Safety data sheet

according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU

o-Toluidine ≥99,5 %, p.a.

article number: 4788 date of compilation: 2019-08-22

Version: 1.0 en

SECTION 1: Identification of the substance/mixture and of the company/

undertaking
1.1 Product identifier
Identification of the substance o-Toluidine
Article number 4788
Registration number (REACH) It is not required to list the identified uses be-
cause the substance is not subject to registration
according to REACH (< 1 t/a)
Index No 612-091-00-X
EC number 202-429-0
CAS number 95-53-4
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses: laboratory chemical
laboratory and analytical use
1.3 Details of the supplier of the safety data sheet
Carl Roth GmbH + Co KG
Schoemperlenstr. 3-5
D-76185 Karlsruhe
Germany

Telephone: +49 (0) 721 - 56 06 0

Telefax: +49 (0) 721 - 56 06 149
e-mail: [email protected]
Website: www.carlroth.de
Competent person responsible for the safety data : Department Health, Safety and Environment
sheet
e-mail (competent person) : [email protected]
1.4 Emergency telephone number
Name Street Postal code/city Telephone Website

National Poisons In- Beaumont Road Dublin 9 01 809 2166 https://

formation Centre www.poisons.ie/
Beaumont Hospital

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 (CLP)

Classification acc. to GHS

Section Hazard class Hazard class and cat- Hazard

egory state-
ment

3.1O acute toxicity (oral) (Acute Tox. 3) H301

3.1I acute toxicity (inhal.) (Acute Tox. 3) H331

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Safety data sheet
according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU

o-Toluidine ≥99,5 %, p.a.

article number: 4788

Classification acc. to GHS

Section Hazard class Hazard class and cat- Hazard

egory state-
ment

3.3 serious eye damage/eye irritation (Eye Irrit. 2) H319

3.6 carcinogenicity (Carc. 1B) H350

4.1A hazardous to the aquatic environment - acute hazard (Aquatic Acute 1) H400

4.1C hazardous to the aquatic environment - chronic hazard (Aquatic Chronic 2) H411

2.2 Label elements

Labelling according to Regulation (EC) No 1272/2008 (CLP)

Signal word Danger

Pictograms

GHS06, GHS08,
GHS09

Hazard statements
H301+H331 Toxic if swallowed or if inhaled
H319 Causes serious eye irritation
H350 May cause cancer
H410 Very toxic to aquatic life with long lasting effects
Precautionary statements
Precautionary statements - prevention
P261 Avoid breathing gas/mist/vapours/spray.
P280 Wear protective gloves/eye protection.
Precautionary statements - response
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P337+P313 If eye irritation persists: Get medical advice/attention.

For professional users only

Labelling of packages where the contents do not exceed 125 ml
Signal word: Danger

Symbol(s)

H301+H331 Toxic if swallowed or if inhaled.

H350 May cause cancer.

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Safety data sheet
according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU

o-Toluidine ≥99,5 %, p.a.

article number: 4788

P261 Avoid breathing gas/mist/vapours/spray.
P280 Wear protective gloves/eye protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor.
P308+P313 IF exposed or concerned: Get medical advice/attention.

2.3 Other hazards

There is no additional information.

SECTION 3: Composition/information on ingredients

3.1 Substances
Name of substance o-Toluidine
Index No 612-091-00-X
EC number 202-429-0
CAS number 95-53-4
Molecular formula C7H9N
Molar mass 107,2 g/mol

Substance of Very High Concern (SVHC)

Name of substance CAS No Wt% Listed in Remarks

o-Toluidine 95-53-4 100 Candidate list Carc. A57a

Legend
candidate list Substances meeting the criteria referred to in Article 57 and for eventual inclusion in Annex XIV
Carc. A57a Carcinogenic (article 57a)

SECTION 4: First aid measures

4.1 Description of first aid measures

General notes
Self-protection of the first aider.
Following inhalation
Call a physician immediately. If breathing is irregular or stopped, administer artificial respiration.
Following skin contact
Rinse skin with water/shower.
Following eye contact
Irrigate copiously with clean, fresh water for at least 10 minutes, holding the eyelids apart. In case of
eye irritation consult an ophthalmologist.
Following ingestion
Rinse mouth immediately and drink plenty of water. Call a physician immediately. In case of accident
or unwellness, seek medical advice immediately (show directions for use or safety data sheet if pos-
sible).

