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Bioanalysis is a sub-discipline of analytical chemistry covering the quantitative
measurement drugs and their metabolites in biological systems. Bioanalysis in the
pharmaceutical industry is to provide a quantitative measure of the active drug and/or its metabolite(s) for the purpose of pharmacokinetics, toxicokinetics, bioequivalence and exposure–response (pharmacokinetics /pharmacodynamics studies). Bioanalysis also applies to drugs used for illicit purposes, forensic investigations, anti-doping testing in sports, and environmental concerns. Bioanalytical assays to accurately and reliably determine these drugs at lower concentrations. This has driven improvements in technology and analytical methods. Some techniques commonly used in bioanalytical studies include:
The principle objectives of sample preparation from biological matrix are :
1. Isolation of the analytes of interest from the interfering compounds
2. Dissolution of the analytes in a suitable solvent and pre- concentration Bioanalysis is a sub-discipline of analytical chemistry covering the quantitative measurement drugs and their metabolites in biological systems. Bioanalysis in the pharmaceutical industry is to provide a quantitative measure of the active drug and/or its metabolite(s) for the purpose of pharmacokinetics, toxicokinetics, bioequivalence and exposure–response (pharmacokinetics /pharmacodynamics studies). Bioanalysis also applies to drugs used for illicit purposes, forensic investigations, anti-doping testing in sports, and environmental concerns. Bioanalytical assays to accurately and reliably determine these drugs at lower concentrations. This has driven improvements in technology and analytical methods. Some techniques commonly used in bioanalytical studies include:
