DR.
KALYAN KUMAR SETHI
M. Pharm, PhD
Assistant Professor, Department of Medicinal Chemistry
National Institute of Pharmaceutical Education and Research (NIPER),
Guwahati (Assam), India
Research Areas of Interest
• Drug Design, Discovery, and Development
• Natural product chemistry (Extraction, isolation, purification, and characterization of
Active Pharmaceutical Ingredients from natural resources)
• Organic synthetic chemistry related to drug discovery and pharmaceutical chemistry.
• Human Carbonic Anhydrases Inhibitors, Hypoxia Induced Cancer
• Analytical and Bio-analytical studies of Pharmaceutical and Nutraceutical compounds
Technical Skills
• Computer Based Drug Design: SYBYL7.1 (QSAR, CoMFA and CoMSIA), Maestro 5.0
(SCHRODINGER) (Docking and QSAR study), Autodock-4 (Docking), Sequence
alignment, UCSF Chimera, Chem. sk. and Chem 3D Ultra.
• Natural Product Chemistry: Extraction, isolation, purification, and Characterization of
Active Pharmaceutical Ingredients from natural sources i.e., Hydroxy citric acid,
Curcumin, Gyminic acid, Glucosamine, Lutein, etc.
• Management of Herbal extraction and manufacturing units, API production & Formulation
in commercial scale bulk quantities from natural resources, writing of COA, SOP, BMR,
export of product, etc.
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• Working knowledge on various industrial scale manufacturing instruments like Spray
Dryer, Tray Dryer, Extractor, Evaporator, Shifter, Hammer mill, Grinder, Pulverizer,
Blender, etc.
• Technology transfer from research and development laboratory to commercial scale
manufacturing unit.
• Working knowledge in synthetic organic chemistry with characterization by LC-MS, GC-
MS, NMR, PXRD, Particle size analysis, DSC, TGA/DTG, UV-Vis, and CHNSO of
synthetic/natural organic/inorganic product and analysis.
• Analytical and Bio-analytical study protocols design and development of nutraceuticals
and pharmaceuticals.
• Well versed with the use of various Analytical Instruments such as LC-MS, UV-Visible
Spectroscopy, FT-IR, DSC, TGA, CHNSO, Dissolution apparatus, Microwave
Synthesizer, Paper and Column Chromatography.
• Human Carbonic Anhydease Inhibition (hCAI) Assay, Antimicrobial, and Animal study.
Educational Qualifications
Ph.D. Birla Institute of Technology, Ranchi, India
(Pharmaceutical Science)
M. Pharmacy Birla Institute of Technology, Ranchi, India
(Pharmaceutical Chemistry)
B. Pharmacy Roland Institute of Pharmaceutical Sciences, Berhampur,
India
12th (+2 Science) Jawahar Navodaya Vidyalaya, Balasore, India
10th (HSC) Jawahar Navodaya Vidyalaya, Balasore, India
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Academic and Industrial Experience (11 Years 4 Months)
Assistant Professor: August 2020 - Till Date
National Institute of Pharmaceutical Education and Research,
Guwahati, India
Senior Research Scientist (Analytical): February 2016 - August 2020 (4 years 7 months)
Trivedi Science and Research Laboratory, Bhopal, and Thane,
India
Scientist cum Plant Manager: December 2014 - January 2016 (1 year 2 months)
Biotechayur Pvt. Ltd., Balasore, India
Institute Research Fellow: October 2011 - November 2014 (3 years 2 months)
Dept. of Pharmaceutical Sciences and Technology, BIT, Mesra,
Ranchi, India
Assistant Professor: July 2009 - September 2011 (2 years 3 months)
GITAM Institute of Pharmacy, GITAM University,
Visakhapatnam, India
Experience in Guiding/Supervision
• Ph.D. Student (1 ongoing)
• MS (Pharm) Students (4 ongoing)
• B. Pharm Students (2 completed).
Honours and Awards
• Rajib Gandhi National Fellowship: 2014 (The University Grants Commission,
Government of India)
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• Institution Fellowship: August 2011- June 2014 (Birla Institute of Technology, Mesra,
Ranchi, India)
• All India Council for Technical Education (AICTE) Fellowship: 2007 to 2009
(Government of India)
• Graduate Aptitude Test in Engineering (GATE): Qualified in 2006, 2007 and 2008
• National Cadet Corps (N.C.C.)-A: 1997 (7 Orissa Battalion NCC, Bhadrak, Orissa,
India)
Professional Recognition
• Member in Professional Bodies
Indian Pharmacy Graduates Association (IPGA), India
Pharmaceutical Society, B. I. T. Mesra, Ranchi.