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Safety data sheet
according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU

o-Toluidine ≥99,5 %, p.a.

article number: 4788

4.2 Most important symptoms and effects, both acute and delayed

After eye contact: Irritation,

Following skin contact: Localised redness,
After ingestion: Irritation
4.3 Indication of any immediate medical attention and special treatment needed
none

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media

Co-ordinate fire-fighting measures to the fire surroundings
water spray, foam, dry extinguishing powder, carbon dioxide (CO2)
Unsuitable extinguishing media
water jet
5.2 Special hazards arising from the substance or mixture
Combustible. Vapours are heavier than air, spread along floors and form explosive mixtures with air.
Hazardous combustion products
In case of fire may be liberated: nitrogen oxides (NOx), carbon monoxide (CO), carbon dioxide (CO2)
5.3 Advice for firefighters
Do not allow firefighting water to enter drains or water courses. Fight fire with normal precautions
from a reasonable distance. Wear self-contained breathing apparatus.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

For non-emergency personnel

Wearing of suitable protective equipment (including personal protective equipment referred to un-
der Section 8 of the safety data sheet) to prevent any contamination of skin, eyes and personal cloth-
ing. Avoid contact with skin, eyes and clothes. Do not breathe vapour/spray.
6.2 Environmental precautions
Keep away from drains, surface and ground water. Retain contaminated washing water and dispose
of it.
6.3 Methods and material for containment and cleaning up
Advice on how to contain a spill
Covering of drains.
Advice on how to clean up a spill
Absorb with liquid-binding material (e.g. sand, diatomaceous earth, acid- or universal binding agents).

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Safety data sheet
according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU

o-Toluidine ≥99,5 %, p.a.

article number: 4788

Other information relating to spills and releases
Place in appropriate containers for disposal. Ventilate affected area.
6.4 Reference to other sections
Hazardous combustion products: see section 5. Personal protective equipment: see section 8. Incom-
patible materials: see section 10. Disposal considerations: see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling
Provision of sufficient ventilation. Use extractor hood (laboratory). Clear contaminated areas thor-
oughly.
• Measures to prevent fire as well as aerosol and dust generation

Keep away from sources of ignition - No smoking.

Advice on general occupational hygiene
When using do not eat or drink. Thorough skin-cleansing after handling the product.
7.2 Conditions for safe storage, including any incompatibilities
Keep container tightly closed.
Incompatible substances or mixtures
Observe hints for combined storage.
Consideration of other advice
Store locked up.
• Ventilation requirements
Use local and general ventilation.
• Specific designs for storage rooms or vessels
Recommended storage temperature: 15 – 25 °C.
7.3 Specific end use(s)
No information available.

SECTION 8: Exposure controls/personal protection

8.1 Control parameters
National limit values
Occupational exposure limit values (Workplace Exposure Limits)
Cou Name of agent CAS No Nota- Identifi- TWA TWA STEL STEL Source
ntry tion er [pp [mg/ [pp [mg/
m] m³] m] m³]

EU o-toluidine 95-53-4 IOELV 0,1 0,5 2017/2398/

EU

IE o-toluidine 95-53-4 OELV 0,2 0,9 S.I. No. 619

of 2001

Notation
STEL Short-term exposure limit: a limit value above which exposure should not occur and which is related to a 15-
minute period (unless otherwise specified)
TWA Time-weighted average (long-term exposure limit): measured or calculated in relation to a reference period of 8
hours time-weighted average (unless otherwise specified)

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Safety data sheet
according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU

o-Toluidine ≥99,5 %, p.a.

article number: 4788

Relevant DNELs/DMELs/PNECs and other threshold levels
• environmental values
Endpoint Threshold level Environmental compartment Exposure time

PNEC 0 mg/l freshwater short-term (single instance)

PNEC 0 mg/l marine water short-term (single instance)

PNEC 15,5 mg/l sewage treatment plant (STP) short-term (single instance)

PNEC 0,002 mg/kg freshwater sediment short-term (single instance)

PNEC 0 mg/kg marine sediment short-term (single instance)

PNEC 0 mg/kg soil short-term (single instance)

8.2 Exposure controls

Individual protection measures (personal protective equipment)
Eye/face protection

Use safety goggle with side protection.

