S94 - Harish Kumar Rao Manav Chowk Cc-Sahyogi Juneja Towers, 716, Rattangarh Road, Manav Chowk, Ambala CITY, PH-9996006678
S94 - Harish Kumar Rao Manav Chowk Cc-Sahyogi Juneja Towers, 716, Rattangarh Road, Manav Chowk, Ambala CITY, PH-9996006678
S94 - Harish Kumar Rao Manav Chowk Cc-Sahyogi Juneja Towers, 716, Rattangarh Road, Manav Chowk, Ambala CITY, PH-9996006678
Comments
Anti CCP antibodies are useful for evaluating patients suspected of Rheumatoid arthritis. Positive results
occur in 60-80% of Rheumatoid arthritis patients depending on disease severity. The positive predictive value
of Anti CCP antibodies for Rheumatoid arthritis is far greater than Rheumatoid factor. False positive results
are uncommon. Upto 30% patients with seronegative Rheumatoid arthritis also show Anti CCP antibodies.
Clinical Uses
· For diagnosis of early Rheumatoid arthritis - Anti CCP antibodies are detected in approximately 50-60%
patients of Rheumatoid arthritis usually after 3-6 months of symptoms
· Prediction of severity of disease - Early Rheumatoid arthritis patients with Anti CCP positivity may
develop a more erosive form of the disease as compared with Anti CCP negative patients
· To differentiate elderly onset Rheumatoid arthritis from Polymyalgia rheumatica and erosive SLE
Note
1.
Test performed on EDTA / ACD whole blood
2.
This is an in-house developed assay
3.
In cases of HLA-B27 negative Spondyloarthropathy, further testing recommended is
HLA-C*06 (Positive in Psoriatic arthritis) and HLA-B*07 (Positive in Juvenile and Undifferentiated
Spondyloarthropathy).
Comments
Certain inflammatory and non-inflammatory diseases are associated with the inheritance of HLA alleles .
Ankylosing spondylitis and several postinfectious arthropathies are associated with the presence of HLA -B27.
Individuals who inherit this class I allele have a 90 fold greater chance of developing the disease as compared
to those who do not carry HLA-B27. It is postulated that the mechanism underlying this association most
probably influences T cell response.
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Uses
---------------------------------------------------------------------------------
| DISEASE | STRENGTH OF ASSOCIATION |
|---------------------------------------------|-----------------------------------|
| Ankylosing spondylitis | ++++ |
|---------------------------------------------|-----------------------------------|
| Reiter’s syndrome | ++++ |
|---------------------------------------------|-----------------------------------|
| Reactive arthritis (Yersinia, Salmonella, | +++ |
| Shigella & Chlamydia) | |
|---------------------------------------------|-----------------------------------|
| Acute anterior uveitis | +++ |
|---------------------------------------------|-----------------------------------|
| Psoriatic spondylitis | +++ |
---------------------------------------------------------------------------------
** Test conducted under NABL scope MC-2113,LPL-NATIONAL REFERENCE LAB at NEW DELHI
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IMPORTANT INSTRUCTIONS
ŸTest results released pertain to the specimen submitted .ŸAll test results are dependent on the quality of the sample received by the Laboratory .
ŸLaboratory investigations are only a tool to facilitate in arriving at a diagnosis and should be clinically correlated by the Referring
Physician.ŸSample repeats are accepted on request of Referring Physician within 7 days post reporting.ŸReport delivery may be delayed due to
unforeseen circumstances. Inconvenience is regretted .ŸCertain tests may require further testing at additional cost for derivation of exact value .
Kindly submit request within 72 hours post reporting.ŸTest results may show interlaboratory variations .ŸThe Courts/Forum at Delhi shall have
exclusive jurisdiction in all disputes /claims concerning the test(s) & or results of test(s).ŸTest results are not valid for medico legal purposes .
ŸContact customer care Tel No. +91-11-39885050 for all queries related to test results.
(#) Sample drawn from outside source.
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