rheumatic fever,Glumerulonephritis
ii.Pyoderma\impetigo: infection of skin ( formation of blisters +pus)
2-invastive:
i. Erypiselas:skin infection ( redness,oedem)
ii.Puerperal spesis :Uterus infection after (endometritis+spetic shock)
iii.Soft tissue spesis: Wound infection ,cellulitis,lymphadenitis,speticaemia
iv.Acute bacteria endocaditis
Streptococcus pyogenes 3-Toxigenic:
i.Fulminat infection shock,bacteraemia,respiratory failure,necrotiszing fasciitis
ii.toxic shock syndrome
iii.Scarlet fever sore throat,erythematous rash
4-post Streptococcal immunologic :
i.Acute glomonephritis: Bythroat & skin infectin
(oedema, BP,urea nitrogen retention) antigen-anitbody complex on glumerular
basment membrane
ii.Acute Rheumatic fever:By throat infection
( damage of heart valves & muscle) Fever,polyarthritis,carditis

1-neonatal septicemia
2-meningitis
Streptococcus agalactiae
3-pneummonia

1-endocarditis
Streptococcus viridance

1-pneumonia
Streptococcus pneumoniae 2- meningitis

Enterococci 1-urinary tract infection,prostitis

“hospital aquired infections” 2- endocarditis
3- neonatal meningitis

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 4- neonatal bactereamia
5- cholecystits
6-Wound infection
7-intra-abdominal infections
Bacteria Disease
1-male gonorrhoeae:urethritis,dysuria, prostitis,epididymitis
2-Femal gonorrhoeae: urethritis ,cervicitis,salpingits,pelvic inflammatory
3-blood invasion:disseminated gonoccal infection (septic arthritis, tenosyovits,
Neisseria gonorrhoeae endocarditis, skin pustules)
4-opthalmia neonatrum:blindness
5-vulvo-vaginitis

1-meningitis: fever,headache,vomiting,rigdity of neck & back muscles

2-invastive blood : meningoccaemia
Neisseria meningitidis
3waterhouse-friderichsen syndrome : fever,shock

1-bronchits, pneumonia
Moraxella 2-otitis,conjuctivit

tonsillar diphetheria:
i.Inflammation of throat,local necrosis,pseudomembrane formation
Corynebacterium ii.Toxin affecting blood: Toxaemia affect on heart(myocardits) muscles ( paralysis)
diphtheriae iii.Toxin affecting nerve: paralysis of muscles of plate & pharynx lead to hard
speech,hard swallowing

1-granulmatosis infantiseptica: in pregnant women

2-neonatal meningitis : newborn
Listeria monocytogenes 3-meningoencephalitis & bacteraemia
4-gastroentritis :watery diarrhea ,vomiting, myalgia ,fever, abdominal cramps

1-toxin bind with gangliosides receptor & block inhibitory mediator ( glycine) lead
i.Excitory discharge
Clostridium tetani ii.Motor spasm of tetanus (in jaw muscle= lock jaw),(in back m.opisthotonos)
iii.Respiratory& cardiac failure

1-gas gangrene :
Clostridium perfringes
2-food poisoning by dishes : diarrhea, NO vomiting or fever, abdominal cramps

1-food poisoning:NO diarrhea or vomiting or fever

2-Nurotoxin:
i.block release of Ach at neuromuscular junction ( flaccid paralysis)
Clostridium btulinum ii.diplopia,dysphgia , Respiratory & cardiac failure
3-wound botulism
4-infant botulism :”floppy baby”

Clostridium difficle 1-psudomembrane colits

2
“hospital aquired infections” 2-watery diarrhea

1-cutaneus anthrax:
2-Pulmonary anthrax:wool soter’s
Bacilus anthracic 3-intestinal anthrax

Food poisoning:
Bacilus cerceus i.emetic type in rice dishes: HS entrotoxin ( nausa & vomiting )
ii.diarrhoeal type in meat & souces dishes :HL entrotoxin (watery non bloody diarrhe)
Bacteria Disease
1- urinary tract infection
2- neonatal meningitis
3-pneumonia, sepsis, bactaermia,Endotoxic shock
4-Diarhhoeagenic :
E.coli
i.enterotoxigenic E.coli
“hospital aquired infections”
ii.enteropathogenic E.coli
iii.eneteroinvastie E.coli
iv.eneterhaemorrgic E.coli
v.enteroaggregative E.coli