Skin protection

• hand protection
Wear suitable gloves. Chemical protection gloves are suitable, which are tested according to EN 374.
For special purposes, it is recommended to check the resistance to chemicals of the protective gloves
mentioned above together with the supplier of these gloves. The times are approximate values from
measurements at 22 ° C and permanent contact. Increased temperatures due to heated substances,
body heat etc. and a reduction of the effective layer thickness by stretching can lead to a consider-
able reduction of the breakthrough time. If in doubt, contact manufacturer. At an approx. 1.5 times
larger / smaller layer thickness, the respective breakthrough time is doubled / halved. The data apply
only to the pure substance. When transferred to substance mixtures, they may only be considered as
a guide.
• type of material
FKM: fluoro-elastomer
• material thickness
>0,4 mm
• breakthrough times of the glove material
>480 minutes (permeation: level 6)
• other protection measures
Take recovery periods for skin regeneration. Preventive skin protection (barrier creams/ointments) is
recommended.

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Safety data sheet
according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU

o-Toluidine ≥99,5 %, p.a.

article number: 4788

Respiratory protection

Respiratory protection necessary at: Aerosol or mist formation. Type: A (against organic gases and va-
pours with a boiling point of > 65 °C , colour code: Brown).
Environmental exposure controls
Keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties
Appearance
Physical state liquid (fluid)
Colour colourless
Odour characteristic
Odour threshold No data available
Other physical and chemical parameters
pH (value) 7,4 (20 °C)
Melting point/freezing point -24,4 °C
Initial boiling point and boiling range 200,2 °C at 1.013 hPa
Flash point 85 °C at 1.013 hPa
Evaporation rate no data available
Flammability (solid, gas) not relevant (fluid)
Explosive limits
• lower explosion limit (LEL) 1,5 vol%
• upper explosion limit (UEL) 7,5 vol%
Explosion limits of dust clouds not relevant
Vapour pressure 47,6 Pa at 25 °C
Density 0,998 g/cm³ at 20 °C

Vapour density 3,7 (air = 1)

Bulk density Not applicable
Relative density Information on this property is not available.
Solubility(ies)
Water solubility 16,6 g/l at 20 °C

Partition coefficient
n-octanol/water (log KOW) 1,4 (pH value: 7,9, 24,5 °C) (ECHA)
Soil organic carbon/water (log KOC) 1,678 (ECHA)
Auto-ignition temperature 480 °C at 1 atm - ECHA

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Safety data sheet
according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU

o-Toluidine ≥99,5 %, p.a.

article number: 4788

Decomposition temperature no data available
Viscosity not determined
Explosive properties Shall not be classified as explosive
Oxidising properties none
9.2 Other information
Temperature class (EU, acc. to ATEX) T1 (Maximum permissible surface temperature
on the equipment: 450°C)

SECTION 10: Stability and reactivity

10.1 Reactivity
In case of warming: Vapours can form explosive mixtures with air.
10.2 Chemical stability
The material is stable under normal ambient and anticipated storage and handling conditions of tem-
perature and pressure.
10.3 Possibility of hazardous reactions
Violent reaction with: Mineral acids, Strong oxidiser
10.4 Conditions to avoid
There are no specific conditions known which have to be avoided.
10.5 Incompatible materials
different plastics
10.6 Hazardous decomposition products
Hazardous combustion products: see section 5.

SECTION 11: Toxicological information

11.1 Information on toxicological effects
Acute toxicity
Exposure route Endpoint Value Species Source

inhalation: vapour LC50 3,78 mg/l/4h rat

oral LD50 750 mg/kg rat ECHA

dermal LD50 3.250 mg/kg rabbit ECHA

Skin corrosion/irritation
Shall not be classified as corrosive/irritant to skin.
Serious eye damage/eye irritation
Causes serious eye irritation.
Respiratory or skin sensitisation
Shall not be classified as a respiratory or skin sensitiser.
Summary of evaluation of the CMR properties
Carcinogenicity:
May cause cancer

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Safety data sheet
according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU

o-Toluidine ≥99,5 %, p.a.

article number: 4788

• Specific target organ toxicity - single exposure
Shall not be classified as a specific target organ toxicant (single exposure).
• Specific target organ toxicity - repeated exposure
Shall not be classified as a specific target organ toxicant (repeated exposure).
Aspiration hazard
Shall not be classified as presenting an aspiration hazard.