• Editorial Board
Assistant Editor in “Journal of Global Trends in Pharmaceutical Sciences”
Editorial Board Member in “EC Pharmacology and Toxicology”
• Reviewer in International Journals
Bioorganic & Medicinal Chemistry (Elsevier/Science Direct); Bioorganic &
Medicinal Chemistry Letters (Elsevier/Science Direct); Arabian Journal of Chemistry
(Elsevier/Science Direct); Letters in Drug Design & Discovery (Bentham Science);
Journal of Enzyme Inhibition and Medicinal Chemistry (Informa Health Care);
Sensors and Materials (An International Journal on Sensor Technology); Journal of
Medicinal Plant Research (Academic Journals); Studies in Natural Products
Chemistry (Elsevier/Science Direct); Organic & Biomolecular Chemistry (Royal
Society of Chemistry), etc.
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Patent
• Sethi KK, Verma SM. 4,5,6,7-tetrachloro-1,3-dioxoisoindolin-2-yl benzenesulfonamide
derivatives. Ref. no.: E-2/2088/2013-KOL, Application no. 568/KOL/2013. Indian
Patent office, at Kolkata, India. (Published)
• Sethi KK. Active human Carbonic Anhydrase Inhibitors (hCAIs) benzenesulfonamide
compounds. Ref. no.: E-12/134/2021/KOL, Application no. 202131017895. Indian
Patent office, at Kolkata, India. (Complete Specification Filed)
Publications (International)
1. Sethi KK*, Verma SM, Prasanthi N, Sahoo SK, Parhi RN, Suresh P. 3D-QSAR study of
Benzene Sulfonamides as human Carbonic Anhydrase II Inhibitor. Bioorganic and
Medicinal Chemistry Letters, 2010, 20, 3089-3093. I.F.: 2.823
2. Hathi DK*, Bhatnagar SP, Sethi KK*. Devlopment and Evaluation of Polyherbal
Antidandruff Hail Oil. Pharmacognosy Journal. 2010, 2, 328-334. I.F.: 0.82
3. Sethi KK*, Verma SM, Prasanthi N, Annapurna MM. Synthesis, neurotoxicity and
anticonvulsant study of some benzothiazole analogs. Letters in Drug Design & Discovery,
2011, 8, 774-777. I.F.: 1.169.
4. Sethi KK*, Suresh P, and Mondal S. Carbonic Anhydrase I and II inhibition with natural
products: Abrus Precatorius. Current Enzyme Inhibition, 2011, 7, 119-124.
5. Sethi KK*, Verma SM, Kumar PM, Mishra R. Carbonic Anhydrase I and II inhibition with
natural products: Leucas Cephalotes. Pharmacognosy Communication, 2011, 1, 40-45.
6. Sethi KK*, Pichikala JN, Sahoo SK, Suresh P. Carbonic Anhydrase I and II inhibition with
natural products: Caffeine and Piperine. Journal of Enzyme Inhibition and Medicinal
Chemistry, 2012, 27, 97-100. I.F.: 5.051
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7. Mishra R *, Ganguly S, Sethi KK, Mazumder PM. Synthesis and Anticonvulsant Activity
of Some Novel 2-Methyl Imidazole Derivatives. Letters in Drug Design & Discovery,
2012, 9(4), 402-408. I.F.: 1.169
8. Verma SM, Saha A, Mishra R, and Sethi KK*. 3D-QSAR study of some heterocyclic
sulfonamide analogs as hCAII inhibitors. Letters in Drug Design & Discovery, 2012, 9,
581-586. I.F.: 1.169
9. Sethi KK* and Verma SM. Pharmacophore modeling and 3D QSAR studies of novel
human carbonic anhydrase IX inhibitors. Letters in Drug Design & Discovery, 2013, 10,
808-816. I.F.: 1.169
10. Brijesh Patel, Verma SM *, and Sethi KK. 3D-QSAR and Docking studies of N-hydroxy
1,8-naphthyridine 2-one analogues as Ribonuclease H Inhibitors. Letters in Drug Design &
Discovery, 2013, 10(9), 823-835. I.F.: 1.169
11. Sethi KK*, Verma SM, Tanç M, Carta F, and Supuran CT. Carbonic Anhydrase Inhibitors:
Synthesis and Inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and
VII withbenzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalic anhydride moiety.
