Scribd Logo
Upload

Welcome to Scribd!

  • 49 views

    Bombay Blood Group

    Uploaded by

    Sanjay Gupta
    Bombay Blood Group does not express the H antigen and therefore lacks A and B antigens, similar to type O blood. However, it can only be differentiated from type O through specific H antigen testing, which is often unavailable in India. The monoclonal antibody against the H antigen described in the document can be used to detect the H antigen in blood and other body fluids through techniques like ELISA and inhibition assays, in order to distinguish Bombay Blood Group from type O.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd

    Bombay Blood Group

    Uploaded by

    Sanjay Gupta
    49 views1 page
    Bombay Blood Group does not express the H antigen and therefore lacks A and B antigens, similar to type O blood. However, it can only be differentiated from type O through specific H antigen testing, which is often unavailable in India. The monoclonal antibody against the H antigen described in the document can be used to detect the H antigen in blood and other body fluids through techniques like ELISA and inhibition assays, in order to distinguish Bombay Blood Group from type O.

    Original Description:

    Know Bombay Blood Group

    Copyright

    © © All Rights Reserved

    Available Formats

    DOCX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Bombay Blood Group does not express the H antigen and therefore lacks A and B antigens, similar to type O blood. However, it can only be differentiated from type O through specific H antigen testing, which is often unavailable in India. The monoclonal antibody against the H antigen described in the document can be used to detect the H antigen in blood and other body fluids through techniques like ELISA and inhibition assays, in order to distinguish Bombay Blood Group from type O.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    49 views1 page

    Bombay Blood Group

    Uploaded by

    Sanjay Gupta
    Bombay Blood Group does not express the H antigen and therefore lacks A and B antigens, similar to type O blood. However, it can only be differentiated from type O through specific H antigen testing, which is often unavailable in India. The monoclonal antibody against the H antigen described in the document can be used to detect the H antigen in blood and other body fluids through techniques like ELISA and inhibition assays, in order to distinguish Bombay Blood Group from type O.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 1

    Bombay Blood Group does not have A or B antigens 

    and hence can be mistakenly typed as


    O blood. It is only when a specific test, often unavailable in India, for H antigen is done that it can
    be differentiated between O and Bombay Blood group

    Blood Group H Antigen Monoclonal Antibody


    100 µg
    INR 30,845.00

    Product Details
    Applications,Tested Dilution
    ELISA (ELISA) Assay-dependent
    Inhibition Assays (IA) 1:100
    -Agglutination (AGG) 1:50
    -

    Product Specifications
    Species Reactivity Human
    Host/Isotype Mouse / IgM
    Class Monoclonal
    Type Antibody
    Clone 97-I
    Immunogen H human blood protein.
    Conjugate Unconjugated
    Form Liquid
    Concentration 1 mg/mL
    Purification Protein A
    Storage buffer PBS ,pH 7.2
    Contains 0.01% sodium azide
    Storage conditions 4°C short term, -80°C long term
    RRID AB_1070772

    Product Specific Information


    This anti-H INH blood antigen antibody can be used to detect the the H antigen of red blood cells and body fluids.
    It can be used for the testing of I-antigen in blood, blood stains, saliva, and for spot analysis in forensic medicine
    by absorption-elution, ELISA, and Inhibition assays.

    Target Information
    The H antigen is a precursor to the ABO blood group antigens, present in people of all common blood types. The
    Bombay phenotype (hh) does not express antigen H on red blood cells, and therefore this type will also lack A or
    B antigens, similar to the O blood group. However, unlike O group, the H antigen is absent, hence the individuals
    produce isoantibodies to antigen H as well as to both A and B antigens. If they receive blood from someone with
    O blood group, the anti-H antibodies will bind to the H antigen on the red blood cells of the donor blood and
    destroy the RBCs by complement-mediated lysis. Therefore, people with Bombay phenotype can receive blood
    only from other hh donors, although they can donate as though they were type O. Some individuals with the
    blood group A1 may also be able to produce anti-H antibodies due to the complete conversion of all the H
    antigen to A1 antigen. Production of the H antigen, or its deficiency in the Bombay phenotype, is controlled at the
    H locus on chromosome 19. The H locus contains three exons that span more than 5 kb of genomic DNA, and
    encodes the fucosyltransferase that produces the H antigen on RBCs. The H antigen is a carbohydrate sequence
    with carbohydrates linked mainly to protein (with a minor fraction attached to ceramide moiety).

    For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

    You might also like