Symptoms related to the physical, chemical and toxicological characteristics

• If swallowed
renal impairment
• If in eyes
Irritating to eyes
• If inhaled
cough, pain, choking, and breathing difficulties, irritant effects
• If on skin
Irritating to skin
Other information
None

SECTION 12: Ecological information

12.1 Toxicity
Toxic to aquatic life with long lasting effects.
Aquatic toxicity (acute)
Very toxic to aquatic organisms.
Endpoint Value Species Source Exposure
time

LC50 0,52 mg/l aquatic invertebrates ECHA 48 h

EC50 30,9 mg/l algae ECHA 72 h

ErC50 110,5 mg/l algae ECHA 72 h

Aquatic toxicity (chronic)

May cause long-term adverse effects in the aquatic environment.
Endpoint Value Species Source Exposure
time

LC50 81,3 mg/l fish ECHA 14 d

EC50 0,066 mg/l aquatic invertebrates ECHA 21 d

NOEC 0,013 mg/l aquatic invertebrates ECHA 21 d

LOEC 0,04 mg/l aquatic invertebrates ECHA 21 d

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Safety data sheet
according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU

o-Toluidine ≥99,5 %, p.a.

article number: 4788

12.2 Process of degradability
The substance is readily biodegradable.
Theoretical Oxygen Demand with nitrification: 3,061 mg/mg
Theoretical Oxygen Demand: 2,538 mg/mg
Theoretical Carbon Dioxide: 2,875 mg/mg
Process Degradation rate Time

biotic/abiotic 88 – 90 % 28 d

DOC removal 88 – 90 % 28 d

12.3 Bioaccumulative potential

Does not significantly accumulate in organisms.
n-octanol/water (log KOW) 1,4 (pH value: 7,9, 24,5 °C)
BCF <1,3 (ECHA)
12.4 Mobility in soil
The Organic Carbon normalised adsorption 1,678
coefficient
12.5 Results of PBT and vPvB assessment
Data are not available.
12.6 Other adverse effects
Data are not available.

SECTION 13: Disposal considerations

13.1 Waste treatment methods

This material and its container must be disposed of as hazardous waste. Dispose of contents/contain-
er in accordance with local/regional/national/international regulations.
Sewage disposal-relevant information
Do not empty into drains. Avoid release to the environment. Refer to special instructions/safety data
sheets.
Waste treatment of containers/packagings
It is a dangerous waste; only packagings which are approved (e.g. acc. to ADR) may be used.
Sewage disposal-relevant information
Do not empty into drains. Avoid release to the environment. Refer to special instructions/safety data
sheets.
Waste treatment of containers/packagings
It is a dangerous waste; only packagings which are approved (e.g. acc. to ADR) may be used.
13.2 Relevant provisions relating to waste
The allocation of waste identity numbers/waste descriptions must be carried out according to the
EEC, specific to the industry and process.

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Safety data sheet
according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU

o-Toluidine ≥99,5 %, p.a.

article number: 4788

13.3 Remarks
Waste shall be separated into the categories that can be handled separately by the local or national
waste management facilities. Please consider the relevant national or regional provisions.

SECTION 14: Transport information

14.1 UN number 1708
14.2 UN proper shipping name TOLUIDINES, LIQUID
Hazardous ingredients o-Toluidine
14.3 Transport hazard class(es)

Class 6.1 (toxic substances)

14.4 Packing group II (substance presenting medium danger)
14.5 Environmental hazards hazardous to the aquatic environment
14.6 Special precautions for user
Provisions for dangerous goods (ADR) should be complied within the premises.
14.7 Transport in bulk according to Annex II of MARPOL and the IBC Code
The cargo is not intended to be carried in bulk.
14.8 Information for each of the UN Model Regulations
• Transport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN)
UN number 1708
Proper shipping name TOLUIDINES, LIQUID
Particulars in the transport document UN1708, TOLUIDINES, LIQUID, 6.1, II, (D/E), envir-
onmentally hazardous
Class 6.1
Classification code T1
Packing group II
Danger label(s) 6.1 + "fish and tree"

Environmental hazards yes (hazardous to the aquatic environment)

Special provisions (SP) 279, 802(ADN)
Excepted quantities (EQ) E4
Limited quantities (LQ) 100 ml
Transport category (TC) 2
Tunnel restriction code (TRC) D/E
Hazard identification No 60