1- urinary tract infection

Klebsbilla
2- neonatal meningitis
“hospital aquired infections”
3-lobar pneumonia, septicaemia

Enterobacter,citobacter 1- urinary tract infection

serratia 2-Wound,blood infection

Salmonella typi 1-entric fever: fever,malaise,headache,delirum,constipation

S.typhimurum & 2-eneterocolitis( Food poisoning) : nausa,vomiting,abdominal discomfort,dirrhea
eteritidis
S.cheslaraesuis 3-Septicaemia:

1-shigllosis:
Shigella i.invasion of mucosa of large intestine : necrosis,psudomembrane formation
ii.toxin :desntery( blood +pus + mucus in stool)

1-bubonic plague (multiplies in LN & become enlarged )

Yersinia pestis 2-pneumonic plague ( abcess in many organs)
3-septicaemic plague

Proteus 1- urinary tract infection

2- pneumonia,otits, meningitis,bacteraemia

1- urinary tract infection

Actinobacter 2- pneumonia, , meningitis,wound infections

1-rare pneumonia, meningitis,bacteraemia

2-eterocolits: watery foul diarrhea+blood,fever
camylobacter
3-guillian barre syndrome
4-toxogenic : (enteritis) invasion tissue, bacteraemia

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 1-adhesins to mucous secreting clles
Helicobacter pylori 2-production of ammonia from Urea TO nuterlize HCl (peptic ulcer,carcinoma
3-damage of mucosa by cytotoxins ( gastritis,peptic ulcer)

Pseudomonas 1- urinary tract infection

aeruginosa 2- pneumonia ,wound infection,otits,endocarditis,osteomylits

1-cholera :
Vibrio cholerae i.rice water stool:( fever,vomiting,diarrhea)
ii.No blood invasion

V. parahaemolytica dirrhea,vomiting, abdominal cramps,nausa

1-undulant fever\malta fever:

i.bacteraemia effect reticul-endothelial system
Brocella ii.survive inside phagocytes
iii.weakness,malaise,sweating,headache,joint & muscle pain,enlarged LN
iv.meningitis, osteomylitis,cholecystits
Bacteria Disease
Haemophilus influenzae 1-meningits,Epiglottis,otits

1-conjuctivitis
Haemophilus aeryptius
2-brazilian purpuric fever

Haemophilus ducreyi Chncroid\soft sore in external genitalia

Whooping couph:
Brodetella perussis
Vomiting,cynosis,convulsion,luecocytosis,lymphocytosis& maybe pnuemonia,otits

Tuberculosis:
i.inhibtion phagosomes formation
ii.stimulates Cell mediated immunity
Mycobacteria T.B
iii.hypersenstiviy:tissue damage,progression disease
iv.lymphatic & haematogenous spread
v.latent tuberculosis infection : No symptomes but still inactive T.B

Mycobacteria avium, Pulomanry disease in immunocomprimised patients

interacellar,kansasii

Mycobacteria ulcerance Ulcer in skin (buruli ulcer )

Mycobacteria marium Swimming pool granuloma
Mycobacteria smegmatis Normal flora living in foreskin of peins ( Not pathogenic )

Tubercloid leprosy LT Lepromatous leprosy LL

Benign & non progressive Malignant & progressive
Lepromin Test (+) Lepromin Test(-)
Mycobacteria lyprae
Hypopigmented & anastheic site of lesion Multiple nodular skin of nasal bone
Cell mediated immunity is intact Cell mediated immunity is
suppression

Treponema pallidum 1-syphilis:

i.chancre& ulcer in regoinal lymph nodes (heal within 4-6 weeks)
ii.skin rash ,condylomata of anus & vulva Then fever, weight loss,joint pain

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 iii.latent stag : no signs or symptoms
iv.if not threathed couse granulomas in skin & bons
v.congenital :intestinal keratits,hutchinon’s teeth,saddle nose,CNS abnormalies

1-EpidemicRelapsing fever:By lice

Borellia Recurrentis i.fever(4days) afebrile (3-10 days) fever
ii.found in blood during afebrile stage invade many organs (heart,spleen…)
Lyme disease:By tick
Borellia burgodroferi i.erythema margans
ii.later:myocarditis,meningitis,arthritis
Vincent angina:
Fusospichaetal
i.acute ulcerative gingivostomatits + pseudomembrane + pus + necrosis
Weil disease:
Leptospira
(fever,jaundice,haemorrahage,renal failure & maybe meningitis)
icterohaemorrhagia