Bioorganic & Medicinal Chemistry, 2013, 21(17), 5168-5174. I.F.: 3.641
12. Sethi KK*, Vullo D, Verma SM, Tanç M, Carta F, and Supuran CT. Carbonic Anhydrase
Inhibitors: Synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII,
IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalic anhydride
moiety. Bioorganic & Medicinal Chemistry, 2013, 21, 5973-5982. I.F.: 3.641
13. Sethi KK* and Verma SM. A systematic quantitative approach to rational drug design and
discovery of novel human carbonic anhydrase IX inhibitors. Journal of Enzyme Inhibition
& Medicinal Chemistry, 2014, 29, 571-581. I.F.: 5.051
14. Sethi KK*, Verma SM, Tanç M, Carta F, and Supuran CT. Carbonic Anhydrase Inhibitors:
Synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with
benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties. Bioorganic &
Medicinal Chemistry, 2014, 22, 1586-1595. I.F.: 3.641
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15. Sethi KK*, Nayak PK., Sarkar H, Verma SM. A rational approach towards the
development of human carbonic anhydrase inhibitors as antiepileptic agent. Medicinal
chemistry. 2016, 6, 405-410.
16. Trivedi MK, Sethi KK, Panda P, Jana S*. Metabolite profiling of Withania somnifera roots
hydroalcoholic extract using LC-MS, GC-MS and NMR spectroscopy. Chemistry and
Biodiversity, 2017, 14, e1600280. I.F.: 2.039
17. Trivedi MK, Sethi KK, Panda P, Jana S*. Physicochemical, thermal and spectroscopic
characterization of sodium selenate using XRD, PSD, DSC, TGA/DTG, UV-vis, and FT-
IR. Marmara Pharmaceutical Journal, 2017, 21(2), 311-318.
18. Trivedi MK, Sethi KK, Panda P, Jana S*. A comprehensive physicochemical, thermal, and
spectroscopic characterization of zinc (II) chloride using X-ray diffraction, particle size
distribution, differential scanning calorimetry, thermogravimetric analysis/differential
thermogravimetric analysis, ultraviolet-visible, and Fourier transform-infrared
spectroscopy. Int J Pharma Investig, 2017, 7, 33-44.
19. Trivedi MK, Panda P, Sethi KK, Jana S*. Liquid Chromatography Tandem Mass
Spectrometry and Nuclear Magnetic Resonance Spectroscopy of Magnesium (II)
Gluconate Solution. Journal of Solution Chemistry, 2017, 46, 896-907. I.F.: 1.677
20. Trivedi MK, Dixit N, Panda P, Sethi KK, Jana S*. In-depth Investigation on
Physicochemical and Thermal Properties of Magnesium (II) Gluconate Using
Spectroscopic and Thermoanalytical Techniques. Journal of Pharmaceutical Analysis,
2017, 7, 332-337. I.F.: 4.769
21. Sethi KK. Human Carbonic Anhydrase Inhibitors (hCAIs) a Druggable Target for Cancer
Therapy. Editorial. EC Pharmacology and Toxicology, 4.4 (2017): 135-137.
22. Trivedi MK, Panda P, Sethi KK, Gangwar M, Mondal SC, Jana S *. Solid and liquid state
characterization of tetrahydrocurcumin using XRPD, FT-IR, DSC, TGA, LC-MS, GC-MS,
NMR and its biological activities. Journal of Pharmaceutical Analysis, 2020, 10, 334-345.
I.F.: 4.769
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23. Sethi KK*, Mishra KA, Verma SM, Vullo D, Carta F, Supuran CT. Synthesis and Human
Carbonic Anhydrase I, II, IX, and XII Inhibition Studies of Sulphonamides Incorporating
Mono-, Bi- and Tricyclic Imide Moieties. Pharmaceuticals, 2021, 14(7), 693. I.F.: 5.863
Conference Attended (National Poster Presentation)
1. Kalyan K Sethi, Pramod Dewangan, N. Padma, S. M. Verma. Docking studies of N, N1-bis
substituted aryl guanidine derivatives as NMDA receptor antagonist. 13th Association of
Pharmaceutical Teachers of India National Convention, Bilaspur, 2008, Chattishgarh,
India.