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Safety data sheet
according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU

o-Toluidine ≥99,5 %, p.a.

article number: 4788

• International Maritime Dangerous Goods Code (IMDG)
UN number 1708
Proper shipping name TOLUIDINES, LIQUID
Particulars in the shipper's declaration UN1708, TOLUIDINES, LIQUID, 6.1, II, MARINE
POLLUTANT
Class 6.1
Marine pollutant yes (P) (hazardous to the aquatic environment)
Packing group II
Danger label(s) 6.1 + "fish and tree"

Special provisions (SP) 279

Excepted quantities (EQ) E4
Limited quantities (LQ) 100 mL
EmS F-A, S-A
Stowage category A
• International Civil Aviation Organization (ICAO-IATA/DGR)
UN number 1708
Proper shipping name Toluidines, liquid
Particulars in the shipper's declaration UN1708, Toluidines, liquid, 6.1, II
Class 6.1
Environmental hazards yes (hazardous to the aquatic environment)
Packing group II
Danger label(s) 6.1

Special provisions (SP) A113

Excepted quantities (EQ) E4
Limited quantities (LQ) 1L

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Safety data sheet
according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU

o-Toluidine ≥99,5 %, p.a.

article number: 4788

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
Relevant provisions of the European Union (EU)
• Regulation 649/2012/EU concerning the export and import of hazardous chemicals (PIC)
Not listed.
• Regulation 1005/2009/EC on substances that deplete the ozone layer (ODS)
Not listed.
• Regulation 850/2004/EC on persistent organic pollutants (POP)
Not listed.
• Restrictions according to REACH, Annex XVII
Name of substance CAS No Wt% Type of registration Conditions No
of restric-
tion

o-Toluidine 100 1907/2006/EC annex R3 3

XVII

o-Toluidine 100 1907/2006/EC annex R28-30 28

XVII

Legend
R28-30 1. Shall not be placed on the market, or used,
- as substances,
- as constituents of other substances, or,
- in mixtures,
for supply to the general public when the individual concentration in the substance or mixture is equal to or great-
er than:
- either the relevant specific concentration limit specified in Part 3 of Annex VI to Regulation (EC) No 1272/2008, or,
- the relevant concentration specified in Directive 1999/45/EC where no specific concentration limit is set out in
Part 3 of Annex VI to Regulation (EC) No 1272/2008.
Without prejudice to the implementation of other Community provisions relating to the classification, packaging
and labelling of substances and mixtures, suppliers shall ensure before the placing on the market that the pack-
aging of such substances and mixtures is marked visibly, legibly and indelibly as follows:
‘Restricted to professional users’.
2. By way of derogation, paragraph 1 shall not apply to:
(a) medicinal or veterinary products as defined by Directive 2001/82/EC and Directive 2001/83/EC;
(b) cosmetic products as defined by Directive 76/768/EEC;
(c) the following fuels and oil products:
- motor fuels which are covered by Directive 98/70/EC,
- mineral oil products intended for use as fuel in mobile or fixed combustion plants,
- fuels sold in closed systems (e.g. liquid gas bottles);
(d) artists’ paints covered by Directive 1999/45/EC;
(e) the substances listed in Appendix 11, column 1, for the applications or uses listed in Appendix 11, column 2.
Where a date is specified in column 2 of Appendix 11, the derogation shall apply until the said date.

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Safety data sheet
according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU

o-Toluidine ≥99,5 %, p.a.

