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DRUGS (Topotecan)

Topotecan is an antitumor drug that works by inhibiting topoisomerase I, relieving torsional strain in DNA and causing single- and double-strand breaks. It is indicated for metastatic ovarian cancer after traditional chemotherapy failure, relapsed small cell lung cancer, and cervical cancer. Common side effects include neutropenia, leukopenia, thrombocytopenia, anemia, and gastrointestinal issues. Nursing responsibilities include monitoring liver enzymes, assessing for oral issues, and educating patients.

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108 views2 pages

DRUGS (Topotecan)

Topotecan is an antitumor drug that works by inhibiting topoisomerase I, relieving torsional strain in DNA and causing single- and double-strand breaks. It is indicated for metastatic ovarian cancer after traditional chemotherapy failure, relapsed small cell lung cancer, and cervical cancer. Common side effects include neutropenia, leukopenia, thrombocytopenia, anemia, and gastrointestinal issues. Nursing responsibilities include monitoring liver enzymes, assessing for oral issues, and educating patients.

Uploaded by

BARRISTERFLOWERSEAURCHIN6
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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DRUGS MECHANISM OF INDICATION CONTRAINDICATION SIDE EFFECTS NURSING

ACTION RESPONSIBILITIES
Generic Name: Antitumor  Therapeutic Pregnancy D, CNS: Arthralgia,  Assessment
topotecan (Rx) product with  outcome: breastfeeding, asthenia, • Monitor liver
topoisomerase I– Decreased  hypersensitivity, severe headache, myalgia, function tests: AST, ALT,
Brand Name: tumor  bone marrow pain, weakness alkaline
inhibitory activity; 
Hycamtin Size. depression phosphatase, which
topoisomerase  I GI: Abdominal may be elevated;
Classification: relieves torsional USES: Metastatic  pain, constipation, creatinine,
Avastin is classified strain in DNA by ovarian cancer  diarrhea, BUN
as a "monoclonal causing single-strand after failure of  obstruction, • Assess buccal cavity
antibody" and breaks; causes double- traditional  nausea, stomatitis, for dryness, sores or
"anti- strand DNA damage chemotherapy,  vomiting, ulceration, white
angiogenesis" drug relapsed small  increased ALT, AST, patches, oral pain,
cell lung cancer, anorexia bleeding,
Dosage and routes: cervical cancer dysphagia
Adult: HEMA:
- 0.75 mg/m² by Neutropenia, Patient/family
intravenous leukopenia, education
infusion over 30 thrombocytopenia, • Advise patient to
minutes daily on anemia, sepsis avoid foods with citric
Days 1, 2, and 3, in acid
combination with INTEG: Total or hot flavor or rough
cisplatin 50 mg/m² alopecia texture if stomatitis is
on Day 1, of a 21- present; to drink
day cycle. RESP: Dyspnea,  adequate fluids
cough, interstitial • Advise patient that
lung total alopecia may
disease occur;
hair grows back but may
be different in color
and texture
• Advise patient to
report stomatitis; any
bleeding, white spots,
ulcerations in mouth;
tell patient to examine
mouth daily; report
symptoms

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