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Experiment 10 Hardy Weinberg Principle Tutorial

This document contains an experiment on the Hardy-Weinberg principle with 6 questions. It establishes a founder population on an island and asks questions about allele and genotype frequencies over multiple generations. It also contains questions about genotype frequencies in other populations, phenotypes related to taste, definitions of genetic terms, and calculations of allele frequencies and Hardy-Weinberg equilibrium in human populations based on blood type data.

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Kim Seok Jin
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0% found this document useful (0 votes)
110 views4 pages

Experiment 10 Hardy Weinberg Principle Tutorial

This document contains an experiment on the Hardy-Weinberg principle with 6 questions. It establishes a founder population on an island and asks questions about allele and genotype frequencies over multiple generations. It also contains questions about genotype frequencies in other populations, phenotypes related to taste, definitions of genetic terms, and calculations of allele frequencies and Hardy-Weinberg equilibrium in human populations based on blood type data.

Uploaded by

Kim Seok Jin
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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ABT 10603 (FUNDAMENTAL GENETICS)

EXPERIMENT 10

THE HARDY WEINBERG PRINCIPLE (TUTORIAL)

NAME :

MATRIX NUMBER :

DATE OF SUBMISSION :

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ABT 10603 (FUNDAMENTAL GENETICS)

EXPERIMENT 10

1. A population called the “founder generation” consisting of 2,000 AA individuals, 2,000


Aa individuals and 6,000 aa individuals is established on a remote island. Mating within
this population occurs at the random, three genotype are selectively neutral and
mutations occur at a negligible rate.
a) What are the frequencies of alleles A and a in the founder generation?
b) Is the founder generation at Hardy Weinberg equilibrium?
c) What is the frequency of the allele A in the second generation (that is, the
generation subsequent to the founder generation)?
d) What are the frequencies for the AA, Aa and aa genotypes in the second
generation?
e) Is the second generation at the Hardy Weinberg equilibrium?
f) What are the frequencies for the AA, Aa and aa genotype in the third
generation?

2. Two alleles have been found at the X-linked phosphoglucomutase gene in Drosophilla
persimilis populations in California. The frequency of the PgmA allele is 0.25, while the
frequency of the PgmB allele is 0.75. Assuming the population is at Hardy Weinberg
equilibrium, what are the expected genotype frequencies in males and females?

3. Two hypothetical lizard population found on opposite side of a mountain in the Arizonan
desert have two alleles (AF, AS) of a single gene A with the following three genotype
frequencies:

AF AF AF AS AS AS
Population 1 38 44 18
Population 2 0 80 20

a) What is the allele frequency of AF in the two populations?


b) Do either of the two population appear to be at Hardy Weinberg equilibrium?
c) A huge flood opened a canyon in the mountain range separating population 1
and 2. They were then able to migrate such that the two populations, which were
of equal size, mixed completely and mated at random. What are the frequencies
of the three genotypes in the next generation of the single new population of
lizards? (AF AF, AF AS and AS AS)

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ABT 10603 (FUNDAMENTAL GENETICS)

4. The famous European geneticist, Professor Ed V. Otek, tested his rather large genetics
class for the ability to taste the chemical phenylthiocarbamide, PTC. He knew that the
gene for this ability to taste PTC had two alleles, the dominant allele for tasting called T,
and the recessive allele called t. He found that out of 1000 students, there were 700
students with the ability to taste PTC and 300 who lacked the ability to taste PTC.
a) Calculate the gene frequencies of T and t
b) Calculate genotype frequencies for PTC taster
c) Calculate genotype frequencies for non-PTC taster

5. Choose the best matching phrase in the right column for each of the terms in the left
column.

Fitness The genotype with the highest fitness is the


heterozygote
Gene pool Chance fluctuations in allele frequency
Fitness cost Ability to survive and reproduce
Allele frequency Proportion of total phenotypic variance
representation attributed to genetic variance
Genotype frequency Collection of alleles carried by all members of
representation a population
Heterozygote advantage p2 and q2
Equilibrium frequency p and q
Genetic drift The advantage of a particular genotype in one
situation is a disadvantage in another situation
Heritability Frequency of an allele at which ∆q=0

6. The human MN blood group is determined by two codominant alleles, M and N. The
following data were obtained from various human populations:

Percentages

Population Place MM MN NN

Inuit East Greenland 83.5 15.6 0.9

Navajo Indians New Mexico 84.5 14.4 1.1

Finns Karajala 45.7 43.1 11.2

Russians Moscow 39.9 44.0 16.1

Aborigines Queensland 2.4 30.4 67.2

(Data from Seipss, E.B (1990). Genes in Populations, 2d ed,NY: Wiley-Liss)

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ABT 10603 (FUNDAMENTAL GENETICS)

a) Calculate the allele frequencies in these five populations.

b) Are Inuit and Russians populations appearing to be in Hardy Weinberg equilibrium?

Report must be submitted within ONE week after practical.

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