article number: 4788

Legend
R3 1. Shall not be used in:
- ornamental articles intended to produce light or colour effects by means of different phases, for example in or-
namental lamps and ashtrays,
- tricks and jokes,
- games for one or more participants, or any article intended to be used as such, even with ornamental aspects,
2. Articles not complying with paragraph 1 shall not be placed on the market.
3. Shall not be placed on the market if they contain a colouring agent, unless required for fiscal reasons, or per-
fume, or both, if they:
- can be used as fuel in decorative oil lamps for supply to the general public, and,
- present an aspiration hazard and are labelled with R65 or H304,
4. Decorative oil lamps for supply to the general public shall not be placed on the market unless they conform to
the European Standard on Decorative oil lamps (EN 14059) adopted by the European Committee for Standardisa-
tion (CEN).
5. Without prejudice to the implementation of other Community provisions relating to the classification, pack-
aging and labelling of dangerous substances and mixtures, suppliers shall ensure, before the placing on the mar-
ket, that the following requirements are met:
(a) lamp oils, labelled with R65 or H304, intended for supply to the general public are visibly, legibly and indelibly
marked as follows: ‘Keep lamps filled with this liquid out of the reach of children’; and, by 1 December 2010, ‘Just a
sip of lamp oil - or even sucking the wick of lamps - may lead to life-threatening lung damage’;
(b) grill lighter fluids, labelled with R65 or H304, intended for supply to the general public are legibly and indelibly
marked by 1 December 2010 as follows: ‘Just a sip of grill lighter may lead to life threatening lung damage’;
(c) lamp oils and grill lighters, labelled with R65 or H304, intended for supply to the general public are packaged in
black opaque containers not exceeding 1 litre by 1 December 2010.
6. No later than 1 June 2014, the Commission shall request the European Chemicals Agency to prepare a dossier,
in accordance with Article 69 of the present Regulation with a view to ban, if appropriate, grill lighter fluids and
fuel for decorative lamps, labelled R65 or H304, intended for supply to the general public.
7. Natural or legal persons placing on the market for the first time lamp oils and grill lighter fluids, labelled with
R65 or H304, shall by 1 December 2011, and annually thereafter, provide data on alternatives to lamp oils and grill
lighter fluids labelled R65 or H304 to the competent authority in the Member State concerned. Member States
shall make those data available to the Commission.

• Restrictions according to REACH, Title VIII

None.
• List of substances subject to authorisation (REACH, Annex XIV)/SVHC - candidate list

Substance of Very High Concern (SVHC)

Name acc. to inventory CAS No Listed in Remarks

o-toluidine 95-53-4 Candidate list Carc. A57a

Legend
candidate list Substances meeting the criteria referred to in Article 57 and for eventual inclusion in Annex XIV
Carc. A57a Carcinogenic (article 57a)

• Seveso Directive

2012/18/EU (Seveso III)

No Dangerous substance/hazard categories Qualifying quantity (tonnes) for the ap- Notes
plication of lower and upper-tier re-
quirements

H2 acute toxic (cat. 2 + cat. 3, inhal.) 50 200 41)

Notation
41) - Category 2, all exposure routes
- category 3, inhalation exposure route

• Directive 75/324/EEC relating to aerosol dispensers

Filling batch
Deco-Paint Directive (2004/42/EC)
VOC content 100 %
998 g/l

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Safety data sheet
according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU

o-Toluidine ≥99,5 %, p.a.

article number: 4788

Directive on industrial emissions (VOCs, 2010/75/EU)
VOC content 100 %

VOC content 998 g/l

Directive 2011/65/EU on the restriction of the use of certain hazardous substances in electrical
and electronic equipment (RoHS) - Annex II
not listed
Regulation 166/2006/EC concerning the establishment of a European Pollutant Release and
Transfer Register (PRTR)
not listed
Directive 2000/60/EC establishing a framework for Community action in the field of water policy
(WFD)
not listed
Regulation 98/2013/EU on the marketing and use of explosives precursors
not listed
Regulation 111/2005/EC laying down rules for the monitoring of trade between the Community
and third countries in drug precursors
not listed

National inventories
Substance is listed in the following national inventories:
Country National inventories Status

AU AICS substance is listed

CA DSL substance is listed

CN IECSC substance is listed

EU ECSI substance is listed

EU REACH Reg. substance is listed

JP CSCL-ENCS substance is listed

JP ISHA-ENCS substance is listed

KR KECI substance is listed

MX INSQ substance is listed

NZ NZIoC substance is listed

PH PICCS substance is listed

TW TCSI substance is listed

US TSCA substance is listed

Legend
AICS Australian Inventory of Chemical Substances
CSCL-ENCS List of Existing and New Chemical Substances (CSCL-ENCS)
DSL Domestic Substances List (DSL)
ECSI EC Substance Inventory (EINECS, ELINCS, NLP)
IECSC Inventory of Existing Chemical Substances Produced or Imported in China
INSQ National Inventory of Chemical Substances
ISHA-ENCS Inventory of Existing and New Chemical Substances (ISHA-ENCS)
KECI Korea Existing Chemicals Inventory
NZIoC New Zealand Inventory of Chemicals
PICCS Philippine Inventory of Chemicals and Chemical Substances
REACH Reg. REACH registered substances

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according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU

o-Toluidine ≥99,5 %, p.a.

article number: 4788

Legend
TCSI Taiwan Chemical Substance Inventory
TSCA Toxic Substance Control Act

15.2 Chemical Safety Assessment

No Chemical Safety Assessment has been carried out for this substance.

