Epigenetic modifications

Histone modifications binding proteins

hKAT3A hKAT3A (CBP) hKAT3A (CBP)
hKAT5B hKAT3B (p300) hKAT3B (p300)
Chromodomain proteins
NH2 dKAT3 (dCBP/NEJ) dKAT3 (dCBP/NEJ)
ac chromo CHD1 H3K4me2/3
RNF20/RNF40
Msk1
PKC N MST1 hKAT3B ARDT1
UBCH6 HP1/spSwi6 H3K9me2/3
ScRad6
ac spChp1 H3K9me2/3
TDG, MBT

PRMT6 BER O N CDY1 H3K9me2/3

spMst1 P io n DNMT P ac ac adp ub me
spSir2
at
PHD PC1/PC2/PC/LHP1 H3K27me3, H3K9me3
PADI4
NH2 O lic NH2
ep MSL3 H3K36me3
S
R
C K
hKDM1 (LSD1/BHC110) N OH N
ac
K K K K me 14-3-3 hMRG15 H3K36me, H3K4me3
spKDM1 (Swm1/Saf110)
dKDM1 (Su(var)3-3) 1 me cit hKAT3A (CBP)
14 15 20 30 120 scEaf3 H3K36me, H3K4me3
hKDM2B (JHDM1b/FBXL10) hKAT3B (p300)
hKDM5A (JARID1A/RBP2) dKAT3 (dCBP/NEJ) O N O N cit tudor CBX1,3,5 H3K9me3/2
hKDM5B (JARID1B/PLU1)
hKDM5C (JARID1C/SMCX) R
hKAT1
hKAT5 TDG, K MPP8 H3K9me3/2
BER ac

on
ScKAT5

Re
hKDM5D (JARID1D/SMCY) P Tip60 H3K9me3/2
3 5caC 5mC 12 bromo

ati

plic
scKDM5 (Jhd2)
CBX2,4,6,7,8 H3K27me3/2, H3K9me3/2

plic
spKDM5 (Jmj2)

ati
PRMT6 ac chromo
dKDM5 (Lid)
ac K
ub

o
hKAT1 (HAT1)

Re
MBT proteins
ZF - CW

n
PRMT5 PRMT1 TET scKAT1 (Hat1)
PADI4 PRMT6 TET spKAT1 (Hat1/Hag603)
ac PHF20L1 H3K4me1, H4K20me1
SETMAR 5 dKAT1 (CG2051) iso
MBT

K
ANKYRIN
hKMT2A (MLL1)
PADI4
NH2 NH2 hKAT3A (CBP) SFMBT H3K9me1/2, H4K20me1/2
hKMT2B (MLL2) hKAT3B (p300)
me cit hKMT2C (MLL3)
5 me N O N OH
dKAT3 (dCBP/NEJ) me
o-p
PHD
PWWP
L3MBTL1 H4K20me1/2, H1bK26me1/2
hKMT2D (MLL4) hKAT5 (TIP60/PLIP)
SIRT6 L3MBTL1 H3K20me
hKMT2E (MLL5) ARTD1 scKAT5 (Esa1) ac chromo
hKMT2F (hSET1A) L3MBTL1/2 H3K9me
R
spKAT5 (Mst1)
Haspin
Vrk1
hKMT2G (hSET1B)
hKMT2H (ASH1)
hKAT2A (hGCN5) R O N TET O N dKAT5 (dTIP60)
hKAT7 (HBO1/MYST2)
hKAT1 (HAT1)
scKAT1 (Hat1)
me
adp
14-3-3
BRCT
MBTD1 H3K20me
2 hKMT3C (SMYD2)
hKAT2B (PCAF) adp spKAT1 (Hat1/Hag603) ac
hKMT3G (NSD3)
scKAT2 (Gcn5) 11 PRMT1
spKAT7 (Mst2)
dKAT7 (CHM) dKAT1 (CG2051) cit
MBT
PHD proteins
tudor
spKAT2 (Gcn5) P BIR

P hKMT7 (SETD7) dKAT2 (dGCN5/PCAF)

