CASE Study
CASE Study
CASE Study
C. Psychosocial Stage
In relation to the case presented, the patient has a positive resolution with the Psychosocial Stage for
the reason that he had regretted nothing. He had nurtured a daughter who had helped him during this
time and he has a neighbor who have eyes on him in times that he is out of their household. Apart from
the presence of his mental illness there is none negative resolution in terms of the psychosocial stage.
Source: https://www.verywellmind.com/integrity-versus-despair-2795738
D. DIAGNOSIS
Dementia's pathophysiology isn't totally known. The accumulation of native proteins in the brain causes
most kinds of dementia, with the exception of vascular dementia.
Alzheimer's disease is characterized by extensive cortical atrophy and the formation of amyloid plaques
and tangles of hyperphosphorylated tau protein in neurons, all of which contribute to the destruction of
the neurons. The intracellular deposition of Lewy bodies (insoluble aggregates of alpha-synuclein) in
neurons, primarily in the cortex, is a hallmark of Lewy body dementia. Deposition of ubiquitinated TDP-
43 and hyperphosphorylated tau proteins in the frontal and temporal lobes causes dementia, early
personality and behavioral abnormalities, and aphasia in frontotemporal dementia. Vascular dementia is
caused by ischemic brain injury (such as a stroke), which results in persistent neuronal loss.
Source: https://www.ncbi.nlm.nih.gov/books/NBK557444/#article-20337.s5
Medication Indication Mechanism of Action Contraindication Adverse Effects Nursing Responsibilities
Generic Name: treatment of The commonly accepted Hypersensitivity to Body as a Monitor patient for therapeutic
dementia of the cholinergic hypothesis proposes donepezil or tracine, Whole: Headache, fatigue. effectiveness: Improvement as noted on
Donepezil Alzheimer's type, that a portion of the cognitive GI bleeding, and the Alzheimer's Disease Assessment
Off-label uses and behavioral decline jaundice. CNS: Insomnia, dizziness, Scale.
include the associated with Alzheimer's are depression, tremor, irritability, Monitor patient closely for S&S of GI
Brand Name: management of the result of decreased vertigo, ataxia. ulceration and bleeding
vascular dementia, cholinergic transmission in the
Parkinson's central nervous system. Monitor cardiovascular status; drug may have
CV: Syncope, hypertension, vagotonic effect on the heart, causing
Aricept Disease-associated Donepezil selectively and
atrial fibrillation, hot flashes, bradycardia
dementia, and Lewy reversibly inhibits the
hypotension. Educate patient with Exercise caution.
body dementia acetylcholinesterase enzyme,
Dosage: which normally breaks down Fainting episodes related to slowing the
acetylcholine. The main GI: Nausea, diarrhea,
heart rate may occur.
pharmacological actions of this vomiting, muscle cramps,
5mg PO/ day at night
drug are believed to occur as anorexia, GI bleeding,
the result of this enzyme bloating, fecal incontinence,
inhibition, enhancing cholinergic epigastric pain.
transmission, which relieves the
symptoms of Alzheimer's Respiratory: Dyspnea.
dementia. In addition to the
above, other mechanisms of Skin: Pruritus, sweating,
action of donepezil are possible, urticaria.
including the opposition of
glutamate-induced excitatory
transmission via downregulation
of NMDA receptors and the
regulation of amyloid proteins,
which have demonstrated
significant effects on the disease
process of Alzheimer's.
Source: https://go.drugbank.com/drugs/DB00843
Problem Rationale