SECTION 16: Other information

Abbreviations and acronyms
Abbr. Descriptions of used abbreviations

2017/2398/ Directive of the European Parliament and of the Council amending Directive 2004/37/EC on the protection
EU of workers from the risks related to exposure to carcinogens or mutagens at work

ADN Accord européen relatif au transport international des marchandises dangereuses par voies de navigation
intérieures (European Agreement concerning the International Carriage of Dangerous Goods by Inland Wa-
terways)

ADR Accord européen relatif au transport international des marchandises dangereuses par route (European
Agreement concerning the International Carriage of Dangerous Goods by Road)

BCF bioconcentration factor

Carc. carcinogenicity

CAS Chemical Abstracts Service (service that maintains the most comprehensive list of chemical substances)

CLP Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures

CMR Carcinogenic, Mutagenic or toxic for Reproduction

DGR Dangerous Goods Regulations (see IATA/DGR)

DMEL Derived Minimal Effect Level

DNEL Derived No-Effect Level

EC50 Effective Concentration 50 %. The EC50 corresponds to the concentration of a tested substance causing 50
% changes in response (e.g. on growth) during a specified time interval

EINECS European Inventory of Existing Commercial Chemical Substances

ELINCS European List of Notified Chemical Substances

EmS Emergency Schedule

ErC50 ≡ EC50: in this method, that concentration of test substance which results in a 50 % reduction in either
growth (EbC50) or growth rate (ErC50) relative to the control

GHS "Globally Harmonized System of Classification and Labelling of Chemicals" developed by the United Nations

IATA International Air Transport Association

IATA/DGR Dangerous Goods Regulations (DGR) for the air transport (IATA)

ICAO International Civil Aviation Organization

IMDG International Maritime Dangerous Goods Code

index No the Index number is the identification code given to the substance in Part 3 of Annex VI to Regulation (EC)
No 1272/2008

IOELV indicative occupational exposure limit value

LC50 Lethal Concentration 50%: the LC50 corresponds to the concentration of a tested substance causing 50 %
lethality during a specified time interval

LD50 Lethal Dose 50 %: the LD50 corresponds to the dose of a tested substance causing 50 % lethality during a
specified time interval

LOEC Lowest Observed Effect Concentration

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Safety data sheet
according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU

o-Toluidine ≥99,5 %, p.a.

article number: 4788

Abbr. Descriptions of used abbreviations

MARPOL International Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NLP No-Longer Polymer

NOEC No Observed Effect Concentration

PBT Persistent, Bioaccumulative and Toxic

PNEC Predicted No-Effect Concentration

ppm parts per million

REACH Registration, Evaluation, Authorisation and Restriction of Chemicals

RID Règlement concernant le transport International ferroviaire des marchandises Dangereuses (Regulations
concerning the International carriage of Dangerous goods by Rail)

S.I. No. 619 of Safety, Health and Welfare at Work (Chemical Agents) Regulations 2001
2001

STEL short-term exposure limit

SVHC Substance of Very High Concern

TWA time-weighted average

VOC Volatile Organic Compounds

vPvB very Persistent and very Bioaccumulative

Key literature references and sources for data

- Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU
- Regulation (EC) No. 1272/2008 (CLP, EU GHS)
- Dangerous Goods Regulations (DGR) for the air transport (IATA)
- International Maritime Dangerous Goods Code (IMDG)

List of relevant phrases (code and full text as stated in chapter 2 and 3)
Code Text

H301 toxic if swallowed

H319 causes serious eye irritation

H331 toxic if inhaled

H350 may cause cancer

H400 very toxic to aquatic life

H411 toxic to aquatic life with long lasting effects

Disclaimer
The above information describes exclusively the safety requirements of the product and is based on
our present-day knowledge. The information is intended to give you advice about the safe handling of
the product named in this safety data sheet, for storage, processing, transport and disposal. The in-
formation cannot be transferred to other products. In the case of mixing the product with other
products or in the case of processing, the information on this safety data sheet is not necessarily val-
id for the new made-up material.

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