Mycoplasma pneumonia Atypical pneumonia

Ureaplasma urealyticum Urethritis,neonatal sepsis
Mycoplasma genitalium urethritis

Bacteria Disease
1-legionnaire’s disease ( + pneumonia)
i.inhibit phagosomal lysosome granules
Legionella pneumphilia
ii.bactremia with damage to vacular endothelium in brain & kidney
2-pontiac fever (without pneumonia)

Epidemic typhus:
i.fever,hepatomegly & spleenomegly
Rickettisa prowazeki
ii.invade capillary enothelium causing Vasculitis in Brain & heart..
iii.Brill zinsser: still remain in lymph nodes after recocery
Rickettisa Typhi Endemic typhus
Rocky mountain spotted fever
Rickettisa Rickettsii
(fever,headache,malaise,prostration.deliurm,Coma,circulatory collapse)

Q –fever:
Coxiella Burnetti i.acute:pneumonia + hepatits
ii.chornic : endocarditis

Ocular infection 1-Trachoma : sterotype A,B,C

i.infection of conjuctiva & cornea= blindness
ii.transmitted from eye To eye by finger\flies
2-inclusion conjuctivitis: sterotype D,K
Calymydiae i. infection of cornea & heal without Scar formation
trchomatis Gential infection 1-non-gonococcal Urethrits,cervicitis,salpingitis
D&K 2-Reiter syndrome:urethrits,arthrits,uveitis
Lymphgranuloma 1-painless papule on external genuital organs + ulcer
L-1,L-2 & l-3 2-heal with Scar formation
3-use frie test (hypersensity skin )
Respiratory 1-Otitis,pharyngits,nasal obstruction

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 infection 2-Neonatal pneumonia

Calymydiae psittaci Bronchitis, pneumonia

Calymydiae pneumonia Atypical pneumonia

Actionomycosis:
Actinomyces israelli i.chronic inflammation,granulomatous lesion + pus
ii.common site in cervico-facial ,abdomin,thoracic

nocardiosis:
Nocarida asteroides i.chronic –pulmonary infection
ii.maybe spread to Brain,skin,kidney…

Bacterial vaginosis:
i.foul smelling discharge
Gardnerella vaginalis ii.detection Clue cells (epithelial cells coated with orginsm)
iii.Whiff test

Tularaemia:
Francisella tularnesis
( fever,lymphadenopathy “ulceroglandular”)

1-Wound infectin
Aeromans hydophila 2-dirrhea like cholera or desyntry
3-bacrtremia & spepticemia

Cat –Scratch fever :

Bartonella henselae
( lymphadenopathy + bacillary angiomatosis)
Bartonella quintana Tranch fever

Fungi Disease
Malassezia furfur Tinea vericolor “ pitryiasis versicolor” :
“superfical mycosis “ i.buddy yeasts cells

Epidermophton 1-coutenous keratinzed tissue infection

Trichophyton 2-produce like Ring-like lesion : ringworm,tinea
microsporum 3-GROW on Sabouraud’s dextrose agar & contain cycloheximide

Nocardia,actinomadura Mycetoma “madura foot” :subcutaneous mycosis

streptomyces (chronic inflammation of lower limb ( swelling,purpish discolouration, pus)
Maduerella mycetomatis

Histoplasma capsulatum Histoplasmosis:

i.infection of lung as acute pneumonia
” Systemic mycosis” ii.spread to spleen & liver lead to hepto-splenomegaly
Coccidiodes immitis Coccidiodomycosis :
i.infection of lungs
” Systemic mycosis” ii.spread to blood then to CNS ,bone
Blastomyces Blastomycosis :
dermatitidis repirtory infection
” Systemic mycosis”

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Candida albicans 1-oral thrush \moniliasis
2-skin invaion in warm moist area
“Opprtunistic mycosis” 3-painful redness & swelling OF nail
4-Chornic mucocutaneous candiasis

Cryptococcus Infection lung : pneumonian,maybe meningitis

neoformans
“Opprtunistic mycosis”

Aspergillus fumigatus, 1-allregy

Flavus,niger 2-aspergilloma “ fungus ball” :growth fungi inside lung cavitis
“Opprtunistic mycosis” 3-Aflatoxin:heptotoxic & carcinogenic effect

Pneumocystic jiroveci Interstial peumonia

“Opprtunistic mycosis”