Dr. Sazia Nowshin
Dr. Sazia Nowshin
Dr. Sazia Nowshin
Immunity
Inflammation
Neutrophil
WBC…. Neutrophil
Site of development: Bone marrow
Cell size: 12-15 µm
Nucleus: Multilobes (2-5)
Cytoplasm: Pink
Granules: Purple
Half-life:
4-8 hours in circulation
macrophage
Mature macrophages forms RE system in tissue
Enzymes inhibitors
Lipids
Matrix proteins
Prostaglandins of E-series
Clot-promoting factors
Mononuclear phagocyte system…
Functions of macrophages:
1. Phagocytosis
2. Secretory function
3. Regulation of haemopoiesis
4. Killing of tumor cells
5. Tissue repair & remodeling
Brain storming
You have an infection in a peripheral tissue
The immune cells you need to fight infection are in
the blood, moving rapidly, with no connection to
solid tissue
How do you get them to exit the blood, or
extravasate, at the right place?
Solution
1. Get the cell to slow down & contact the blood
vessel wall, where they can sense the signals to stop
& exit
2. Provide stop signals where it is needed
3. Stop the cells
4. Provide signals that guide into the tissues
WBC Properties :
Properties of WBC:
Diapedesis
Amoeboid motion
Chemotaxis
Phagocytosis
Extravasation/Diapedesis
Process by which WBC come out of the lumen of the
blood vessels into the tissue space is known as
Extravasation/diapedesis
Diapedesis….
Process:
1. Rolling: Selectin binding to Mucin-CAM
2. Activation: Chemokine on endothelial cell binding to
chemokine receptor
3. Adhesion: Integrin binding to ICAM. After firm adhesion
4. Migration: Chemokine in tissue binding to chemokine
receptor
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