Thermo Scientific Antaris II

Near-IR Analyzers

with superior engineering

comes instrument matching
and method transferability
Antaris II FT-NIR analyzer
solve industrial quality problems on
a common near-infrared platform
The Thermo Scientific Antaris II Fourier transform near-infrared (FT-NIR)
analyzer sets the standard for process and quality control analytics
through its intuitive operation and unique combination of performance,
power, and support. This analyzer is designed for use at production lines
and on factory floors, loading docks or warehouses, while retaining the
performance and flexibility necessary for method development work.

Antaris™ II defines the standard for the Total Solutions

design and manufacture of full spectral The Antaris II analyzer was developed to
range, near-infrared analyzers including: meet the unique needs of the pharma-
• High performance combined with ceutical, food and beverage, chemical,
rugged design and polymer industries. The instrument’s
• Reproducible regardless of configuration, design and extensive support programs
maintenance, user, or environment were developed with input from industry
market leaders to offer a solution to your
• R egulatory traceability incorporated into every
specific problem. The Antaris II analyzer
facet of the system, from the ground up
provides:
• Suitable platform for each point in your
• System-to-system repeatability for
product-development lifecycle, facilitating
method transfer
method development, deployment,
transfer, and routine operation • Easy software setup via dedicated
validation and application programs
• A regulatory and validation-ready
instrument
• Complete worldwide support programs
• Low cost of ownership

Why FT Near-infrared?
FT-NIR spectroscopy offers a practical alternative
to time-consuming, solvent-intensive, wet-testing
methods and liquid chromatography techniques.
Its ability to test materials quickly in their production
state allows routine analyses to be carried out at
the line, rather than in the lab.
 the right software
for the right environment
The Antaris II analyzers can be used with a complementary choice of software
matched to the end user and environment. Whether used for spectroscopic
analysis, method development, routine use or process analysis, there is no
need to force fit software into a use for which it was not designed.

RESULT Analysis Software OMNIC™ Software

Routine operation of the Antaris II Thermo Scientific OMNIC software has
industrial analyzer is accomplished with been the industry benchmark for molecular
Thermo Scientific RESULT software. The spectroscopy work for over twenty years,
revolutionary design of RESULT™ provides and now it’s available for the Antaris II. It
easy-to-use tools, method develop­ment, provides a data work environment for even
method transfer, and operational setup. the most demanding, raw-data analysis
RESULT includes the powerful predictive and provides seamless data portability to
model builder Thermo Scientific TQ Analyst. any of the four chemometric packages
•C
 omplete regulatory and validation-compliant available for sample prediction, with full
software package for GMP environments 21 CFR Part 11 compliance tools.
(including 21 CFR Part 11)
The Unscrambler Software
• Method and workflow developed to create
by Camo
automated SOPs without programming
We offer The Unscrambler® software for
• Intuitive, flexible,
users performing extensive investigation
easy-to-use graphical
and modeling. The Unscrambler is the
interface
standard in chemometric software for
• Workflow-based near-infrared spectroscopy and can
operation allows SOP be used to discover, understand, and
control of analysis, capitalize on complex sample relationships.
report generation and In today’s race for process
data archival understanding, this software tool
provides a powerful component to
applying analytics to operational
problems in industry.

Advantages of NIR Analysis Over Traditional Techniques Advantages of FT-NIR Analysis

NIR is ideal for quick, reliable raw-material identification and is a powerful FT-NIR provides several clear advantages over dispersive NIR techniques:
tool used for multi-component quantitative analysis. Remote sampling with • Fast – all frequencies are measured simultaneously
an NIR fiber optic probe is also an ideal option for process monitoring. • Mechanical simplicity for improved reliability – the moving mirror is the only
• No sample preparation – sampling can be done through glass and other continuously moving part
packaging materials • Internally calibrated for better accuracy and precision – based on the HeNe
• Non-destructive measurement laser as an internal wavelength calibration standard
• Accurate, reliable analysis • High spectral resolution – resolution is determined by the stroke length of the
• Reduced cost moving mirror, so there is no degradation to optical throughput or system sensitivity

• Increased sample throughput • Fewer standards and less complex methods are required due to superior
resolution, precision and accuracy of FT-NIR data; methods are more robust
• Remote sampling with low-cost fiber optics
and easier to develop
 Antaris II FT-NIR method
development sampling system
Bridge the gap between method development and analyzer
deployment with the NIR platform that does it all.

