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Dynamical Systems in Neuroscience

The document discusses dynamical systems in neuroscience. It describes the structure of neurons and how action potentials are generated. It explains integrators and resonators in neurons and introduces the Hodgkin-Huxley model of neuronal firing. The document discusses phase portraits and bifurcations in neuronal dynamics and provides a classification of different types of neurons based on their dynamical properties.

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118 views14 pages

Dynamical Systems in Neuroscience

The document discusses dynamical systems in neuroscience. It describes the structure of neurons and how action potentials are generated. It explains integrators and resonators in neurons and introduces the Hodgkin-Huxley model of neuronal firing. The document discusses phase portraits and bifurcations in neuronal dynamics and provides a classification of different types of neurons based on their dynamical properties.

Uploaded by

Rana Danish
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Dynamical Systems in Neuroscience

Danish Hafeez Rana

IBA-KARACHI

August 15, 2022

Danish Hafeez Rana Dynamical Systems in Neuroscience


Structure of a Neuron

Danish Hafeez Rana Dynamical Systems in Neuroscience


Action Potential (or Spike)[1]

Danish Hafeez Rana Dynamical Systems in Neuroscience


Where Is the Threshold [2]

Danish Hafeez Rana Dynamical Systems in Neuroscience


Integrators versus resonators [5]

Danish Hafeez Rana Dynamical Systems in Neuroscience


Integrators versus resonators [5]

Danish Hafeez Rana Dynamical Systems in Neuroscience


Dynamical Systems and Building Models

A dynamical system
consists of a set of variables that describe its state and a law that
describes the evolution of the state variables with time (i.e., how
the state of the system in the next moment of time depends on the
input and its state in the previous moment of time).

Danish Hafeez Rana Dynamical Systems in Neuroscience


The Hodgkin-Huxley Model[3]

IK INa IL
z }| { z }| { z }| {
C V̇ = I − ḡK n4 (V − EK ) − ḡNa m3 h (V − ENa ) − gL (V − EL )
ṅ = αn (V )(1 − n) − βn (V )n
ṁ = αm (V )(1 − m) − βm (V )m
ḣ = αh (V )(1 − h) − βh (V )h

The variables n and m are called activation variables and h is


inactivation variable. The coefficients αn , βn , αm , βm , αh and βh
denote rate constants for the opening and closing of gates.

Danish Hafeez Rana Dynamical Systems in Neuroscience


Action potential in the Hodgkin-Huxley model

Danish Hafeez Rana Dynamical Systems in Neuroscience


Phase Portraits and Bifurcations

Danish Hafeez Rana Dynamical Systems in Neuroscience


Bifurcations

Danish Hafeez Rana Dynamical Systems in Neuroscience


Danish Hafeez Rana Dynamical Systems in Neuroscience
Classification of neurons

Danish Hafeez Rana Dynamical Systems in Neuroscience


References

Verma, Parul, et al. ”Using bifurcation theory for exploring


pain.” Industrial and Engineering Chemistry Research 59.6
(2019): 2524-2535.
Izhikevich, Eugene M. Dynamical systems in neuroscience.
MIT press, 2007.
Hodgkin, Alan L., and Andrew F. Huxley. ”A quantitative
description of membrane current and its application to
conduction and excitation in nerve.” The Journal of physiology
117.4 (1952): 500.
Fitzhugh, Richard. ”Thresholds and plateaus in the
Hodgkin-Huxley nerve equations.” The Journal of general
physiology 43.5 (1960): 867-896.
Izhikevich, Eugene M. ”Resonate-and-fire neurons.” Neural
networks 14.6-7 (2001): 883-894.

Danish Hafeez Rana Dynamical Systems in Neuroscience

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