HIV

1. HIV is characterized by the following EXCEPT : a. It infects CD4 positive cells b. It causes immunosuppression c. It has reverse transcriptase enzyme d. It is transmitted by blood, sexual intercourse and feco-oral routes 2. HIV attaches to special receptors on surface of host cells. These receptors are : a. CD8 receptors b. CD4 receptors c. Both of them d. None of them 3. HIV antigen which is important for viral attachment to host cells is : a. gp120 b. gp41 c. gp160 d. P24 4. The main function of gp120 Ag of HIV is : a. Integration of proviral DNA into host genome b. Synthesis of DNA copy from viral genome c. Attachment of the virus to CD4 receptor d. All of the above 5. HIV infects the following cells EXCEPT : a. Cytotoxic T cells b. Helper T cells c. Monocytes d. Langerhans cells 6. The following condition is responsible for HIV antigenic variation : a. gp120 antigen mutation b. Lack of reverse transcriptase enzyme c. Integration of proviral DNA copy into host cell genome d. All of the above 7. Laboratory diagnosis of HIV infection is done by the following tests EXCEPT : a. Detection of HIV antibodies by ELISA test b. Western blot test c. PCR to detect viral genome d. Detection of inclusion bodies

8. The main function of HIV reverse transcriptase enzyme is : a. Release of virus particles from the infected cells b. Cleavage of viral proteins c. Production of neutralizing antibodies d. Synthesis of proviral DNA copy from viral RNA genome during viral replication 9. HIV affects T4 cells by : a. It causes cell fusion with formation of syncytial cells b. It causes death of infected and non-infected T4 cells c. It causes depletion of T4 cells with inversion of T4/T8 ratio d. All of the above 10. HIV infects monocytes with the following effect : a. It causes death of these cells due to CPE & syncytia formation b. It survives inside these cells which act as reservoir for the virus c. It causes transformation of these cells d. All of the above 11. HIV reaches the CNS of the host by the following main route : a. Along peripheral neurons b. Through monocytes which act as reservoir for the virus c. By blood d. All of the above 12. Preparation of HIV vaccine is still difficult because : a. The virus cannot be isolated b. The virus undergoes continuous antigenic variation c. Both of them d. None of them 13. HIV can be transmitted by : a. Blood transfusion b. Sexual intercourse c. Transplacental d. All of the above 14. All a. b. c. d. of the following are correct for HIV EXCEPT : It causes AIDS It infects CD4 positive cells It causes inversion of T4/T8 ratio It is an oncogenic variation

TRUE/FALSE
HIV infection may lead to : 1. 2. 3. 4. 5. Dementia Chronic diarrhea CMV infection Esophageal candidiasis Lymphadenopathy

The following maybe useful for prognostic purposes in HIV-infected individuals : 6. HIV envelope antibody level 7. HIV-p24 antigen 8. CD4 count 9. HIV proviral DNA in leukocytes 10. HIV plasma RNA HIV may respond to : 11. Nucleoside analogues 12. Protease inhibitors 13. Neuraminidase inhibitors 14. Reverse transcriptase inhibitors 15. Acyclovir

ANSWERS
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 HIV D B A C A A D D D B B B D D TRUE/FALSE T T T T T F T T F T T T F T F