When you have to solve a problem, selecting the correct sampling tool is crucial.
The Antaris II MDS system provides a simple solution. It contains all the tools
you need to analyze solids, liquids, powders, pastes, and tablets. More impor-
tantly, the system allows you to select the best technique for your environment,
without reconfiguring the analyzer or changing accessories. It offers everything
you need to run any sample, without compromising repeatability or ease of use:
• Integrating sphere module for diffuse reflectance sampling
• Automated transmission sampling
• Fiber optic sampling with the Thermo Scientific SabIR probe
• Optional Tablet Analyzer module

After choosing a sampling technique, it is simple to transfer the method to

any Antaris II analyzer, regardless of location. Additional Antaris II systems
are configured with only the specific sampling techniques required for the
method you developed, for streamlined deployment into at-line QC operations.
Because every module uses the same beam path, each Antaris II system has
identical alignment and performance results, making method and calibration
transferability achievable. This not only saves you time and money, it provides
you with systems that are dedicated for your operations.

Liquids and Films:

Transmission Sample Compartment
• Automated, three-position holder
• Dual-load sampling
• Automatic background handling with samples in position
• Automatic backgrounds with matrix or reference material
• Heating with automatic temperature control

Building an Analyzer for the Lab and the Plant

Rugged Design for Internal Beam Path Use Design Qualification Design for Method
Working Environments Development
• Internal background handling • Quality system design consistent with
• Heavy-duty, aluminum housing eliminates operator error CFR 820 quality system rules • Optical matching between
and cover protects the system • Elimination of external references • Performance and design traceable to Antaris II MDS and dedi-
while, accommodating perma- reduces sampling variability specification for intended use cated systems facilitates
nently aligned precision optics • United States Pharmacopoeia- • Documentation of product develop- calibration transfer
• Best-in-class thermal stability recommended performance testing ment process • Dedicated optimal choice
• Source is replaced from is both internal and automated • Project documentation, including of sampling for intended
the outside without opening change control, verification and vali- task and location
the cover dation plans, ensures quality design
 Tablet Transmission Analysis:
Antaris II Tablet Detector
• Allows cross-sectional assay of solid
dosage cores or coated tablets
• True simultaneous measurement of
transmission and reflection data in
conjunction with integrating sphere
• Optimized detection maximizes tablet
signal and rejects stray light
• Sensitivity and spectral range can be This dedicated analyzer is a powerful, fast
and easy-to-use tool for tablet uniformity
optimized for tablets or softgels
verification.
• Tablets of all shapes and sizes
accommodated

Taking the Analysis to

Remote or In-situ Samples:
SabIR™ Fiber Optic Sampling
• Trigger operation makes complete
analysis simple
• Integrated indicator lights communicate
pass, fail, prompt
• Adapts quickly between solids and
liquids with a single probe
• Ideal for material identification at
point-of-use Methods can
be transferred
to the compact
Antaris MX
Reflection Sampling of Solids, Powders, process analyzer
for mobile field
Pastes, and Suspensions: Integrating Sphere analysis.
• Ultra high-efficiency light collection
• Sample materials directly or through glass containers
• High-sensitivity, high-stability detection system
• Automated internal background collection with
samples in position
• Wide range of options for different sample types,
shapes, and sizes
This dedicated system is ideal for
measuring solids and powders.

Dedicated Antaris II Configurations

Reflectance Sampling Liquids and Transmission Analysis Tablet Analysis Liquids and Solids
 method transferability
through precision engineering and manufacturing
Every Antaris II instrument is a high-performance FT-NIR spectrometer.
The design excellence and manufacturing precision of every Thermo
Scientific analyzer allows for reproducible results for method transferability.
Permanently aligned, pinned-in-place optics, and state-of-the-art hardware
components make the Antaris II an instrument you can rely on.

The Optics The Source The Laser

Method transferability is Internally, the Antaris II The HeNe laser is
made possible with the uses a long-life, high- the source of the
Antaris II because every intensity NIR source. Antaris II’s high
system is manufactured • Pinned-in-place, wavenumber accu-
using exactly the same pre-aligned holder racy and precision.
process, and to very ensures accurate and • Ensures you never need to calibrate the
tight specifications. continuous instrument operation Antaris II – it uses a HeNe reference laser to
• Pinned-in-place, permanently aligned optics • Pre-aligned to filament image level repeatability calibrate itself
ensure that every instrument we manufacture to ensure calibration continuity • Permits reproducible spectral measurements,
uses the same optical path • Hassle-free replacement (no need to open enables fewer standards needed for method
• All components are housed in a sealed and the instrument, and the source has a development, and reduces development time
desiccated enclosure, allowing operation in the lock-and-key fit)
• Ensures simpler, more transferrable qualitative
harshest industrial environments
and quantitative models
The Interferometer
At the heart of the Antaris II is the Thermo
Scientific MagnaFlex interferometer offering:
• Best scan-to-scan repeatability of any high-
resolution NIR technology available today
• Stability, long life, and fast scanning capabilities

High Throughput Automation and Specialized Sampling

The Antaris II analyzer features several dedicated automation options to facilitate large-volume sampling.
These tools allow the system to analyze up to 120 samples per hour.