PRMT6
5fC AM-AR 5hmC hKAT5 (TIP60/PLIP)
scYng1 H3K4me2/3
K
scKMT2 (Set1) scKAT5 (Esa1) me
hKAT12 (TFIIIC90) spKAT5 (Mst1)
PHD
spKMT2 (Set1) hKAT3A (CBP) P
AM-PD dKAT5 (dTIP60)
bromo
ING1,2,3,4,5 H3K4me2/3
dKMT2A (Trx)
me PRMT1 hKAT3B (p300)
T hKDM1 (LSD1/BHC110)
hKDM3A (JHDM2a)
13 CKII
ScCK1 PADI4
PRMT5
PRMT6
dKAT3 (dCBP/NEJ)
hKAT5 (TIP60/PLIP)
hKAT7 (HBO1/MYST2)
spKAT7 (Mst2) me
ub
14-3-3
BPTF/dmNURF301 H3K4me2/3
Bmi/Ring1A dKAT7 (CHM) ZF - CW
scSpp1 H3K4me2/3
3 ac me hKDM3B (JHDM2b) scKAT5 (Esa1)
hKDM4A (JMJD2A/JHDM3A)
R spKAT5 (Mst1)
cit scSet3 H3K4me2/3
cit me ac dKAT5 (dTIP60) tudor
hKDM4B (JMJD2B)
ub P iso

H2B H4
ANKYRIN
hKDM4C (JMJD2C/GASC1)
29 hKAT7 (HBO1/MYST2) hKAT5 (TIP60/PLIP) scJhd1 H3K4me3
K hKDM4D (JMJD2D)
scKDM4 (Rph1) NHK-1
spKAT7 (Mst2)
dKAT7 (CHM)
scKAT5 (Esa1)
spKAT5 (Mst1) P bromo
RAG2 H3K4me3
S R K
PKC beta dKAT5 (dTIP60)
P PHF8 o-p PWWP
TAF3 H3K4me3
4
K hKAT8 (hMOF/MYST1)
scKAT8 (Sas2) ICBP90 (Np95) H3K9me2/3
BIR P 1 3 5 ac spKAT8 (Mst2)
ub ZF - CW

P hKMT1A (SUV39H1)
hKMT1B (SUV39H2) 119 dKAT8 (dMOF/CG1894)
adp BRCT
JARID1C H3K9me3
hKMT1C (G9a) JARID1A H3K4me2/3
iso
me T K
hKMT1D (EuHMTase/GLP) ANKYRIN

T hKMT1E (ESET/SETDB1) SIRT2

spSir2
P BIR
KIAA1718 H3K4me2/3

chromo me cit
hKMT1F (CLL8)
hKMT8 (RIZ1) 120 8 ac o-p Lid H3K4me2/3
6 spKMT1 (Clr4)
PWWP

H2A
MLL1 H3K4me2/3
dKMT1 (Su(var)3-9) ARDT1

PHD
R
hKAT2A (hGCN5)
hKAT2B (PCAF)
K hKMT5A (Pr-SET7/8)
adp BRCT
PHF2,8
PHO23
H3K4me2/3
H3K4me2/3
ac me
PP1
scKAT2 (Gcn5)
12 ac adp hKMT5B (SUV4-20H1)
Pygo H3K4me2/3
8 spKAT2 (Gcn5) hKMT5C (SUV4-20H2) P BIR
tudor dKAT2 (dGCN5/PCAF) spKMT5 (Set9) ac chromo
Aurora B
hKAT3A (CBP) ac CHD4 H3K9me
K
dKMT5A (PR-set7) chromo
Pim1

MBT
K MSK1
MSK2
hKAT3B (p300)
dKAT3 (dCBP/NEJ)
dKMT5B (Su(var)4-20)
hKMT3B (NSD1) ac MBT
ICBP90 H3K9me