Autosampler RS MultiPro Autosampler Sample Cup Spinner

Ideal for sampling Designed for tablet analysis, the Obtain bulk or average
powders through vials. MultiPro Autosampler can be information from inhomoge-
Analyze bulk solids: optimized for opaque or softgel neous samples quickly and
pellets, beads, powders. tablets. It allows rapid, simul- reliably. The Sample Cup
taneous sampling (reflection Spinner is ideal for powders,
and transmission) for maximum grains, pellets, and other
sample information in minimal granular samples.
time. It can also be used for
reflection sampling of vials,
bottles, and other sample types.
the standard
for analyzer qualification and validation tools
Product specifications traceable to use in regulated manufacturing environments require
qualification and validation support. The Thermo Scientific ValPro system qualification
package was developed in conjunction with the design of the analyzer and software platform
it supports, ensuring a truly integrated and comprehensive qualification tool. ValPro™ is
not a software package or an instrument test. It is an integrated approach to system
qualification traceable to the manufacture and original design of the product.

Development and USP General Chapter <1119> ValPro TQ Analyst™

Manufacturing Procedures ValPro provides the full USP NIR test suite, Algorithms
Our contribution to your DQ processes as well as additional tests for performance. Calibration equations used for prediction of
begin with strictly controlled processes traits from near-infrared data are a critical
in product development and production. Internal and External Fully part of near-infrared deployment. However,
All project records are available for Traceable Standards the generation of these equations, and the
on-site audit at the factory. We provide stan- execution of a calibrated method, is rarely
dards and test understood beyond what appears in the
Extensive Documentation limits that are fully software application interface. Validation of
ValPro’s documentation set covers design traceable, both and proof statements about chemometrics
qualification (DQ, including documentation internal and external with the ValPro TQ Algorithms system goes
of the product development process), IQ to the system. beyond, the “black box” approach. For the
and OQ procedures, and PQ guidance. first time, near-infrared chemometrics can
Qualification Services be backed up by documentation and trace-
Certified service ability. Components of ValPro’s traceable
engineers provide approach to algorithm and method validation:
qualification test
• F ully documented algorithms, as implemented
services that can
in the software
be used to satisfy
• A set of open, user-accessible reference
initial and ongoing
calculations for all algorithms
analyzer-use
requirements. • Reference calculations applied to known
calibration problems using standard data
Use-specific Testing sets and predict known samples (in spread-
ValPro allows workflow-based authoring sheet format)
and implementation of your own PQ or • Calibrations implemented in the software
suitability tests. using the same data sets
• Known samples can be predicted and
compared with reference calculations
About the Antaris Line of Analyzers and Sensors
Solving industrial analytical challenges requires bringing the right
tools to the job. The cumulative years of reliable spectroscopic
technology from Thermo Fisher Scientific have been combined with
the knowledge of experts and everyday users in industry to produce
a range of analyzers that set a new standard in task suitability. We
are pleased to offer a full line of analyzers with common platform
elements in software, validation tools, methodology, support, and
implementation. The Antaris product line represents an industry-
driven migration of spectroscopy from science to industry, in a
solution that connects the lab and the plant for the first time.

Our Pledge of Support: A Fundamental Analyzer Requirement

The Antaris analyzer product family is backed by our worldwide 3 Qualification Services
applications and process support team. With dedicated support We offer a full line of installation and operation qualification
for most countries and regions around the world, our customer services and annual requalification services, which can be used
support organization is the best in the industry. We provide: in conjunction with the ValPro system, to demonstrate proper
• Applications Assistance performance and suitability.
• Qualification Support
4 Training
• Preventive Maintenance
• 24/7 Services Our team of Antaris support specialists can provide:
• On-site or factory-based training on the use of the system
We offer a full suite of product and customer services tailored to
• Customized training to ready your staff or plant
near-infrared and process analysis. Let us recommend a support
• Service training and certification to your plant personnel
configuration, or ask us how we can customize these services
specifically to your requirements: 5 Method Development Services
1 Feasibility and Site Survey If you do not have the time or resources to model your process
We will work with you to evaluate the feasibility of near-infrared parameters using near-infrared, let us provide calibration services
as a solution to your process analytical challenge. A Thermo for you:
Scientific NIR specialist will visit your intended use site to gather • Method Development
key information related to process analyzer integration and the • Maintenance
necessary components, services, and preparations. We will • Transfer Services
provide a thorough proposal to ensure a smooth implementation.
6 Repair and Technical Support Services
2 Installation From depot repair to critical support, we offer repair and technical
Our certified field-service engineers ensure proper installation support services that include 24/7 options to help meet the
and operation of the analyzer. Prior to installation, we provide uptime requirements of your application.
a site-readiness form to synchronize installation preparedness
between your site and our engineers.

Thermo Electron Scientific Instruments

www.thermoscientific.com LLC, Madison, WI USA is ISO Certified.
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registered trademark of Camo. All other trademarks are the property of Thermo Fisher Scientific Inc. and its subsidiaries. Specifications, terms
and pricing are subject to change. Not all products are available in all countries. Please consult your local sales representative for details.

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