9 IKK alpha
hKAT6A (MOZ/MYST3)
hKAT6B (MORF/MYST4)
PP4
ac 16 ac MBT
SMCX H3K9me
scKAT6 (Sas3) EYA1/3 DPF3 H3K14ac
me
H2AX H3
ZF - CW spKAT6 (Mst2) Mst1 me PHD
P ATM
bromo me 14-3-3 PHD
proteins
dKAT6 (CG1894)
DLK/ZIP hKAT10 ATR WSTF
Lpcat1 14-3-3 H3S10p, H3S28p
me
K
PRK1 scKAT10 (Hap2)
me 14-3-3

S hKAT12 (TFIIIC90)

ac ub
me 14-3-3
Tudor proteins
P P me 20 o-p HAT4
chromo 10 P hPRMT4
cit
ac
cit
tudor
chromo
tudor JMJD2A H3K4me3, H4K20me3
BBAP/DTX3L

PHD
T PADI4 K K S Y tudor
S P
ac bromo
MBT
53BP1
spCrb2
H4K20me1/2
H4K20me2
P
ac ub
bromo

ac 5 119 139 142 47

MBT
P 11 hKAT2A (hGCN5)
MBT ac ub
me ZFPHD
- CW
PHF20 H4K20me2
hKAT2B (PCAF) ub ZF - CW
TDRD3 H3R17me2a, H4R3me2a

K
scKAT2 (Gcn5)
chromo ac 14-3-3
K spKAT2 (Gcn5) hPRMT4 P PWWP bromo scSgf29 H3K4me2/3
Epigenetic modifications ANKYRIN dKAT2 (dGCN5/PCAF)
iso
me
iso
ANKYRIN
14-3-3
PHF19 H3K36me3
me cit
hHDAC1 ANKYRIN
hKAT3A (CBP) BRCT 91
Histone modifications and DNA ac chromo
14 hKAT3B (p300) PADI4 hHDAC2
o-p
PHF1 H3K36me3
dKAT3 (dCBP/NEJ) cit PWWP
tudor
methylation are epigenetic ac marks that MBT ac chromo hKAT12 (TFIIIC90) o-p Bromodomain proteins
PWWP

R
hKAT3B (P300)
affect gene expression. This poster highlights scKAT11 (Rtt109)
spKAT11 (Rtt109) adp
P BRCT Polybromo/BAF180 H3ac
ac
bromo

the different types of epigenetic modifications ac MBT ac 17 hKAT3B (p300)

hKAT2A (hGCN5)
hKAT2B (PCAF)
hKAT2A (GCN5) adp BRCT
scSnf2 H3ac, H4ac

and their writers, readers, me ac hKAT3A

Brd2,3,4,7 H3ac, H4ac
and erasers. PHD MBT
bromo hKAT5B
scKAT2 (Gcn5)
spKAT2 (Gcn5)
P
ub ZFBIR
- CW

R
hKMT4 (DOT1L)
KDM6A (UTX)
P BIR
TAF1 H3ac, H4ac
dKAT2 (dGCN5/PCAF) scKMT4 (Dot1)
me PHD ac
KDM6B (JMJD3)
iso P/CAF H3ac, H4ac, H4K16ac
Epigenetic modifications me at Abcam 14-3-3 18
ANKYRIN

me PHD hKDM2A (JHDM1a/FBXL11) CBP/p300 H3ac, H4ac

To help support your research, we have a range ofac
hKMT6B (EZH1) hKDM2B (JHDM1b/FBXL10) ac me ac chromo
chromo hKMT6 (EZH2) ac scBdf1 H4ac
K
scKDM2 (Jhd1) hPKC-delta o-p chromo
PWWP
hKMT3G (NSD)
resources, including sample ac preparation chromo me assays 14-3-3
kits, detection dKMT6 (E/(Z))
hKDM4A (JMJD2A/JHDM3A) ac chromo hBRG1 H3K14ac
K K ac
hKDM4B (JMJD2B)

for epigenetic modifications, cit recombinant me

tudor active proteins, 23 me cit hKDM4C (JMJD2C/GASC1)
MBT
scRsc1,2,4 H3K14ac (Rsc4)
ac ac
14-3-3
ARTD1
scKDM4 (Rph1) P ac
adp
ac
MBT
BRCT
scGcn5 H4ac, H4K16ac
chromo MBT 56 79 MBT
inhibitors of epigenetic pathways, ac andchromo
peptide array-tested
cit
dKDM2 Rv1988
me PHD

monoclonal antibodies to Phistone modifications.

MBT
cit
tudor R T
me
ac
P BIR
chromo
PHD
ATAD2 H3K14ac
bromo tudor
26
ac me adp hKMT3A (SET2)
hKMT3B (NSD1) me me
me
PHD
14-3-3
BRDT H4K5ac, H4K8ac, H3K18ac
ac MBT me PHD MSK1 hKMT3C (SMYD2) hJAK2 45 me
ac 14-3-3
MBT
CBP/p300 H4K20ac, H3K36ac
MSK2
To find out more, check out ac our epigenetics
me contentP library where you can NSD2 me GCN5 H4K16ac
MBT
PHD bromo
K R
14-3-3
scKMT3 (Set2) cit
P
tudor

find more posters, guides, protocols, and ub webinars. P

ZF - CW bromo spKMT3 (Set2) cit
me PB-2 H3K14ac
P
tudor
PHD
Zfh Setd3
me PHD me 14-3-3
27 42 cit tudor TRIM24 H3K23ac
P bromo
me 14-3-3
PHD ub ZF - CW scFPR4 ARTD1 scFPR4
Y me
P ZF-CWbromo
proteins
www.abcam.com/epigenetics iso ANKYRIN ub ZF - CW S P
14-3-3
bromo
41 ub ZF - CW ZCWPW1 H3K4me1/2
me 14-3-3 cit tudor me 28 iso ac me adp iso ub
cit ZF - CW
tudor
ac chromo me
cit 14-3-3
tudor iso ANKYRIN ub
iso
ANKYRIN
ZF - CWproteins

Histone modifications
ANKYRIN
ac o-p iso chromo
P K K P G9a/GLP H3K9me2/1
chromo PWWP ANKYRIN iso
P ANKYRIN
bromo
ac chromo cit tudor P bromo iso
ac
o-p
ANKYRIN
chromo
PWWPPWWP
proteins
ac Acetylation chromo
MBT cit
P Deimination tudor
bromo o-p O-palmitoylation
PWWP P 30 36 37 38 o-p
ub PWWP
ZF - CW

ac adp BRCT o-p PWWP o-p

ac PWWP BRPF1 H3K36me3
MBT MBT
14-3-3 adp BRCT
DNMT3A H3K36me3
ac Deacetylation MBT P Phosphorylation
bromo ub Ubiquitination
ZF - CW iso
adp BRCT
ANKYRIN

ac
me ub PDP1 H4K20me1
MBT
PHD P ZF -
bromoCW adp BRCT me
adp
me
P
BRCT
PHD
BIR
me HDGF2 H3K36me3
Methylation PHD P Dephosphorylation
BIR adp ADPRibosylation
BRCT o-p
P BIR
PWWP
me PHD ub ZF - CW iso ANKYRIN chromo P
me BRCT 14-3-3
proteins
BIR

me Demethylation 14-3-3
PHD ub
iso Isomerization
ANKYRIN
ZF - CW P BIR adp BRCT MDC1 H2AXS139p (γH2AX)
me PWWP
14-3-3 P BIR cit tudor
BIR proteins
me 14-3-3 iso ANKYRIN o-p PWWP P BIR

me
cit
Created by Abcam 14-3-3 tudor
in
o-p
iso ANKYRIN
PWWP
collaboration with Tony Kouzarides and Andy Bannister (Gurdon Institute, Cambridge).
P bromo Survivin H3T3p
cit tudor
cit tudor o-p PWWP adp BRCT ub ZF - CW

cit
P bromo
tudor o-p
adp BRCT
PWWP
P bromo iso ANKYRIN

P2018 Abcam, All rightsbromo

Copyright © reserved. adp BRCT P BIR
ub
P ZF - CW
bromo P
adp BIR
BRCT o-p PWWP